Research outline - Vascular Immunology Laboratory

Within: Bosch Institute, Discipline of Pathology

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Overview of research program

Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes.

Major funding sources

2009

  • Pathophysiological alterations of brain microvascular endothelial cells in cerebral malaria
    NHMRC Project Grants $344,250 over 3 years
  • Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis
    NHMRC Project Grants $438,000 over 3 years

2008

  • Dysregulation of cytokine networks: a key determinant of the pathogenesis of cerebral malaria
    NHMRC Project Grant $461,625 over 3 years

Selected publications

  • Mitchell, A, Pradel, L, Chasson, L, Van Rooijen, N, Grau, G, Hunt, N, Chimini, G. Technical Advance: Autofluorescence as a tool for myeloid cell analysis. Journal of leukocyte biology. 2010; 88:597-603
  • Hunt, N, Grau, G, Engwerda, C, Barnum, S, van der Heyde, H, Hansen, D, Schofield, L, Golenser, J. Murine cerebral malaria: the whole story. Trends in parasitology. 2010. p. 272-4.
  • Bridges, D, Bunn, J, van Mourik, J, Grau, G, Preston, R, Molyneux, M, Combes, V, O'Donnell, J, de Laat, B, Craig, A. Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings. Blood. 2010; 115:1472-4

Major collaborations

  • Dr Ronan Jambou, Pasteur Institute