Muscle Cell Function Laboratory

Within: Bosch Institute, Discipline of Physiology

Overview

Research conducted by this laboratory is concerned with the regulation of intracellular ions, particularly calcium, sodium and protons, and with their effects on muscle function. This laboratory is particularly interested in situations where ionic regulation has major effects on cell function, for instance in cardiac pacemaker cells, in the heart during ischaemia and reperfusion and in skeletal muscle during fatigue. Much of the focus of this laboratory is on single cells in which ionic concentrations can be measured using fluorescent methods and study of the distribution of ionic changes using confocal microscopy.