Renal Research Laboratory

Lab head: Professor Carol Pollock
Location: Kolling Institute of Medical Research

We areinterested in determining the effect of maternal programming on renal disease progression in offspring. We have interesting discoveries about the mechanisms involved andwe are currently examining a possible intervention to prevent or slow disease progression. We arekeen to get one of the student involved.

Website: http://www.kolling.usyd.edu.au/
Lab members: One PostDoc, four Senior Research Fellow, 2 Research Assistants, Four PhD students and one Master Student.
Funding: Australian Research Council, NHMRC, Ramsay Foundation.
Research approach equipment: The project involves animal work. The student will have general experience in animal studies, protein and gene quantitation, histology, renal pathology and function, oxidative stress and epigenetics upon the completion of this project. Equipments required for this project are available at the Kolling Institute. All the techniques are well developed in the Department.
Publications:

1. Stangenberg S, ¿.S Saad. Oxidative Stress, Mitochondrial perturbations and Fetal Programming of Renal Disease induced by Maternal Smoking.Int J Biochem Cell Biol 2015,July; 64: 81-90

2. L Nguyen, ¿S Saad. L carnitine reverses maternal cigarette smoke exposure induced renal oxidative stress and mitochondrial dysfunction in mouse offspring.AJP-Renal Physiol 2015 Apr 1;308(7):F689-96

3. S Stangenberg,¿S Saad. Fetal programming of chronic kidney disease: The role of maternal smoking, mitochondrial dysfunction and epigenetic modification.AJP-Renal Physiology 2015 Jun1;308(11):F1189

4.Glastras SJ, Tsang M, Teh R, Chen H, McGrath RT, Zaky AA, Pollock CA, Saad S. Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring.Sci Rep. 2016 Jun 9;6:27769. doi: 10.1038/srep27769.

5. Sarah J. Glastras, Rachel Teh, Hui Chen, Michael Tsang, Rachel T. McGrath, Carol A. Pollock & Sonia Saad. Mouse Models of Diabetes, Obesity and Related Kidney Disease. PLoS One. 2016Aug 31;11(8):e0162131.


The role of mitochondrial specific anti-oxidants in chronic kidney disease induced by maternal smoking

Primary supervisor: Sonia Saad

The project involves using in vitro and in vivo studies. Students will have expertise in Immunohistochemistry, protein, DNA and RNA extraction, oxidative stress and mitochondrial function upon the completion of this degree.


Discipline: Pathology
Co-supervisors: Hui Chen, Carol Pollock
Keywords: Maternal and child health, Research translation
Contact: