Research outline - Cardiovascular Neuroscience Laboratory

Within: Bosch Institute

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Major funding sources

  • 2009-2011: NHMRC grant "Cardiovascular responses to stress and arousal: hypothalamic and brainstem mechanisms"

Selected publications

Horiuchi, J., McDowall, L.M., Dampney, R.A.L. Vasomotor and respiratory responses evoked from the dorsolateral PAG are mediated by the dorsomedial hypothalamus. Journal of Physiology, 2009;587:5149-5162.

Dampney, R.A.L., Horiuchi, J. and McDowall, L.M. Hypothalamic mechanisms coordinating cardiorespiratory function during exercise and defensive behaviour. Autonomic Neuroscience, 2008;42:3-10.

McDowall, L.M., Horiuchi, J. and Dampney, R.A.L. Effects of disinhibition of neurons in the dorsomedial hypothalamus on central respiratory drive. American Journal of Physiology. 2007;293:R1728-R1735.

McDowall, L.M., Horiuchi, J., Killinger, S., and Dampney, R.A.L. Modulation of the baroreceptor reflex by the dorsomedial hypothalamic nucleus and perifornical area. American Journal of Physiology. 2006;290:R1020-1026.

Horiuchi, J., Wakabayashi, S. and Dampney, R.A.L. Activation of 5-HT1A receptors suppresses the cardiovascular response evoked from the dorsomedial hypothalamic nucleus. Hypertension. 2005;46:1-7.

Horiuchi, J., McAllen, R.M., Allen, A.M., Killinger, S., Fontes, M.A.P. and Dampney, R.A.L. (2004) Descending vasomotor pathways from the dorsomedial hypothalamic nucleus: role of medullary raphe and RVLM. American Journal of Physiology, 287: R824-R832.

Dampney, R.A.L. and Horiuchi, J. Functional organisation of central cardiovascular pathways: studies using c-fos gene expression. Progress in Neurobiology. 2003;23:597-616.

Fontes, M.A.P., Tagawa, T., Polson, J.W., Cavanagh, S.-J. and Dampney, R.A.L. Descending pathways mediating cardiovascular response from the dorsomedial hypothalamic nucleus. American Journal of Physiology. 2001;280:H2891-H2901.

Tagawa, T. and Dampney, R.A.L. AT1 receptors mediate excitatory inputs to RVLM pressor neurons from hypothalamus. Hypertension. 1999;34:1301-1307.

Hirooka, Y., Polson, J.W., Potts, P.D. & Dampney, R.A.L. Hypoxia-induced Fos expression in neurons projecting to the pressor region in the rostral ventrolateral medulla. Neuroscience. 1997;80:1209-1224.

Li, Y.-W. & Dampney, R.A.L. Expression of fos-like protein in brain following sustained hypertension and hypotension in conscious rabbits. Neuroscience. 1994;61:613-634.

Dampney, R.A.L. Functional organization of central pathways regulating the cardiovascular system. Physiological Reviews. 1994;74:323-364.

Major collaborations

Assoc Professor Robin McAllen, Howard Florey Institute, University of Melbourne.
Project: Central command mechanisms regulating cardiorespiratory function.