Associate Professor Alexandra Sharland

Associate Professor
Surgery, Central Clinical School
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 2897 or +61 2 9515 5416
F: +61 2 9036 7083
E:

Research interests

Basic and translational research in transplantation

Current national competitive grants*

2012

Strategies to achieve kidney transplant tolerance in a clinically-relevant model
Sharland A, Chadban S, Bishop A, Wu H
NHMRC Project Grants ($641,010 over 3 years)

* Grants administered through the University of Sydney

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Wang, Z., Wang, C., Cunningham, E., Allen, R., Sharland, A., Bishop, G. (2014), Optimized method for ureteric reconstruction in a mouse kidney transplant model. ANZ Journal of Surgery. 84(6), 481-485. [Abstract]

2013

   
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Sparwasser, T., Bishop, G., Sharland, A., Alexander, S. (2013), Infiltrating Foxp3(+) Regulatory T Cells From Spontaneously Tolerant Kidney Allografts Demonstrate Donor-Specific Tolerance. American Journal of Transplantation. 13(11), 2819-2830. [Abstract]
  • Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, G. (2013), Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation. 95(1), 70-77. [Abstract]
  • Cunningham, E., Sharland, A., Bishop, G. (2013), Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?. Clinical & Developmental Immunology. 2013, 419692. [Abstract]

2012

   
  • Ganbold, A., Andersen, S., Tay, S., Cunningham, E., Ilie, V., Krishnan, S., Wang, C., McCaughan, G., Sharland, A., Bishop, G. (2012), Expression of common gamma chain signalling cytokines and their receptors distinguishes rejection from tolerance in a rat organ transplant model. Transplant Immunology. 27(2-3), 89-94. [Abstract]
  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012), Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International. 32(10), 1527-1534. [Abstract]
  • Cubitt, J., Pennington, T., Wang, C., Allen, R., Bishop, A., Sharland, A. (2012), Reliable and reproducible murine models for commonly used abdominal plastic surgical flaps. Journal of Reconstructive Microsurgery. 28(3), 161-166. [Abstract]
  • Sharland, A. (2012), Pancreatic beta-cell failure in the pathogenesis of type 1 diabetes. In: A Modern Epidemic. (pp.70-86).Australia: Sydney University Press.

2011

   
  • Chen, G., Wu, H., Ma, J., Chadban, S., Sharland, A. (2011), Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 26(12), 3873-81. [Abstract]
  • Bishop, G., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011), Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation. 92(8), e39. [Abstract]
  • Bishop, G., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011), Approaching the Promise of Operational Tolerance in Clinical Transplantation. Transplantation. 91(10), 1065-1074. [Abstract]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, G. (2011), Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant immunology. 24(3), 149-56. [Abstract]

2010

   
  • Sharland, A., Logan, G., Bishop, A., Alexander, I. (2010), Liver-directed gene expression using recombinant AAV 2/8 vectors -- a tolerogenic strategy for gene delivery?. Discovery Medicine. 9(49), 519-527. [Abstract]
  • Wang, C., Tay, S., Tran, G., Hodgkinson, S., Allen, R., Hall, B., McCaughan, G., Sharland, A., Bishop, G. (2010), Donor IL-4 treatment induces alternatively activated liver macrophages and IDO-Expressing NK cells and promotes rat liver allograft acceptance. Transplant immunology. 22(3-4), 172-8. [Abstract]

2009

   
  • Obeidy, P., Sharland, A. (2009), Molecules in Focus NKG2D and its ligands. The international journal of biochemistry & cell biology. 41(12), 2364-7. [Abstract]
  • Sharland, A., Gorrell, M. (2009), Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run. Hepatology (Baltimore, Md.). 50(6), 2037-40. [Abstract]
  • Laurence, J., Allen, R., McCaughan, G., Logan, G., Alexander, I., Bishop, G., Sharland, A. (2009), Gene therapy in transplantation. Transplantation Reviews. 23(3), 159-170. [Abstract]
  • Laurence, J., Wang, C., Zheng, M., Cunningham, S., Earl, J., Tay, S., Allen, R., McCaughan, G., Alexander, I., Bishop, G., Sharland, A. (2009), Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transplantation. 15(2), 233-241. [Abstract]

2008

   
  • Laurence, J., Wang, C., Park, E., Buchanan, A., Clouston, A., Allen, R., Mccaughan, G., Bishop, G., Sharland, A. (2008), Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection. Transplantation. 85(9), 1357-1361. [Abstract]
  • Lam, V., Taylor, C., Laurence, J., Wang, C., Sharland, A., McCaughan, G., Hodgkinson, S., Allen, R., Hall, B., Bishop, G. (2008), Heart allograft acceptance induced by anti-CD3 antibody in high-responder rats: Effect on foxp3 and cytokine expression and graft infiltration. Transplant Immunology. 19(1), 20-24. [Abstract]
  • Sharland, A. (2008), The inhaled route to improved liver function. Hepatology (Baltimore, Md.). 47(2), 755-756. [Abstract]
  • Tran, P., Christiansen, D., Winterhalter, A., Brooks, A., Gorrell, M., Lilienfeld, B., Seebach, J., Sandrin, M., Sharland, A. (2008), Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation. 15(5), 321-32. [Abstract]