Find an Honours Project

Honours Project Search Results

Results 1 - 25 of 163

Search again | Next >
Regulating extracellular matrix degradation
Primary supervisor: Mark Gorrell
Aim: Identification of the FAP sheddase. Rationale: Extracellular matrix (ECM) dysregulation is the core process of tissue scarring and is driven by myofibroblasts. FAP is a unique protease that causes ECM degradation, and increases
Full project details | Other projects by this supervisor
Thiol isomerases as novel antithrombotic targets
Primary supervisor: Freda Passam
Aim:To discover alternative pathways in the clotting system that can be targeted to develop efficient and safer antithrombotic drugs. Background:An exciting recent discovery in the thrombosis field is that thiol isomerases form a new clotting
Full project details | Other projects by this supervisor
Pathogenic proteases: DPP4 and fibroblast activation protein
Primary supervisor: Mark Gorrell
AIMS: 1. Use existing protein expression constructs to produce recombinant proteins. Obtain purified FAP and DPP4 using established methods. 2. Use purified FAP and DPP4 for discovery of new enzyme - inhibitory compounds. 3. Attempt to
Full project details | Other projects by this supervisor
Investigating a new innovative approach to the treatment of ischaemic stroke
Primary supervisor: Simone Schoenwaelder
The development of a thrombosis or embolus in the cerebral circulation (ischaemic stroke [IS]) is the third most common cause of death and the most common cause of adult disability globally. Whilst considerable progress has been made in
Full project details | Other projects by this supervisor
Identification of circulating miRNAs in drinkers associated with risk for alcoholic liver cirrhosis
Primary supervisor: Devanshi Seth
Despite the recognition of alcohol as an important cause of liver cirrhosis, the molecular and cellular mechanisms of liver injury remain unclear. There is evidence that genetic risk factors may predispose drinkers to develop cirrhosis but these
Full project details | Other projects by this supervisor
Roles of a bispecific enzyme in the pathogenesis of chronic liver injury 2019
Primary supervisor: Mark Gorrell
HYPOTHESIS: The enzymatic activity ofFAP is important in the pathogenesis of chronic liver injury.   AIMS: 1)    To investigate the role of FAP in chronic liver injury (fibrosis and steatosis) using our novel FAP mouse
Full project details | Other projects by this supervisor
A potential role for androgens in improving ovarian response to IVF stimulation
Primary supervisor: Kirsty Walters
Over 5 million babies have been born using assisted reproduction technologies (ART) in the 35 years since Louise Brown’s birth. In Australia, ~3% of babies born are now born through IVF wherein a live birth rate of 40% per
Full project details | Other projects by this supervisor
Prostate cancer and benign prostatic hyperplasia
Primary supervisor: Stephen Assinder
Our research is focused on: 1.   Endocrine regulation of cancer cell proliferation. In particular we are interested in how various hormones and cytokines affect tumourigenesis. 2.   Oxytocin, the hormone of love. Our recent work has
Full project details | Other projects by this supervisor
The role of endogenous glucocorticoid signalling in diet-induced bone loss and fuel metabolism
Primary supervisor: Hong Zhou
Recent research has revolutionised our understanding of the way the skeleton interacts with other organs and body functions. Of particular relevance was the recent discovery that bone and its cells, in particular osteoblasts (bone forming cells),
Full project details | Other projects by this supervisor
Investigating the role of neuraminidases in platelets during storage
Primary supervisor: Denese Marks
Platelets deteriorate during storage, leading to a short shelf-life. Interestingly, platelets donated by some donors do not store as well as others, leading to reduced survival and potentially reduced clinical effectiveness following transfusion
Full project details | Other projects by this supervisor
The role of neuraminidases in platelet function
Primary supervisor: Denese Marks
Platelets deteriorate during storage, leading to a short shelf-life. Interestingly, platelets donated by some donors do not store as well as others, leading to reduced survival and potentially reduced clinical effectiveness following transfusion
Full project details | Other projects by this supervisor
Unraveling the Molecular Basis of Motor and Sensory Nerve Death
Primary supervisor: Marina Kennerson
In recent years significant progress has been made in finding the molecular causes of the premature death of neurons (neurodegeneration). The mechanisms of neurodegeneration can be divided into those that result in death of cell bodies
Full project details | Other projects by this supervisor
Interactions between Hepatitis Delta Virus (HDV) and Hepatitis B Virus (HBV)
Primary supervisor: Mark Douglas
Hepatitis B virus (HBV) is the leading cause of chronic hepatitis globally, but is also an oncogenic virus, with recent estimates that 53% of all  cases of hepatocellular carcinoma (HCC) in the world are HBV-induced. Co-infection or
Full project details | Other projects by this supervisor
The role of endogenous glucocorticoid signalling in diet-induced bone loss and fuel metabolism.
Primary supervisor: Hong Zhou
Recent research has revolutionised our understanding of the way the skeleton interacts with other organs and body functions. Of particular relevance was the recent discovery that bone and its cells, in particular osteoblasts (bone forming cells),
Full project details | Other projects by this supervisor
The role of androgens in burn wound repair
Primary supervisor: Yiwei Wang
Background Wound healing is an innate response which involves several overlapping phases including inflammation, cell recruitment, epithelialization, matrix synthesis and tissue remodelling1. Wound repair is vitally important as it restores
Full project details | Other projects by this supervisor
How does the promising vaccine adjuvant AS01 work in humans?
Primary supervisor: Kerrie Sandgren
Research Background Part of our lab’s research is focused on improving vaccines. A new, recently trialled vaccine for shingles has proven to be highly efficacious, even in older adults (>70 y.o.). We are intrigued to know whether the
Full project details | Other projects by this supervisor
Redox biomarkers in thrombotic disease.
Primary supervisor: Freda Passam
Aim: To identify new biological markers that can be used in the monitoring and treatment of patients with thrombotic disease. Background: The redox balance (balance of reduction and oxidation reactions in our blood) is essential for a healthy
Full project details | Other projects by this supervisor
How does abnormal gene processing lead to breast cancer?
Primary supervisor: Justin Wong
Background: Our team has been studying one of the hottest areas in gene regulation – alternative splicing. In 2013, we reported in the prestigious journal, Cell, that a form of alternative splicing called intron retention (IR) is an
Full project details | Other projects by this supervisor
Receptor identification of AAV capsids used in gene therapy
Primary supervisor: Charles Bailey
Recombinant adeno-associated virus (rAAV) has gained widespread use as a gene delivery vector for corrective gene therapies due to its lack of association with any human disease and its ability to safely and efficiently deliver a genetic payload
Full project details | Other projects by this supervisor
Why Apolipoprotein E variants are the biggest genetic risk factor for Alzheimer's disease.
Primary supervisor: Anthony Don
Alzheimer’s disease is the most common form of dementia and its prevalence is increasing rapidly as populations around the world age. Despite massive academic and pharmaceutical investment over the past 20 years, there are no treatments
Full project details | Other projects by this supervisor
Functional consequences of mutations in the tumour suppressor CTCF in cancer
Primary supervisor: Charles Bailey
Whole genome sequencing of cancer patient cohorts has revealed ~120 significantly mutated genes (SMGs) which play a key role in cancer development.The ‘master weaver of the genome’ protein CTCF, is a SMG primarily in endometrial
Full project details | Other projects by this supervisor
Consequences of mutations in the tumour suppressor gene MGA in chronic lymphocytic leukaemia (CLL)
Primary supervisor: Charles Bailey
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in senior Australians. Every year nearly 1000 Australians are diagnosed with CLL and typically 80% of all new diagnoses are in patients over the age of 60 years. CLL is a slow
Full project details | Other projects by this supervisor
Molecular modeling of cancer-associated mutations in tumour suppressor genes
Primary supervisor: Charles Bailey
The ‘master weaver of the genome’ protein CTCF, is one of 120 significantly mutated genes primarily in endometrial cancer, as well as colorectal, stomach, breast and haemopoietic cancers. Our group was the first to demonstrate that
Full project details | Other projects by this supervisor
Important crosstalk between dying platelets and neutrophils – Role in microvascular dysfunction
Primary supervisor: Shaun Jackson
Ischemia reperfusion (IR) injury commonly occurs in a wide range of human diseases, including acute myocardial infarction (AMI) and ischemic stroke. IR injury is characterised by poor blood flow in micro-vasculature despite the re-open of
Full project details | Other projects by this supervisor
Noradrenaline and Cognitive Function – Investigating the forgotten symptoms of Parkinson’s disease
Primary supervisor: Mac Shine
Although Parkinson’s disease has been traditionally thought of as a disorder of movement, people with the disease also suffer from impairments in cognitive function. Unfortunately, the classical models that people have used to understand
Full project details | Other projects by this supervisor
Results 1 - 25 of 163 Search again | Next >