Redox Biology Laboratory

Lab head: Dr Paul Witting
Location: Blackburn Building, Camperdown Campus

Protein modifications that potentially underlie the severity of acute myocardial infarct in hearts from diabetic rats. In addition, we have an established interest in monitoring oxidative stress in disease states including atherosclerosis, acute renal failure and cerebral ischemia injury (stroke).

Funding: ARC; National Heart Foundation; Diabetes Australia
Research approach equipment: Analytical Biochemistry: using analytical techniques such as liquid chromatography and liquid chromatography coupled with mass spectrometry, the redox biology lab assesses the mechanism of acute pathological processes. Molecular biology: we use quantitative gene analysis techniques to assess cellular and tissue response to experimental ischaemia reperfusion injury as a model for stroke and heart attack.

Investigating the pro-atherogenic action of the acute phase protein serum amyloid A

Primary supervisor: Paul Witting

Atherosclerosis and its cardiovascular complications are a major cause of morbidity and mortality in both developed and developing countries. The recent characterization of the acute phase protein, serum amyloid A (SAA), as an important inducer of endothelial dysfunction has opened a new area of research that focuses on SAA as a therapeutic target for strategies to combat atherogenesis. SAA levels have also been correlated with the severity of human coronary artery atherosclerosis and many cardiovascular risk factors including diabetes and insulin resistance, obesity, and rheumatoid arthritis.  Current studies with apo E -/- mice injected with SAA and parallel studies with cultured endothelial cells will allow us to assess the pro-atherogenic action of this acute phase protein on the vascular endothelium.

Discipline: Pathology
Co-supervisors: Ben Freedman
Keywords: Inflammation, Aortic disease, cellular signalling