Publications list for Emeritus Professor Graham Johnston

2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Chebib, M., Johnston, G., Allan, R. (2013), γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry. 56(13), 5626-5630. [Abstract]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Chebib, M. (2013), Potency of GABA at human recombinant GABA (A) alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids. 44(4), 1139-1149. [Abstract]
  • Johnston, G. (2013), Advantages of an antagonist: bicuculline and other gaba antagonists. British Journal of Pharmacology. 169(2), 328-336. [Abstract]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Collins, M., Hanrahan, J. (2013), Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. ACS Medicinal Chemistry Letters. 4(4), 402-407.


  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Chebib, M., Johnston, G., Duke, R. (2012), Mixed antagonistic effects of the ginkgolides at recombinant human ρ(1)GABA(C) receptors. Neuropharmacology. 63(6), 1127-1139. [Abstract]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Chebib, M. (2012), Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABA(C) ρ(1) Receptors. ACS Chemical Neuroscience. 3(9), 665-673. [Abstract]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Chebib, M. (2012), Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology. 84(4), 549-557. [Abstract]
  • Thompson, A., McGonigle, I., Duke, R., Johnston, G., Lummis, S. (2012), A single amino acid determines the toxicity of Ginkgo biloba extracts. The FASEB Journal. 26(5), 1884-1891. [Abstract]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012), Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the ρ1 Receptor. ACS Chemical Neuroscience. 3(4), 293–301.
  • Fernandez, S., Karim, N., Mewett, K., Chebib, M., Johnston, G., Hanrahan, J. (2012), Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors. British Journal of Pharmacology. 165(4), 965-977. [Abstract]
  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, M., Chebib, M. (2012), 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British journal of pharmacology. 165(4), 880-96. [Abstract]


  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Chebib, M. (2011), 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. Biochemical pharmacology. 82(12), 1971-83. [Abstract]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Chebib, M. (2011), Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABA(A) Receptors. ChemMedChem. 6(8), 1340-6, 1317. [Abstract]
  • Yamamoto, I., Deniau, G., Gavande, N., Chebib, M., Johnston, G., O'Hagan, D. (2011), Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical communications (Cambridge, England). 47(28), 7956-8. [Abstract]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Chebib, M. (2011), Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British journal of pharmacology. 163(5), 1017-33. [Abstract]
  • Hanrahan, J., Chebib, M., Johnston, G. (2011), Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology. 163(2), 234-245. [Abstract]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Chebib, M. (2011), Medicinal chemistry of ρ GABAC receptors. Future Medicinal Chemistry. 3(2), 197-209. [Abstract]
  • Thompson, A., Jarvis, G., Duke, R., Johnston, G., Lummis, S. (2011), Ginkgolide B and bilobalide block the pore of the 5-HT?receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 60(2-3), 488-495. [Abstract]


  • Johnston, G., Chebib, M., Hanrahan, J., Mewett, K. (2010), Neurochemicals for the Investigation of GABA(C) Receptors. Neurochemical research. 35(12), 1970-7. [Abstract]
  • Gavande, N., Johnston, G., Hanrahan, J., Chebib, M. (2010), Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). Organic & biomolecular chemistry. 8(18), 4131-6. [Abstract]
  • Skilbeck, K., Johnston, G., Hinton, T. (2010), Stress and GABA(A) Receptors. Journal of neurochemistry. 112(5), 1115-30. [Abstract]


  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Chebib, M., Johnston, G., Hanrahan, J. (2009), Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic & Medicinal Chemistry. 17(20), 7156-7173. [Abstract]
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Chebib, M. (2009), The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice. Neurochemical research. 34(10), 1867-75. [Abstract]
  • Chebib, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009), Guanidino Acids Act as rho1 GABA(C) Receptor Antagonists. Neurochemical research. 34(10), 1704-11. [Abstract]
  • Locock, K., Johnston, G., Allan, R. (2009), GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid. Neurochemical research. 34(0), 1698-703. [Abstract]
  • Chebib, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009), Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. The Journal of pharmacology and experimental therapeutics. 328(0), 448-57. [Abstract]
  • Hanrahan, J., Johnston, G. (2009), Synthesis of gamma-aminobutyric acid analogs. In: Amino Acids, Peptides and Proteins in Organic Chemistry. Volume 1 - Origins and Synthesis of Amino Acids. (pp.573-689).Germany: Wiley-VCH.


  • Fernandez, S., Mewett, K., Hanrahan, J., Chebib, M., Johnston, G. (2008), Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology. 55(5), 900-7. [Abstract]
  • Kumar, R., Chebib, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008), Novel gamma-Aminobutyric Acid rho1 Receptor Antagonists; Synthesis, Pharmacological Activity and Structure-Activity Relationships. Journal of medicinal chemistry. 51(13), 3825-40. [Abstract]
  • Skilbeck, K., Hinton, T., Johnston, G. (2008), Sex-differences and stress: effects on regional high and low affinity [3H]GABA binding. Neurochemistry International. 52(6), 1212-1219. [Abstract]
  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Chebib, M. (2008), A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology & Drug Design. 71(4), 306-327. [Abstract]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2008), Antipsychotic drug administration differentially affects [(3)H]muscimol and [(3)H]flunitrazepam GABA(A) receptor binding sites. Progress in neuro-psychopharmacology & biological psychiatry. 32(0), 492-8. [Abstract]
  • Carland, J., Johnston, G., Chebib, M. (2008), Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European journal of pharmacology. 580(1-2), 27-35. [Abstract]
  • Hinton, T., Chebib, M., Johnston, G. (2008), Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic & medicinal chemistry letters. 18(1), 402-4. [Abstract]
  • Hinton, T., Johnston, G. (2008), The role of GABA-A receptors in schizophrenia. Cell Science Reviews. 5, 180-194.