PROFESSOR WILLIAM STANLEY

PROFESSOR WILLIAM STANLEY

Chair in Cardiovascular Physiology
Physiology, School of Medical Sciences
T: +61 2 9351 4603
E:

Location:
Room N640
Stanley Lab
Anderson Stuart Bldg F13

 

Biographical details

William C. Stanley is a native of California and attended the University of California, Berkeley. He received his PhD in exercise physiology, and then did his postdoctoral fellowship at the Cardiovascular Research Institute at the University of California, San Francisco, where he received training in cardiac physiology and myocardial metabolism. In 1989, he joined the faculty of the University of Wisconsin and initiated studies addressing cardiac metabolism in health and disease. In 1992, he left academic research and worked in the pharmaceutical industry on the discovery and development of cardiovascular drugs. He return to academics in 1996 to join the Department of Physiology and Biophysics at Case Western Reserve University, and established a research program focused on integrative approaches to metabolic dysfunction in heart failure and ischemia. In 2007 he joined the Division of Cardiology at the University of Maryland. In 2013 he moved down under to become Chair of Cardiovascular Physiology at the University of Sydney. He is a recognized expert on cardiac metabolism and physiology, and is the Editor in Chief of the American Journal of Physiology – Heart & Circulation.

Research Interest

Dr. Stanley has broad experience in integrative cardiovascular physiology and has worked with a wide array of experimental systems and approaches, from isolated organelles to whole animals. His research program addresses questions regarding the role of energy metabolism and diet in the pathophysiology of heart failure and ischemic injury using a broad systems approach. Current interested include understanding mitochondrial dysfunction in heart disease, assessing the effects of dietary lipids on cardiac function. Specifically, his group has investigated the mechanisms for the beneficial effects of marine n3 polyunsaturated fatty acids and other long chain lipids on the structure and function of cardiac mitochondria. Their ultimate goal is to develop new diets to prevent and treat heart failure. The lab uses a wide variety of methods, including mitochondrial isolation and biochemical evaluation, and in vivo assessment of cardiac function using clinically relevant endpoints in animals models.

PhD and Masters’ project opportunities

“Dietary Fatty Acids and Mitochondrial Pathophysiology in Heart Failure”
“Proteome Dynamics in Heart Failure Assessed with Heavy Water”.