Current funding

Cancer Australia Priority-driven Collaborative Cancer Research Scheme

1064731 Hitting the Target: Real-Time Prostate Cancer Radiotherapy

CIs: Keall, Eade, Kneebone, Booth

Goal: During this grant we will enable real-time kilovoltage intrafraction monitoring (KIM) to accurately track the prostate during treatment and realign the radiation beam when the prostate motion exceeds 3mm. In a clinical trial we will test the hypothesis that KIM can reduce tumour dose errors from 30% to less than 5%. more


NHMRC Australia Fellowship

633000 Innovations in medical physics to improve human health.

CI: Keall

Goal: The scientific goal is an improved understanding of macroscopic and microscopic response of cancerous and normal tissue to radiation. The clinical goal is to translate more accurate radiation-tumor targeting into improved cancer therapy success through higher local tumor control with decreased treatment-related toxicity and reduced metastatic spread. more


NHMRC Program Grant

1036078 The Australian MRI-linac Program: Improving cancer treatment through real-time image guided radiotherapy.

CIs: Keall, Barton, Crozier

Goal: To develop MRI technology to improve the way in which cancer can be tracked as it moves within the body, assisting in improving the effectiveness of radiation therapy. more


NHMRC Project Grant

1034060 Respiratory motion-guided 4D cone beam CT imaging.

CI: Keall

Goal: More advanced image guidance methods are being implemented in radiation therapy. These advances facilitate shaping the radiation beam to the anatomically changing tumour during a course of treatment. More accurate targeting facilitates increased survival and reduces treatment-related toxicities for cancer patients. In this project we will develop and investigate our research innovation and create 2nd generation ‘respirator modulated’ 4D cone beam CT to allow the improved visualization of lung tumours at the time of treatment. more


ARC Discovery Grant

DP120100821 A hybrid magnetic resonance imaging: linear accelerator for highly accurate radiotherapy cancer treatment.

CI: Crozier, Keall

Goal: Radiotherapy is often used to treat cancer, however it is very difficult to ensure the radiation doses the tumour properly as the tumour moves during treatment due to breathing, etc. This project will produce an image-guidance system that will allow much better targeting of the treatment and thus produce better outcomes. more


ARC LIEF Grant

LE120100006 An adaptable and dedicated linear accelerator for medical radiation research.

CIs: Keall, Jackson, Rozenfeld, Barton, Greer, Vial, Baldock, Meltcalfe, Thwaites, Kuncic, Holloway, Bosi, Eslick, Downes

Goal: Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using an adaptable and dedicated linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected. more


NHMRC Project Grant

1042375 Cancer radiotherapy 2020: accounting for tumour deformation in real time to improve treatment outcome

CI: Ge

Goal: To develop an internationally unique radiotherapy system that can adjust the radiation beam in real time to follow the changing tumour shape. more


US NIH/NCI R21

1R21EB015957-01 MR-Compatible Linac gun for Robotic Linac Adaptation

PI: Fahrig/Keall

Goal: The specific aims of this project are: 1. to develop an optimized electron gun design for use within a parallel fringe field with strengths up to 0.2 T and 2. to build and verify the us of this gun when placed in parallel at up to 0.2 T fringe magnetic field in the In-Line MRI-Linac and/or the RLA MRI- Linac. more


US NIH/NCI R21

R21 CA 156068R21 Real-time tumour tracking with beam's-eye-view-imaging.

CIs: Berbeco, Keall

Goal: The major goal of this project is to develop methods and investigate the hypothesis that tracking lung tumors directly during SBRT, using beam’s-eye-view (BEV) imaging coupled with a dynamic multileaf collimator (DMLC), will lead to clinically significant normal tissue sparing. more