Molecular Neuroscience Laboratory
Lab head: William (Bill) Phillips
Location: F13 - Anderson Stuart Building
The Phillips lab studies the molecular mechanisms of synapse development and adaptation, focusing on the mammalian neuromuscular synapse. Developmental signalling pathways such as the muscle specific kinase (MuSK) system are thought to help the neuromuscular synapse adapt and survive. We use mouse and cell culture models to study how the MuSK system can help protect the synapse in mouse and cell culture models of several neuromuscular disease.
Lab members: W Phillips (head)
Loss of mitochondrial function and disruption of the neuromuscular junction
Primary supervisor: William Phillips
The neuromuscular junction (NMJ) is the synapse through which motor nerves control our voluntary muscle fibres. There is growing evidence that NMJs are disrupted and degenerate, leading to muscle weakness, in conditions where the function of muscle mitochondria is impaired (normal aging and some forms of motor neuron disease). This project will employ cell culture methods to investigate the possibility that mitochondrial dysfunction (and associated redox signalling), interfere with the known molecular signalling systems involved in development and homeostasis of the NMJ