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Professor Leigh Delbridge

Professor of Surgery
Surgery, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9926 7113 / 7014
F: +61 2 9906 3385
E:

Research interests

Leigh Delbridge is Professor and Head of the Discipline of Surgery at the University of Sydney. He heads the University of Sydney Endocrine Surgical Unit which is the largest such unit in Australia. His clinical practice is now confined entirely to thyroid and parathyroid surgery, perfoming over 500 such procedures each year. A major clinical interest is minimally invasive parathyroidectomy and minimally invasive diagnostic thyroid surgery. His research interests include the development of techniques for minimally invasive endocrine surgery, epidemiological studies in relation to thyroid and parathyroid disease, collaborative studies on the molecular genetics of thyroid and parathyroid tumourogenesis, and collaborative studies on parathyroid hormone physiology. He is the immediate Past President of the International Association of Endocrine Surgeons, and President-Elect of the Surgical Research Society of Australia.

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Keywords

Endocrinology; Surgery

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Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007

2012

   
  • Bullock, M., O'Neill, C., Chou, A., Clarkson, A., Dodds, T., Toon, C., Sywak, M., Delbridge, L., Robinson, B., Learoyd, D., Capper, D., von Deimling, A., Clifton-Bligh, R., Gill, A. (2012), Utilisation of a monoclonal antibody for BRAFV600E detection in papillary thyroid carcinoma. Endocrine-Related Cancer. 19(6), 779-784. [Abstract]
  • Lee, J., Zhao, J., Clifton-Bligh, R., Gill, A., Gundara, J., Ip, J., Sywak, M., Delbridge, L., Robinson, B., Sidhu, S. (2012), Papillary Thyroid Carcinoma in Pregnancy: A Variant of the Disease?. Annals of Surgical Oncology. 19(13), 4210-4216. [Abstract]
  • Zhang, J., Gill, A., Issacs, J., Atmore, B., Johns, A., Delbridge, L., Lai, R., McMullen, T. (2012), The Wnt/β-catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer. Human Pathology. 43(7), 1044-1050. [Abstract]
  • Prichard, R., O'Neill, C., Oucharek, J., Colinda, Y., Delbridge, L., Sywak, M. (2012), A Prospective Study of Heart Rate Variability in Endocrine Surgery: Surgical Training Increases Consultant's Mental Strain. Journal of Surgical Education. 69(4), 453-458. [Abstract]
  • Bullock, M., Duncan, E., O'Neill, C., Tacon, L., Sywak, M., Sidhu, S., Delbridge, L., Learoyd, D., Robinson, B., Ludgate, M., Clifton-Bligh, R. (2012), Association of FOXE1 Polyalanine Repeat Region with Papillary Thyroid Cancer. Journal of Clinical Endocrinology and Metabolism. 97(9), E1814-E1819. [Abstract]
  • Vasica, G., O'Neill, C., Sidhu, S., Sywak, M., Reeve, T., Delbridge, L. (2012), Reoperative surgery for bilateral multinodular goitre in the era of total thyroidectomy. British Journal of Surgery. 99(5), 688-692. [Abstract]
  • Delbridge, L. (2012), "Selective rather than routine": using sound clinical judgment. Archives of Surgery. 147(4), 344. [Abstract]
  • Prichard, R., O'Neill, C., Oucharek, J., Sippel, R., Delbridge, L., Sidhu, S., Chen, H. (2012), Is Focused Minimally Invasive Parathyroidectomy Appropriate for Patients With Familial Primary Hyperparathyroidism?. Annals of Surgical Oncology. 19(4), 1264-1268. [Abstract]
  • Prichard, R., Lee, J., Gill, A., Sywak, M., Fingleton, L., Robinson, B., Sidhu, S., Delbridge, L. (2012), Mucoepidermoid carcinoma of the thyroid: a report of three cases and postulated histogenesis. Thyroid. 22(2), 205-209. [Abstract]

2011

   
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  • Popadich, A., Levin, O., Lee, J., Smooke-Praw, S., Ro, K., Fazel, M., Arora, A., Tolley, N., Palazzo, F., Learoyd, D., Sidhu, S., Delbridge, L., Sywak, M., Yeh, M. (2011), A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer. Surgery. 150(6), 1048-1057. [Abstract]
  • Abraham, D., Jackson, N., Gundara, J., Zhao, J., Gill, A., Delbridge, L., Robinson, B., Sidhu, S. (2011), MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis and potential therapeutic targets. Clinical Cancer Research. 17(14), 4772-4781. [Abstract]
  • Suliburk, J., Sywak, M., Sidhu, S., Delbridge, L. (2011), 1000 minimally invasive parathyroidectomies without intra-operative parathyroid hormone measurement: lessons learned. ANZ Journal of Surgery. 81(5), 362-365. [Abstract]
  • Oucharek, J., O'Neill, C., Suliburk, J., Sywak, M., Delbridge, L., Sidhu, S. (2011), Durability of Focused Minimally Invasive Parathyroidectomy in Young Patients with Sporadic Primary Hyperparathyroidism. Annals of Surgical Oncology. 18(5), 1290-1292. [Abstract]
  • Zhang, J., Gill, A., Atmore, B., Johns, A., Delbridge, L., Lai, R., McMullen, T. (2011), Upregulation of the signal transducers and activators of transcription 3 (STAT3) pathway in lymphatic metastases of papillary thyroid cancer. International journal of clinical and experimental pathology. 4(4), 356-362. [Abstract]
  • Broadhead, G., Mun, H., Avlani, V., Jourdon, O., Church, W., Christopoulos, A., Delbridge, L., Conigrave, A. (2011), Allosteric modulation of the calcium-sensing receptor by {gamma}-glutamyl peptides inhibition of PTH secretion, suppression of intracellular cAMP levels and a common mechanism of action with L-amino acids. The Journal of biological chemistry. 286(11), 8786-97. [Abstract]
  • O'Neill, C., Vaughan, L., Learoyd, D., Sidhu, S., Delbridge, L., Sywak, M. (2011), Management of follicular thyroid carcinoma should be individualised based on degree of capsular and vascular invasion. European Journal of Surgical Oncology. 37(2), 181-185. [Abstract]
  • O'Neill, C., Chan, C., Symons, J., Learoyd, D., Sidhu, S., Delbridge, L., Gill, A., Sywak, M. (2011), Parathyroid Carcinoma Encountered After Minimally Invasive Focused Parathyroidectomy may not Require Further Radical Surgery. World Journal of Surgery. 35(1), 147-153. [Abstract]
  • Abraham, D., Low, T., Messina, M., Jackson, N., Gill, A., Chou, A., Delbridge, L., Learoyd, D., Robinson, B., Sidhu, S., Sywak, M. (2011), Medullary Thyroid Carcinoma: Long-Term Outcomes of Surgical Treatment. Annals of Surgical Oncology. 18(1), 219-225. [Abstract]
  • Chang, L., O'Neill, C., Suliburk, J., Sidhu, S., Delbridge, L., Sywak, M. (2011), Sutureless total thyroidectomy: A safe and cost-effective alternative. ANZ Journal of Surgery. 81(7-8), 510-514.
  • Brown, S., O'Neill, C., Suliburk, J., Sidhu, S., Sywak, M., Gill, A., Robinson, B., Delbridge, L. (2011), Parathyroid carcinoma: increasing incidence and changing presentation. ANZ Journal of Surgery. 81(7-8), 528-532. [Abstract]
  • Prichard, R., Edhouse, P., Sidhu, S., Sywak, M., Delbridge, L. (2011), Post-operative partial hypoparathyroidism: an under-recognized disorder. ANZ Journal of Surgery. 81(7-8), 524-527. [Abstract]
  • O'Neill, C., Chang, L., Suliburk, J., Sidhu, S., Delbridge, L., Sywak, M. (2011), Sutureless thyroidectomy: surgical technique. ANZ Journal of Surgery. 81(7-8), 515-518. [Abstract]
  • Mevawalla, N., McMullen, T., Sidhu, S., Sywak, M., Robinson, B., Delbridge, L. (2011), Presentation of Clinically Solitary Thyroid Nodules in Surgical Patients. Thyroid. 21(1), 55-59. [Abstract]

2010

   
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  • O'Neill, C., Bullock, M., Chou, A., Sidhu, S., Delbridge, L., Robinson, B., Gill, A., Learoyd, D., Clifton-Bligh, R., Sywak, M. (2010), BRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancer. Surgery. 148(6), 1139-1146. [Abstract]
  • Isaacs, J., McMullen, T., Sidhu, S., Sywak, M., Robinson, B., Delbridge, L. (2010), Predictive value of the Delphian and level VI nodes in papillary thyroid cancer. ANZ Journal of Surgery. 80(11), 834-838. [Abstract]
  • Abraham, D., Delbridge, L., Clifton-Bligh, R., Clifton-Bligh, P., Grodski, S., Robinson, B., Messina, M., Sidhu, S. (2010), Medullary thyroid carcinoma presenting with an initial CEA elevation. ANZ Journal of Surgery. 80(11), 831-833. [Abstract]
  • Pang, T., Ihre-Lundgren, C., Gill, A., McMullen, T., Sywak, M., Sidhu, S., Delbridge, L. (2010), Correlation between indeterminate aspiration cytology and final histopathology of thyroid neoplasms. Surgery. 148(3), 532-537. [Abstract]
  • McLean, T., Delbridge, L. (2010), Comparison of Consumer Information on the Internet to the Current Evidence Base for Minimally Invasive Parathyroidectomy. World journal of surgery. 34(0), 1304-11. [Abstract]
  • Alvarado, R., Meyer-Rochow, G., Sywak, M., Delbridge, L., Sidhu, S. (2010), Bilateral Internal Jugular Venous Sampling for Parathyroid Hormone Determination in Patients with Nonlocalizing Primary Hyperparathyroidism. World Journal of Surgery. 34(6), 1299-1303. [Abstract]
  • Hahn, M., Howell, V., Gill, A., Clarkson, A., Weaire-Buchanan, G., Robinson, B., Delbridge, L., Gimm, O., Schmitt, W., Teh, B., Marsh, D. (2010), CDC73/HRPT2 CpG island hypermethylation and mutation of 5'-untranslated sequence are uncommon mechanisms of silencing parafibromin in parathyroid tumors. Endocrine-related cancer. 17(1), 273-82. [Abstract]
  • Meyer-Rochow, G., Schembri, G., Benn, D., Sywak, M., Delbridge, L., Robinson, B., Roach, P., Sidhu, S. (2010), The Utility of Metaiodobenzylguanidine Single Photon Emission Computed Tomography/Computed Tomography (MIBG SPECT/CT) for the Diagnosis of Pheochromocytoma. Annals of Surgical Oncology. 17(2), 392-400. [Abstract]
  • Bargren, A., Meyer-Rochow, G., Sywak, M., Delbridge, L., Chen, H., Sidhu, S. (2010), Diagnostic Utility of Fine-Needle Aspiration Cytology in Pediatric Differentiated Thyroid Cancer. World Journal of Surgery. 34(6), 1254-1260. [Abstract]
  • McMullen, T., Learoyd, D., Williams, D., Sywak, M., Sidhu, S., Delbridge, L. (2010), Hyperparathyroidism in Pregnancy: Options for Localization and Surgical Therapy. World Journal of Surgery. 34(8), 1811-1816. [Abstract]

2009

   
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  • Mun, H., Brennan, S., Delbridge, L., Wilkinson, M., Brown, E., Conigrave, A. (2009), Adenomatous human parathyroid cells exhibit impaired sensitivity to L-amino acids. The Journal of clinical endocrinology and metabolism. 94(9), 3567-74. [Abstract]
  • Ebrahimi, H., Edhouse, P., Lundgren, C., McMullen, T., Sidhu, S., Sywak, M., Delbridge, L. (2009), Does autoimmune thyroid disease affect parathyroid autotransplantation and survival?. ANZ Journal of Surgery. 79(5), 383-385. [Abstract]
  • Meyer-Rochow, G., Soon, P., Delbridge, L., Sywak, M., Bambach, C., Clifton-Bligh, R., Robinson, B., Sidhu, S. (2009), Outcomes of minimally invasive surgery for phaeochromocytoma. ANZ Journal of Surgery. 79(5), 367-370. [Abstract]
  • Tan, C., Sidhu, S., Sywak, M., Delbridge, L. (2009), Management of hyperfunctioning single thyroid nodules in the era of minimally invasive thyroid surgery. ANZ Journal of Surgery. 79(5), 386-389. [Abstract]
  • Delbridge, L. (2009), Endocrine surgery--a 23-hour specialty?. ANZ Journal of Surgery. 79(5), 320-322. [Abstract]
  • Tan, C., Meyer-Rochow, G., Sywak, M., Delbridge, L., Sidhu, S. (2009), Reoperative adrenal surgery: lessons learnt. ANZ Journal of Surgery. 79(5), 371-377. [Abstract]
  • Alvarado, R., Sywak, M., Delbridge, L., Sidhu, S. (2009), Central lymph node dissection as a secondary procedure for papillary thyroid cancer: Is there added morbidity?. Surgery. 145(5), 514-518. [Abstract]
  • McMullen, T., Bodie, G., Gill, A., Ihre-Lundgren, C., Shun, A., Bergin, M., Stevens, G., Delbridge, L. (2009), Hyperparathyroidism After Irradiation for Childhood Malignancy. International journal of radiation oncology, biology, physics. 73(0), 1164-8. [Abstract]
  • Grodski, S., Lundgren, C., Sidhu, S., Sywak, M., Delbridge, L. (2009), Post-operative PTH measurement facilitates day 1 discharge after total thyroidectomy. Clinical endocrinology. 70(2), 322-325. [Abstract]
  • Howell, V., Gill, A., Clarkson, A., Nelson, A., Dunne, R., Delbridge, L., Robinson, B., Teh, B., Gimm, O., Marsh, D. (2009), Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma. The Journal of clinical endocrinology and metabolism. 94(2), 434-41. [Abstract]
  • Bargren, A., Meyer-Rochow, G., Delbridge, L., Sidhu, S., Chen, H. (2009), Outcomes of Surgically Managed Pediatric Thyroid Cancer. Journal of Surgical Research. 156(1), 70-73. [Abstract]

2008

   
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  • Sywak, M., Yeh, M., McMullen, T., Stalberg, P., Low, H., Alvarado, R., Sidhu, S., Delbridge, L. (2008), A randomized controlled trial of minimally invasive thyroidectomy using the lateral direct approach versus conventional hemithyroidectomy. Surgery. 144(6), 1016-1022. [Abstract]
  • Grodski, S., Brown, T., Sidhu, S., Gill, A., Robinson, B., Learoyd, D., Sywak, M., Reeve, T., Delbridge, L. (2008), Increasing incidence of thyroid cancer is due to increased pathologic detection. Surgery. 144(6), 1038-1043. [Abstract]
  • Ho Shon, I., Yan, W., Roach, P., Bernard, E., Shields, M., Sywak, M., Sidhu, S., Delbridge, L. (2008), Comparison of pinhole and SPECT 99mTc-MIBI imaging in primary hyperparathyroidism. Nuclear Medicine Communications. 29(11), 949-955. [Abstract]
  • Low, T., Delbridge, L., Sidhu, S., Learoyd, D., Robinson, B., Roach, P., Sywak, M. (2008), Lymph Node Status Influences Follow-Up Thyroglobulin Levels in Papillary Thyroid Cancer. Annals of Surgical Oncology. 15(10), 2827-2832. [Abstract]
  • Lee, J., Au, A., Foukakis, T., Barbaro, M., Kiss, N., Clifton-Bligh, R., Staaf, J., Borg, A., Delbridge, L., Robinson, B., Wallin, G., Höög, A., Larsson, C. (2008), Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma. Endocrine-Related Cancer. 15(3), 801-815. [Abstract]
  • Delbridge, L. (2008), Symposium on Evidence-Based Endocrine Surgery (2): Benign Thyroid Disease. World journal of surgery. 32(7), 1235-6. [Abstract]
  • Tan, C., Cheah, W., Delbridge, L. (2008), "Scarless" (in the neck) endoscopic thyroidectomy (SET): an evidence-based review of published techniques. World journal of surgery. 32(7), 1349-57. [Abstract]
  • Alvarado, R., McMullen, T., Sidhu, S., Delbridge, L., Sywak, M. (2008), Minimally Invasive Thyroid Surgery for Single Nodules: An Evidence-based Review of the Lateral Mini-incision Technique. World Journal of Surgery. 32(7), 1341-1348. [Abstract]
  • Gill, A., Delbridge, L. (2008), Prevalence and Prognostic Significance of Poor Differentiation and Tall Cell Variant in Papillary Carcinoma in Japan. World journal of surgery. 32(7), 1544-1545. [Abstract]
  • Lu, M., Forsberg, L., Höög, A., Juhlin, C., Vukojević, V., Larsson, C., Conigrave, A., Delbridge, L., Gill, A., Bark, C., Farnebo, L., Bränström, R. (2008), Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. Molecular and cellular endocrinology. 287(1-2), 72-80. [Abstract]
  • Soon, P., Delbridge, L., Sywak, M., Barraclough, B., Edhouse, P., Sidhu, S. (2008), Surgeon Performed Ultrasound Facilitates Minimally Invasive Parathyroidectomy by the Focused Lateral Mini-incision Approach. World Journal of Surgery. 32(5), 766-771. [Abstract]
  • Meyer-Rochow, G., Sywak, M., Reeve, T., Delbridge, L., Sidhu, S. (2008), Surgical trends in the management of thyroid lymphoma. European Journal of Surgical Oncology. 34(5), 576-580. [Abstract]
  • Isaacs, J., Lundgren, C., Sidhu, S., Sywak, M., Edhouse, P., Delbridge, L. (2008), The Delphian lymph node in thyroid cancer. Annals of Surgery. 247(3), 477-482. [Abstract]
  • Stalberg, P., Yeh, M., Ketteridge, G., Delbridge, H., Delbridge, L. (2008), E-mail access and improved communication between patient and surgeon. Archives of Surgery. 143(2), 164-8; discussion 168-9. [Abstract]
  • Soon, P., Yeh, M., Delbridge, L., Bambach, C., Sywak, M., Robinson, B., Sidhu, S. (2008), Laparoscopic surgery is safe for large adrenal lesions. European Journal of Surgical Oncology. 34(1), 67-70. [Abstract]
  • Reeve, T., Ihre-Lundgren, C., Poole, A., Bambach, C., Barraclough, B., Sidhu, S., Sywak, M., Edhouse, P., Delbridge, L. (2008), The University of Sydney Endocrine Surgery Database: 50 years of data accrual. ANZ Journal of Surgery. 78(1-2), 7-12. [Abstract]

2007

   
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  • Delbridge, L., Palazzo, F. (2007), First parathyroid surgeon: sir john bland-sutton and the parathyroids. ANZ journal of surgery. 77(12), 1058-1061. [Abstract]
  • Lundgren, C., Stalberg, P., Grodski, S., Sidhu, S., Sywak, M., Delbridge, L. (2007), Minimally Invasive Thyroid Surgery for Diagnostic Excision of Solitary Thyroid Nodules. Asian Journal of Surgery. 30(4), 250-254. [Abstract]
  • Pang, T., Bambach, C., Monaghan, J., Sidhu, S., Bune, A., Delbridge, L., Sywak, M. (2007), Outcomes of laparoscopic adrenalectomy for hyperaldosteronism. ANZ Journal of Surgery. 77(9), 768-773. [Abstract]
  • Sywak, M., Palazzo, F., Yeh, M., Wilkinson, M., Snook, K., Sidhu, S., Delbridge, L. (2007), Parathyroid hormone assay predicts hypocalcaemia after total thyroidectomy. ANZ Journal of Surgery. 77(8), 667-670. [Abstract]
  • Meyer-Rochow, G., Alvarado, R., Sywak, M., Sidhu, S., Delbridge, L., Gill, A. (2007), Letter 2: Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma (Br J Surg 2007; 94: 566-570). The British Journal of Surgery. 94(8), 1044. [Abstract]
  • Lundgren, C., Delbridg, L., Learoyd, D., Robinson, B. (2007), Surgical approach to medullary thyroid cancer. Arquivos Brasileiros de Endocrinologia e Metabologia. 51(5), 818-824. [Abstract]
  • Stalberg, P., Grodski, S., Sidhu, S., Sywak, M., Delbridge, L. (2007), Cervical thymectomy for intrathymic parathyroid adenomas during minimally invasive parathyroidectomy. Surgery. 141(5), 626-629. [Abstract]
  • Loch-Wilkinson, T., Stalberg, P., Sidhu, S., Sywak, M., Wilkinson, J., Delbridge, L. (2007), Nerve stimulation in thyroid surgery: is it really useful?. ANZ Journal of Surgery. 77(5), 377-380. [Abstract]
  • Grodski, S., Cornford, L., Sywak, M., Sidhu, S., Delbridge, L. (2007), Routine level VI lymph node dissection for papillary thyroid cancer: surgical technique. ANZ journal of surgery. 77(4), 203-208. [Abstract]
  • Snook, K., Stalberg, P., Sidhu, S., Sywak, M., Edhouse, P., Delbridge, L. (2007), Recurrence after total thyroidectomy for benign multinodular goiter. World Journal of Surgery. 31(3), 593-598. [Abstract]
  • Pang, T., Stalberg, P., Sidhu, S., Sywak, M., Wilkinson, M., Reeve, T., Delbridge, L. (2007), Minimally invasive parathyroidectomy using the lateral focused mini-incision technique without intraoperative parathyroid hormone monitoring. British Journal of Surgery. 94(3), 315-319. [Abstract]
  • Grodski, S., Stalberg, P., Robinson, B., Delbridge, L. (2007), Surgery versus Radioiodine Therapy as Definitive Management for Graves' Disease: The Role of Patient Preference. Thyroid. 17(2), 157-160. [Abstract]
  • Soon, P., Yeh, M., Sywak, M., Roach, P., Delbridge, L., Sidhu, S. (2007), Minimally invasive parathyroidectomy using the lateral focused miniincision approach: Is there a learning curve for surgeons experienced in the open procedure?. Journal of the American College of Surgeons. 204(1), 91-95. [Abstract]