Cerebral Microvasculature and Inflammation Laboratory

Within: Bosch Institute, Discipline of Anatomy and Histology

Head of laboratory

Overview

The central hypothesis of the studies conducted by this laboratory is that capillary microhaemorrhages result in the classic neuropathology of Alzheimer's Disease. These microhaemorrhages (>200micro-meters) around capillaries coincide with beta-A plaques. They occur chronically and result in both acute neuronal death and slowly developing neurofibrillary degeneration. This hypothesis can account for the key disease features, including late age onset cardiovascular risk factors, progression of cognitive changes, cortical shrinkage, the inflammatory profile and the anatomy of neurodegeneration.
Understanding the causes of microvascular breakdown and inflammatory sequelae are important in the early diagnosis, prevention and treatment of Alzheimer's Disease.