Associate Professor Wayne John Hawthorne

Associate Professor & Principal Research Fellow
Surgery, Westmead Clinical School
Westmead Millennium Institute for Medical Research

C24 - Westmead Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 7365
F: +61 2 9893 7440

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Themes | Keywords | Publications



Immunology; Diabetes; Transplantation; Surgery


2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014), Enhanced suppression of the xenogeneic t-cell response in vitro by xenoantigen stimulated and expanded regulatory t cells. Transplantation. 97(1), 30-38. [Abstract]
  • Hawthorne, W., Salvaris, E., Phillips, P., Hawkes, J., Liuwantara, D., Burns, H., Barlow, H., Stewart, A., Peirce, S., Hu, M., Lew, A., Robson, S., Nottle, M., D'Apice, A., O'Connell, P., Cowan, P. (2014), Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons. American Journal of Transplantation. 14, 1300-1309. [Abstract]
  • Chen, Y., Stewart, J., Gunthart, M., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., d'Apice, A., Cowan, P., Kearns-Jonker, M. (2014), Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors. Xenotransplantation. 21(3), 244-253. [Abstract]
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014), Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Diabetes & Metabolism. 40, 229-234. [Abstract]


  • Cantley, J., Walters, S., Jung, M., Weinberg, A., Cowley, M., Whitworth, P., Kaplan, W., Hawthorne, W., O'Connell, P., Weir, G., Grey, S. (2013), A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis. Cell Transplantation. 22(11), 2147-2159. [Abstract]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013), Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation. 22(10), 1929-1941. [Abstract]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Sparwasser, T., Bishop, G., Sharland, A., Alexander, S. (2013), Infiltrating Foxp3(+) Regulatory T Cells From Spontaneously Tolerant Kidney Allografts Demonstrate Donor-Specific Tolerance. American Journal of Transplantation. 13(11), 2819-2830. [Abstract]
  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013), Transplantation of Xenogeneic Islets: Are We There Yet?. Current Diabetes Reports. 13(5), 687-694. [Abstract]
  • Stokes, R., Cheng, K., Deters, N., Lau, S., Hawthorne, W., O'Connell, P., Stolp, J., Grey, S., Loudovaris, T., Kay, T., Thomas, H., Gonzalez, F., Gunton, J. (2013), Hypoxia-inducible factor 1α (HIF-1α ) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell Transplantation. 22(2), 253-266. [Abstract]
  • Gerace, D., Ren, B., Hawthorne, W., Byrne, M., Phillips, P., O'Brien, B., Nassif, N., Alexander, I., Simpson, A. (2013), Pancreatic transdifferentiation in porcine liver following lentiviral delivery of human furin-cleavable insulin. Transplantation Proceedings. 45(5), 1869-1874. [Abstract]
  • O'Connell, P., Holmes-Walker, D., Goodman, D., Hawthorne, W., Loudovaris, T., Gunton, J., Thomas, H., Grey, S., Drogemuller, C., Ward, G., Torpy, D., Coates, P., Kay, T. (2013), Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. American Journal of Transplantation. 13(7), 1850-1858. [Abstract]
  • Brady, J., Sutherland, R., Hancock, M., Kitsoulis, S., Lahoud, M., Phillips, P., Hawthorne, W., d'Apice, A., Cowan, P., Harrison, L., O'Connell, P., Lew, A. (2013), Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation. 20(2), 100-109. [Abstract]
  • Thwaites, S., Pleass, H., Allen, R., Lam, V., Yao, J., Kable, K., Jenkins, L., Chen, C., Robertson, P., Hawthorne, W., Ryan, B. (2013), Surgical Morbidity of Simultaneous Kidney and Pancreas Transplantation: A Single-Centre Experience in the Tacrolimus Era. ISRN Transplantation. 2013, 685850.


  • Thwaites, S., Gurung, B., Yao, J., Kable, K., Robertson, P., Ryan, B., Lam, V., Pleass, H., Chapman, J., Hawthorne, W., Allen, R. (2012), Excellent Outcomes of Simultaneous Pancreas Kidney Transplantation in Patients From Rural and Urban Australia: A National Service Experience. Transplantation. 94(12), 1230-1235. [Abstract]
  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012), Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes. 61(5), 1180-1191. [Abstract]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., Kaplan, W., Chapman, J., O'Connell, P., Grey, S. (2012), Human islets express a marked pro-inflammatory molecular signature prior to transplantation. Cell Transplantation. 21(9), 2063-2078. [Abstract]
  • Tran, H., Saliba, L., Chandratnam, E., Turingan, I., Hawthorne, W. (2012), Strategies to minimize adhesions to intraperitoneally placed mesh in laparoscopic ventral hernia repair. Journal of the Society of Laparoendoscopic Surgeons. 16(1), 89-94. [Abstract]
  • Campbell, P., Weinberg, A., Chee, J., Mariana, L., Ayala, R., Hawthorne, W., O'Connell, P., Loudovaris, T., Cowley, M., Kay, T., Grey, S., Thomas, H. (2012), Expression of pro- and anti-apoptotic molecules of the Bcl-2 family in human islets post-isolation. Cell Transplantation. 21(1), 49-60. [Abstract]


  • Lucewicz, A., Wong, G., Lam, V., Hawthorne, W., Allen, R., Craig, J., Pleass, H. (2011), Management of Primary Symptomatic Lymphocele After Kidney Transplantation: A Systematic Review. Transplantation. 92(6), 663-73. [Abstract]
  • Chew, M., Hawthorne, W., Bendall, J., Whereat, S., Huang, S., Ting, I., Simond, D., McLean, A. (2011), No beneficial effects of levosimendan in acute porcine endotoxaemia. Acta anaesthesiologica Scandinavica. 55(7), 851-61. [Abstract]
  • Ji, M., Yi, S., Smith-Hurst, H., Phillips, P., Wu, J., Hawthorne, W., O'connell, P. (2011), The Importance of Tissue Factor Expression by Porcine NICC in Triggering IBMIR in the Xenograft Setting. Transplantation. 91(8), 841-846. [Abstract]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011), Subcapsular Fetal Pig Pancreas Fragment Transplantation Provides Normal Blood Glucose Control in a Preclinical Model of Diabetes. Transplantation. 91(5), 515-21. [Abstract]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011), Pre-clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes. Xenotransplantation. 18(6), 390-9. [Abstract]


  • Wong, M., Hawthorne, W., Manolios, N. (2010), Gene therapy in diabetes. Self Nonself. 1(3), 165-175. [Abstract]
  • Lam, V., Pleass, H., Hawthorne, W., Allen, R. (2010), Evolution of pancreas transplant surgery. ANZ Journal of Surgery. 80(6), 411-418. [Abstract]
  • Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S., Hawthorne, W., O'Connell, P., Loudovaris, T., Kay, T., Kulkarni, R., Okada, T., Wang, X., Yim, S., Shah, Y., Grey, S., Biankin, A., Kench, J., Laybutt, D., Gonzalez, F., Kahn, C., Gunton, J. (2010), Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. The Journal of Clinical Investigation. 120(6), 2171-2183. [Abstract]
  • Wang, W., Liu, S., Zheng, W., Gao, F., Hawthorne, W., Yi, S. (2010), Hepatic artery vs. portal vein infusion of microbeads: a large animal pre-clinical model evaluating the intrahepatic capacity for cell infusion and imaging. Xenotransplantation. 17(3), 207-214. [Abstract]


  • Xing, X., Hawthorne, W., Yi, S., Simond, D., Dong, Q., Ye, B., Tong, Q., Ye, Z., Wang, W. (2009), Investigation of porcine endogenous retrovirus in the conservation population of ningxiang pig. Transplantation Proceedings. 41(10), 4389-4393. [Abstract]
  • Akima, S., Hawthorne, W., Favaloro, E., Patel, A., Blyth, K., Mudaliar, Y., Chapman, J., O'Connell, P. (2009), Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood. American Journal of Transplantation. 9(7), 1533-1540. [Abstract]
  • Lam, V., Laurence, J., Robertson, P., Hawthorne, W., Ryan, B., Lau, H., Allen, R., Pleass, H. (2009), En bloc paediatric kidney transplant: is this the best use of a scarce resource?. ANZ Journal of Surgery. 79(1-2), 27-32. [Abstract]
  • Londrigan, S., Brady, J., Sutherland, R., Cowan, P., d'Apice, A., Hawthorne, W., O'Connell, P., Lew, A. (2009), Optimizing transduction of pig islet cell clusters for xenotransplantation. Xenotransplantation. , 45-46. [Abstract]


  • Horton, P., Hawthorne, W., Walters, S., Patel, T., Stewart, G., Allen, R., Chapman, J. (2008), Tolerance induction in a large-animal model using total lymphoid irradiation and intrathymic bone marrow. Transplantation. 86(12), 1830-1836. [Abstract]
  • Fu, Y., Yi, S., Wu, J., Jimenez, E., Simond, D., Hawthorne, W., O'Connell, P. (2008), In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation. 86(6), 865-874. [Abstract]
  • Feller, J., Simpson, A., Nelson, M., Swan, M., O'Connell, P., Hawthorne, W., Tao, C., O'Brien, B. (2008), Growth Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells. The Journal of clinical endocrinology and metabolism. 93(9), 3560-7. [Abstract]
  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'connell, P. (2008), In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation. 85(12), 1841-1848. [Abstract]
  • Fu, Y., Lu, X., Yi, S., Wu, J., O'Hara, J., Hawthorne, W., Hucker, K., O'Connell, P. (2008), Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation. 15(5), 307-12. [Abstract]