Cardiovascular Signaling Group

Lab head: Dr Xiangjian Zheng
Location: Centenary Institute

The laboratory of Cardiovascular Signaling studies how blood vessel and heart form and maintain their function at molecular and cellular level. Cardiovascular system delivers oxygen, nutrients and circulatory cells to every part of human body and removes metabolic wastes. The precisely regulated development and function of heart and blood vessels are essential for the normal function of every organ systems.

Understanding of how blood vessels form and maintain has important implication in many human disease states such as congenital vascular diseases, stroke, cancer, wound healing, diabetic complications, coronary artery diseases and vascular dementia.

For many genetically associated vascular diseases, such as cerebral cavernous malformation (CCM) and aortic aneurysm, the efficient treatment strategy is still lacking, better understanding of how the malformed vessels develop should be the first step toward the search for therapeutic method.

Pathogenesis of Cerebral Cavernous Malformations in the brain

Primary supervisor: Jaesung Choi

The laboratory of Cardiovascular Signaling studies how blood vessel and heart form and maintain their function at molecular and cellular level. Cardiovascular system delivers oxygen, nutrients and circulatory cells to every part of human body and removes metabolic wastes. The precisely regulated development and function of heart and blood vessels are essential for the normal function of every organ systems.

Understanding of how blood vessels form and maintain has important implication in many human disease states such as congenital vascular diseases, stroke, cancer, wound healing, diabetic complications, coronary artery diseases and vascular dementia.

For many genetically associated vascular diseases, such as cerebral cavernous malformation (CCM) and aortic aneurysm, the efficient treatment strategy is still lacking, better understanding of how the malformed vessels develop should be the first step toward the search for therapeutic method.


Discipline: Pathology
Co-supervisors: Xiangjian Zheng
Keywords: Cardiovascular diseases, mouse models, Brain imaging
Contact: