Faculty of Dentistry

Lab head: Joerg Eberhard
Location: Westmead Centre for Oral Health

Website: http://www.sydney.edu.au/dentistry

Temporal immune cells traffic and IL-17 secretion in oral tissues during an experimental study of host response in humans: Observing inflammation in humans.

Primary supervisor: Joerg Eberhard

The temporal in- and outflow of immune cells in inflamed tissues is highly interesting to understand the regulatory mechanisms involved in host response. Experimental in vitro settings only in part reproduce the complex interplay between pathogens and the host response, therefore human studies are highly warranted. A 21-days experimental gingivitis model was used to induce a reversible inflammatory host response in 14 volunteers and oral biopsies were taken at day 1, 3, 5, 14 and 21. The biopsies were prepared for immunohistochemical staining.
The proposed Honours Student project will be based on these existing biopsies and is aimed to stain a subset of the specimens with diverse antibodies to study the temporal immune cell trafficking and interleukin-17 expression in certain areas of the inflamed gums.
The project will significantly contribute to the understanding of the immune cell response in bacterial induced inflammatory host responses.

Discipline: Applied Medical Sciences, Westmead
Co-supervisors: Anthony Cunningham, Andrew Harman