Current research

The Laboratory's research is directed towards the development of drugs selectively active at multiple excitatory amino acid and GABA receptor sites and transporters, and to drugs acting on ATP-gated potassium channels using structure-activity studies and computer-assisted modelling. New chemical entities synthesised in the Adrien Albert Laboratory are evaluated in house on a variety of test preparations.

Structure-activity models of the above receptors suggest new compounds to be investigated as neuroactive substances possibly as agonists, antagonists or modulators at these receptors. Much of the work involves development of routes for the chemical synthesis of these target molecules. One of the important features of this work is that the new compounds are designed, synthesised and tested in isolated tissue preparations and whole animal models within the research group.

Current major research projects include:

New agents acting on GABAA receptors

Contact: Dr Katherine Locock, phone 02 9036 6498, fax 02 9351 3868, e-mail klocock@med.usyd.edu.au

Agents acting on GABAB receptors

Contact: Dr Jan Hanrahan, phone 02 9351 2078, fax 02 9351 4391, e-mail janeh@pharm.usyd.edu.au

Agents acting on GABAC receptors

Contact: Dr Mary Collins, phone 02 9351 8584, fax 02 9351 4391, e-mail mcollins@pharm.usyd.edu.au

Effects of stress on GABAA receptors

Contact: Professor Graham Johnston, phone 02 9351 6117, fax 02 9351 3868, e-mail grahamj@mail.usyd.edu.au

Positive modulators of GABAA receptors

Contact: Professor Graham Johnston, phone 02 9351 6117, fax 02 9351 3868, e-mail grahamj@mail.usyd.edu.au

Effects of agents from Ginkgo biloba on GABA receptors

Contact: Dr Rujee Duke, phone 02 9351 6204, fax 02 9351 3868, e-mail rujeek@pharmacol.usyd.edu.au