Vascular Immunology Laboratory
Lab head: Professor Georges Grau
Location: K25 - Medical Foundation Building
This laboratory seeks to decipher the fine interactions between microvascular endothelial cells and circulating blood cells, by studying the biology and pathophysiology of microvascular endothelial cells. Diseases such as cerebral malaria, multiple sclerosis and viral encephalitis are being modelled using brain-derived endothelium, while lung-derived cell-lines are being used to study adult respiratory distress syndrome, asthma, and other pulmonary illnesses. In addition to functional studies, the latest imaging technology is being used to visualise the diverse players involved in inflammation. Using these integrated approaches, the cellular, molecular and genetic features of microvascular biology will be explored.
Improved understanding of pathophysiological mechanisms will lead not only to significant advances in fundamental knowledge of biology, but also will identify new targets for the development of drugs intended to treat the many diseases caused by inflammatory processes.
Investigating mechanisms of microparticle production by microvascular endothelial cells and defining clinically useful inhibitors.
Primary supervisor: Georges Grau
Co-cultures of human brain microvascular endothelial cells with parasites and blood cells, in which various inhibitors of intracellular pathways will be added, to assess their ability to reduce the number of MP released upon stimulation by parasites, or to alter their phenotype. Apart from classical inhibitors, we already have new candidate molecules with obvious effects on MP. Analysis of immunological and haemostatic parameters of the MP produced.
Co-supervisors: Valery Combes