The Ageing Brain Clinic: Parkinson's Disease and Dementia

Lab head: A/Prof Simon Lewis
Location: Brain & Mind Research Institute

The Ageing Brain Clinic for Parkinson's Disease and Dementia is based at the Brain & Mind Research Institute. We are attempting to improve the quality of life for these patients by improving our understanding of the neurobiology underlying neurodegenerative diseases. We believe this will lead to earlier and more accurate diagnosis as well as novel therapeutic approaches.

Lab members: Simon Lewis Sharon Naismith
Funding: NHMRC, ARC, Michael J Fox Foundation
Research approach equipment: This opportunity will utilise a range of novel neuroimaging, neurophysiological and biomedical techniques to explore clinical features, which will in turn lead to advances in the field of neurodegenerative disease and hopefully translation into improved clinical practice. Techniques include Functional and Structural MRI, eye tracking, polysomnography, ultrasound, acceleometry and electroencephalography. Successful candidates will be responsible for developing and testing novel methods for investigating the pathophysiology associated with clinical symptoms. There is a focus on the creation of novel biomarkers that can be used to monitor treatment efficacy, predict transition and ultimately, identify the emergence symptoms earlier in the course of the disease. The successful applicant will be working in a multidisciplinary research environment with a team of Neurologists, Neuropsychologists and Neuroscientists as well as other academic staff and students within the field of ageing.
Publications: Jayaweera K, Hickie IB, Duffy SL, Hermens DF, Mowszowski L, Diamond K, Terpening Z, Paradise M, Lewis SJG, Lagopoulos J, Naismith SL. MCI subtypes in older adults with depressive symptoms: Relationship with clinical variables and hippocampal change. Journal of Geriatric Psychiatry and Neurology, In press (accepted November 2014). O¿Callaghan C, Shine JM, Lewis SJG and Andrews-Hanna JR. Shaped by our thoughts - A new task to assess spontaneous cognition and its associated neural correlates in the default network. Brain Cogn, In press (accepted November 2014) Elcombe E, Lagopoulos J, Duffy S, Lewis SJG, Norrie L, Hickie IB, Naismith SL. Hippocampal volume in older adults at risk of cognitive decline: the role of sleep, vascular risk and depression. J Alzheimers Dis, In press (accepted October 2014). Shine JM, Keogh R, O¿Callaghan C, Muller A, Lewis SJG and Pearson J. Imagine that: visual hallucinations are related to the strength of mental imagery in Parkinson¿s disease. Proc R Soc B, In press (accepted October 2014). Lewis SJG and ShineJM. The next step: a common neural mechanism for freezing of gait. The Neuroscientist, In press (accepted October 2014). Diamond K, Mowszowski L, Cockayne N, Norrie L, Paradise M, Hermens DF, Lewis SJG, Hickie IB, Naismith SL. Randomised controlled trial of a healthy brain ageing cognitive training program: Effects on memory, mood and sleep. J Alzheimers Dis, In press (accepted October 2014). Walton CC, Shine JM, Hall J, O¿Callaghan C, Mowszowski L, Gilat M, Szeto JYY, Naismith SL and Lewis SJG. The major impact of freezing of gait on quality of life in Parkinson's disease. J Neurol Epub October 2014. Hall JM, Gilat M, Lewis SJG and Shine JM. Does dominant pedunculopontine nucleus exist? Probably not. Brain, In press (accepted October 2014). McCann H, McGeachie A, Silberstein P, Lewis SJG and Halliday GM. Restricted disease propogation in Multiple System Atrophy with prolonged disease duration. Neuropath Appl Neuro, In press (accepted October 2014). Bolitho SJ, Grunstein RR, Naismith SL, Melehan K and Lewis SJG. Unified techniques are needed to diagnose REM sleep behavior disorder. Mov Disord Epub September 2014. Olley J, Alex Blaszczynski A and Lewis SJG. Dopaminergic medication in Parkinson's disease and problem gambling. Journal of Gambling Studies. In press (accepted September 2104). Bolitho SJ, Naismith SL, Terpening Z, Melehan K, Yee BJ, Grunstein RR and Lewis SJG. Investigating the night to night variability of REM without atonia in Parkinson¿s disease. Sleep Medicine. In press (accepted August 2014). Lee JM, Shine JM, Lewis SJG. What matters to people with Parkinson¿s disease living in Australia? J Clin Neurosci. In press (accepted July 2014). Walton CC, Shine JM, Mowszowski L, Gilat M, Hall J, O¿Callaghan C, Naismith SL and Lewis SJG. Impaired cognitive control in Parkinson¿s Disease patients with Freezing of Gait in response to cognitive load. J Neural Transm. In press (accepted July 2014). Yungher D, Morris TR, Dilda V, Shine JM, Naismith SL, Lewis SJG and Moore ST. Temporal characteristics of high-frequency lower-limb oscillation during freezing of gait in Parkinson's disease. Parkinson's disease. In press (accepted June 2014). Matar E, Shine JM, Naismith SL and Lewis SJG. Virtual reality walking and dopamine: Opening new doorways to understanding freezing of gait in Parkinson's disease. J Neurol Sci 2014; 344:182-5. O¿Callaghan C, Shine JM, Lewis SJG and Hornberger M. Neuropsychiatric symptoms in Parkinson's disease: Fronto-striatal atrophy contributions. Parkinsonism Relat Disord Epub May 2014. Handojoseno AM, Shine JM, Gilat M, Nguyen TN, Tran Y, Lewis SJG, Nguyen HT. Prediction of Freezing of Gait using analysis of brain effective connectivity. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. In press (accepted May 2014). Paradise M, McCade D, Hickie IB, Diamond K, Lewis SJG, Naismith SL. Caregiver burden in mild cognitive impairment. Aging Ment Health Epub May 2014. Bolitho SJ, Naismith SL, Rajaratnam SM, Grunstein RR, Hodges JR, Rogers N, Lewis SJG. Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. Sleep Med 2014; 15: 342-7. Mowszowski L, Hermens DF, Diamond K, Norrie L, Cockayne N, Ward PB, Hickie IB, Lewis SJG, Batchelor J and Naismith SL. Cognitive training enhances pre-attentive neurophysiological responses in older adults ¿at risk¿ of dementia. Journal of Alzheimer¿s Disease, In press (accepted 11/03/2014). Walton CC, Mowszowski L, Lewis SJG and Naismith SL. Stuck in the mud: Time for change in the implementation of cognitive training research in ageing? Frontiers in Aging Neuroscience 2014: 5:43. doi: 10.3389/fnagi.2014.00043. Hall JM, Shine JM, Walton C. Gilat M, Kamsma YPT, Lewis SJG. Early phenotypic differences between Parkinson¿s disease patients with and without freezing of gait. Parkinsonism Relat Disord 2014; 20: 604-607. Dunn CJD, Duffy SL, Hickie IB, Lagopoulos J, Lewis SJG, Naismith SL, Shine JM. Deficits in episodic memory retrieval reveal impaired Default Mode Network connectivity in amnestic Mild Cognitive Impairment. Neuroimage: Clinical 2014; 4: 473-480. Walton C, Shine JM, Mowzowski L, Naismith SL and Lewis SJG. Freezing of gait in Parkinson¿s disease: Current treatments and the potential role for cognitive training. Restor Neurol Neurosci 2014; 32: 411-22. Shine JM, O¿Callaghan, Halliday GM and Lewis SJG. Tricks of the Mind: Visual Hallucinations as Disorders of Attention. Prog Neurobiol 2014; 116: 58-65. McKinnon A, Terpening Z, Hickie IB, Batchelor J, Grunstein RR, Lewis SJG, Naismith SL. Prevalence and predictors of poor sleep quality in mild cognitive impairment. Journal of Geriatric Psychiatry and Neurology, In press (accepted January 2014). Bolitho SJ, Naismith SL, Terpening Z, Grunstein RR, Melehan K, Yee BJ, Coeytaux A, Gilat M, Lewis SJG. Investigating REM without atonia in Parkinson¿s disease using the RBD Screening Questionnaire. Mov Disord 2014; 29: 736-742. Muralidharan V, Balasubramani PP, Chakravarthy S, Lewis SJG, Ahmed A. Moustafa. A computational model of altered gait patterns in Parkinson¿s disease patients negotiating narrow doorways. Front Comp Neurosci, 2014; 7: 190. Wilson GM, Terpening Z, Wong KH, Grunstein RR, Norrie L, Lewis SJG, Naismith SL. Screening for sleep apnoea in Mild Cognitive Impairment: The utility of the Multivariable Apnoea Prediction index. Sleep Disorders 2014 p. 945287. Duffy S, Paradise M, Hickie IB, Lewis SJG, Naismith SL, Lagopoulos J. Cognitive impairment with and without depression history: An analysis of white matter microstructure. J Psychiatry Neurosci 2014; 39: 135-143. O'Callaghan C, Moustafa AA, de Wit S, Shine JM, Robbins TW, Lewis SJG, Hornberger M. Fronto-striatal grey matter contributions to discrimination learning in Parkinson¿s disease. Front Comp Neurosci 2013; 7: 180. Coeytaux A, Wong K, Grunstein R, Lewis SJG. REM sleep behaviour disorder - More than just a parasomnia. Aust Fam Physician. 2013; 42:785-8. Aitken D, Naismith SL, Terpening, Lewis SJG. Dysfunctional beliefs about sleep in Parkinson¿s Disease: Relationships with subjective and objective sleep measures. J Clin Neurosci, In press (accepted November 2013). Bolitho SJ, Naismith SL, Salahuddin P, Terpening Z, Grunstein RR, Lewis SJG. Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease. PLoS One. 2013 Nov 21;8(11):e81233. doi: 10.1371/journal.pone.0081233. Cross NE, Lagopoulos J, Duffy SL, Cockayne NL, Hickie IB, Lewis SJG, Naismith SL. Sleep quality in healthy older people: relationship with ¹H magnetic resonance spectroscopy markers of glial and neuronal integrity. Behav Neurosci. 2013; 127: 803-10. Gunn D, Naismith SL, Bolitho SJ, Lewis SJG. Actigraphically-defined sleep disturbance in Parkinson¿s disease is associated with differential aspects of cognitive functioning. J Clin Neurosci, In press (accepted October 2013). Shine JM, Moustafa AA, Matar E, Frank MJ and Lewis SJG. The role of frontostriatal impairment in freezing of gait in Parkinson¿s disease. Front Syst Neurosci, Epub October 2013. Gunn D, Naismith SL, Terpening Z, Lewis SJG. The relationships between poor sleep efficiency and Mild Cognitive Impairment in Parkinson¿s disease. J Ger Psych Neur, In press (accepted October 2013). Shine JM, Handojoseno AMA, Nguyen TN, Tran Y, Naismith SL, Nguyen H, Lewis SJG. Abnormal patterns of theta frequency oscillations during the temporal evolution of freezing of gait in Parkinson¿s disease. Clin Neurophysiol, Epub October 2013. Elcombe E, Lagopoulos J, Mowszowski L, Diamond K, Paradise M, Hickie IB, Lewis SJG, Naismith SL. Clinical and cognitive correlates of structural hippocampal change in at risk older adults. Journal of Geriatric Psychiatry and Neurology, In press (accepted September 2013). Shine JM, Matar E, Ward PB, Frank MJ, Moustafa AA, Pearson M, Naismith SL and Lewis SJG. Freezing of gait in Parkinson¿s disease represents a functional de-coupling between the Cognitive Control Network and the Basal Ganglia. Brain, Epub October 2013. Naismith SL, Hickie IB, Terpening Z, Rajaratnam SW, Hodges JR, Bolitho S, Rogers NL, Lewis SJG. Circadian misalignment and sleep disruption in mild cognitive impairment. Journal of Alzheimer¿s Disease, Epub October 2013. Tew EH, Pereira M, Naismith SL, Lewis SJG. Quality of life in Parkinson¿s disease caregivers: the contribution of personality traits. BioMed Res Int, Epub August 2013. Zhong G, Bolitho SJ, Grunstein RG, Naismith SL, Lewis SJG. The relationship between thermoregulation and REM sleep behaviour disorder in Parkinson¿s disease. PLoS One, Epub August 2013. Palavra NC, Naismith SL and Lewis SJG. Mild Cognitive Impairment in Parkinson¿s Disease: A Review of Current Concepts. Neurol Res Int, Epub July 2013. Matar E, Shine JM, Naismith SL and Lewis SJG. Using virtual reality to explore the role of conflict resolution and environmental salience in freezing of gait in Parkinson¿s disease. Parkinsonism Relat Disord, Epub July 2013. Gilat M, Shine JM, Matar E, Bolitho SJ, Kamsma YPT, Naismith SL and Lewis SJG. Variability of stepping during a Virtual Reality Paradigm in Parkinson's disease patients with and without Freezing of Gait. PLoS One, Epub June 2013. Handojoseno AM, Shine JM, Nguyen TN, Tran Y, Lewis SJG, Nguyen HT. Using EEG Spatial Correlation, Cross Frequency Energy, and Wavelet Coefficients for the Prediction of Freezing of Gait in Parkinson's Disease Patients. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2013, Epub July 2013. McCade D, Savage G, Guastella A, Hickie IB, Lewis SJG, Naismith SL. Emotion recognition in Mild Cognitive Impairment: relationship to psychosocial disability and caregiver burden. J Ger Psych Neur, Epub September 2013. O'Callaghan C, Naismith SL, Shine JM, Bertoux M, Lewis SJG, Hornberger M. A novel bedside task to tap inhibitory dysfunction and fronto-striatal atrophy in Parkinson's disease. Parkinsonism Relat Disord (Epub May 2013). Naismith SL, Mowzowski L, Diamond K, Lewis SJG. Improving memory in Parkinson¿s Disease: a healthy brain ageing cognitive training program. Mov Disord (Epub April 2013). Duffy S, Lagopoulos J, Hickie IB, Diamond K, Graeber M, Lewis SJG, Naismith SL. Glutathione relates to neuropsychological functioning in mild cognitive impairment. Alzheimers Dementia (Epub May 2013). McCade D, Savage G, Guastella A, Lewis SJG, Naismith SL. Emotion recognition deficits exist in mild cognitive impairment, but only in the amnestic subtype. Psychology and Ageing In press (accepted 19/03/13). Terpening Z, Naismith SL, Melehan K, Gittins C, Bolitho SJ, Lewis SJG. The contribution of nocturnal sleep to the consolidation of motor skill learning in healthy ageing and Parkinson¿s disease. J Sleep Res Epub 2013. Shine JM, Matar E, Ward PB, Bolitho SJ, Gilat M, Pearson M, Naismith SL and Lewis SJG. Exploring the cortical and subcortical fMRI changes associated with freezing in Parkinson's disease. Brain 2013; Epub March 2013. Shine JM, Halliday GM, Bolitho SJ, Matar E, Gilat M, Carlos M, Naismith SL and Lewis SJG. The role of dysfunctional attentional control networks in visual misperceptions in Parkinson¿s disease. Hum Brain Mapp, Epub June 2013. Shine JM, Matar E, Ward PB, Bolitho SJ, Pearson M, Naismith SL, Lewis SJG. Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load. PLoS One, Epub January 2013. Handojoseno AM, Shine JM, Nguyen TN, Tran Y, Lewis SJG, Nguyen HT. The detection of Freezing of Gait in Parkinson's disease patients using EEG signals based on Wavelet decomposition. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2012: 69-72. Epub 2013/02/01. Morris TR, Cho C, Dilda V, Shine JM, Naismith SL, Lewis SJG and Moore ST. Clinical assessment of freezing of gait in Parkinson's disease from computer-generated animation. Gait Posture, In press 2012. O¿Callaghan C, Naismith SL, Hodges JR, Lewis SJG and Hornberger M. Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia. Cortex, Epub December 2012. Shine JM, Matar E, Bolitho SJ, Dilda V, Morris TR, Naismith SL, Moore ST, Lewis SJG. Modeling freezing of gait in Parkinson's disease with a virtual reality paradigm. Gait Posture, Epub December 2012. Moore ST, Yungher DA, Morris TR, Dilda V, MacDougall HG, Shine JM, Naismith SL, Lewis SJG. Autonomous identification of freezing of gait in Parkinson's disease from lower-body segmental accelerometry. J Neuroeng Rehabil, In press 2012. Shine JM, Naismith SL, Palavra NC, Morris TR, Dilda V, Moore ST, Lewis SJG. Attentional set-shifting deficits correlate with the severity of freezing of gait in Parkinson's disease. Parkinsonism Relat Disord, Epub August 2012. Lewis SJG, Shine JM, Halliday GM, Duffy S, Naismith SL. Anterior cingulate integrity: Executive and neuropsychiatric features in Parkinson Disease. Mov Disord 2012; 27:1262-7. Shine JM, Naismith SL, Lewis SJG. The differential yet concurrent contributions of motor, cognitive and affective disturbance to freezing of gait in Parkinson's Disease. Clin Neurol Neurosurg, Epub July 2012. Morris TR, Cho C, Dilda V, Shine JM, Naismith SL, Lewis SJG, Moore ST. A comparison of clinical and objective measures of freezing of gait in Parkinson's disease. Parkinsonism Relat Disord 2012; 5: 572-7. Mowszowski L, Hermens DF, Diamond K,Norrie L, Hickie IB, Lewis SJG, Naismith SL. Reduced Mismatch Negativity in Mild Cognitive Impairment: associations with neuropsychological performance. Journal of Alzheimer's Disease 2012; 1: 209-19. Tsang RSM, Diamond K, Mowzowski L, Lewis SJG and Naismith SL. Using Informant Reports to Detect Cognitive Decline in Mild Cognitive Impairment. Int Psychogeriatr 2012; 6: 967-73. Naismith SL, Mowszowski L, Ward PB, Diamond K, Paradise M, Kaur M, Lewis SJG, Hickie IB, Hermens DF. Reduced temporal mismatch negativity in late-life depression: An event-related potential index of cognitive deficit and functional disability? J Affect Disord 2012; 138: 71-8. Shine JM, Halliday GM, Carlos M, Naismith SL and Lewis SJG. Investigating visual misperceptions in Parkinson¿s disease: a novel behavioural paradigm. Mov Disord 2012; 4: 500-5. Shine JM, Naismith SL, Halliday GM and Lewis SJG. Visual misperceptions and hallucinations in Parkinson¿s disease: dysfunction of attentional control networks? Mov Disord 2011; 26: 2154-59. Shine JM, Moore ST, Bolitho SJ, Morris TR, Dilda V, Naismith SL, Lewis SJG. Assessing the utility of Freezing of Gait Questionnaires in Parkinson's Disease. Parkinsonism Relat Disord 2011; 18: 25-9. Abbott L, Naismith SL, Lewis SJG. Parkinson's Disease in General Practice: assessing knowledge, confidence and the potential role of education. J Clin Neurosci; Epub June 2011. Shine JM, Naismith SL, Lewis SJG. The pathophysiological mechanisms underlying freezing of gait in Parkinson's Disease. J Clin Neurosci 2011; 18, 1154-7. Komadina NC, Terpening Z, Huang Y, Halliday GM, Naismith SL and Lewis SJG. The utility and limitations of the Addenbrooke¿s Cognitive Examination ¿ Revised for detecting Mild Cognitive Impairment in Parkinson¿s Disease. Dement Geriatr Cogn Disord 2011; 31: 349-357. Zhong G, Naismith SL, Rogers NL, Lewis SJG. Sleep-wake disturbances in common neurodegenerative diseases: a closer look at selected aspects of the neural circuitry. J Neurol Sci 2011; 307: 9-14. Naismith SL, Lewis SJG, Rogers NL. Sleep-wake changes and cognition in neurodegenerative disease. Prog Brain Res 2011; 190: 21-52. Naismith SL, Rogers NL, Lewis SJG, Terpening Z, Ip T, Diamond K, Norrie L, Hickie IB. Neuropsychological functioning in older people with depression: relationships with actigraphy-defined sleep-wake disturbance. J Aff Disord 2011; 132: 139-145. Shine JM, Ward PB, Naismith SL, Pearson M, Lewis SJG. Utilising fMRI to identify the neural correlates of the freezing phenomenon in Parkinson¿s Disease. J Clin Neurosci 2011; 18: 807-810. Lewis SJG. Commentary: An evaluation of mechanisms underlying the influence of step cues on gait in Parkinson's disease. J Clin Neurosci 2011; 18: 803. Naismith SL, Terpening Z, Shine JM, Lewis SJG. Neuropsychological functioning in Parkinson¿s Disease: Differential relationships with self-reported sleep disturbance. Mov Disord 2011; 26: 1537-1541. Hardy TA, Garsia RJ, Halmagyi GM, Lewis SJG, Harrisberg B, Fulham MJ, Barnett MH. Tumour necrosis factor (TNF) inhibitor therapy in Susac¿s syndrome. J Neurol Sci 2011; 302: 126-8. Naismith SL, Lewis SJG. ¿DASH¿ symptoms in Parkinson¿s Disease: Red flags for early cognitive decline. J Clin Neurosci 2011; 18: 352-255. Hurelbrink CB, Lewis SJG. Pathological considerations in the treatment of Parkinson's disease: more than just a wiring diagram. Clin Neurol Neurosurg 2011; 113: 1-6. Naismith SL, Pereira MMM, Shine JM, Lewis SJG. How well do caregivers detect mild cognitive change in Parkinson¿s Disease? Mov Disord 2011; 26: 161-4. Naismith SL, Diamond K, Carter P, Norrie L, Redoblado-Hodge M-A, Lewis SJG, Hickie IB. Enhancing memory in late-life depression: effects of a combined psychoeducation and cognitive training program. Am J Ger Psychiatry 2011; 19: 240-8. Naismith SL, Hickie IB, Lewis SJG. The role of mild depression in sleep disturbance and quality of life in Parkinson¿s Disease. J Neuropsychiatry Clin Neurosci 2010; 22: 384-389. Naismith SL, Rogers NL, Mackenzie J, Hickie IB, Lewis SJG. The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in Parkinson's Disease. Clin Neurol Neurosurg. 2010; 112: 420-3. Naismith SL and Lewis SJG. A novel paradigm for modelling freezing of gait in Parkinson's disease. J Clin Neurosci 2010; 17: 984-987. Naismith SL, Shine JM, Lewis SJG. The specific contributions of set-shifting to freezing of gait in Parkinson¿s Disease. Mov Disord 2010; 25: 1000-1004. Naismith SL, Rogers NL, Hickie IB, Mackenzie J, Norrie LM, Lewis SJG. Sleep well, think well: Sleep-wake disturbance in mild cognitive impairment. J Ger Psych Neur 2010; 23: 123-130. Gunn D, Naismith SL, Lewis SJG. Sleep disturbances in Parkinson¿s Disease. J Ger Psych Neur 2010; 23: 131-137. Ahmed RM, Green T, Halmagyi GM, Lewis SJG. A new model for neurology care in the Emergency Department. Med J Aust 2010; 192: 30-32. Parratt KL, Allan M, Lewis SJG, Dalmau J, Halmagyi GM, Spies JM. Acute psychiatric illness in a young woman: an unusual form of encephalitis. Med J Aust 2009; 191: 284-286. Naismith SL, Redoblado-Hodge MA, Lewis SJG, Scott EM, Hickie IB. Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approach. J Affect Disord 2010; 121: 258-262. Naismith SL, Norrie L, Lewis SJG, Rogers NL, Scott E, Hickie IB. Does sleep disturbance mediate neuropsychological functioning in older people with depression? J Affect Disord 2009; 116: 139-143. Lewis SJG. Parkinson¿s Disease: New approaches to treatment, non-drug management, and how to monitor response or side effects of medications. Geriatric Medicine in General Practice 2009; 1: 18-20. Clatworthy P, Lewis SJG, Brichard L, Hong Y, Izquierdo D, Clark L et al. Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory. J Neurosci 2009; 29: 4960-4966. Lewis SJG, Barker RA. Understanding the dopaminergic deficits in Parkinson¿s Disease: Insights into disease heterogeneity. J Clin Neurosci 2009; 16: 620-625. Lewis SJG, Barker RA. A pathophysiological model of freezing of gait in Parkinson¿s disease. Parkinsonism and Relat Disord 2009; 15: 333-338. Stacpoole SR, McGuigan C, Lewis SJG, Phadke R, Stevens J, Choi D, Kapoor R. Spinal claudication due to myxopapillary ependymoma. Pract Neurol 2007;7:394-6. Goris A, Williams-Gray CH, Clark GR, Foltynie T, Lewis SJG, Brown J, Ban M, Spillantini MG, Compston DAS, Burn DJ, Chinnery PF, Barker RA, Sawcer SJ. Tau and -synuclein in susceptibility to, and dementia in, Parkinson¿s Disease. Ann Neurol 2007; 62: 145-153. Cools R, Lewis SJG, Clark L, Barker RA, Robbins TW. L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease. Neuropsychopharmacology 2007; 32: 180-189. Brown J, Lewis SJG. The use of Rasagiline with levodopa in Parkinson¿s Disease. British Journal of Neuroscience Nursing 2006; 2: 404-409. Slabosz A, Lewis SJG, Smigasiewicz K, Syzmura B, Barker RA, Owen AM. The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease. Neuropsychology 2006; 20: 578-88. Williams-Gray CH, Foltynie T, Lewis SJG, Barker RA. Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options. CNS Drugs 2006; 20: 477-505. Michell AW, Xu Z, Fritz D, Lewis SJG, Foltynie T, Williams-Gray CH, Robbins TW, Carpenter RH, Barker RA. Saccadic latency distributions in Parkinson's disease and the effects of L: -dopa. Exp Brain Res 2006; 174: 7-18. Lewis SJG, Foltynie T, Blackwell A, Robbins TW, Owen AM, Barker RA. Heterogeneity of Parkinson¿s disease in the early clinical stages using a data-driven approach. J Neurol Neurosurgery Psychiatry 2005; 76: 343-348. Lewis SJG, Dove A, Robbins TW, Barker RA, Owen AM. Dopaminergic basis for deficits in working memory but not attentional set-shifting in Parkinson's disease. Neuropsychologia 2005; 43: 823-832. Hurelbrink CB, Lewis SJG, Barker RA. The use of the Actiwatch-Neurologica system to objectively assess the involuntary movements and sleep-wake activity in patients with mild-moderate Huntington's disease. J Neurol 2005; 252: 642-647. Foltynie T, Lewis SJG, Goldberg TE, Blackwell AD, Kolachana BS, Weinberger DR, Robbins TW, Barker RA. The BDNF Val(66)Met polymorphism has a gender specific influence on planning ability in Parkinson's disease. J Neurol 2005; 252: 833-838. Cheesman AL, Barker RA, Lewis SJG, Robbins TW, Owen AM, Brooks DJ. Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson's disease. J Neurol Neurosurg Psychiatry 2005; 76: 1204-10. Foltynie T, Hicks A, Sawcer S, Jonasdottir A, Setakis E, Maranian M, Yeo T, Lewis SJG, Brayne C, Stefansson K, Compston A, Gulcher J, Barker RA. A genome wide linkage disequilibrium screen in Parkinson's disease. J Neurol 2005; 252: 597-602. Pyle A, Foltynie T, Tiangyou W, Lambert C, Keers SM, Allcock LM, Davison J, Lewis SJG, Perry RH, Barker R, Burn DJ, Chinnery PF. Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD. Ann Neurol 2005; 57; 564-567. Ersche KD, Fletcher PC, Lewis SJG, Clark L, Stocks-Gee G, London M, Deakin JB, Robbins TW, Sahakian BJ. Abnormal frontal activations related to decision making in current and former amphetamine- and opiate-dependent individuals. Psychopharmacology (Berl) 2005; 180: 612-623. Lewis SJG, Dove A, Robbins TW, Barker RA, Owen AM. Striatal contributions to working memory: a functional magnetic resonance imaging study in humans. Eur J Neurosci 2004; 19: 755-760. Foltynie T, Goldberg TE, Lewis SJG, Blackwell AD, Kolachana BS, Weinberger DR, Robbins TW, Barker RA. Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism. Mov Disord 2004; 19: 885-91. Michell AW, Lewis SJG, Foltynie T, Barker RA. Biomarkers and Parkinson's disease. Brain 2004; 127: 1693-705. Shaw-Smith CJ, Lewis SJG, Reid E. X-linked adrenoleukodystrophy presenting as autosomal dominant pure hereditary spastic paraparesis. J Neurol Neurosurg Psychiatry 2004; 75: 686-8. Lewis SJG, Dove A, Robbins TW, Barker RA, Owen AM. Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry. J Neurosci 2003; 23: 6351-6356. Lewis SJG, Cools R, Robbins TW, Dove A, Barker RA, Owen AM. Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease. Neuropsychologia 2003; 41: 645-654. Lewis SJG, Caldwell M, Barker RA. Modern therapeutic approaches in Parkinson¿s disease. Expert Rev Mol Med 2003; 3: 1-20.

Exploring the neurobiology of Dementia and Parkinson¿s disease with multimodal techniques

Primary supervisor: Simon Lewis

This study will examine the neurobiology underlying some of the most troubling features of Dementia and Parkinson's disease. This opportunity will utilise a range of novel neuroimaging, neurophysiological and biomedical techniques to explore these clinical features, which will in turn lead to advances in the field of neurodegenerative disease and hopefully translation into improved clinical practice. The proposed research will utilise a broad range of objective measures to investigate neurobiology in Dementia and Parkinson's disease using techniques including Functional and Structural MRI, eye tracking, accelerometry, polysomnography and electroencephalography. The successful candidate will be responsible for developing and testing novel methods for investigating the pathophysiology associated with clinical symptoms. There will be a focus on the creation of novel biomarkers that can be used to monitor treatment efficacy, predict transition and ultimately, identify the emergence symptoms earlier in the course of the disease. Successful applicants will be working in a multidisciplinary research environment with a team of Neurologists, Neuropsychologists and Neuroscientists as well as other academic staff and students within the field of ageing.


Discipline: Physiology
Co-supervisors: Sharon Naismith, Ron Grunstein
Keywords: Dementia, Parkinson's disease, Sleep
Contact: