Epithelial Transport Laboratory

Lab head: David Cook
Location: Medical Foundation Building

This laboratory investigates the transport processes in the cell membrane and the manner in which cells control their membrane transport activity.  Particular emphasis has been placed on the mechanisms of sodium ion channel regulation and calcium signalling in epithelial cells.

Current research:

  • The mechanisms by which epithelial sodium (Na+) channels are controlled

  • The control of Na+/H+ exchange in epithelial cells

  • The mechanisms by which ion transport systems are controlled

  • The development of replication-deficient adenoviruses as a tool in studying the role of membrane transport systems in cellular function

Lab members: D Cook (head)

Use of replication-deficient adenoviruses to investigate regulation of cytosolic calcium

Primary supervisor: David Cook

This project combine molecular biological and fura-2 methods to investigate the mechanisms by which agonists such as acetylcholine and ATP regulate the rate of Calcium transport out of cells.

Discipline: Physiology