Macromolecular Structure Laboratory

Within: Bosch Institute, Discipline of Pathology

Head of laboratory

On this page:

Overview

Dr Hambly has over 20 years experience in cardiovascular disease research, encompassing basic muscle biochemistry through to the pathology of cardiovascular disease. He was the first to demonstrate experimentally that the myosin head generates force by “bending” near its centre [Biophys. J. (1991) 59:127], work which continues to today [Biophys. J. (2004) 86:3030]. He was involved in the discovery of the most common cause of Familial Hypertrophic Cardiomyopathy - mutations in the cardiac regulatory protein, myosin binding protein C [J. Med. Genet. (1998) 35:205] and biophysical studies of this protein remain a focus [eg Int J Biochem Cell Biol (2007) 39:2161-6]. In the area of I/R injury, in collaboration with SI Cordwell, he has gener-ated novel data that has shifted the paradigm for the aetiology of injury away from the concept of a single cause, to our current understanding that I/R is a consequence of damage to multiple proteins.

Research achievements

The research programme in my laboratory has two strands: (i) determination of the molecular structure and function of proteins, using the contractile proteins as a model system, and (ii) understanding cardiovascular disease at a molecular and cellular level.

  • Functional effects of familial hypertrophic cardiomyopathy mutations in sarcomeric proteins
  • Protein degradation leading to cardiac stunning following myocardial ischaemia
  • Electrical instability in revascularised myocardium following myocardial infarction
  • Regulation of arterial smooth muscle proliferation during atherogenesis