Using yellow and purple to detect bacteria
30 April 2009
Professor Paul Groundwater has recently been appointed as Professor of Medicinal Chemistry in the Faculty of Pharmacy. Paul will be presenting his research on bacterial detection and the design of new drugs for the treatment of psoriasis on 7th May as part of the Faculty's Seminar Series in the Pharmacy Lecture Theatre, 1-2pm. His research interests include the design and synthesis of novel agents for the treatment of cancer and psoriasis, the identification of the active principle of medicinal plants, and new methods for the detection of bacteria. Please click here to enter this event into your desk calendar.
Paul has recently been part of a multi-disciplinary team whose work has led to amethod for the detection of the bacterium Pseudomonas aeruginosa, which can lead to dangerous secondary infections in intensive care patients. A simple test using a specific enzyme that turns a substrate from yellow to purple can confirm the presence of P. aeruginosa in patients within 24 hours. Paul and his collaborators now hope to extend this work to the detection of MRSA.
Another aspect to Paul's work is the discovery of new drugs for the treatment of psoriasis and cancer by inhibiting some common growth mechanisms. Using computer modelling, new targets for the treatment of these diseases have been identified and then developed and tested in the laboratory.
Paul says "I love making and characterising new molecules for a particular application. In pharmacy there is every research speciality from microbiology and chemistry to patient care, giving me fantastic opportunities for collaboration".
Paul's research profile:
Paul has a Bachelor of Science and Doctorate in Chemistry from the University of Edinburgh. He was a postdoctoral fellow at the Australian National University, Canberra with Professor Ron Warrener then returned to the UK to join Professor Malcolm Stevens at the Cancer Research Campaign Experimental Chemotherapy Research Group, Aston University. In 1989 Paul was appointed as a lecturer in the Department of Chemistry, Cardiff University. In 1996 he was appointed to a Readership in Organic Chemistry in the Institute of Pharmacy and Chemistry at the University of Sunderland and was promoted to Professor, in the Sunderland Pharmacy School, in 2001. Paul was the Centre Director of ChemiSPEC, a business providing spectroscopic services to industry, and was the Team Leader of the Drug Design and Analysis group in the Sunderland University Pharmacy School in the UK. He has published more than 60 papers, two books and 3 patents. He is a Guest Professor in the School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.
Contact: Holly Bax-Norman
Phone: 02 9351 2311