Research outline - Viral Immunopathology Unit

Within: Bosch Institute, Discipline of Pathology

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Overview of research program

We are interested in the neurotropic flavivirus, West Nile virus, and how our immune response, in trying to get rid of virus infection, lethally damages the host nervous system in this response.

We are studying the pathogenesis of West Nile virus encephalitis to understand which components cause lethal damage in the brain and which are crucial for virus clearance.

We are also investigating early immune responses to infection in specialised organs and sites, including the brain, the skin, the genitourinary tract, the embryo and the eye, as being the key to modulating this process before damage occurs.

Major funding sources

  • Interaction of anti-viral IDO and NOS2 in vivo in a novel murine STD model. King N, Thomas S
    NHMRC Project Grants ($551,250 over 3 years)
  • Lipocalin 2 in host defence of the central nervous system. Campbell I, King N, Richardson D
    NHMRC Project Grant ($549,500 over 4 years)
  • Immunopathological role of monocyte/macrophages in flavivirus encephalitis. King N, Campbell I
    NHMRC Project Grant ($427,125 over 3 years)

Selected publications

  • Arnold SJ, Osvath SR, Hall RA, King NJC and Sedger LM. 2004. Regulation of antigen processing and presentation molecules in WNV-infected human skin fibroblasts. Virology; 324: 286-296.
  • Burke SA, Wen L and King NJC. 2004. Routes of inoculation and the immune response to a resolving genital flavivirus infection in a novel murine model. Immunology and Cell Biology; 82: 174-183.
  • Byrne SN, Halliday GM, Johnston LJ and King NJC. 2001. Interleukin-1beta but not tumor necrosis factor is involved in West Nile virus-induced Langerhans cell migration from the skin in C57BL/6 mice. Journal of Investigative Dermatology; 117: 702-709.
  • Chen Y, King NJC and Kesson AM. 2004. Major Histocompatibility Complex Class I (MHC-I) Induction by West Nile Virus: Involvement of 2 Signaling Pathways in MHC-I Up-Regulation. Journal of Infectious Diseases; 189: 658-668.
  • Cheng Y, King NJC and Kesson AM. 2004 (accepted). The Role of Tumour Necrosis Factor in modulating responses of Murine Embryo Fibroblasts by Flavivirus, West Nile. Virology.
  • Johnston LJ, Halliday GM and King NJC. 2000. Langerhans cells migrate to local lymph nodes following cutaneous infection with an arbovirus. Journal of Investigative Dermatology; 114: 560-568.
  • Kesson AM and King NJC. 2001. Transcriptional regulation of major histocompatibility complex class I by flavivirus West Nile is dependent on NF-kappaB activation. Journal of Infectious Diseases; 184: 947-954.
  • King NJC, Shrestha B and Kesson AM. Immune modulation by flavivirus. In: Chambers TJ, Monath TP, editors. The Flaviviruses: Pathogenesis and Immunity. San Diego: Elsevier Academic Press; 2003. p. 121-155.
  • King NJC, Parr EL and Parr MB. 1998. Migration of lymphoid cells from vaginal epithelium to iliac lymph nodes in relation to vaginal infection by herpes simplex virus type 2. Journal of Immunology; 160: 1173-1180.
  • Shen J, SS TT, Schrieber L and King NJC. 1997. Early E-selectin, VCAM-1, ICAM-1, and late major histocompatibility complex antigen induction on human endothelial cells by flavivirus and comodulation of adhesion molecule expression by immune cytokines. Journal of Virology; 71: 9323-9332.

Major collaborations

Germany. (University of Muenster) Collaborative Research into diagnostic imaging approaches to viral encephalitis.