The Center for Children's Bone Health

Lab head: David Little, Aaron Schindeler, Craig Munns
Location: The Kids Research Institute at The Children's Hospital at Westmead

The Center for Children's Bone Health (CCBH) aims to advance orthopaedic care and bone health through an improved understanding of bone diseases, bone healing and pharmaceutical therapies. Its research approach is highly translational, bridging the gap from bench to bedside.

The CCBH encompasses an array of basic scientists, engineers, technicians and research assistants, postgraduate scholars, medical doctors and other clinical staff across the Sydney Children's Hospitals Network (SCHN).  Members of the CCBH have had significant academic and grant success and has a robust publication records, particularly in high impact bone, orthopaedic, and tissue engineering journals.

Website: http://www.kidsresearch.org.au/research/orthopaedic-biotechnology/index.php
Research approach equipment: Advanced genetically modified mouse models Culture of cell lines and primary bone & muscle cells from mice & humans Gene expression & protein analysis by qPCR and western blotting Tissue histology & histomorphometry XR, DEXA, QCT and microCT scanning Virus induced gene excision Surgical models in rodents(fracture models, BMP-induced bone, spine fusion) & drug administration Manufacturing of polymer scaffolds and other tissue engineering constructs

Serum analysis of circulating drugs by mass spectrometry (MS)

Primary supervisor: Aaron Schindeler

Bone health is a major concern in both adults and children and abnormal bone metabolism is treated using a variety of pharmacological interventions. Our groups study how these agents interact with bone cells in a normal physiological situation, as well as during bone healing and bone infection.

Mass spectrometry is a valuable technique for measurement of small molecule agents and larger macromolecules. The honours student will work with existing senior MS experts to develop new systems for measuring established and experimental drugs. This will support existing preclinical and clinical research studies and is likely to result in multiple co-authored publications.

 

Contact Dr Aaron Schindeler (0404032645 or aaron.schindeler@sydney.edu.au) for further information.


Discipline: Applied Medical Sciences, Westmead
Keywords: Bone health, Mass spectrometry, Infection and immunity
Contact: