The ACRF Image-X Institute: Eradicating Cancer through Innovation in Imaging and Targeted X-ray Therapy\
CIs: Keall, Barton, Jackson, Thwaites, Kuncic, Fulton, Foster
Goal: The institute will (1) Revolutionise cancer
imaging, (2) Pioneer functionally targeted radiotherapy and (3) Enable global access to cancer radiotherapy.
Breathe Well: Improving cancer imaging and targeted radiotherapy using audiovisual biofeedback
CIs: Keall, Kay, O'Brien, Kron, Greer, Wright, Sawant
Goal: We have developed the Breathe Well AudioVisual (AV) biofeedback device to assist cancer patients in breathing predictably during a course of radiotherapy. Breathe Well will overcome the deleterious consequences of irregular breathing and improve the therapeutic benefit of cancer imaging and targeted radiotherapy. In this Development Grant we will perform a comprehensive clinical evaluation and technology assessment of the Breathe Well device in several trials, with the flagship trial the prospective multi-institutional phase II randomised clinical trial ‘AVIATOR’. Successful completion of this project will lead to a clinically proven, market-ready device that will be integrated with cancer imaging and targeted radiotherapy systems. more
Reducing Thoracic Imaging Dose and Improving Image Quality in Radiotherapy Treatments
CIs: O'Brien, Froyland, Sonke
Goal The aim of this project is to reduce imaging dose, or alternatively improve image quality, in radiotherapy treatment rooms when imaging the thorax or upper abdomen using a technique known as four dimensional cone beam computed tomography. For the same image quality, we expect to reduce imaging dose by at least 50%. more
Real-time Six Degree of Freedom Tumour Motion Management in Cancer Radiotherapy
CIs: Huang, Booth, Fahrig, Poulsen, Kneebone, Eade
Goal The rationale of this study is to adapt the radiation beam to the moving tumour by dynamically moving the MLC leaves in real time, so that the irradiated healthy tissue (blue area) surrounding the tumour can be greatly reduced by the proposed strategy relative to the current clinical practice. We will develop a real-time six degree of freedom (6 DoF; 3 DoF of translation and 3 DoF of rotation) tumour motion management system. more
SPARK: Stereotactic Prostate Adaptive Radiotherapy utilising Kilovoltage intrafraction monitoring
CIs: Keall, Martin, Foroudi, Kneebone, Gebski, Poulsen
Goal: The SPARK trial will measure the cancer targeting accuracy and patient outcomes for 48 patients treated in five sessions as opposed to the conventional 40 sessions, with the reduced number of treatment sessions enabled by the KIM’s increased cancer targeting accuracy. more
1064731 Hitting the Target: Real-Time Prostate Cancer Radiotherapy
CIs: Keall, Eade, Kneebone, Booth
Goal: During this grant we will enable real-time kilovoltage intrafraction monitoring (KIM) to accurately track the prostate during treatment and realign the radiation beam when the prostate motion exceeds 3mm. In a clinical trial we will test the hypothesis that KIM can reduce tumour dose errors from 30% to less than 5%. more
633000 Innovations in medical physics to improve human health.
Goal: The scientific goal is an improved understanding of macroscopic and microscopic response of cancerous and normal tissue to radiation. The clinical goal is to translate more accurate radiation-tumor targeting into improved cancer therapy success through higher local tumor control with decreased treatment-related toxicity and reduced metastatic spread. more
1036078 The Australian MRI-linac Program: Improving cancer treatment through real-time image guided radiotherapy.
CIs: Keall, Barton, Crozier
Goal: To develop MRI technology to improve the way in which cancer can be tracked as it moves within the body, assisting in improving the effectiveness of radiation therapy. more
1034060 Respiratory motion-guided 4D cone beam CT imaging.
Goal: More advanced image guidance methods are being implemented in radiation therapy. These advances facilitate shaping the radiation beam to the anatomically changing tumour during a course of treatment. More accurate targeting facilitates increased survival and reduces treatment-related toxicities for cancer patients. In this project we will develop and investigate our research innovation and create 2nd generation ‘respirator modulated’ 4D cone beam CT to allow the improved visualization of lung tumours at the time of treatment. more
DP120100821 A hybrid magnetic resonance imaging: linear accelerator for highly accurate radiotherapy cancer treatment.
CI: Crozier, Keall
Goal: Radiotherapy is often used to treat cancer, however it is very difficult to ensure the radiation doses the tumour properly as the tumour moves during treatment due to breathing, etc. This project will produce an image-guidance system that will allow much better targeting of the treatment and thus produce better outcomes. more
LE120100006 An adaptable and dedicated linear accelerator for medical radiation research.
CIs: Keall, Jackson, Rozenfeld, Barton, Greer, Vial, Baldock, Meltcalfe, Thwaites, Kuncic, Holloway, Bosi, Eslick, Downes
Goal: Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using an adaptable and dedicated linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected. more
1042375 Cancer radiotherapy 2020: accounting for tumour deformation in real time to improve treatment outcome.
Goal: To develop an internationally unique radiotherapy system that can adjust the radiation beam in real time to follow the changing tumour shape. more
1R21EB015957-01 MR-Compatible Linac gun for Robotic Linac Adaptation
Goal: The specific aims of this project are: 1. to develop an optimized electron gun design for use within a parallel fringe field with strengths up to 0.2 T and 2. to build and verify the us of this gun when placed in parallel at up to 0.2 T fringe magnetic field in the In-Line MRI-Linac and/or the RLA MRI- Linac. more
R21 CA 156068R21 Real-time tumour tracking with beam's-eye-view-imaging.
CIs: Berbeco, Keall
Goal: The major goal of this project is to develop methods and investigate the hypothesis that tracking lung tumors directly during SBRT, using beam’s-eye-view (BEV) imaging coupled with a dynamic multileaf collimator (DMLC), will lead to clinically significant normal tissue sparing. more