Publications list for Associate Professor Paul Witting

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • Talib, J., Kwan, J., Suryo Rahmanto, A., Witting, P., Davies, M. (2014), The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction. The Biochemical Journal. 457(1), 89-97. [Abstract]


  • Freewan, M., Rees, M., Sempertegui Plaza, T., Glaros, E., Lim, Y., Wang, X., Yeung, A., Witting, P., Terentis, A., Thomas, S. (2013), Human Indoleamine 2,3-Dioxygenase is a Catalyst of Physiological Heme Peroxidase Reactions - Implications for the Inhibition of Dioxygenase Activity by Hydrogen Peroxide. Journal of Biological Chemistry. 288(3), 1548-1567. [Abstract]
  • McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013), Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica. 50(4), 645-649. [Abstract]
  • Shanu, A., Groebler, L., Kim, H., Wood, S., Weekly, C., Aitken, J., Harris, H., Witting, P. (2013), Selenium inhibits renal oxidation and inflammation but not acute kidney injury in an animal model of rhabdomyolysis. Antioxidants & Redox Signaling. 18(7), 756-769. [Abstract]
  • Cai, X., Freedman, S., Witting, P. (2013), Serum amyloid A stimulates cultured endothelial cells to migrate and proliferate: inhibition by the multi-kinase inhibitor BIBF1120. Clinical and Experimental Pharmacology & Physiology. 40(9), 662-670. [Abstract]
  • Weekley, C., Aitken, J., Finney, L., Vogt, S., Witting, P., Harris, H. (2013), Selenium metabolism in cancer cells: the combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems. Nutrients. 5(5), 1734-1756. [Abstract]
  • Hua, S., Yao, M., Vignarajan, S., Witting, P., Hejazi, L., Gong, Z., Teng, Y., Niknami, M., Assinder, S., Richardson, D., Dong, Q. (2013), Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochimica et Biophysica Acta. 1831(6), 1146-1157. [Abstract]
  • Sutherland, G., Chami, B., Youssef, P., Witting, P. (2013), Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product?. Redox Report. 18(4), 134-141. [Abstract]
  • Wang, X., Cai, X., Freedman, B., Witting, P. (2013), Role of SAA in Promoting Endothelial Activation: Inhibition by High-Density Lipoprotein. In: Acute Phase Proteins. (pp.77-102).Croatia: InTech.
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Khachigian, L., Bhindi, R. (2013), Selective inhibition of the master regulator transcription factor egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction. Journal of the American Heart Association. 2(4), e000023. [Abstract]


  • Ding, A., Kalaignanasundaram, P., Ricardo, S., Abdelkader, A., Witting, P., Broughton, B., Kim, H., Wyse, B., Phillips, J., Evans, R. (2012), Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Clinical and Experimental Pharmacology & Physiology. 39(11), 917-929. [Abstract]
  • Groebler, L., Wang, X., Kim, H., Shanu, A., Hossain, F., McMahon, A., Witting, P. (2012), Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis. Free Radical Biology & Medicine. 52(9), 1918-1928. [Abstract]
  • Aitken, J., Lay, P., Duong, T., Aran, R., Witting, P., Harris, H., Lai, B., Vogt, S., Giles, G. (2012), Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen. Journal of Biological Inorganic Chemistry. 17(4), 589-598. [Abstract]


  • Weekley, C., Aitken, J., Vogt, S., Finney, L., Paterson, D., de Jonge, M., Howard, D., Witting, P., Musgrave, I., Harris, H. (2011), Metabolism of Selenite in Human Lung Cancer Cells: X-Ray Absorption and Fluorescence Studies. Journal of the American Chemical Society. 133(45), 18272-9. [Abstract]
  • Witting, P., Song, C., Hsu, K., Hua, S., Parry, S., Aran, R., Geczy, C., Freedman, S. (2011), The acute-phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein. Free radical biology & medicine. 51(7), 1390-8. [Abstract]
  • Kim, H., Shanu, A., Wood, S., Parry, S., Collet, M., McMahon, A., Witting, P. (2011), Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free radical research. 45(9), 1000-12. [Abstract]
  • Dong, L., Jameson, V., Tilly, D., Prochazka, L., Rohlena, J., Valis, K., Truksa, J., Zobalova, R., Mahdavian, E., Kluckova, K., Stantic, M., Stursa, J., Freeman, R., Witting, P., Norberg, E., Goodwin, J., Salvatore, B., Novotna, J., Turanek, J., Ledvina, M., Hozak, P., Zhivotovsky, B., Coster, M., Ralph, S., Smith, R., Neuzil, J. (2011), Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy. Free radical biology & medicine. 50(11), 1546-55. [Abstract]
  • Cho, J., Witting, P., Verma, M., Wu, B., Shanu, A., Kairaitis, K., Amis, T., Wheatley, J. (2011), Tissue vibration induces carotid artery endothelial dysfunction: a mechanism linking snoring and carotid atherosclerosis?. Sleep. 34(6), 751-757. [Abstract]
  • Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011), Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl)carboxamide in a cell model of myoglobinuria. The Biochemical Journal. 435(3), 669-677. [Abstract]
  • Dong, L., Jameson, V., Tilly, D., Cerny, J., Mahdavian, E., Marín-Hernández, A., Hernández-Esquivel, L., Rodríguez-Enríquez, S., Stursa, J., Witting, P., Stantic, B., Rohlena, J., Truksa, J., Kluckova, K., Dyason, J., Ledvina, M., Salvatore, B., Moreno-Sánchez, R., Coster, M., Ralph, S., Smith, R., Neuzil, J. (2011), Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II. Journal of Biological Chemistry. 286(5), 3717-3128. [Abstract]


  • Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010), Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 15, 1305-18. [Abstract]
  • Antao, S., Duong, T., Aran, R., Witting, P. (2010), Neuroglobin over-expression in cultured human neuronal cells protects against hydrogen peroxide insult via activating phosphoinositide-3 kinase and opening the mitochondrial KATP channel. Antioxidants & redox signaling. 13(6), 769-81. [Abstract]
  • Shanu, A., Parry, S., Wood, S., Rodas, E., Witting, P. (2010), The synthetic polyphenol tert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kidney epithelial cells. Free radical research. 44(8), 843-53. [Abstract]
  • Niknami, M., Vignarajan, S., Yao, M., Hua, S., Witting, P., Kita, Y., Shimizu, T., Sved, P., Patel, M., Dong, Q. (2010), Decrease in expression or activity of cytosolic phospholipase A(2)alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Biochimica et Biophysica Acta. 1801(7), 731-737. [Abstract]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Vogt, S., Lee, Y., Chen, C., Tobin, M., Harris, H., Lay, P. (2010), Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular bioSystems. 6(7), 1316-22. [Abstract]
  • Wu, B., Yan, L., Charlton, F., Witting, P., Barter, P., Rye, K. (2010), Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arteriosclerosis, Thrombosis, and Vascular Biology. 30(5), 968-975. [Abstract]
  • Wang, Y., Liu, H., McKenzie, G., Witting, P., Stasch, J., Hahn, M., Changsirivathanathamrong, D., Wu, B., Ball, H., Thomas, S., Kapoor, V., Celermajer, D., Mellor, A., Keaney, J., Hunt, N., Stocker, R. (2010), Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature Medicine. 16(3), 279-285. [Abstract]
  • Liu, J., Obando, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010), Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of medicinal chemistry. 53(3), 1370-82. [Abstract]
  • Szuchman-Sapir, A., Pattison, D., Davies, M., Witting, P. (2010), Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b(5)-mediated heme reduction. Free radical biology & medicine. 48(1), 35-46. [Abstract]


  • Song, C., Hsu, K., Yamen, E., Yan, W., Fock, J., Witting, P., Geczy, C., Freedman, S. (2009), Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes. Atherosclerosis. 207(2), 374-83. [Abstract]
  • Sabaretnam, T., Harris, M., Kockx, M., Witting, P., Le Couteur, D., Kritharides, L. (2009), The Effects Of Hydrogen Peroxide And Apolipoprotein E Isoforms On Apolipoprotein E Trafficking In Hepg2 Cells. Clinical and Experimental Pharmacology & Physiology. 36(12), e96-102. [Abstract]
  • Reichelt, M., Shanau, A., Willems, L., Witting, P., Ellis, N., Blackburn, M., Headrick, J. (2009), Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts. Antioxidants & redox signaling. 11(11), 2641-50. [Abstract]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009), Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal. 423(2), 169-177. [Abstract]
  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009), Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of neuroscience. 29(41), 12994-13005. [Abstract]
  • Niknami, M., Dong, Q., Witting, P. (2009), Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. Free Radical Research. 43(10), 951-956. [Abstract]
  • Niknami, M., Patel, M., Witting, P., Dong, Q. (2009), Molecules in focus: Cytosolic phospholipase A(2)-alpha. The International Journal of Biochemistry & Cell Biology. 41(5), 994-997. [Abstract]
  • Dong, L., Freeman, R., Liu, J., Zobalova, R., Marin-Hernandez, A., Stantic, M., Rohlena, J., Valis, K., Rodriguez-Enriquez, S., Butcher, B., Goodwin, J., Brunk, U., Witting, P., Moreno-Sanchez, R., Scheffler, I., Ralph, S., Neuzil, J. (2009), Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clinical Cancer Research. 15(5), 1593-1600. [Abstract]
  • Duong, T., Witting, P., Antao, S., Parry, S., Kennerson, M., Lai, B., Vogt, S., Lay, P., Harris, H. (2009), Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury. Journal of neurochemistry. 108(5), 1143-1154. [Abstract]
  • Song, C., Shen, Y., Yamen, E., Hsu, K., Yan, W., Witting, P., Geczy, C., Freedman, S. (2009), Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes. Atherosclerosis. 202(2), 596-604. [Abstract]
  • Hua, S., Song, C., Geczy, C., Freedman, S., Witting, P. (2009), A role for acute-phase serum amyloid A and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis. Redox Report. 14(5), 187-196. [Abstract]


  • Thomas, S., Witting, P., Drummond, G. (2008), Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxidants & Redox Signaling. 10(10), 1713-1765. [Abstract]
  • Szuchman-Sapir, A., Pattison, D., Ellis, N., Hawkins, C., Davies, M., Witting, P. (2008), Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin. Free radical biology & medicine. 45(6), 789-98. [Abstract]
  • Dong, L., Low, P., Dyason, J., Wang, X., Prochazka, L., Witting, P., Freeman, R., Swettenham, E., Valis, K., Liu, J., Zobalova, R., Turanek, J., Spitz, D., Domann, F., Scheffler, I., Ralph, S., Neuzil, J. (2008), Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene. 27(31), 4324-4335. [Abstract]
  • Duong, T., Antao, S., Ellis, N., Myers, S., Witting, P. (2008), Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia-re-oxygenation injury. Brain research. 1219(0), 8-18. [Abstract]
  • Nikinami, M., Patel, M., Witting, P., Dong, Q. (2008), Aberrant activation of arachidonic acid and eicosanoid pathways-targets for treating prostate cancer. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. 2, 9-15.
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, S., Brieger, D. (2008), Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis research. 122(5), 674-82. [Abstract]
  • Parry, S., Ellis, N., Li, Z., Maitz, P., Witting, P. (2008), Myoglobin induces oxidative stress and decreases endocytosis and monolayer permissiveness in cultured kidney epithelial cells without affecting viability. Kidney & blood pressure research. 31(1), 16-28. [Abstract]