Bosch Prostate Cancer Focus Group

Lab head: Chris Murphy
Location: F13 - Anderson Stuart Building

Lab members: S Assinder (senior), Q Dong (senior), C Murphy (senior), J Reichardt (senior), D Richardson (senior)

Prostate cancer and benign prostatic hyperplasia

Primary supervisor: Stephen Assinder

Our research is focused on:

  1. Understanding how the loss of structural proteins involved in organization of the cell cytoskeleton contribute to the development of prostate cancer phenotypes.
  1. Hormone regulation of prostate cell proliferation. In particular we are interested in how oxytocin, a hormone usually associated with females, regulates enzymes that are essential to growth of the prostate and to determine if different cell signal pathways are involved.
  1. The roles of Ca2+ activated K+ channels in the abnormal proliferation of prostate stromal cells. Several studies have described and Ca2+ - inactivated K+ channels in regulation of cell proliferation of prostatic epithelial cancer cell lines. There are scant reports of such channels in human prostate stromal cells (PrSC) and no knowledge of the estrogen regulation of these cells and effects on cell proliferation. This work is in collaboration with Dr Kirk Hamilton, University of Otago.

Projects are available in these areas of interest. They will employ many techniques including cell culture, proliferation assays, RT-PCR, real time PCR, siRNA knock downs, Western blot, Immunohistochemistry, thin layer chromatography and radioimmunoassay.

Discipline: Physiology