Improved strategies for attaining and maintaining an optimum body weight
19 July 2012
Non-surgical obesity treatments are ineffective for most, in part due to adaptive responses to energy restriction that increase appetite & reduce metabolic rate. Not only do these adaptations oppose ongoing weight loss, they may also adversely affect body composition via hormonal changes that favor abdominal fat accretion with loss of muscle mass and bone. Thus, current obesity treatments may inadvertently increase the risk of metabolic diseases such as atherosclerosis, as well as that of structural diseases such as sarcopenia and osteoporosis.
This talk examines potential new strategies for reducing the adaptive responses to energy restriction through use of ketogenic diets or intermittent energy restriction. The potential is to provide both more effective methods of weight management for immediate use, as well as to obtain the necessary mechanistic insights to further improve the approach.
Amanda Sainsbury-Salis, PhD
With a BSc (Hons) from the University of Western Australia and a PhD from the University of Geneva, Switzerland, Amanda Sainsbury-Salis leads a research team at the Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders that aims to help people to attain and maintain an optimum body weight and composition. Adept in translating novel research findings into human benefits, Amanda's NHMRC-funded research into hypothalamic control of energy homeostasis spans studies with conditional transgenic mice to randomized controlled clinical trials in humans.
Time: 11.30am - 12.30pm
Location: MFB room 143
Contact: RSVP to firstname.lastname@example.org