Publications: 2011, 2012, 2013, 2014 and in press

Refereed Journal Articles

  1. Abdelhalim A, Chebib M, Aburjai T, Johnston GAR and Hanrahan JR (2014) "GABAa receptor modulation by compounds isolated from Salvia triloba L." Advances in Biological Chemistry, Special Issue on Phytochemicals, 4, 148-159)
  2. Ayer, J., Harmer, J., David, C., S Steinbeck, K., Seale, J., Celermajer, D. (2011) Severe Obesity Is Associated With Impaired Arterial Smooth Muscle Function in Young Adults. Obesity, 19:54-60
  3. Bagley EE, Hacker J, Chefer VI, Mallet C, McNally GP, Chieng BC, Perroud J, Shippenberg TS, Christie MJ. (2011) Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nature Neuroscience 14(12):1548-54
  4. Bagley, EE and Westbrook, GL. (2012) Short-term field stimulation mimics synaptic maturation of hippocampal synapses. Journal of Physiology, 590 (7):1641 - 1654
  5. Bailey CG, Ryan RM, Thoeng AD, Ng C, King K, Vanslambrouck JM, Auray-Blais C, Vandenberg RJ, Bröer S, Rasko JE. (2011) Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. Journal of Clinical Investigation, 121(1):446-53
  6. Bastug T, Heinzelmann G, Kuyucak S, Salim M, Vandenberg RJ, Ryan RM (2012) Position of the Third Na+ Site in the Aspartate Transporter GltPh and the Human Glutamate Transporter, EAAT1. PLoS ONE 7(3): e33058.
  7. Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek C, Johnson D, Borghese CM, Hanrahan JR, Johnston GAR, Chebib M and Harris RA (2014) GABA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice PLoS One, 9(1): e85525. doi:10.1371/journal.pone.0085525
  8. Boucher, AA, Arnold, JC, Hunt, GE, Spiro, A, Spencer, J, Brown, C, McGregor, IS, Bennett, MR, Kassiou, M (2011) Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test. Neuroscience 189: 170-177.
  9. Boucher, AA, Hunt, GE, Micheau, J, Huang, X, McGregor, IS, Karl, T, Arnold, JC (2011) The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. Int J Neuropsychopharmacol 14(5): 631-643.
  10. Bowen, MT, Carson, DS, Spiro, A, Arnold, JC, McGregor, IS (2011) Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats. PLoS One 6(11): e27237.
  11. Chesworth, R, Yulyaningsih, E, Cappas, E, C., Arnold J.C., Sainsbury, A, Karl, T (2012) The response of neuregulin 1 mutant mice to acute restraint stress. Neurosci Lett 515: 82-86
  12. Dang VC, Chieng BC, Christie MJ (2012) Prolonged stimulation of µ-opioid receptors produces beta-arrestin-2 mediated heterologous desensitization of alpha2-adrenoceptor function in locus coeruleus neurons. Molecular Pharmacology 82:473-80
  13. Dang VC, Christie MJ (2012) Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons. British Journal of Pharmacology 165; 1704-1716
  14. Ejje N, Lacey E, Codd R. (2012) Analytical-scale purification of trichostatin A from bacterial culture in a single step and with high selectivity using immobilised metal affinity chromatography. RSC Advances, 2(1):333-7.
  15. Enoksson T, Bertran-Gonzalez J, Christie MJ (2012) Nucleus accumbens D2- and D1-receptor expressing medium spiny neurones are selectively activated by morphine withdrawal and acute morphine, respectively. Neuropharmacology, 62(8):2463-71
  16. Fernandez SP, Karin N, Mewett KN, Chebib M, Johnston GAR and Hanrahan JR (2012) Flavan-3-ol esters: new agents for exploring modulatory sites on GABA-A receptors. British Journal of Pharmacology, 165, 965-977
  17. Gavande N, Karim N, Johnston GAR,Hanrahan JR and Chebib M (2011) Identification of benzopyran-4-one derivatives (isoflavones) as positive modulators of GABA-A receptors, ChemMedChem, 6, 1340–1346
  18. Groebler LK, Liu J, Shanu A, Codd R, Witting PK. (2011) Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl)carboxamide in a cell model of myoglobinuria, Biochemical Journal 435(3):669-77.
  19. Hall BJ, Karim N, Chebib M, Johnston GAR and Hanrahan JR "Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone" Neurochemical Research, accepted 14 September 2013
  20. Hanrahan JR, Chebib M and Johnston GAR (2011) Flavonoid modulation of GABA-A receptors. British Journal of Pharmacology, 163, 234-245
  21. Hare NJ, Soe CZ, Rose B, Harbour C, Codd R, Manos J, Cordwell SJ. (2012) Proteomics of Pseudomonas aeruginosa Australian epidemic strain 1 (AES-1) cultured under conditions mimicking the cystic fibrosis lung reveals increased iron acquisition via the siderophore pyochelin. Journal of Proteome Research, 11(2):776-95.
  22. Huang SH, Lewis TG, Lummis SCR, Thompson AJ, Chebib M, Johnston GAR and Duke RK (2012) Mixed antagonistic effects of the ginkgolides at recombinant human rho1 GABAc receptors. Neuropharmacology, 63, 1127-1139
  23. Johnston CF, Carroll PR, Matthews ST, Mitchell SJ, Hilmer SN (2011) ‘You Look Like a 240 mg’: Gentamicin Dosing in a Sydney Teaching Hospital. Journal of Pharmacy Practice and Research. 41 (4) 267-9.
  24. Johnston GAR (2014) Muscimol as an ionotropic GABA receptor agonist" Neurochemical Research, accepted 21 January 2014
  25. Johnston GAR (2013) Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology, 169, 328–336.
  26. Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li Y, Li GQ. (2012) The protective effects of natural products on blood-brain barrier breakdown. Current Medicinal Chemistry, 19 (12):1830-45
  27. Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ (2012). Combination of TNF-alpha, Homocysteine and Adenosine Exacerbated Cytotoxicity in Human Cardiovascular and Cerebrovascular Endothelial Cells. Cell Physiol Biochem 30(3): 805-814
  28. Kane A, Carroll PR, Matthews ST, Hilmer SN (2012) Characteristics of Younger and Older Patients with Suspected Paracetamol Toxicity. Australasian Journal on Ageing.
  29. Karanges E, Li KM, Motbey C, Callaghan PD, Katsifis A, McGregor IS. (2011) Differential behavioural and neurochemical outcomes from chronic paroxetine treatment in adolescent and adult rats: a model of adverse antidepressant effects in human adolescents? International Journal of Neuropsychopharmacology, 14(4):491-504
  30. Karim N, Curmi J, Gavande N, Johnston GAR, Hanrahan JR, Tierney ML and Chebib M (2012) 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA-A receptors, British Journal of Pharmacology, 165, 880-896
  31. Karim N, Wellendorph P, Absalom N, Bang LH, Jensen ML, Hansen MM, Lee HJ, Johnston GAR, Hanrahan JR and Chebib M (2012) Low nanomolar GABA effects at extrasynaptic α4β1/3δ GABAa receptor subtypes indicate a different binding mode for GABA at these receptors Biochemical Pharmacology, 84, 549-557
  32. Karim N, Gavande N, Wellendorph P, Johnston GAR, Hanrahan JR, and Chebib M (2011) 3-Hydroxy-2’-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABA-A receptor subtypes. Biochemical Pharmacology, 82, 1971-1983
  33. Karim N, Wellendorph P, Absalom N, Johnston GAR, Hanrahan JR and Chebib M (2013) Potency of GABA at human recombinant GABAa receptors expressed in Xenopus oocytes: a mini review. Amino Acids, 44, 1139-1149
  34. Kemp AH, Quintana DS, Felmingham KL, Matthews S, Jelinek HF, (2012) Depression, Comorbid Anxiety Disorders, and Heart Rate Variability in Physically Healthy, Unmedicated Patients: Implications for Cardiovascular Risk. PLoS ONE (Feb 15 2012)
  35. Klein, C, Karanges, E, Spiro, A, Wong, A, Spencer, J, Huynh, T, Gunasekaran, N, Karl, T, Long, LE, Huang, XF, Liu, K, Arnold, JC, McGregor, IS (2011) Cannabidiol potentiates Delta-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology 218(2): 443-457.
  36. Lifa T, Ejje N, Codd R. (2012) Coordinate-bond-dependent solid-phase organic synthesis of biotinylated desferrioxamine B: a new route for metal-specific probes. Chemical Communications, 48(14):2003-5.
  37. Liu J, Obando D, Liao V, Codd R. (2011) The many faces of the adamantyl group in drug design. European Journal of Medicinal Chemistry, 46(6):1949-63.
  38. Locock KES, Yamamoto I, Tran P, Hanrahan JR, Chebib M, Johnston GAR and Allan RD (2013) γ-Aminobutyric acid(C) (GABAc) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates. Journal of Medicinal Chemistry, 56:5626-5630
  39. Long, LE, Chesworth, R, Huang, X, Wong, A, Spiro, A, McGregor, IS, Arnold, JC*, Karl, T* (2012) Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice. PLoS ONE 7(4): e34129. *Joint senior authors
  40. Macindoe I, Kwan AH, Ren Q, Morris VK, Yang W, Mackay JP, Sunde M. (2012) Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS. Proc Natl Acad Sci USA. Acc. 23/01/12
  41. Matthews S, Succar P, McParland B, Jelinek H, Buckland M, McLachlan CS. (2012) Classification of Oligodendrogliomas: molecular and immuno-histochemical targets in the context of diagnostic “classical” histological assessment. Asia Pacific Journal of Clinical Oncology (accepted 9/1/2012).
  42. Matthews S, Vafaeiafraz S, Jelinek H, McLachlan CS. (2012) Heart rate stability and decreased parasympathetic heart rate variability in healthy young adults during perceived stress. International Journal of Cardiology (accepted 6/2/2012)
  43. McMahon VA, Matthews S, Capper H, Chudleigh JB, McLachlan CS (2011). Understanding decision and enabling factors influencing clinical trial participation in australia: a view point. Asian Pacific journal of cancer prevention : APJCP 12(11): 3153-3156.
  44. Murali SS, Napier IA, Rycroft BK, Christie MJ (2012) ORL1 receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. Journal of Physiology, 590(Pt 7):1655-67.
  45. Napier IA, Klimis H, Rycroft BK, Jin AH, Alewood PF, Motin L, Adams DJ, Christie MJ. (2012) Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology, 62(7):2201-6.
  46. Ng CKL, Kim H-L, Gavande N, Yamamoto I, Kumar RJ, Mewett KN, Johnston GAR, Hanrahan JR and Chebib M (2011) Medicinal chemistry of ρ GABA-C receptors. Future Medicinal Chemistry, 3, 197-209
  47. Pakchung AAH, Soe CZ, Lifa T, Codd R. (2011) Complexes formed in solution between vanadium(IV)/(V) and the cyclic dihydroxamic acid putrebactin or linear suberodihydroxamic acid. Inorganic Chemistry, 50(13):5978-89.
  48. Scott, H., Gebhardt, F., Mitrovic, A., Vandenberg, R., Dodd, P. Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease (2011). Neurobiology of aging, 32:553.e1-553.e11
  49. Simpson PJL, Codd R. (2011) Cold adaptation of the mononuclear molybdoenzyme periplasmic nitrate reductase from the Antarctic bacterium Shewanella gelidimarina. Biochemical and Biophysical Research Communications, 414(4):783-88.
  50. Sokolic, L, Long, LE, Hunt, GE, Arnold, JC, McGregor, IS (2011) Disruptive effects of the prototypical cannabinoid Delta-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats. Behav Pharmacol 22(3): 191-202.
  51. Tan, Y., Kamal, M., Wang, Z., Xiao, W., Seale, J., Qu, X. Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome (2011). Clinical science, 120:297-305
  52. Tan, Y, Sun, L-Q, Kamal, MA, Wang, X, Seale JP, Qu, X (2011) Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolicsyndrome and non-alcoholic fatty liver disease in mice. Biochima BiophysicaActa, 1811, 1045 – 1053
  53. Thompson AJ, Jarvis GE, Duke RK, Johnston GAR and Lummis SCR (2011) Ginkgolide and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps with the picrotoxin binding site. Neuropharmacology, 60, 488-495
  54. Thompson AJ, McGonigle I, Duke RK, Johnston GAR and Lummis SCR (2012) A single amino acid determines the toxicity of Ginkgo biloba extracts. FASEB Journal, 26, 1884-1891
  55. Vandenberg R, Handford CA, Campbell EM, Ryan RM, Yool AJ (2011) Water and Urea Permeation Pathways of the Human Excitatory Amino Acid Transporter EAAT1. Biochemical Journal, 439(2):333-40.
  56. Vetter I, Mozar CA, Durek T, Wingerd JS, Alewood PF, Christie MJ, Lewis RJ (2012). Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83(11):1562-71.
  57. Wong, A, Gunasekaran, N, Hancock, DP, Denyer, GS, Meng, L, Radford, JL, McGregor, IS, Arnold, JC (2012) The major plant-derived cannabinoid ?9-tetrahydrocannabinol promotes hypertrophy and macrophage infiltration in adipose tissue. Horm Metab Res 44: 105-113.
  58. Wong KH, Li GQ, Li KM, Razmovski-Naumovski V, Chan K. (2011) Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. Journal of Ethnopharmacology, 134(3):584-607
  59. Yamamoto I, Absalom N, Carland JE, Doddareddy MR, Gavande N, Johnston GAR, Hanrahan JR and Chebib M (2012) Differentiating enantioselective actions of GABOB: A possible role for threonine 244 in the binding site of GABAc ρ1 receptors, ACS Chemical Neuroscience, 3, 665-673
  60. Yamamoto I, Carland JE, Locock KES, Gavande N, Absalom N, Hanrahan JR, Allan, RD, Johnston GAR and Chebib M (2012) Structurally diverse GABA antagonists interact differently with open and closed conformational states of the rho1 receptor, ACS Chemical Neuroscience, 3, 293-301
  61. Yamamoto, Deniau GP, Gavande N, Chebib M, Johnston GAR, O'Hagen D (2011) Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABAc receptors, 47, 7956-7958
  62. Yow TT, Pera E, Absalom N, Heblinski M, Johnston GAR, Hanrahan JR and Chebib M (2011) Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163, 1017-1033

Other Publications

  1. Johnston GAR (2011) Glutamate as a neurotransmitter and the ISN’ Neurochemistry News, issue 39, page 7