Vascular Immunology Laboratory

Lab head: Professor Georges Grau
Location: K25 - Medical Foundation Building

This laboratory seeks to decipher the fine interactions between microvascular endothelial cells and circulating blood cells, by studying the biology and pathophysiology of microvascular endothelial cells. Diseases such as cerebral malaria, multiple sclerosis and viral encephalitis are being modelled using brain-derived endothelium, while lung-derived cell-lines are being used to study adult respiratory distress syndrome, asthma, and other pulmonary illnesses. In addition to functional studies, the latest imaging technology is being used to visualise the diverse players involved in inflammation. Using these integrated approaches, the cellular, molecular and genetic features of microvascular biology will be explored.

Improved understanding of pathophysiological mechanisms will lead not only to significant advances in fundamental knowledge of biology, but also will identify new targets for the development of drugs intended to treat the many diseases caused by inflammatory processes.

Assessing microparticles as effectors in the microvascular lesion of cerebral malaria

Primary supervisor: Georges Grau

Co-cultures of human brain microvascular endothelial cells with parasites and blood cells, in which purified microparticles will be added, to assess the functional consequences. Analysis of immunological and physiological parameters, such as monolayer permeability and trans-endothelial electrical resistance.

Discipline: Pathology
Co-supervisors: Valery Combes