Vascular Biology Laboratory

Within: Kolling Institute of Medical Research

Head of laboratory

On this page:

Overview of research program

Mechanisms of arterial remodelling

Vascular Biology Laboratory aims to study the processes regulating arterial remodelling (used strictly to define change in area within the external elastic lamina) in both restenosis and atherosclerosis. Recent investigations have focussed on the mechanisms by which flow affects remodelling and restenosis after angioplasty and stenting, particularly focussing on redox-sensitive transcription factor signalling and the independent effects of selective inhibition of these transcription factors on the remodelling process. Other studies have examined the effect of altered flow on atherosclerotic remodelling and the roles of matrix metalloproteinases (MMPs), vessel wall inflammation and aldosterone-mediated vessel constriction in atherosclerotic remodelling with plaque growth and after plaque rupture.

Major funding sources

  • North Shore Heart Research Foundation.

Selected publications

The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting. M Murrell, L Khachigian, MR Ward. Atherosclerosis 2007;194:364-371.

Probucol inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E deficient mice. BJ Wu, N Di Girolamo, K Beck, CG Hanratty, K Choy, JY Hou, MR Ward, R Stocker. J Pharmacol Exp Ther 2007;321:477-484.; 286:C398-405.

Low flow promotes Instent Intimal Hyperplasia. Comparison with Lumen Loss in Balloon-injured and Uninjured Vessels and the Effects of the Antioxidant Pyrrolidine Dithiocarbamate. Atherosclerosis. 2004;177:269-74. CG Hanratty, M Murrell, LM Khachigian, PS Tsao, MR Ward.

Flow-responsive Remodeling after Angioplasty is Enhanced by High Cholesterol Diet. Prevention with Pyrrolidine Dithiocarbamate. Atherosclerosis 2003;168:333-41. MR Ward, PS Tsao, NA Herity, JP Cooke, AC Yeung.

Effect of Stent Implantation on Upstream Coronary Artery Compliance – A Cause of Late Plaque Rupture? MR Ward, K Hibi, JA Shaw, E Furokawa, F Resnic, K Kimura. Am J Cardiol 2005;96:673-675.

Major collaborations

National

  • Prof. Levon Khachigian (Centre for Vascular Research, University of New South Wales)
  • Prof. Roland Stocker (University of Sydney)

International

  • Dr Philip Tsao (Stanford University, California)