Cancer Biology Group

Lab head: Qihan Dong
Location: Room 371, Blackburn Building

Block cell cycle re-entry by quiescent prostate cancer cells

Primary supervisor: Qihan Dong

Background:
Recurrent cancer following initial remission is the main cause of cancer mortality. Cell cycle re-entry by quiescent cancer cells is ought to be central to cancer recurrence, after actively dividing cancer cells are eliminated by chemo- or radio-therapy. One can envisage if cell cycle re-entry by these quiescent cancer cells is blocked, cancer recurrence can be prevented or delayed. We have identified several molecules required for quiescent prostate cancer cells to re-enter the cell cycle. Recently, we have also found several chemicals that are able to impede cell cycle re-entry by quiescent prostate cancer cells.
  
Aim of Study:
To determine the effect of newly identified chemicals on cell cycle re-entry by quiescent prostate cancer cells.
 
Methods:
Honours students will learn cell culture and immunoblot and use these techniques to determine the effect on cell cycle re-entry by quiescent cancer cells.
 
Ethics Application Requirements:
Not required as all are in vitro studies.
 
Key References:
Desoize B, Jardillier J. Multicellular resistance: a paradigm for clinical resistance? Crit Rev Oncol Hematol 2000;36:193-207.
 


Discipline: Pathology
Co-supervisors: Brett Hambly
Keywords: Cell biology, Cancer, cell cycle
Contact: