Publications list for Professor Roger R Reddel

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Lee, M., Hills, M., Conomos, D., Stutz, M., Dagg, R., Lau, L., Reddel, R., Pickett, H. (2014), Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Research. 42(3), 1733-1746. [Abstract]

2013

   
  • Lau, L., Dagg, R., Henson, J., Au, A., Royds, J., Reddel, R. (2013), Detection of alternative lengthening of telomeres by telomere quantitative PCR. Nucleic Acids Research. 41(2), e34. [Abstract]
  • Pena, C., Cespedes, M., Lindh, M., Kiflemariam, S., Mezheyeuski, A., Edqvist, P., Hagglof, C., Birgisson, H., Bojmar, L., Jirstrom, K., Sandstrom, P., Olsson, E., Veerla, S., Gallardo, A., Sjoblom, T., Chang, A., Reddel, R., Mangues, R., Augsten, M., Ostman, A. (2013), STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer Research. 73(4), 1287-1297. [Abstract]
  • Durukan Tolvanen, A., Westberg, J., Serlachius, M., Chang, A., Reddel, R., Andersson, L., Tatlisumak, T. (2013), Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance. Neuroscience. 229, 49-54. [Abstract]
  • Conomos, D., Pickett, H., Reddel, R. (2013), Alternative lengthening of telomeres: remodeling the telomere architecture. Frontiers in Oncology. 3, 27. [Abstract]
  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013), Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Development. 27(1), 18-23. [Abstract]

2012

   
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012), Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology. 199(6), 893-906. [Abstract]
  • Huschtscha, L., Napier, C., Noble, J., Bower, K., Au, A., Campbell, H., Braithwaite, A., Reddel, R. (2012), Enhanced isolation of fibroblasts from human skin explants. BioTechniques. 53(4), 239-244. [Abstract]
  • Lovejoy, C., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., de Lange, T., De, S., Petrini, J., Sung, P., Jasin, M., Rosenbluh, J., Zwang, Y., Weir, B., Hatton, C., Ivanova, E., Macconaill, L., Hanna, M., Hahn, W., Lue, N., Reddel, R., Jiao, Y., Kinzler, K., Vogelstein, B., Papadopoulos, N., Meeker, A. (2012), Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway. PLoS Genetics. 8(7), e1002772. [Abstract]
  • Shay, J., Reddel, R., Wright, W. (2012), Cancer. Cancer and telomeres--an ALTernative to telomerase. Science. 336(6087), 1388-1390. [Abstract]
  • Pickett, H., Reddel, R. (2012), The role of telomere trimming in normal telomere length dynamics. Cell Cycle. 11(7), 1309-1315. [Abstract]
  • Bower, K., Napier, C., Cole, S., Dagg, R., Lau, L., Duncan, E., Moy, E., Reddel, R. (2012), Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres. PloS One. 7(11), e50062. [Abstract]
  • Bender, H., Murchison, E., Pickett, H., Deakin, J., Strong, M., Conlan, C., McMillan, D., Neumann, A., Greider, C., Hannon, G., Reddel, R., Graves, J. (2012), Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS One. 7(9), e46195. [Abstract]
  • Kaul, Z., Cesare, A., Huschtscha, L., Neumann, A., Reddel, R. (2012), Five dysfunctional telomeres predict onset of senescence in human cells. EMBO reports. 13(1), 52-9. [Abstract]

2011

   
  • Pickett, H., Henson, J., Au, A., Neumann, A., Reddel, R. (2011), Normal mammalian cells negatively regulate telomere length by telomere trimming. Human Molecular Genetics. 20(23), 4684-4692. [Abstract]
  • Yoon, A., Gao, R., Kaul, Z., Choi, I., Ryu, J., Noble, J., Kato, Y., Saito, S., Hirano, T., Ishii, T., Reddel, R., Yun, C., Kaul, S., Wadhwa, R. (2011), MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic acids research. 39(18), 8078-91. [Abstract]
  • Au, A., Hackl, T., Yeager, T., Cohen, S., Pass, H., Harris, C., Reddel, R. (2011), Telomerase activity in pleural malignant mesotheliomas. Lung cancer (Amsterdam, Netherlands). 73(3), 283-8. [Abstract]
  • Beesley, J., Pickett, H., Johnatty, S., Dunning, A., Chen, X., Li, J., Michailidou, K., Lu, Y., Rider, D., Palmieri, R., Stutz, M., Lambrechts, D., Despierre, E., Lambrechts, S., Vergote, I., Chang-Claude, J., Nickels, S., Vrieling, A., Flesch-Janys, D., Wang-Gohrke, S., Eilber, U., Bogdanova, N., Antonenkova, N., Runnebaum, I., Dörk, T., Goodman, M., Lurie, G., Wilkens, L., Matsuno, R., Kiemeney, L., Aben, K., Marees, T., Massuger, L., Fridley, B., Vierkant, R., Bandera, E., Olson, S., Orlow, I., Rodriguez-Rodriguez, L., Cook, L., Le, N., Brooks-Wilson, A., Kelemen, L., Campbell, I., Gayther, S., Ramus, S., Gentry-Maharaj, A., Menon, U., Ahmed, S., Baynes, C., Pharoah, P., Muir, K., Lophatananon, A., Chaiwerawattana, A., Wiangnon, S., Macgregor, S., Easton, D., Reddel, R., Goode, E., Chenevix-Trench, G. (2011), Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLoS One. 6(9), e24987. [Abstract]
  • Jiang, W., Nguyen, A., Cao, Y., Chang, A., Reddel, R. (2011), HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a. PloS one. 6(2), e17036. [Abstract]

2010

   
  • Henson, J., Reddel, R. (2010), Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers. FEBS letters. 584(17), 3800-11. [Abstract]
  • McDonald, K., McDonnell, J., Muntoni, A., Henson, J., Hegi, M., von Deimling, A., Wheeler, H., Cook, R., Biggs, M., Little, N., Robinson, B., Reddel, R., Royds, J. (2010), Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival. Journal of neuropathology and experimental neurology. 69(7), 729-36. [Abstract]
  • Capes-Davis, A., Theodosopoulos, G., Atkin, I., Drexler, H., Kohara, A., Macleod, R., Masters, J., Nakamura, Y., Reid, Y., Reddel, R., Freshney, R. (2010), Check your cultures! A list of cross-contaminated or misidentified cell lines. International journal of cancer. Journal international du cancer. 127(1), 1-8. [Abstract]
  • Cesare, A., Reddel, R. (2010), Alternative lengthening of telomeres: models, mechanisms and implications. Nature reviews. Genetics. 11(5), 319-30. [Abstract]
  • Reddel, R. (2010), Senescence: an antiviral defense that is tumor suppressive?. Carcinogenesis. 31(1), 19-26. [Abstract]

2009

   
  • Cesare, A., Kaul, Z., Cohen, S., Napier, C., Pickett, H., Neumann, A., Reddel, R. (2009), Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nature structural & molecular biology. 16(12), 1244-51. [Abstract]
  • Henson, J., Cao, Y., Huschtscha, L., Chang, A., Au, A., Pickett, H., Reddel, R. (2009), DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nature biotechnology. 27(12), 1181-5. [Abstract]
  • Hinshelwood, R., Melki, J., Huschtscha, L., Paul, C., Song, J., Stirzaker, C., Reddel, R., Clark, S. (2009), Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning. Human Molecular Genetics. 18(16), 3098-3109. [Abstract]
  • Huschtscha, L., Moore, J., Noble, J., Campbell, H., Royds, J., Braithwaite, A., Reddel, R. (2009), Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. Journal of Cell Science. 122(Pt 16), 2989-2995. [Abstract]
  • Yuan, J., Yang, B., Zhong, Z., Shats, I., Milyavsky, M., Rotter, V., Lock, R., Reddel, R., Mackenzie, K. (2009), Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene. 28(29), 2678-89. [Abstract]
  • Graham, J., Mote, P., Salagame, U., van Dijk, J., Balleine, R., Huschtscha, L., Reddel, R., Clarke, C. (2009), DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology. 150(7), 3318-3326. [Abstract]
  • Jiang, W., Zhong, Z., Nguyen, A., Henson, J., Toouli, C., Braithwaite, A., Reddel, R. (2009), Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. The Journal of Cell Biology. 185(5), 797-810. [Abstract]
  • Nguyen, A., Chang, A., Reddel, R. (2009), Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. Oncogene. 28(18), 1982-1992. [Abstract]
  • Pickett, H., Cesare, A., Johnston, R., Neumann, A., Reddel, R. (2009), Control of telomere length by a trimming mechanism that involves generation of t-circles. The EMBO journal. 28(7), 799-809. [Abstract]
  • Muntoni, A., Neumann, A., Hills, M., Reddel, R. (2009), Telomere elongation involves intra-molecular DNA replication in cells utilizing Alternative Lengthening of Telomeres. Human molecular genetics. 18(0), 1017-27. [Abstract]
  • Ng, L., Cropley, J., Pickett, H., Reddel, R., Suter, C. (2009), Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Research. 37(4), 1152-1159. [Abstract]
  • Jiang, W., Henson, J., Neuman, A., Reddel, R. (2009), Protocol III: Detection of alternative lengthening of telomeres. In: Telomeres and Telomerase in Cancer. (pp.351-364).United States: Humana Press.
  • Reddel, R. (2009), Senescence and immortalization. In: Encyclopedia of Cancer. (pp.2697-2699).Germany: Springer.
  • Pickett, H., Reddel, R. (2009), Alternative lengthening of telomeres in human cells. In: Telomeres and Telomerase in Cancer. (pp.127-148).United States: Humana Press.

2008

   
  • Chen, Y., Campbell, H., Wiles, A., Eccles, M., Reddel, R., Braithwaite, A., Royds, J. (2008), PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research. 68(14), 5724-5732. [Abstract]
  • Villa, R., Daidone, M., Motta, R., Venturini, L., De Marco, C., Vannelli, A., Kusamura, S., Baratti, D., Deraco, M., Costa, A., Reddel, R., Zaffaroni, N. (2008), Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma. Clinical cancer research : an official journal of the American Association for Cancer Research. 14(13), 4134-4140. [Abstract]
  • Cao, Y., Bryan, T., Reddel, R. (2008), Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Science. 99(6), 1092-1099. [Abstract]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008), The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology. 149(5), 2403-2410. [Abstract]
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008), Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels. Cancer research. 68(9), 3115-3123. [Abstract]
  • Cohen, S., Reddel, R. (2008), A sensitive direct human telomerase activity assay. Nature Methods. 5(4), 355-360. [Abstract]
  • Cesare, A., Reddel, R. (2008), Alternative Lengthening of Telomeres in Mammalian Cells. In: Origin and Evolution of Telomeres. (pp.45-57).United States: Landes Bioscience.
  • Cesare, A., Reddel, R. (2008), Telomere uncapping and alternative lengthening of telomeres. Mechanisms of ageing and development. 129(0), 99-108. [Abstract]