Neuropathology Unit - Dementia, Neurodegeneration, Ageing

Lab head: Jillian Kril
Location: Blackburn Building, Camperdown

Our laboratory focuses upon understanding the effects of ageing and dementia.

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Lab members: J Kril (head)

Clinicopathological correlations in Frontotemporal dementia (FTD)

Primary supervisor: Jillian Kril

FTD is a form of dementia which is as common as Alzheimer's disease (AD) in the <65y age group and accounts for 12-20% of all dementia. It is characterised by disturbances in social and interpersonal conduct and language and motor abnormalities. Unlike other type of dementia, FTD shows marked phenotypic variation as there are both clinical and pathological subtypes of FTD. Interestingly, one clinical phenotype (eg behavioural variant FTD) may have several different pathological subtypes (eg tau or TDP-43 deposition). This lack of direct clinicopathological correlation hampers the devlopement of disease modifying therapies.

Human postmortem tissue from a prospective brain donor program is available for study. The type, severity and distribution of pathology will be examined in patients with different clinical phenotypes to determine predictors of pathology during life.

Discipline: Pathology
Keywords: Dementia