SIDS and Sleep Apnea Research

Lab head: Karen Waters
Location: Rm 206 Blackburn Building D06

Lab members: K Waters (head), R Machaalani (co-head)

Nicotinic Receptors in the smoking and pre-eclamptic placenta.

Primary supervisor: Rita Machaalani

Despite the well known adverse effects of smoking during pregnancy, there has been little investigation of how the nicotinic receptors are affected in the placenta. Surprisingly, cigarette smoking has consistently been linked with a reduced risk of preeclampsia (PE). PE is a common pregnancy-related disease, where its main symptoms are increased blood pressure and protein excretion in the urine. It is a leading cause of health problems and death of mother and child in Australia. This project will involve studying the expression of several nicotinic acetylcholine receptors in the placenta from women who smoked during pregnancy and comparing this expression to non-smoking placentas and those from PE pregnancies. 

Main method to be undertaken by student is immunohistochemistry (IHC). 

Discipline: Pathology
Co-supervisors: AnneMarie Hennessy, Karen Waters