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How do herpes simplex viruses interact with dendritic cells in human skin: clues for vaccine development
Primary supervisor: Anthony Cunningham
Herpes Simplex Virus (HSV) can cause cold sores, genital herpes, keratitis, encephalitis and neonatal herpes, as well as increasing the risk of acquiring HIV by at least 3-fold. 70-80% of the Australian population is infected with HSV-1 and 12%
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Alzheimer's Disease in the Canine Brain using Advanced Multispectral Multiplex Imaging
Primary supervisor: Michael Valenzuela
The Regenerative Neuroscience Group has been at the forefront in defining the “dementia” syndrome in older pet dogs. It is incredibly common and has many fascinating parallels with human dementia. Much less is known about the
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Finding the causes of motor neuron disease
Primary supervisor: Roger Pamphlett
Dr Pamphlett’s research interest is finding the causes of motor neuron disease (also known as amyotrophic lateral sclerosis). He uses a variety of epidemiological, genetic and toxicological methods in an attempt to find these causes. His
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Pathogenesis of Cerebral Cavernous Malformations in the brain
Primary supervisor: Jaesung Choi
The laboratory of Cardiovascular Signaling studies how blood vessel and heart form and maintain their function at molecular and cellular level. Cardiovascular system delivers oxygen, nutrients and circulatory cells to every part of human body and
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Mechanisms of insulin resistance
Primary supervisor: David James
Insulin resistance is a risk factor for the development of a number of diseases including type 2 diabetes, cardiovascular disease and some cancers. Our group has discovered several links between how nutrients are processed and insulin resistance.
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Injury, disability and chronic pain research
Primary supervisor: Kevin Keay
Recent work from our laboratory has demonstrated that nerve injury evokes both pain and disabilities (i.e., disrupted social behaviours, disrupted sleep-wake cycle, changed in appetite, metabolic and endocrine function, loss of the ability to
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Maternal cell surface autoantibodies and association with neurodevelopmental and neuropsychiatric disease in offspring.
Primary supervisor: Fabienne Brilot-Turville
Autism and associated neuropsychiatric problems such as obsessive-compulsive disorder and Tourette syndrome are common neurodevelopmental and neuropsychiatric problems that affect 1% of the population, have a major impact on society, and at
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The interaction between diet and the genome in mice
Primary supervisor: David James
We have a highly unique population of diversity outbred mice that we are screening for gene x environment interactions to better understand complex biological problems and diseases.  The project will entail learning how to do genetic
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The Contribution of Mast Cells to Diabetic Cardiomyopathy
Primary supervisor: Scott Levick
A major outcome of diabetes is cardiovascular disease. Mast cells are an immune cell typically associate with acute hypersensitivity reactions and chronic allergy. However, they are also important in cardiac disease. We have previously
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Mapping new functions of insulin and exercise
Primary supervisor: David James
Insulin and exercise activate extensive signalling cascades to regulate an array of cellular processes. Identifying the composition of these signalling networks and the proteins responsible for eliciting specific functions of insulin and exercise
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Is Sacubitril effective in treating diabetic cardiomyopathy?
Primary supervisor: Scott Levick
Sacubitril is the latest pharmacological approach approved for use in heart failure patients. It is a combination angiotensin receptor antagonist/neprilysin inhibitor that has been shown to be more effective than standard angiotensin converting
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Bacterial stress and bacteriophage predation
Primary supervisor: Jonathan Iredell
Bacteriophage therapy is the use of predatory virus combinations to attack bacteria that are causing infection in or colonising a (e.g. human) host. This is typically part of a therapeutic approach that combines antibiotics and specfic lytic
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Regulating extracellular matrix degradation
Primary supervisor: Mark Gorrell
Aim: Identification of the FAP sheddase. Rationale: Extracellular matrix (ECM) dysregulation is the core process of tissue scarring and is driven by myofibroblasts. FAP is a unique protease that causes ECM degradation, and increases
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Biomechanical and Cellular Aspects of Tooth Development in the Maxilla
Primary supervisor: Babak Sarrafpour
Several theories have been proposed for tooth eruption, most of which rely on a presupposition of there being a true eruptive force. Earlier work demonstrated by finite element analysis of the mandible, that tooth eruption could be accounted for
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Mechanobiological role of endosteum and periosteum in bone remodelling
Primary supervisor: Babak Sarrafpour
We earlier demonstrated by finite element analysis (FEA), that soft tissue dental follicle surrounding unerupted teeth experiences compression over crowns, and tension beneath roots during normal functional loading of the jaw, with the effect
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Intermittent hypoxia during sleep: Interactions with melanoma biology
Primary supervisor: Kristina Kairaitis
Studies have demonstrated obstructive sleep apnoea (OSA) is linked with an increased chance of cancer, and an increased chance of dying of cancer. This association is particularly strong for melanoma and fluctuating oxygen levels related to OSA.
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Imaging atherogenesis in a zebrafish model
Primary supervisor: Stefan Oehlers
Atherosclerosis and complications from atherosclerotic plaques are a leading cause of death and disability in Australia. The paradigm of foamy macrophages and lipid accumulation in the walls of blood vessels is well known. However, our
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Defining T cell subsets in human anogential tissues and their interactions with HIV
Primary supervisor: Kirstie Bertram
We will define the human T cell subsets in anogential tissues and their interactions with HIV. Using a range of techniques, including tissue digestion, flow cytometry and fluorescence
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Influenza Vaccination: Fever, antipyretics and immunogenicity
Primary supervisor: Robert Booy
Professor Robert Booy is head of Clinical Research at the National Centre for Immunisation Research and Surveillance.  He is involved in research on vaccine preventable diseases, be they in infants, children, adults or the elderly. His
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Human Papilloma Virus (HPV) vaccine: long term protection against infection and cancer
Primary supervisor: Robert Booy
Australia was the first country to introduce the human papilloma vaccine (HPV) and it has proven very successful in preventing early stages of cervical cancer and other long term complications of HPV.  There are two special
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ROLE OF THE CYTOSKELETON ON THE EXIT OF HERPES SIMPLEX VIRUS FROM SENSORY NERVES
Primary supervisor: Monica Miranda Saksena
BACKGROUND Herpes simplex virus type 1 (HSV-1) is a contagious human pathogen prevalent in 40 –80% of the human population. HSV-1 initially infects the skin and/or mucosal membranes where its spreads to nerve cells of the peripheral
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Developing Novel Cancer Drugs: Do C-terminal HSP90 inhibitors block the HIF hypoxic response?
Primary supervisor: Kristina Cook
Background: Hypoxia Inducible Factor (HIF) is a transcription factor activated by low oxygen, a common condition in solid tumours. HIF controls the expression of over 1000 genes, many of them important in cancer with roles involved in
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Understanding protein dephosphorylation in the DNA damage response
Primary supervisor: Hilda Pickett
By screening breast cancer samples, we have identified a novel protein phosphatase that regulates DNA repair pathway engagement at telomeres. We aim to investigate the role of this protein in the DNA damage response specifically at telomeres,
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Monocyte inflammatory profile in people with Peripheral arterial disease and Diabetic foot ulcers
Primary supervisor: Helen Williams
Diabetic foot ulcers (DFUs) are a common complication of diabetes and delayed healing of these ulcers can have a large impact on the quality of life. The presence of peripheral arterial disease (PAD), which is common in diabetes, is thought
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Unexpected effects of blocking IGFBP-3-mediated signalling on tumour T cells in breast cancer
Primary supervisor: Robert Baxter
Triple-negative breast cancer (TNBC) is the most dangerous type of breast cancer because it affects younger women and there are currently no targeted therapies available. We discovered that TNBC growth can be blocked by a novel drug combination
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