Laboratory of Blood Cell Development

Lab head: Dr. Stuart Fraser
Location: Room 233, Medical Foundation Building

Our group is interested in the processes that regulate the formation and production of blood cells. This first occurs in the developing embryo. In fact, blood cells are the first mature cell types to form in the embryo. We are interested in how red blood cells form as well as haematopoietic stem cells (HSC), the "master" cells that can give rise to all blood cells.


We are interested in;

*Red blood cell formation in the embryo

*Production of HSC in developing embryo

*The processes regulating the condensation and expulsion of the nucleus from developing red blood cells.

*The evolutionary and molecular biology behind red blood cell enucleation.

*Understanding how macrophages regulate blood cell production.

*Relating our findings to human blood diseases. 

Lab members: Miss Veronica Antas-Masters Student Dr. Angeles Sanchez-Perez, Senior Research Associate
Research approach equipment: Flow cytometry, cell culture, embryonic stem cells, hematopoietic stem cells, immunohistochemistry

Enucleation of red blood cells.

Primary supervisor: Stuart Fraser

Healthy adult humans generate 2 million new red blood cells every second. The final stage of red blood cell, or erythroid, differentiation is the condensation and expulsion of the nucleus to produce an erythrocyte without a nucleus to circulate freely in the blood stream. This process is unique to mammals. We aim to explore the regulation of this process and to get a better understanding of how this may go awry in disease and why it is restricted to mammals by examining the evolutionary biology of red blood cell development. 

Discipline: Physiology
Keywords: Cell & Molecular Biology, Haematology