Current funding

NHMRC Senior Professorial Research Fellowship

Innovations in cancer imaging and targeted radiotherapy to improve human health
CIs: Keall
Goal: The Fellowship has three integrated themes for global impact: (1) Revolutionise cancer imaging, (2) Pioneer functionally targeted radiotherapy and (3) Enable global access to cancer radiotherapy.

Australian Cancer Research Foundation (ACRF)

The ACRF Image-X Institute: Eradicating Cancer through Innovation in Imaging and Targeted X-ray Therapy\
CIs: Keall, Barton, Jackson, Thwaites, Kuncic, Fulton, Foster
Goal: The institute will (1) Revolutionise cancer
imaging, (2) Pioneer functionally targeted radiotherapy and (3) Enable global access to cancer radiotherapy.

NHMRC Development Grant

Breathe Well: Improving cancer imaging and targeted radiotherapy using audiovisual biofeedback
CIs: Keall, Kay, O'Brien, Kron, Greer, Wright, Sawant
Goal: We have developed the Breathe Well AudioVisual (AV) biofeedback device to assist cancer patients in breathing predictably during a course of radiotherapy. Breathe Well will overcome the deleterious consequences of irregular breathing and improve the therapeutic benefit of cancer imaging and targeted radiotherapy. In this Development Grant we will perform a comprehensive clinical evaluation and technology assessment of the Breathe Well device in several trials, with the flagship trial the prospective multi-institutional phase II randomised clinical trial ‘AVIATOR’. Successful completion of this project will lead to a clinically proven, market-ready device that will be integrated with cancer imaging and targeted radiotherapy systems. more

Nano-X: A new class of cancer radiotherapy
CIs: Keall, Feain, Mackie, Prather, Wright, O'Brien, Jackson, Barton, Bennet
Goal: To create a new class of cancer radiotherapy system that solves the complex problem of how to target a tumour
with precision and accuracy even as the patient’s anatomy changes during treatment. Our Nano-X system is built with real-time imaging guidance and treatment adaptation at the heart of the design process; and complex processing tasks have been moved from hardware to software, enabling radical changes to machine design. Together, these innovations will ensure better treatment outcomes and increased safety and
reliability. more

Cancer Australia Priority-driven Collaborative Cancer Research Scheme

Reducing Thoracic Imaging Dose and Improving Image Quality in Radiotherapy Treatments
CIs: O'Brien, Froyland, Sonke
Goal The aim of this project is to reduce imaging dose, or alternatively improve image quality, in radiotherapy treatment rooms when imaging the thorax or upper abdomen using a technique known as four dimensional cone beam computed tomography. For the same image quality, we expect to reduce imaging dose by at least 50%. more

Real-time Six Degree of Freedom Tumour Motion Management in Cancer Radiotherapy
CIs: Huang, Booth, Fahrig, Poulsen, Kneebone, Eade
Goal The rationale of this study is to adapt the radiation beam to the moving tumour by dynamically moving the MLC leaves in real time, so that the irradiated healthy tissue (blue area) surrounding the tumour can be greatly reduced by the proposed strategy relative to the current clinical practice. We will develop a real-time six degree of freedom (6 DoF; 3 DoF of translation and 3 DoF of rotation) tumour motion management system. more

SPARK: Stereotactic Prostate Adaptive Radiotherapy utilising Kilovoltage intrafraction monitoring
CIs: Keall, Martin, Foroudi, Kneebone, Gebski, Poulsen
Goal: The SPARK trial will measure the cancer targeting accuracy and patient outcomes for 48 patients treated in five sessions as opposed to the conventional 40 sessions, with the reduced number of treatment sessions enabled by the KIM’s increased cancer targeting accuracy. more

1064731 Hitting the Target: Real-Time Prostate Cancer Radiotherapy
CIs: Keall, Eade, Kneebone, Booth
Goal: During this grant we will enable real-time kilovoltage intrafraction monitoring (KIM) to accurately track the prostate during treatment and realign the radiation beam when the prostate motion exceeds 3mm. In a clinical trial we will test the hypothesis that KIM can reduce tumour dose errors from 30% to less than 5%. more

NHMRC Program Grant

1036078 The Australian MRI-linac Program: Improving cancer treatment through real-time image guided radiotherapy.
CIs: Keall, Barton, Crozier
Goal: To develop MRI technology to improve the way in which cancer can be tracked as it moves within the body, assisting in improving the effectiveness of radiation therapy. more

NHMRC Project Grant

1034060 Respiratory motion-guided 4D cone beam CT imaging.
CI: Keall
Goal: More advanced image guidance methods are being implemented in radiation therapy. These advances facilitate shaping the radiation beam to the anatomically changing tumour during a course of treatment. More accurate targeting facilitates increased survival and reduces treatment-related toxicities for cancer patients. In this project we will develop and investigate our research innovation and create 2nd generation ‘respirator modulated’ 4D cone beam CT to allow the improved visualization of lung tumours at the time of treatment. more

NHMRC Early Career Fellowship and CINSW Early Career Fellowship

1120333 and CS00481 Real-time in-vivo imaging during Lung Cancer Radiotherapy.
CI: Shieh
Goal: To develop and clinically implement Real-time 3D Anatomic Imaging for lung cancer radiotherapy treatment. The proposed approach utilises x-ray fluoroscopy, which is available on 90% of the 10,000 commercial radiotherapy systems worldwide. Real-time 3D Anatomic Imaging is achieved by combining real-time x-ray fluoroscopic images with pre-treatment anatomic modelling using principal-component analysis and advanced image processing algorithms. Completion of this project will render a software technology for improving treatment outcome that is widely applicable to existing radiotherapy workflows and equipment. more


LE120100006 An adaptable and dedicated linear accelerator for medical radiation research.
CIs: Keall, Jackson, Rozenfeld, Barton, Greer, Vial, Baldock, Meltcalfe, Thwaites, Kuncic, Holloway, Bosi, Eslick, Downes
Goal: Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using an adaptable and dedicated linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected. more