Mucosal Immunology Laboratory

Lab head: Shi San Bao
Location: Blackburn Building, Camperdown

Research conducted by this unit focuses on mucosal immunity, at both a molecular and cellular level. More specifically, this unit investigates the involvement of a number of genes (traditionally associated with the control of the immune response) in experimental models of idiopathic inflammatory bowel disease and atherosclerosis, with a view to gaining new insights into the mechanisms which underlie these disorders.

Lab members: S Bao (head)

Inflammatory bowel disease (IBD)

Primary supervisor: Bob Bao

Affecting 61,000, at a cost of 2.7 billion per annum, IBD consists of ulcerative colitis (UC) and Crohn's disease. Its aetiology remains poorly understood, despite decades of research.

Our preliminary data showed Kruppel-like Factors (KLF) involved in GI immunity, but its role in IBD is unclear. The role of KLF in the development of colitis in the animal model will be investigated.

Discipline: Pathology
Co-supervisors: Merlin Crossley