Diabetic Complications Group

Lab head: Professor Stephen Twigg
Location: Blackburn Building

This group is headed by  Stephen Twigg and Susan McLennan.

The research conducted by this group addresses a number of key complications associated with diabetes including: diabetic wound healing, neuropathy, cardiomyopathy, and diabetic nephropathy, as well as insulin resistance.

A/Profesoor McLennan also has an established interest in thyroid cancer 

 

Lab members: S Twigg (head), S McLennan (Principal Research Fellow), D. Min (Senior Research Fellow), X Wang ( Post doctoral fellow), C Tam (Post doctoral fellow)
Publications:

The role of hepatocyte microvesicles in NASH progression

Primary supervisor: Susan McLennan

We have developed a research program examining the role of hyperglycemia in extracellular matrix remodelling in a disease called Non Alcoholic Steatohepatitis (NASH) which causes liver fibrosis and can ultimately lead to liver cancer. In association with A/Prof Nicholas Shackel and Prof Georges Grau we have shown that the number of microvesicles from the liver and in the circulation is altered as the liver disease progresses from simple fatty liver disease to NASH. In this project we would seek to further characterise in animal studies and cell culture models the role of these changes in development of disease.   Liver and plasma samples as well as hepatocytes from our mouse model of NASH or cell lines will be used to examine the content of the microvesicle and their relationship with the development of liver fibrosis.  A broad range of techniques including transmission electron microscopy, confocal microscopy, real-time RT-PCR, mammalian cell culture, transfection, animal models, primary cell isolation and flow cytometry, could  be used in these studies. 


Discipline: Pathology
Co-supervisors: Charles George, Nicholas Shackel
Keywords: Hepatology, Fibrosis, Inflammation
Contact: