Dementia and Movement Disorder Lab

Lab head: Surabhi Bhatia
Location: Brain and Mind Centre

Funding: NHMRC-ARC Dementia Research Fellowship
Research approach equipment: Molecular biology, cell models, Immunohistochemistry, lipidomics

Role of lipids in frontotemporal dementia

Primary supervisor: Surabhi Bhatia

Frontotemporal dementia (FTD) is the most common type of dementia affecting people under the age of 65 years. The current studies have focussed on assessing the changes in genes and proteins to determine the pathways involved in FTD. Gene expression studies have shown that lipid metabolic genes are altered in FTD. Furthermore, lipidomics analysis of FTD plasma has revealed significant changes in the level of a number of different lipids. Despite the significant brain atrophy in FTD very little is known about any changes in lipid levels in FTD brain. The aims of the present study will be to determine the changes in lipids and expression of various lipid associated genes in FTD and control brain.

Skills and techniques-Lipid extraction, mass–spectrometry, RNA isolation, qPCR, Western blotting

Discipline: Pathology
Co-supervisors: Glenda Halliday
Keywords: Frontotemporal Dementia , Molecular biology