Honours Project Search Results

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How do herpes simplex viruses interact with dendritic cells in human skin: clues for vaccine development
Primary supervisor: Anthony Cunningham
Herpes Simplex Virus (HSV) can cause cold sores, genital herpes, keratitis, encephalitis and neonatal herpes, as well as increasing the risk of acquiring HIV by at least 3-fold. 70-80% of the Australian population is infected with HSV-1 and 12%
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Alzheimer's Disease in the Canine Brain using Advanced Multispectral Multiplex Imaging
Primary supervisor: Michael Valenzuela
The Regenerative Neuroscience Group has been at the forefront in defining the “dementia” syndrome in older pet dogs. It is incredibly common and has many fascinating parallels with human dementia. Much less is known about the
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Finding the causes of motor neuron disease
Primary supervisor: Roger Pamphlett
Dr Pamphlett’s research interest is finding the causes of motor neuron disease (also known as amyotrophic lateral sclerosis). He uses a variety of epidemiological, genetic and toxicological methods in an attempt to find these causes. His
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Gene copy number in sporadic Amyotrophic Lateral Sclerosis
Primary supervisor: Bing Yu
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder where there is a progressive loss of motor neurons. It causes death in about 3 years. The familial form of this disease occurs in 10% of cases and is linked to the gene for
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Metabolomics of mental disease: effects of clozapine on brain metabolome
Primary supervisor: Vladimir Balcar
Neuroleptics of the second generation (NSG's, e.g. clozapine, introduced c. 1980) promised more refined and subtler therapy for mental disorders. However, despite many successful applications wider use of NSG's has been limited because of
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Biology of fertilisation and early development of embryos
Primary supervisor: Maria Byrne
Research in the Animal Development lab involves comparison of game to genesis and development between closely related species that have contrasting patterns of embryogenesis. For this work we use several starfish and sea urchin species from which
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Enhanced Inner Ear Drug Delivery
Primary supervisor: Daniel Brown
There is an increasing body of evidence to suggest that hearing and balance disorders, originating from an inner ear pathology, can be treated with drugs delivered directly to the cochlea. Unfortunately, the inner ear has a very high rate of
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Pathogenesis of Cerebral Cavernous Malformations in the brain
Primary supervisor: Jaesung Choi
The laboratory of Cardiovascular Signaling studies how blood vessel and heart form and maintain their function at molecular and cellular level. Cardiovascular system delivers oxygen, nutrients and circulatory cells to every part of human body and
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Injury, disability and chronic pain research
Primary supervisor: Kevin Keay
Recent work from our laboratory has demonstrated that nerve injury evokes both pain and disabilities (i.e., disrupted social behaviours, disrupted sleep-wake cycle, changed in appetite, metabolic and endocrine function, loss of the ability to cope
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Mechanisms of insulin resistance
Primary supervisor: David James
Insulin resistance is a risk factor for the development of a number of diseases including type 2 diabetes, cardiovascular disease and some cancers. Our group has discovered several links between how nutrients are processed and insulin resistance.
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Maternal cell surface autoantibodies and association with neurodevelopmental and neuropsychiatric disease in offspring.
Primary supervisor: Fabienne Brilot-Turville
Autism and associated neuropsychiatric problems such as obsessive-compulsive disorder and Tourette syndrome are common neurodevelopmental and neuropsychiatric problems that affect 1% of the population, have a major impact on society, and at
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The interaction between diet and the genome in flies and mice
Primary supervisor: David James
How does our genetic background interact with the nutrients in our diet to promote a long and healthy life? The first studies on longevity demonstrated that calorie restriction increases lifespan in various model organisms including mice, worms
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The Contribution of Mast Cells to Diabetic Cardiomyopathy
Primary supervisor: Scott Levick
A major outcome of diabetes is cardiovascular disease. Mast cells are an immune cell typically associate with acute hypersensitivity reactions and chronic allergy. However, they are also important in cardiac disease. We have previously
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Mapping new functions of insulin and exercise
Primary supervisor: David James
Insulin and exercise activate extensive signalling cascades to regulate an array of cellular processes. Identifying the composition of these signalling networks and the proteins responsible for eliciting specific functions of insulin and exercise
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Is Sacubitril effective in treating diabetic cardiomyopathy?
Primary supervisor: Scott Levick
Sacubitril is the latest pharmacological approach approved for use in heart failure patients. It is a combination angiotensin receptor antagonist/neprilysin inhibitor that has been shown to be more effective than standard angiotensin converting
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Measuring transcutaneous bilirubin: a comparative analysis of correlation between three devices and serum bilirubin measurements
Primary supervisor: Marjan Khajehei
Hyperbilirubinemia is one of the most common causes of healthy newborns’ readmission to the hospital after discharge. Transcutaneous bilirubinometry (TCB) has been developed as a non-invasive, safe, pain-free and convenient approach for the
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Bacterial stress and bacteriophage predation
Primary supervisor: Jonathan Iredell
Bacteriophage therapy is the use of predatory virus combinations to attack bacteria that are causing infection in or colonising a (e.g. human) host. This is typically part of a therapeutic approach that combines antibiotics and specfic lytic
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Regulating extracellular matrix degradation
Primary supervisor: Mark Gorrell
Aim: Identification of the FAP sheddase. Rationale: Extracellular matrix (ECM) dysregulation is the core process of tissue scarring and is driven by myofibroblasts. FAP is a unique protease that causes ECM degradation, and increases
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Biomechanical and Cellular Aspects of Tooth Development in the Maxilla
Primary supervisor: Babak Sarrafpour
Several theories have been proposed for tooth eruption, most of which rely on a presupposition of there being a true eruptive force. Earlier work demonstrated by finite element analysis of the mandible, that tooth eruption could be accounted for
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Mechanobiological role of endosteum and periosteum in bone remodelling
Primary supervisor: Babak Sarrafpour
We earlier demonstrated by finite element analysis (FEA), that soft tissue dental follicle surrounding unerupted teeth experiences compression over crowns, and tension beneath roots during normal functional loading of the jaw, with the effect
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Intermittent hypoxia during sleep: Interactions with melanoma biology
Primary supervisor: Kristina Kairaitis
Studies have demonstrated obstructive sleep apnoea (OSA) is linked with an increased chance of cancer, and an increased chance of dying of cancer. This association is particularly strong for melanoma and fluctuating oxygen levels related to OSA.
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Imaging atherogenesis in a zebrafish model
Primary supervisor: Stefan Oehlers
Atherosclerosis and complications from atherosclerotic plaques are a leading cause of death and disability in Australia. The paradigm of foamy macrophages and lipid accumulation in the walls of blood vessels is well known. However, our
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Defining T cell subsets in human anogential tissues and their interactions with HIV
Primary supervisor: Kirstie Bertram
We will define the human T cell subsets in anogential tissues and their interactions with HIV. Using a range of techniques, including tissue digestion, flow cytometry and fluorescence
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Influenza Vaccination: Fever, antipyretics and immunogenicity
Primary supervisor: Robert Booy
Professor Robert Booy is head of Clinical Research at the National Centre for Immunisation Research and Surveillance.  He is involved in research on vaccine preventable diseases, be they in infants, children, adults or the elderly. His
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Human Papilloma Virus (HPV) vaccine: long term protection against infection and cancer
Primary supervisor: Robert Booy
Australia was the first country to introduce the human papilloma vaccine (HPV) and it has proven very successful in preventing early stages of cervical cancer and other long term complications of HPV.  There are two special
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