VZV Research Laboratory

Lab head: Dr Allison Abendroth
Location: Blackburn Building D06 Camperdown

Alphaherpesvirus manipulation of human immune cells

Primary supervisor: Allison Abendroth

The VZV Research Laboratory is the only research group in Australia with a major focus on the study of Varicella zoster virus (VZV) immunobiology and pathogenesis. Her lab has developed a range of approaches to study various aspects of VZV infection, including the development of models to study VZV infection and functions in human neuronal cells, ganglia, dendritic cells, natural killer cells and T cell interactions. The overall aim of Prof Abendroth’s work is to define molecular mechanisms underlying VZV infection and the host response to infection, which may lead to new strategies for the development of therapies to lessen the impact of VZV disease on the community.

VZV and herpes simplex virus (HSV) are medically important human alphaherpesviruses. These viruses encode a number of functions that modulate a range of immune cell functions that are likely to limit the efficacy of both innate and adaptive arms of the anti-viral immune response. This project will explore how alphaherpesvirus can manipulate key human immune cell types.

This project provides a student the opportunity to learn a variety of virology techniques and cellular and molecular immunological techniques.

Supervisors: Allison Abendroth, Megan Steain, Barry Slobedman

Discipline: Infectious diseases and Immunology