Publications list for Honorary Associate Professor Lars Ittner

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Delerue, F., White, M., Ittner, L. (2014), Inducible, tightly regulated and non-leaky neuronal gene expression in mice. Transgenic Research. 23(2), 225-233. [Abstract]

2013

   
  • Nilsen, L., Rae, C., Ittner, L., Götz, J., Sonnewald, U. (2013), Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of Cerebral Blood Flow and Metabolism. 33(5), 684-691. [Abstract]
  • Ong, W., Tanaka, K., Dawe, G., Ittner, L., Farooqui, A. (2013), Slow excitotoxicity in Alzheimer's disease. Journal of Alzheimer's Disease. 35(4), 643-668. [Abstract]

2012

   
  • Scarf, A., Luus, C., Da Pozzo, E., Selleri, S., Guarino, C., Martini, C., Ittner, L., Kassiou, M. (2012), Evidence for Complex Binding Profiles and Species Differences at the Translocator Protein (TSPO) (18 kDa). Current Molecular Medicine. 12(4), 488-493. [Abstract]
  • Schonrock, N., Matamales, M., Ittner, L., Götz, J. (2012), MicroRNA networks surrounding APP and amyloid-β metabolism-implications for Alzheimer's disease. Experimental Neurology. 235(2), 447-454. [Abstract]
  • Götz, J., Ittner, A., Ittner, L. (2012), Tau-targeted treatment strategies in Alzheimer's disease. British Journal of Pharmacology. 165(5), 1246-1259. [Abstract]
  • Rosenmann, H., Blum, D., Kayed, R., Ittner, L. (2012), Tau protein: function and pathology. International Journal of Alzheimer's Disease. 2012, 707482. [Abstract]
  • Ke, Y., Suchowerska, A., van der Hoven, J., De Silva, D., Wu, C., van Eersel, J., Ittner, A., Ittner, L. (2012), Lessons from tau-deficient mice. International Journal of Alzheimer's Disease. 2012, 873270. [Abstract]
  • Ke, Y., Dramiga, J., Sch��tz, U., Kril, J., Ittner, L., Schr��der, H., G��tz, J. (2012), Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease. PLoS One. 7(4), e35678. [Abstract]
  • Goetz, J., Matamales, M., Goetz, N., Ittner, L., Eckert, A. (2012), Alzheimer's disease models and functional genomics-How many needles are there in the haystack?. Frontiers in Physiology. 3, 320. [Abstract]

2011

   
  • Götz, J., Eckert, A., Matamales, M., Ittner, L., Liu, X. (2011), Modes of Aβ toxicity in Alzheimer's disease. Cellular and molecular life sciences : CMLS. 68(20), 3359-75. [Abstract]
  • Ittner, A., Ke, Y., Eersel, J., Gladbach, A., Götz, J., Ittner, L. (2011), Brief update on different roles of tau in neurodegeneration. IUBMB Life. 63(7), 495-502. [Abstract]
  • Ittner, L., Götz, J. (2011), Amyloid-β and tau - a toxic pas de deux in Alzheimer's disease. Nature reviews. Neuroscience. 12(2), 65-72. [Abstract]
  • Bi, M., Ittner, A., Ke, Y., Götz, J., Ittner, L. (2011), Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice. PLoS One. 6(12), e26860. [Abstract]
  • Gotz, J., Ittner, L., Gotz, N., Lam, H., Nicholas, H. (2011), Invertebrate and Vertebrate Models of Tauopathies. In: Animal Models for Neurodegenerative Disease. (pp.69-85).Cambridge: RSC Publishing.
  • van Eersel, J., Ke, Y., Gladbach, A., Bi, M., Götz, J., Kril, J., Ittner, L. (2011), Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons. PloS One. 6(7), e22850. [Abstract]
  • Lim, Y., Grimm, A., Giese, M., Mensah-Nyagan, A., Villafranca, J., Ittner, L., Eckert, A., Götz, J. (2011), Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One. 6(12), e28887. [Abstract]
  • Liu, X., Dobbie, M., Tunningley, R., Whittle, B., Zhang, Y., Ittner, L., Götz, J. (2011), ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice. Journal of Biomedicine & Biotechnology. 2011, 130947. [Abstract]

2010

   
  • Götz, J., Gladbach, A., Pennanen, L., van Eersel, J., Schild, A., David, D., Ittner, L. (2010), Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta. 1802(10), 860-871. [Abstract]
  • Ittner, L., Ke, Y., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B., Christie, M., Napier, I., Eckert, A., Staufenbiel, M., Hardeman, E., Götz, J. (2010), Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell. 142(3), 387-397. [Abstract]
  • van Eersel, J., Ke, Y., Liu, X., Delerue, F., Kril, J., Götz, J., Ittner, L. (2010), Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America. 107(31), 13888-13893. [Abstract]
  • Krupka, N., Strappe, P., Götz, J., Ittner, L. (2010), Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid. 63(3), 155-160. [Abstract]
  • Lim, Y., Rhein, V., Baysang, G., Meier, F., Poljak, A., J Raftery, M., Guilhaus, M., Ittner, L., Eckert, A., Götz, J. (2010), Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics. 10(8), 1621-33. [Abstract]
  • Götz, J., Lim, Y., Ke, Y., Eckert, A., Ittner, L. (2010), Dissecting toxicity of tau and beta-amyloid. Neurodegenerative Diseases. 7(1-3), 10-12. [Abstract]
  • Schonrock, N., Ke, Y., Humphreys, D., Staufenbiel, M., Ittner, L., Preiss, T., Götz, J. (2010), Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-beta. PLoS One. 5(6), e11070. [Abstract]

2009

   
  • Rhein, V., Song, X., Wiesner, A., Ittner, L., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., Savaskan, E., Czech, C., Götz, J., Eckert, A. (2009), Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America. 106(47), 20057-20062. [Abstract]
  • van Eersel, J., Bi, M., Ke, Y., Hodges, J., Xuereb, J., Gregory, G., Halliday, G., Götz, J., Kril, J., Ittner, L. (2009), Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of Neural Transmission. 116(10), 1243-1251. [Abstract]
  • Ittner, L., Ke, Y., Gotz, J. (2009), Phosphorylated tau interacts with c-JUN N-terminal kinase (JNK) interacting protein 1 (JIP1) in Alzheimer's disease. The Journal of biological chemistry. 284(31), 20909-16. [Abstract]
  • G��tz, J., Ittner, L., Lim, Y. (2009), Response to the comment 'Iron, type 2 diabetes mellitus, and Alzheimer's disease' to our Visions and Reflections article 'Common features between diabetes mellitus and Alzheimer's disease'. Cellular and Molecular Life Sciences. 66(17), 2945. [Abstract]
  • Götz, J., Ittner, L., Lim, Y. (2009), Common features between diabetes mellitus and Alzheimer's disease. Cellular and molecular life sciences. 66(8), 1321-1325. [Abstract]
  • Scarf, A., Ittner, L., Kassiou, M. (2009), The translocator protein (18 kDa): central nervous system disease and drug design. Journal of Medicinal Chemistry. 52(3), 581-592. [Abstract]
  • Deters, N., Ittner, L., Götz, J. (2009), Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and biophysical research communications. 379(2), 400-405. [Abstract]
  • Ke, Y., Delerue, F., Gladbach, A., Götz, J., Ittner, L. (2009), Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease. PLoS One. 4(11), e7917. [Abstract]
  • Fath, T., Ke, Y., Gunning, P., Götz, J., Ittner, L. (2009), Primary support cultures of hippocampal and substantia nigra neurons. Nature protocols. 4(1), 78-85. [Abstract]
  • Götz, J., Schonrock, N., Vissel, B., Ittner, L. (2009), Alzheimer's Disease Selective Vulnerability and Modelling in Transgenic Mice. Journal of Alzheimer's disease : JAD. 18(2), 243-51. [Abstract]

2008

   
  • Götz, J., Ittner, L., Schonrock, N., Cappai, R. (2008), An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatric disease and treatment. 4(6), 1033-1042. [Abstract]
  • Ittner, L., Fath, T., Ke, Y., Bi, M., van Eersel, J., Li, K., Gunning, P., Götz, J. (2008), Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 105(41), 15997-6002. [Abstract]
  • Götz, J., Ittner, L., Fändrich, M., Schonrock, N. (2008), Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?. Journal of Alzheimer's disease. 14(4), 423-9. [Abstract]
  • Deters, N., Ittner, L., Götz, J. (2008), Divergent phosphorylation pattern of tau in P301L tau transgenic mice. The European Journal of Neuroscience. 28(1), 137-147. [Abstract]
  • Götz, J., Ittner, L. (2008), Animal models of Alzheimer's disease and frontotemporal dementia. Nature Reviews. Neuroscience. 9(7), 532-544. [Abstract]
  • Lim, Y., Ittner, L., Lim, Y., Götz, J. (2008), Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS letters. 582(15), 2188-94. [Abstract]
  • Falk, S., Wurdak, H., Ittner, L., Ille, F., Sumara, G., Schmid, M., Draganova, K., Lang, K., Paratore, C., Leveen, P., Suter, U., Karlsson, S., Born, W., Ricci, R., Götz, M., Sommer, L. (2008), Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell. 2(5), 472-483. [Abstract]
  • Ittner, L., Schwerdtfeger, K., Kunz, T., Muff, R., Husmann, K., Grimm, C., Hafezi, F., Lang, K., Kurrer, M., Götz, J., Born, W., Fischer, J. (2008), Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clinical science. 114(1), 49-58. [Abstract]
  • Götz, J., David, D., Hoerndli, F., Ke, Y., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y., Deters, N., Ittner, L. (2008), Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neuro-Degenerative Diseases. 5(3-4), 179-181. [Abstract]