Research outline - Transporter Biology Group

Within: Bosch Institute, Discipline of Pharmacology

Selected publications

  • Bastug T., Heinzelmann G., Kuyucak S., Salim M., Vandenberg R.J., and Ryan R.M. Position of the Third Na+ Site in the Aspartate Transporter GltPh and the Human Glutamate Transporter, EAAT1. PLoS One. 2012; 7(3):e33058 [Abstract]
  • Bailey, C., Ryan, R., Thoeng, A., Ng, C., King, K., Vanslambrouck, J., Auray-Blais, C., Vandenberg, R., Bröer, S., Rasko, J. Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. Journal of Clinical Investigation. 2011; 121:446-453. [Abstract]
  • Edington, A., McKinzie, A., Reynolds, A., Kassiou, M., Ryan, R., Vandenberg, R. Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonyl-glycine inhibition of glycine transport. The Journal of Biological Chemistry. 2009; 284:36424-30. [Abstract]
  • Vandenberg R.J., Huang S., Ryan R.M. Slips, leaks and channels in glutamate transporters. Channels (Austin). 2008; 2(1):51-8. [Abstract]
  • Ryan, R., Mindell, J. The uncoupled chloride conductance of a bacterial glutamate transporter homolog. Nature structural & molecular biology. 2007; 14:365-371. [Abstract]
  • Boudker, O., Ryan, R., Yernool, D., Shimamoto, K., Gouaux, E. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature. 2007; 445:387-393. [Abstract]
  • Vandenberg R.J., Shaddick K., Ju P. Molecular basis for substrate discrimination by glycine transporters. The Journal of Biological Chemistry. 2007;282(19):14447-53. [Abstract]
  • Ryan R.M., Mitrovic A.D., Vandenberg R.J. The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway. The Journal of Biological Chemistry. 2004; 279(20):20742-51. [Abstract]
  • Aubrey K.R., Vandenberg R.J. Br J Pharmacol. N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology. 2001;134(7):1429-36. [Abstract]
  • Fairman W.A., Vandenberg R.J., Arriza J.L., Kavanaugh M.P., Amara S.G. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 1995; 375:599-603. [Abstract]