Find an Honours Project

Honours Project Search Results

Results 1 - 25 of 164

Search again | Next >
Regulating extracellular matrix degradation
Primary supervisor: Mark Gorrell
Aim: Identification of the FAP sheddase. Rationale: Extracellular matrix (ECM) dysregulation is the core process of tissue scarring and is driven by myofibroblasts. FAP is a unique protease that causes ECM degradation, and increases
Full project details | Other projects by this supervisor
Thiol isomerases as novel antithrombotic targets
Primary supervisor: Freda Passam
Aim:To discover alternative pathways in the clotting system that can be targeted to develop efficient and safer antithrombotic drugs. Background:An exciting recent discovery in the thrombosis field is that thiol isomerases form a new clotting
Full project details | Other projects by this supervisor
Pathogenic proteases: DPP4 and fibroblast activation protein
Primary supervisor: Mark Gorrell
AIMS: 1. Use existing protein expression constructs to produce recombinant proteins. Obtain purified FAP and DPP4 using established methods. 2. Use purified FAP and DPP4 for discovery of new enzyme - inhibitory compounds. 3. Attempt to
Full project details | Other projects by this supervisor
Investigating a new innovative approach to the treatment of ischaemic stroke
Primary supervisor: Simone Schoenwaelder
The development of a thrombosis or embolus in the cerebral circulation (ischaemic stroke [IS]) is the third most common cause of death and the most common cause of adult disability globally. Whilst considerable progress has been made in
Full project details | Other projects by this supervisor
Identification of circulating miRNAs in drinkers associated with risk for alcoholic liver cirrhosis
Primary supervisor: Devanshi Seth
Despite the recognition of alcohol as an important cause of liver cirrhosis, the molecular and cellular mechanisms of liver injury remain unclear. There is evidence that genetic risk factors may predispose drinkers to develop cirrhosis but these
Full project details | Other projects by this supervisor
Roles of a bispecific enzyme in the pathogenesis of chronic liver injury 2019
Primary supervisor: Mark Gorrell
HYPOTHESIS: The enzymatic activity ofFAP is important in the pathogenesis of chronic liver injury.   AIMS: 1)    To investigate the role of FAP in chronic liver injury (fibrosis and steatosis) using our novel FAP mouse
Full project details | Other projects by this supervisor
A potential role for androgens in improving ovarian response to IVF stimulation
Primary supervisor: Kirsty Walters
Over 5 million babies have been born using assisted reproduction technologies (ART) in the 35 years since Louise Brown’s birth. In Australia, ~3% of babies born are now born through IVF wherein a live birth rate of 40% per
Full project details | Other projects by this supervisor
Prostate cancer and benign prostatic hyperplasia
Primary supervisor: Stephen Assinder
Our research is focused on: 1.   Endocrine regulation of cancer cell proliferation. In particular we are interested in how various hormones and cytokines affect tumourigenesis. 2.   Oxytocin, the hormone of love. Our recent work has
Full project details | Other projects by this supervisor
How does abnormal gene processing lead to breast cancer?
Primary supervisor: Justin Wong
Background: Our team has been studying one of the hottest areas in gene regulation – alternative splicing. In 2013, we reported in the prestigious journal, Cell, that a form of alternative splicing called intron retention (IR) is an
Full project details | Other projects by this supervisor
The role of endogenous glucocorticoid signalling in diet-induced bone loss and fuel metabolism
Primary supervisor: Hong Zhou
Recent research has revolutionised our understanding of the way the skeleton interacts with other organs and body functions. Of particular relevance was the recent discovery that bone and its cells, in particular osteoblasts (bone forming cells),
Full project details | Other projects by this supervisor
Investigating the role of neuraminidases in platelets during storage
Primary supervisor: Denese Marks
Platelets deteriorate during storage, leading to a short shelf-life. Interestingly, platelets donated by some donors do not store as well as others, leading to reduced survival and potentially reduced clinical effectiveness following transfusion
Full project details | Other projects by this supervisor
The role of neuraminidases in platelet function
Primary supervisor: Denese Marks
Platelets deteriorate during storage, leading to a short shelf-life. Interestingly, platelets donated by some donors do not store as well as others, leading to reduced survival and potentially reduced clinical effectiveness following transfusion
Full project details | Other projects by this supervisor
Unraveling the Molecular Basis of Motor and Sensory Nerve Death
Primary supervisor: Marina Kennerson
In recent years significant progress has been made in finding the molecular causes of the premature death of neurons (neurodegeneration). The mechanisms of neurodegeneration can be divided into those that result in death of cell bodies
Full project details | Other projects by this supervisor
Sleep and Cancer: Understanding the role of obstructive sleep apnoea in cancer growth and spread
Primary supervisor: Kristina Cook
Background: Recent epidemiological studies have shown that patients with obstructive sleep apnoea (OSA) have higher rates of cancer and cancer mortality however the underlying mechanisms are poorly understood. Obstructive sleep apnoea (OSA) is
Full project details | Other projects by this supervisor
Interactions between Hepatitis Delta Virus (HDV) and Hepatitis B Virus (HBV)
Primary supervisor: Mark Douglas
Hepatitis B virus (HBV) is the leading cause of chronic hepatitis globally, but is also an oncogenic virus, with recent estimates that 53% of all  cases of hepatocellular carcinoma (HCC) in the world are HBV-induced. Co-infection or
Full project details | Other projects by this supervisor
The role of endogenous glucocorticoid signalling in diet-induced bone loss and fuel metabolism.
Primary supervisor: Hong Zhou
Recent research has revolutionised our understanding of the way the skeleton interacts with other organs and body functions. Of particular relevance was the recent discovery that bone and its cells, in particular osteoblasts (bone forming cells),
Full project details | Other projects by this supervisor
The role of androgens in burn wound repair
Primary supervisor: Yiwei Wang
Background Wound healing is an innate response which involves several overlapping phases including inflammation, cell recruitment, epithelialization, matrix synthesis and tissue remodelling1. Wound repair is vitally important as it restores
Full project details | Other projects by this supervisor
Defining the antigen presentation capacity of endothelial cells and their microparticles
Primary supervisor: Georges Grau
Cell arrest in brain microvessels and inflammation are the major fatal determinants of cerebral malaria (CM). There is good evidence in inflammatory diseases that endothelial cells (EC) can behave as antigen presenting cells (APC) but this has
Full project details | Other projects by this supervisor
Developing Novel Cancer Drugs: Do C-terminal HSP90 inhibitors block the HIF hypoxic response?
Primary supervisor: Kristina Cook
Background: Hypoxia Inducible Factor (HIF) is a transcription factor activated by low oxygen, a common condition in solid tumours. HIF controls the expression of over 1000 genes, many of them important in cancer with roles involved in
Full project details | Other projects by this supervisor
How does the promising vaccine adjuvant AS01 work in humans?
Primary supervisor: Kerrie Sandgren
Research Background Part of our lab’s research is focused on improving vaccines. A new, recently trialled vaccine for shingles has proven to be highly efficacious, even in older adults (>70 y.o.). We are intrigued to know whether the
Full project details | Other projects by this supervisor
Novel Pathways in Ischaemic Heart Disease
Primary supervisor: John O'Sullivan
There are now >70 genetic loci associated with coronary artery disease (CAD), and surprisingly over two-thirds of these are not associated with traditional CAD risk factors. Contribution of genetic variation to disease is complex, particularly
Full project details | Other projects by this supervisor
Blocking DNA and RNA synthesis by targeting glutamine metabolism in prostate cancer
Primary supervisor: Jeff Holst
The Origins of Cancer Program is part of the newly established ACRF Centenary Cancer Research Centre, located within the Charles Perkins Centre. We seek to understand how cancer cells obtain their nutrients, and thereby uncover new mechanisms
Full project details | Other projects by this supervisor
Redox biomarkers in thrombotic disease.
Primary supervisor: Freda Passam
Aim: To identify new biological markers that can be used in the monitoring and treatment of patients with thrombotic disease. Background: The redox balance (balance of reduction and oxidation reactions in our blood) is essential for a healthy
Full project details | Other projects by this supervisor
Receptor identification of AAV capsids used in gene therapy
Primary supervisor: Charles Bailey
Recombinant adeno-associated virus (rAAV) has gained widespread use as a gene delivery vector for corrective gene therapies due to its lack of association with any human disease and its ability to safely and efficiently deliver a genetic payload
Full project details | Other projects by this supervisor
Why Apolipoprotein E variants are the biggest genetic risk factor for Alzheimer's disease.
Primary supervisor: Anthony Don
Alzheimer’s disease is the most common form of dementia and its prevalence is increasing rapidly as populations around the world age. Despite massive academic and pharmaceutical investment over the past 20 years, there are no treatments
Full project details | Other projects by this supervisor
Results 1 - 25 of 164 Search again | Next >