Refereed publications

2016 |2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001

2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990


Johnston GAR "Some personal thoughts on the Australasian Society of Clinical and Experimental Pharmacologists in the 1980s" Pharmacological Research, accepted 21 December 2016

Johnston GAR "GABA Australis, some reflections on the history of GABA receptor research in Australia" Pharmacological Research, accepted 21 December 2016


Johnston GAR "Unsaturated analogues of the neurotransmitter GABA: trans-4-aminocrotonic, cis-4-aminocrotonic and 4-aminotetrolic acids" Neurochemical Research, 2016, 41, 476-480 [PDF]

Johnston GAR "Drug analogues and substantial similarity, views of an expert witness" Australian Journal of Forensic Sciences, 2016, DOI: 10.1080/00450618.2016.1194476 [PDF]

Ng CC, Duke RK, Hinton T and Johnston GAR "GABAa receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides" European Journal of Pharmacology, 2016, 777, 136–146 doi:10.1016/j.ejphar.2016.03.007) [PDF]


Abdelhalim A, Karim N, Chebib M, Aburjai T, Khan I, Johnston GAR and Hanrahan JR "Antidepressant, anxiolytic and antinociceptive activities of constituents from Rosmarinus Officinalis" Journal of Pharmacy & Pharmaceutical Sciences, 2015, 718, 448-459 [PDF]

Hanrahan JR, Chebib M and Johnston GAR "Interactions of flavonoids with ionotropic GABA receptors" Advances in Pharmacology, 2015, 72, 189-200 [PDF]

Johnston GAR "Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA" Neurochemistry International, 2015, 89, 120-125) [PDF]

Rae C, Nasralliah FA, Balcat VJ, Rowlands BD, Johnston GAR and Hanrahan J "Metabolomic approaches to defining the role(s) of GABAρ receptors in the brain" Journal of Neuroimmune Pharmacology, 2015, 10, 445-456) [PDF]


Abdelhalim A, Chebib M, Aburjai T, Johnston GAR and Hanrahan JR , "GABAa receptor modulation by compounds isolated from Salvia triloba L." Advances in Biological Chemistry, Special Issue on Phytochemicals, 2014, 4, 148-159 [PDF]

Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek C, Johnson D, Borghese CM, Hanrahan JR, Johnston GAR, Chebib M and Harris RA, "GABA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice" PLOS One, 2014, 9(1): e85525. doi:10.1371/journal.pone.0085525 [PDF]

Hall BJ, Karim N, Chebib M, Johnston GAR and Hanrahan JR "Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone" Neurochemical Research, 2014, 39, 1068–1078 [PDF]

Johnston GAR "Muscimol as an ionotropic GABA receptor agonist" Neurochemical Research, 2014, 39, 1942-1947 [PDF]


Gavande N, Kim HL, Doddareddy M, Johnston GAR, Chebib M and Hanrahan JR "Design, synthesis and pharmacological evaluation of fluorescent and biotinylated antagonists of rho1 GABAc receptors" ACS Medicinal Chemistry Letters, 2013, 4, 402-407) [PDF]

Johnston GAR "Advantages of an antagonist: bicuculline and other GABA antagonists" British Journal of Pharmacology, 2013, 169. 328-336 [PDF]

Karim N, Wellendorph P, Absalom N, Johnston GAR, Hanrahan JR and Chebib M "Potency of GABA at human recombinant GABAa receptors expressed in Xenopus oocytes: A mini review" Amino Acids, 2013, 44, 1139-1149 [PDF]

Locock KES, Yamamoto I, Tran P, Hanrahan JR, Chebib M, Johnston GAR and Allan RD "γ-Aminobutyric acid(C) (GABAc) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates" Journal of Medicinal Chemstry, 2013, 56, 5626-5630 [PDF]


Fernandez SP, Karin N, Mewett KN, Chebib M, Johnston GAR and Hanrahan JR "Flavan-3-ol esters: new agents for exploring modulatory sites on GABA-A receptors" British Journal of Pharmacology, 2012, 165, 965-977 [PDF]

Huang SH, Lewis TG, Lummis SCR, Thompson AJ, Chebib M, Johnston GAR and Duke RK "Mixed antagonistic effects of the ginkgolides at recombinant human rho1 GABAc receptors" Neuropharmacology, 63, 1127-1139 [PDF]

Karim N, Curmi J, Gavande N, Johnston GAR, Hanrahan JR, Tierney ML and Chebib M "2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA-A receptors" British Journal of Pharmacology, 2012, 165, 880-896 [PDF]

Karim N, Wellendorph P, Absalom N, Bang LH, Jensen ML, Hansen MM, Lee HJ, Johnston GAR, Hanrahan JR and Chebib M "Low nanomolar GABA effects at extrasynaptic α4β1/3δ GABAa receptor subtypes indicate a different binding mode for GABA at these receptors" Biochemical Pharmacology, 2012, 84, 549-557 [PDF]

Thompson AJ, McGonigle I, Duke RK, Johnston GAR and Lummis SCR "A single amino acid determines the toxicity of Ginkgo biloba extracts" FASEB Journal, 2012, 26, 1884-1891 [PDF]

Yamamoto I, Absalom N, Carland JE, Doddareddy MR, Gavande N, Johnston GAR, Hanrahan JR, and Chebib M "Differentiating enantioselective actions of GABOB: A possible role for threonine 244 in the binding site of GABAc ρ1 receptors" ACS Chemical Neuroscience, 2012, 3, 665-673) [PDF]

Yamamoto I, Carland JE, Locock KES, Gavande N, Absalom N, Hanrahan JR, Allan, RD, Johnston GAR and Chebib M "Structurally diverse GABA antagonists interact differently with open and closed conformational states of the rho1 receptor" ACS Chemical Neuroscience, 2012, 3, 291-301) [PDF]


Gavande N, Karim N, Johnston GAR, Hanrahan JR and Chebib M "Identification of benzopyran-4-one derivatives (isoflavones) as positive modulators of GABA-A receptors" ChemMedChem, 2011, 6, 1340–1346 [PDF]

Gavande N, Yamamoto I, Salam N, Ai T-H, Burden P, Johnston GAR, Hanrahan JR and Chebib M "Novel cyclic phosphinic acids as GABA-C ρ receptor antagonists: design, synthesis and pharmacology" ACS Med. Chem. Lett. 2011, 2, 11–16 [PDF]

Hanrahan JR. Chebib M and Johnston GAR "Flavonoid modulation of GABA-A receptors" British Journal of Pharmacology 2011, 163, 234-245 [PDF]

Karim N, Gavande N, Wellendorph P, Johnston GAR, Hanrahan JR, and Chebib M "3-Hydroxy-2’-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABA-A receptor subtypes" Biochemical Pharmacology, 2011, 82, 1971-1983 [PDF]

Ng CKL, Kim H-L, Gavande N, Yamamoto I, Kumar RJ, Mewett KN, Johnston GAR, Hanrahan JR and Chebib M "Medicinal chemistry of ρ GABA-C receptors" Future Medicinal Chemistry, 2011, 3, 197-209 [PDF]

Thompson AJ, Jarvis GE, Duke RK, Johnston GAR and Lummis SCR "Ginkgolide and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps with the picrotoxin binding site" Neuropharmacology, 2011, 60, 488-495 [PDF]

Yamamoto I, Deniau GP, Gavande N, Chebib M, Johnston GAR, O’Hagen D "Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA-C receptors" ChemComm, 2011, 47, 7956-7958 [PDF]

Yow TT, Pera E, Absalom N, Heblinski M, Johnston GAR, Hanrahan JR and Chebib M (2011) Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 2011. 163. 1017-1033 [PDF]


Gavande N, Johnston GAR, Hanrahan JR and Chebib M "Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531)" Organic and Biomolecular Chemistry, 2010, 8, 4131–4136 [PDF]

Johnston GAR, Chebib M, Hanrahan JR and Mewett KN "Neurochemicals for the investigation of GABA-C receptors" Neurochemical Research, 2010, 35, 1970-1977 [PDF]

Nasrallah F, Maher, A, Hanrahan JR, Balcar VJ and Rae C "γ-Hydroxybutyrate and the GABAergic footprint. A metabolomic approach to unpicking the actions of GHB" Journal of Neurochemistry, 2010, 115, 58-67.

Skilbeck KJ, Johnston GAR and Hinton T "Stress and GABA-A Receptors" Journal of Neurochemistry, 2010, 112, 1115-1130 [PDF]


Chebib M, Gavande N, Wong KY, Park A, Premoli I, Mewett KN, Allan RD, Duke RK, Johnston GAR and Hanrahan JR "Guanidino acids act as rho1 GABA-C receptor antagonists" Neurochemical Research, 2009, 34, 1704-1711 [PDF]]

Chebib M, Hinton T, Schmid KL,Brinkworth D, Qian H, Matos S, Kim H-L, Abdel-Halim H, Kumar RJ, Johnston GAR and Hanrahan JR (2009) "Novel, potent and selective GABA-C antagonists inhibit myopia development and facilitate learning and memory" Journal of Pharmacology and Experimental Therapeutics, 328, 448-457 [PDF]

Fernandez SP, Nguyen M, Yow TT, Chu C, Johnston GAR, Hanrahan JR and Chebib M "The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice" Neurochemical Research, 2009, 34, 1867-1878 [PDF]

Hanrahan JR and Johnston GAR (2009) Synthesis of γ-aminobutyric acid analogues. In: Amino Acids, Peptides and Proteins in Organic Chemistry, Volume 1, Origins and synthesis of amino acids, Ed AB Hughes, Wiley VCH, Weinheim, pp. 573-689 [PDF]

Hinton T and Johnston GAR "Anxiolytic and hypnotic drugs acting on ionotropic GABA receptors" Encyclopedia of Neuroscience, edited by MD Binder, N Hirokawa, and U Windhorst, Springer-Verlag, 2009, pp 154-159 [PDF]

Johnston GAR, Chebib M, Duke RK, Fernandez SP, Hanrahan JR, Hinton T and Mewett KN "Herbal products and ionotropic GABA receptors" New Encyclopedia of Neuroscience, edited by LR Squire, Elsevier, 2009, 4, 1095-1101 [PDF]

Locock KES, Johnston GAR and Allan RD "GABA analogues derived from 4-aminocyclopent-1-enecarboxylic acid" Neurochemical Research, 2009, 34, 1698-1703 [PDF]

McIntosh JM, Absalom N, Chebib M, Elgoyhen AB, Vincler M "Alpha9 nicotinic acetylcholine receptors and the treatment of pain" Biochemical Pharmacology, 2009, 78, 693-702

Mewett KN, Fernandez SP, Pasricha AK, Pong A, Devenish SO, Chebib M, Johnston GAR, Hibbs DE and Hanrahan JR "Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABA-A receptors" Bioorganic & Medicinal Chemistry, 2009, 17, 7156-7173 [PDF]


Abdel-Halim H, Hanrahan JR, Hibbs DE, Johnston GAR and Chebib M "A molecular basis for agonist and antagonist actions at GABA-Creceptors" Chemical Biology and Drug Design, 2008, 71, 306-327 [PDF]

Carland JE, Johnston GAR and Chebib M "Relative impact of residues at the intracellular and extracellular ends of the human GABA-C rho1 receptor M2 domain on picrotoxinin activity" European Journal ofPharmacology, 2008, 580, 27-35 [PDF]

Fernandez SP, Mewett KN, Hanrahan JR, Chebib M, Johnston GAR "Flavan-3-ol derivatives are positive modulators of GABA-A receptors with higher efficacy for the alpha2 subtype and anxiolytic action in mice" Neuropharmacology, 2008, 55, 900-907 [PDF]

Hinton T, Chebib M and Johnston GAR "Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA-C receptors" Bioorganic & Medicinal Chemistry Letters 2008, 18, 402-404 [PDF]

Hinton T and Johnston GAR "The role of GABA-A receptors in schizophrenia" Cell Science Reviews, 2008, 5, 180-194[PDF]

Kumar RJ, Chebib M, Hibbs DE, Kim H-L, Johnston GAR, Salam NK andHanrahan JR "Novel gamma-aminobutyric acid rho1 receptor antagonists; Synthesis, pharmacological activity and structure activity relationships" Journal of Medicinal Chemistry, 2008, 51, 3825-3840) [PDF]

Skilbeck KJ, Hinton T and Johnston GAR "Sex-differences andstress: effects on regional high and low affinity [3H]GABA binding" Neurochemistry International, 2008, 52,1212-1219 [PDF]

Skillbeck KJ, O'Reilly JN, Johnston GAR and Hinton T "Antipsychotic drug administration differentially affects[3H]muscimol and [3H]flunitrazepam GABA-A receptor binding sites" Progress in Neuropsychopharmacology & Biological Psychiatry, 2008, 32, 492-498 [PDF]


Chebib M, Hanrahan JR, Kumar RJ, Mewett KN, Morriss G, Wooller S and Johnston GAR "(3-Aminocyclopentyl)methylphosphinic acids: NovelGABA-C receptor antagonists" Neuropharmacology, 2007, 52, 779-787 [PDF]

Skilbeck KJ, O'Reilly JN, Johnston GAR and Hinton T "The effects of antipsychotic drugs on GABA-A receptor binding depend on period of drug treatment and binding site examined" Schizophrenia Research, 2007, 90, 76-80 [PDF]


Crittenden DL, Park, A, Qiu J, *Silverman RB, Duke RK, Johnston GAR, **Jordan MJT and Chebib M "Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA-C receptors" Bioorganic and Medicinal Chemistry, 2006, 14, 447-455 [PDF]

Fernandez SP, *Wasowski C , *Loscalzo LM, Granger RE, JohnstonGAR, *Paladini AC and *Marder M "Central nervous system depressant action of flavonoid glycosides" European Journal ofPharmacology, 2006, 539, 168-176 [PDF]

Greenwood JR, Mewett KN, Allan RD, *Martin BO, *Pickering DS (2006) "3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptoragonists". Neuropharmacology, 51, 52-59

Hanrahan JR, Mewett KN, Chebib M, Matos S, Eliopoulos CT, Crean C,Kumar RJ, Burden P, and Johnston GAR "Diastereoselective synthesis of(±)-(3-aminocyclopentanyl)alkylphosphinic acids, conformationally restricted analogues of GABA" Organic & Biomolecular Chemistry, 2006, 4, 2642-2649 [PDF]

Huang SH, Duke RK, Chebib M, Sasaki K, Wada K and Johnston GAR (2006) Mixed antagonistic effects of bilobalide at rho1 GABA-C receptors, Neuroscience, 2006, 137, 607-617 [PDF]

Johnston GAR, Hanrahan JR, Chebib M, Duke RK and Mewett KN. Modulation of ionotropic GABA receptors by natural products of plantorigin, Adv. Pharmacol., 2006, 54, 285-316 [PDF]


Crittenden DL, Chebib M and **Jordan MJT "Stabilization of zwitterions in solution: GABA analogues" Journal of PhysicalChemistry A, 2005, 109, 4195-4201

Crittenden DL, Kumar RJ, Hanrahan JR, Chebib M and **Jordan MJT "Stabilization of zwitterions in solution: phosphinic and phosphonic acid GABA analogues" Journal of Physical Chemistry A, 2005, 109, 8398-8409

*Gibbs ME and Johnston GAR "Opposing roles for GABA-A and GABA-C receptors in short-term memory formation in young chicks" Neuroscience, 2005, 131, 567-576 [PDF]

Granger RE, Campbell EL and Johnston GAR "(+) and (-)-Borneol:efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA-A receptors" Biochemical Pharmacology,2005, 69, 1101-1111 [PDF]

Hall BJ, Chebib M, Hanrahan JR and Johnston GAR "6-Methylflavanone, a more efficacious positive allosteric modulatorof gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA-A receptors expressed in Xenopus oocytes" European Journal of Pharmacology, 2005, 512, 97-104 [PDF]

Henderson JM, Schleimer S, Allbutt H, Dabholkar V, Abela D, JovicJ and Quinlivan M "Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonism" Behavioural BrainResearch 2005, 162, 222-232

James ML, Fulton RR, Henderson DJ,Eberl S, Meikle SR,ThomsonS, Allan RD, Dolle F, Fulham MJ, and Kassiou M. Synthesis and invivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand, Bioorganic & Medicinal Chemistry 2005, 13, 6188-6194

Johnston GAR , GABA-A receptor channel pharmacology, CurrentPharmaceutical Design, 2005, 11, 1867-1885 [PDF]

Schleimer SB, Johnston GAR and Henderson JM "Novel oral drug administration in an animal model of chronic neuroleptic therapy" Journal of Neuroscience Methods, 2005, 146, 159-164 [PDF]


Allan RD, Greenwood J, **Hambley TW, Hanrahan JR, **Hibbs DE, **Itani S, Tran HW and **Turner P. "Studies on Pyridazine Azide Cyclisation Reactions" Organic & Biomolecular Chemistry,2004, 2, 1782-1788

Campbell EL, Chebib M and Johnston GAR "The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA-A receptors" Biochemical Pharmacology, 2004, 68,1631-1638 [PDF]

Carland JE, Moorhouse AJ, Barry PH, Johnston GAR and Chebib M "Charged residues at the 2' position of human GABA-C rho1 receptors invert ion selectivity and influence open state probability" Journal of Biological Chemistry, 2004, 279, 54153-54169[PDF]

Carland JE, *Moore AM, Hanrahan JR, Mewett KN, Duke RK, Johnston GAR and Chebib M "Mutations of the 2' proline in the M2 domain of the human GABA-C rho1 subunit alter agonist responses" Neuropharmacology, 2004, 46, 770-781 [PDF]

Chebib M, Hanrahan JR, Mewett KN, Duke RK and Johnston GAR "Ionotropic GABA receptors as therapeutic targets for memory and sleep disorders" Annual Reports in Medicinal Chemistry, 2004, 39, 13-23 [PDF]

Duje RK, Chebib M, **Hibbs DE, Mewett KN and Johnston GAR "Synthesis and resolution of 2-methyl analogues of GABA" Tetrahedron Asymmetry, 2004, 15, 1745-1751 [PDF]

Hall BJ, Chebib M, Hanrahan JR and Johnston GAR "Flumazenil-independent positive modulation of GABA action by 6-methylflavone at human recombinant alpha1, beta2, gamma2L andalpha1, beta2 GABA-A receptors" European J. Pharmacology,2004, 491, 1-8 [PDF]

Henderson DJ, *Eberl S, *Thomson S, *Smith A, Allan RD, *Fulham MJ, *Loiacono R, Kassiou M. (2004) 3-Pyridyl ethers as SPECT radioligands for imaging nicotinic acetylcholine receptors. ApplRadiation and Isotopes. 60(5):669-76.

Huang SH , Duke RK, Chebib M, Sasaki K, Wada K and Johnston GAR,Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1, beta2, gamma2L GABA-A receptorsEuropean Journal of Pharmacology, 2004, 494, 131-138[PDF]

Johnston GAR and *Beart PM "Flavonoids: some of the wisdom of sage?" British Journal of Pharmacology, 2004, 142,809-810 [PDF]

**Lee NA, **Wang S, Allan RD and **Kennedy IR (2004) A rapidaflatoxin B1 ELISA: development and validation with reduced matrix effects for peanuts, corn, pistachio, and Soybeans. J Agric FoodChem., 2004 , 52, 2746-55.

Schliemer SB, Hinton T, Dixon G and Johnston GAR "GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontalcortex in schizophrenia" Neuropsychobiology, 2004, 50,226-230 [PDF]


Chebib M, Duke RK, Connor M, Mewett KN and Johnston GAR "Convulsant actions of calycanthine" Toxicology and AppliedPharmacology, 2003, 190, 58-64 [PDF]

Hanrahan JR, Chebib M, Davucheron NM, Hall BJ and Johnston GAR(2003) "Semisynthetic preparation of amentoflavone: a negative modulator at GABA-A receptors" Bioorganic & Medicinal Chemistry Letters, 2003, 13, 2281-2284 [PDF]

**Hibbs DE, Hanrahan JR, **Hurtshouse MB, *Knight DW, **OvergaardJ, **Turner P, **Piltz RO and **Waller MP "Experimental and theoretical charge distribution in (Z)-N-methyl-C-phenylnitrone" Organic & Biomolecular Chemistry, 2003, 1,1034-1040

Huang SH, Duke RK, Chebib M, *Sasaki K, *Wada K and Johnston GAR "Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant α1β2γ2LGABA-A receptors" European Journal of Pharmacology, 2003, 464, 1-8 [PDF]

Johnston GAR "Dietary chemicals and brain function" Journal & Proceedings of the Royal Society of New South Wales, 2003, 135, 57-71 [PDF]

Johnston GAR, Chebib M, Hanrahan JR and Mewett KN "GABA-C receptors as drug targets" Current Drug Targets - CNS & Neurological Disorders, 2003, 2, 260-268 [PDF]

*Krehan D, *Frølund B, *Krogsgaard-Larsen, P, *Kehler J, Johnston GAR and Chebib M "Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA-C receptor antagonists" Neurochemistry International, 2003, 42, 561-565 [PDF]

*Krehan D, *Frølund B, *Krogsgaard-Larsen, P, Johnston GARand Chebib M "Aza-THIP and related analogues of THIP as GABA-C antagonists" Bioorganic and Medicinal Chemistry, 2003, 11, 4891-4896) [PDF]

**Waller MP, **Hibbs DE, Overgaard J, Hanrahan JR, **Hambley TW "Flavone" Acta Crystallographia, Section E. Structure ReportsOnline, 2003, E59, o767-768


Duke RK, Chebib M, Duke CC, Johnston GAR and Roufogalis BD "Ginkgo biloba - food for the brain" New Zealand Pharmacy, 2002, 22(5), 27-33 [PDF][[/adrien-albert/images/pdfs/RefsPDFs/350.pdf||]]

Johnston GAR "Medicinal chemistry and molecular pharmacology of GABA-C receptors" Current Topics in Medicinal Chemistry, 2002, 2, 903-913 [PDF]

*Topliss JG, *Clark AM, *Ernst E., *Hufford C, Johnston GAR ,*Rimoldi JM and *Weimann BJ "Natural and synthetic substances related to human health (IUPAC Technical Report)" Pure and Applied Chemistry, 2002, 74, 1957-1985 [PDF]

Vien J, Duke RK, Mewett KN, Johnston GAR, *Shingai R and Chebib M "trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and(±)-trans-2-aminomethylcyclopropanecarboxylic acid ((±)-TAMP) can differentiate rat rho-3 from human rho-1 and rho-2 recombinant GABA-C receptors" British Journal ofPharmacology, 2002, 135, 883-890 [PDF]


Chebib M "Novel agents acting on GABA-C receptors: potential cognitive enhancers" Chemistry in Australia, 2001, 68(9), 19-21

Chebib M, Duke RK, Allan RD and Johnston GAR "The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABA-C receptors" European Journal of Pharmacology, 430, 185-192 [PDF]

Dodds HM, Hanrahan JR and Rivory LP "The inhibition of acetylcholinesterase by irinotecan and related camptothecins: key structural properties and experimental variables" Anti-cancer Drug Design, 2001, 16, 239-249

Farrar NS, Chambers NJ, Carlsson AR, **Denyer G and Johnston GAR "Effect of a series of novel sulfonylthioureas on glucose tolerance in the obese fa/fa Zucker rat" Clinical and Experimental Pharmacology and Physiology, 2001, 28, 386-391 [PDF]

Hall BJ, Hanrahan JR, Johnston GAR, **Hambley TW and Hibbs DE "6-Methylflavone" Acta Crystallographia, 2001, E57,o592-o593) ( [PDF]

Hanrahan JR, Mewett KN, Chebib M, Burden PM and Johnston GAR, An improved, versatile synthesis of the GABA-C antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA) J. Chem. Soc.,Perkin Trans. 1, 2001, 19, 2389-2392 [PDF]

Hanrahan JR, *Knight DW and *Salter R "On the characteristics of reverse-Cope cyclizations of homoallylic sulfoxide nitrone adducts: ahighly stereoselective route to pyrrolidine-N-oxides" Synlee,2001, 10, 1587-1589


Burden PM, Ai TH, Lin HQ, Akinci M, Costandi M, **Hambley TM and Johnston GAR "Chiral derivatives of2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class ofnonsteroidal androgen receptor ligand. Synthesis, X-ray analysis andbiological activity" Journal of Medicinal Chemistry, 2000, 43, 4629-4635 [PDF]

Chebib M and Johnston GAR "GABA-activated ligand gated ionchannels: medicinal chemistry and molecular biology" Journal ofMedicinal Chemistry, 2000, 43, 1427-1447 [PDF]

Chebib M and *Quinn RJ "1-Phenylpyrazolo[3,4-d]pyrimidines: Structure-activityrelationships for C6 substituents at A1 and A2a Adenosine receptors" Bioorganic and Medicinal Chemistry, accepted 1.7.99

Duke RK, Chebib M, **Balcar VJ, Allan RD, Mewett KN and JohnstonGAR "(+)- and (-)-cis-2-Aminomethylcyclopropanecarboxylic acidshow opposite pharmacology at recombinant r1and r2 GABACreceptors" Journal of Neurochemistry, 2000, 75, 2602-2610) [PDF]

Farrar N "New drug balances the diabetic see-saw" AustralasianScience, 2000, 21(9), 30-31

Johnston GAR "The medicinal chemistry-molecular biology interface:recombinant receptors in the search for new drugs" in Technology & Health, Proceedings of the 13th Convocation of the Council ofAcademies of Engineering and Technological Sciences, ISBN2-7430-0386-3, Paris, France, 2000, pp 72-74

Johnston GAR "GABA Chemistry: Analogs of GABA as therapeutic andinvestigational agents" in GABA in the Nervous System: The Viewat Fifty Years, Edited by David L. Martin and Richard W. Olsen,Lippincott Williams & Wilkins Publishers, Philadelphia, PA, USA,65-80

Johnston GAR, Chebib M, Duke RK "Ionotropic GABA receptors: ligandgated ion channels" in Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels, Edited by Y Suketa, E Carafoli,M Lazdunski, K Mikoshiba, Y Okada and EM Wright, Elsevier Science, Amsterdam, The Netherlands, pp. 369-372, 2000

*Li Y, *Wood N, Grimsley P, *Yellowlees D and Donelly PK "In vitroinvasiveness of human breast cancer cells is promoted by low densitylipoprotein receptor-related protein" Invasion Metastasis,2000, 18, 240-251

**Lieb I, Chebib M, **Cooper B, **Dias LS and **Balcar VJ "Quantitative Autoradiography of Na+-dependent[3H]L-aspartate binding to L-glutamatetransporters in rat brain: Structure-activity studies usingL-trans-pyrrolidine-2,4-dicarboxylate (L-t-PDC) and2-(Carboxycyclopropyl)-glycine (CCG)" NeurochemistryInternational, 2000, 36, 319-327


Chebib M and Johnston GAR "The ABC of GABA receptors: A briefreview" Clinical and Experimental Pharmacology and Physiology,1999, 26, 937-940 [PDF]

Chebib M, Johnston GAR, *Mattsson JP, *Rydström K, *NilssonK, *Qiu K, *Stevenson SH and *Silverman RB "Aminomethyl-2,6-difluorophenols as a novel class of increasedlipophilicity GABA-C receptor antagonists" Bioorganic & Medicinal Chemistry Letters, 1999, 9, 3093-3098 [PDF]

Cooper EJ, Johnston GAR and Edwards FA "Effects of a naturallyoccurring neurosteroid on GABA-A IPSCs during development in rathippocampal or cerebellar slices" Journal of Physiology, 1999, 521.2, 437-449 [PDF]

*Cordato DJ, Chebib M, *Mather LE, *Herkes GK and Johnston GAR,Stereoselective interaction of thiopentone enantiomers with theGABAA receptor, British Journal of Pharmacology,1999, 128, 77-82 [PDF]

Johnston GAR, Chebib M, Duke RK, Mewett KN, Mitrovic AD andVandenberg RJ, Medicinal chemistry and molecular pharmacology of GABAreceptors and glutamate transporters: complementarystructure-activity relationships, Drug Development Research,1999, 46, 255-260 [PDF]

Lin HQ, Burden PM, Christie MJ and Johnston GAR "Theanxiogenic-like and anxiolytic-like effects of MDMA on mice in theelevated plus maze: a comparison with amphetamine" Pharmacology,Biochemistry and Behavior, 1999, 62, 403-408 [PDF]

Mitrovic AD, Maddison JE and Johnston GAR "Influence of theoestrous cycle on L-glutamate and L-aspartate transport in rat brainsynaptosomes" Neurochemistry International, 1999, 34,101-108 [PDF]

*Wang S, Allan RD, *Skerritt JH and **Kennedy IR "Development ofa compound-specific ELISA for flufenoxuron and an improvedclass-specific assay for benzoylphenylurea insect growth regulators" Journal of Agricultural & Food Chemistry, 1999, 47, 3416-3424


Burden PM, Allan RD, **Hambley T and Johnston GAR "The Synthesis of 2-Cyclohexylideneoctahydro-4,7-methano-1H-indenes. Non-Steroidal Analogues of Steroidal GABAA Receptor Modulators" Journal of the Chemical Society, Perkin Transactions 1, 1998,3163-3169. [PDF]

Chebib M, Mewett KN and Johnston GAR "GABAC receptorant agonists differentiate between human rho1 and rho2 receptors expressed in Xenopus oocytes" European Journal ofPharmacology, 1998, 357, 227-234. [PDF]

**Cooper B, Chebib M, **Shen J, **King NJC, **Kuchel PW,*Rothstein JD and **Balcar VJ "Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts",Archives of Biochemistry and Biophyscis, 1998, 353,356-364.

Duke RK, Allan RD, Chebib M, Greenwood JR and Johnston GAR "Resolution and conformational analysis of diastereoisomers ofcis- andtrans--2-(aminomethyl)-1-carboxycyclopropanes" Tetrahedron Asymmetry, 1998, 9, 2533-2548. [PDF]

Greenwood JR, Vaccarella G, Capper HR, Allan RD and Johnston GAR(1998) "Heterocycles as bioisosteres for the w-carboxylate moiety of glutamate in AMPA receptor agonists: A review and theoretical study". Internet Journal of Chemistry 1, 38

Lin HG, Burden PM and Johnston GAR "Propylene glycol elicits anxiolytic-like responses to the elevated plus maze in male mice" Journal of Pharmacy and Pharmacology, 1998, 50,1127-1131.

Mitrovic AD, *Amara SG, Johnston GAR and Vandenberg RJ "Identification of functional domains of the human glutamate transporters EAAT1 and EAAT" Journal of Biological Chemistry,1998, 273, 14698-14706. [PDF]

Vandenberg RJ "Molecular pharmacology and physiology of glutamate transporters" Clinical and Experimental Pharmacology and Physiology, 1998, 25, 393-400.

Vandenberg RJ, Mitrovic AD and Johnston GAR "Serine-O-sulfate transport by the human glutamate transporter EAAT2" British Journal of Pharmacology, 1998, 123, 1593-1600. [PDF]

Vandenberg RJ, Mitrovic AD and Johnston GAR "Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions" Molecular Pharmacology, 1998, 54, 189-19.[PDF]

*Wang S, Allan RD, *Skerritt JH and **Kennedy IR "Development of a class-specific competitive ELISA for the benzoylphenylurea insecticides" Journal of Agricultural and Food Chemistry,1998, 46, 3330-3338.


Akinci MK and Johnston GAR "Sex differences in the effects of gonadectomy and acute swim stress on GABAA receptor binding in mouse forebrain membranes" Neurochemistry International, 1997, 31, 1-10 [PDF]

Allan RD, Dickenson HW, Johnston GAR, Kazlauskas R and Mewett KN "Structural analogues of ZAPA as GABAA agonists" Neurochemistry International, 1997, 30, 583-59 [PDF]

Chebib M and Johnston GAR "Stimulation of [3-H]GABA and[3-H]beta-alanine release from rat brain slices bycis-4-aminocrotonic acid" Journal of Neurochemistry , 1997, 68, 786-794 [PDF]

Chebib M and *Quinn RJ "1-Phenylpyrazolo[3,4-d]pyrimidinesas adenosine antagonists: the effects of substituents at C4 and C6" Bioorganic and Medicinal Chemistry, 5, 311-322

Chebib M, Vandenberg RJ, *Froestl W and Johnston GAR "Unsaturatedphosphinic analogues of GABA as GABAC receptor antagonists" European Journal of Pharmacology, 1997, 329, 223-239 [PDF]

Chebib C, Vandenberg RJ and Johnston GAR "Analogues of amma-aminobutryic acid (GABA) and trans–4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists" British Journal of Pharmacology, 1997, 122, 1551-156 [PDF]

Greenwood JR, Capper HR, Allan RD and Johnston GAR "Tautomerism of hydroxy-pyridazines: the N-oxides" Journal of Molecular Structure(Theochem), 1997, 419, 97-11

Johnston GAR "Cerebral chemistry" Chemistry in Australia,1997, 64(5), 34-36; reprinted in the Australian Chemistry Resource Book, 1997, 16, 67-72

Johnston GAR "GABAC receptors: molecular biology, pharmacology and physiology". In: The GABA Receptors, *EnnaSJ, *Bowery NG eds, 2nd edition, Humana Press, New Jersey, 1997,297-323

Maddalena DJ and *Snowdon GM "Applications of genetic algorithms to drug design" Expert Opinion in Therapeutic Patents, 1997, 7, 247-254

Vandenberg R, Mitrovic A, Chebib M, **Balcar VJ and Johnston GAR "Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2" Molecular Pharmacology, 1997, 51, 809-815 [PDF]


Allan RD, Duke RK, **Hambley TW, Johnston GAR, Mewett KN, Quickert N and Tran HW "Synthesis of unsaturated analogues of glutamic acid by amination of trianions from unsaturated dicarboxylic acids with chloramine" Aust. J. Chem., 1996, 49, 785-79)

Cooper EJ, Johnston GAR and Edwards FA "Differential sensitivity during development of GABA-mediated synaptic transmission to a neuroactive steroid in rat hippocampus and cerebellum". In GABA :Receptors, Transporters and Metabolism, edited by C. Tanaka andN.G. Bowery, Birkhäuser, Basel, 1996, pp. 195-200

Dodd P, Kril JJ, *Thomas GJ, Watson WEJ, Johnston GAR and **Harper CG "Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy" Brain Research, 1996, 710, 215-228

Greenwood JR, Vaccarella G, Capper HR, Mewett KN, Allan RD and Johnston GAR "Theoretical studies on the free-radical bromination of methyl-pyridazines in the synthesis of novel heterocyclic analogues of neurotransmitters" Journal of Molecular Structure (Theochem),1996, 368, 235-243

Johnston GAR "GABAA receptor pharmacology" Pharmacology & Therapeutics, 1996, 69, 173-198

Johnston GAR "Small molecules as drugs" Chemistry inAustralia, 1996, 64, 212-213

Johnston GAR "GABA-C receptors: relatively simple transmitter-gated ion channels?" Trends in Pharmacological Sciences, 1996, 17, 319-323 [PDF]

Maddison JE, Watson WEJ and Johnston GAR "Synaptosomal and brain slice cerebrocortical 3H-L-glutamate uptake in a rat model of hepatic encephalopathy" Neurochemistry International,1996, 28, 89-93


Allan RD, Apostopoulos C and **Hambley TW "The synthesis and structure of a cyclobutane analogue of glutamic acid with an acetic acid sidechain" Australian Journal of Chemistry, 1995, 48, 919-928

Duke DK, Allan RD, **Duke CC, **Hambley TW, Johnston GAR, Mewett KN and Mitrovic AD "Idiospermuline, a trimeric pyrroldinoindoline alkaloid from the seed of Idiospermum australiense" Journal of Natural Products Lloydia, 1995 58,1200-1208

Johnston GAR "GABA receptor pharmacology". In Pharmacological Sciences: Perspectives for Research and Therapy in the late 1990s,edited by AC Cuello and B Collier, Birkhäuser, Basel, 1995,pp. 11-15

Maddalena DJ and Johnston GAR "Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABA-A receptors using artificial neural networks" Journal of Medicinal Chemistry, 1995, 38, 715-724)


*Frydenvang K, *Krogsgaard-Larsen P, *Hansen JJ, Mitrovic A, TranH, Drew CA and Johnston GAR "GABAB antagonists:resolution, absolute stereochemistry and pharmacology of (R)- and(S)-phaclofen" Chirality, 1994, 6, 583-589

Johnston GAR "GABAC receptors" Progress in BrainResearch, 1994, 100, 61-65

Johnston GAR "GABA receptors - as complex as ABC?" Clinicaland Experimental Pharmacology and Physiology, 1994, 21,521-526

Maddalena DJ and Johnston GAR "Application of neural networks to quantitative structure-activity relationships of benzodiazepine/GABAA receptor binding compounds" in The Challenge of Neuropharmacology, a Tribute to the Memory of Willy Haefely, edited by H. Möhler & M. Da Prada, EditionesRoche, Basel, 1994, pages 136-139

Mitrovic AD and Johnston GAR "Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes byL-trans-pyrrolidine-2,4-dicarboxylate,threo-3-hydroxy-D-aspartate and D-aspartate" Neurochemistry International, 1994, 24, 583-588


Akinci MK and Johnston GAR "Sex differences in acute swim stress induced changes in the binding of MK-801 to the NMDA subclass of glutamate receptors in mouse forebrain" Journal ofNeurochemistry, 1993, 61, 2290-2293)

Burden PM and Allan RD "A facile synthesis of 2-imino-1-pyrrolidinealkanoic acids" 1993, 23, 1195-1199

Dodd PR, Leong PR and Johnston GAR "A Huntington Disease factor which inhibits [3H]kainate binding also blocks synaptosomal amino acid transport in rat brain" Neurochemistry International, 1993, 23, 131-13

Duke RK, Allan RD, Drew CA, Johnston GAR, Mewett KN, *Long MA and*Than C "The preparation of tritiated E- andZ-4-aminobut-2-enoic acids, conformationally restricted analogues of the inhibitory neurotransmitter 4-aminobutanoic acid (GABA)" Journal of Labelled Compounds and Radiopharmaceuticals, 1993, 33, 527-540

Duke RK, Allan RD, Drew CA, Johnston GAR, Mewett KN, *Long MA and *Than C "The synthesis and resolution of tritiated4-amino-3-phenylbutanoic acid ([3H]R- and[3H]S-beta-phenylGABA" Journal of Labelled Compounds and Radiopharmaceuticals, 1993, 33, 767-775


Capper HR, Mewett KN, Allan RD and Johnston GAR "Molecular modelling of N-methyl-D-aspartate (NMDA) receptor agonists and antagonists" Molecular Neuropharmacology, 1992, 2,83-87

Davies LP, Drew CA, *Duffield PM Johnston GAR and *Jamieson DD "Kava pyrones and resin: studies on GABAA,GABAB and benzodiazepine binding sites in rodent brain" Pharmacology & Toxicology, 1992, 71, 120-126)

Dodd PR, *Williams SH, Gundlach AL, *Harper PAW, *Healy PJ, *Dennis JA and Johnston GAR "The glutamate and GABA neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinaemia encephalopathies in newborn calves" J.Neurochem., 1992, 59, 582-590)

Johnston GAR "GABAA agonists as targets for drug development" Clinical and Experimental Pharmacology and Physiology, 1992, 19, 73-78

Johnston GAR and Akinci MK "Stress-induced changes inGABAA binding sites" Molecular Neuropharmacology,1992, 2, 151-154


Allan RD, Dickenson HW, Duke RK and Johnston GAR "ZAPA, a substrate for the neuronal high affinity GABA uptake system in ratbrain slices" Neurochemistry International, 1991, 18,63-67

Burden PM, Capper HR, Allan RD and Johnston GAR "The synthesis of1,8-disubstituted 10,11-dihydrodibenz-[b,f]oxepin-10-ones.Analogues of anaesthetic steroids" J. Chem. Soc. Perkin Trans.1, 1991, 3291-3294

Fletcher EJ and Johnston GAR "Regional heterogeneity of L-glutamate and L-aspartate high affinity uptake systems in the ratCNS" J. Neurochem., 1991, 57, 911-914

Fletcher EJ, Mewett KN, Drew CA, Allan RD and Johnston GAR "Inhibition of high affinity L-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid" Neuroscience Letters, 1991, 121, 133-135

Johnston GAR "GABAA antagonists" Seminars in the Neurosciences, 1991, 3, 205-210

Maddison JE, Watson WEJ, Dodd PR and Johnston GAR "Alterations incortical [3H]-kainate and[3H]-AMPA binding in a spontaneous animal model of chronic hepatic encephalopathy" J. Neurochem., 1991, 56, 1881-1888


Allan RD and Apostopoulos C "Synthesis of substituted(+)-bicuculline derivatives via chloromethylation" Australian Journal of Chemistry, 1990, 43, 1259-1268

Allan RD, Apostoloulos C and Richardson JA "2-Imino-1,3,4-thiadiazole derivatives of GABA as GABAAantagonists" Australian Journal of Chemistry, 1990, 43, 1767-1772

Allan RD, Bates MC, Drew CA, Duke RK, *Hambley TW, Johnston GAR,Mewett KN and Spence I "A new synthesis, resolution and invitro activities of (R)- and (S)-beta-phenyl-GABA" Tetrahedron, 1990, 46, 2511-2524

Allan RD, Drew CA, Ong J and Tran HW "Thioether analogues ofb aclofen, phaclofen and saclofen" Neuroscience Letters, 1990, 112, 223-228

Allan RD, Hanrahan JR, **Hambley TW, Johnston GAR, Mewett KN and Mitrovic AD "Synthesis and activity of a potentN-methyl-D-aspartic acid agonist,trans--1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids" Journal of Medicinal Chemistry, 1990, 33, 2905-2915

Allan RD and Tran HW "Facile synthesis of beta-phenylethylamine derivatives related to baclofen via aziridine ring opening" Australian Journal of Chemistry, 1990, 43,1123-1127

Bolden SW, Hambley JW, Johnston GAR and Rogers LJ "Neonatal stress and long-term modulation of GABA receptors in rat brain" Neuroscience Letters, 1990, 111, 258-262

Dickenson HW, Duke RK, Balcar VJ, Allan RD and Johnston GAR "Binding to rat brain membranes of(+)-trans-(1S,3S)-3-aminocyclopentane-1-carboxylic acid,(+)-TACP, a selective GABA-A receptor agonist" MolecularNeuropharmacology, 1990, 1, 1-6)

Drew CA, Spence I and Johnston GAR "Effect of chronic exposure tol ead on GABA binding in developing rat brain" NeurochemistryInternational, 1990, 17, 43-51

Drew CA, Johnston GAR, Kerr DIB and Ong J "Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen,3-aminopropylphosphinic acid and related GABA-A receptor antagonists" Neuroscience Letters, 1990, 113, 107-110

Gundlach AL, Grabara CSG, Johnston GAR and Harper PAW "Receptor alterations associated with spinal motoneuron degeneration in bovine Akabane disease" Annals of Neurology, 1990, 27, 513-519)

Huang JH and Johnston GAR "(+)-Hydrastine, a potent competitive antagonist at mammalian GABA-A receptors" Brit. J. Pharmac.,1990, 99, 727-730

Johnston GAR "Anxiety, steroids and GABA receptors" inAnxiety, N. McNaughton and G. Andrews, eds, University of Otago Press, Dunedin, 1990, pp. 201-212)

Johnston GAR "Anxiety chemistry" Chemistry in Australia,1990, 57, 334-337; reprinted in Australian Chemistry Resource Book, 1991, 10, 15-21

Kerr DIB, Ong J and Johnston GAR "Stress and cortisol modulation of GABA receptors" Stress & Anxiety, 1990, 13,209-213

Lummis SCR, Gundlach AL, Johnston GAR, Harper PAW and Dodd PR "Increased GABA receptor function in cerebral cortex of calves witha n inherited deficit of spinal glycine/strychnine receptors" J. Neurochem., 1990, 55, 421-426

Maddison JE, Leong DK, Dodd PR and Johnston GAR "Plasma GABA-like activity in rats with hepatic encephalopathy is due to GABA and taurine" Hepatology, 1990, 11, 105-110

Ong J, Harrison NL, Hall RG, Barker JL, Johnston GAR and Kerr DIB "3-Aminopropanephosphinic acid is a potent agonist at peripheral and central presynaptic GABA-B receptors" Brain Research, 1990, 526, 138-142)

Ong J, Kerr DIB, Capper HR and Johnston GAR "Cortisone, a potent GABA-A antagonist in the guinea-pig isolated ileum" J. Pharm.Pharmacol., 1990, 42, 662-664)

Ong J, Kerr DIB, Johnston GAR and Hall RG "Differing actions of baclofen and 3-amino-propylphosphinic acid in rat neocortical slices" Neuroscience Letters, 1990, 109, 169-173

Ong J, Kerr DIB and Johnston GAR "Effects of potassium channel blockers on baclofen-induced suppression of paroxysmal discharges inrat neo-cortical slices" Neuroscience Letters, 1990, 112, 216-222