Professor Alaina Ammit

BAppSc (UTS) MSc PhD
Professor

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 6099
Fax +61 2 9351 4391

Biographical details

Professor Alaina J. Ammit has earned an international reputation for her work elucidating the mechanistic basis of inflammation in asthma and airway remodelling. Her findings have important implications for identifying novel targets for drug therapy that will underpin new therapeutic opportunities to treat and prevent respiratory disease, which is a National Health Priority Area. Associate Professor Ammit has received more than $6 million in peer-reviewed research funding (more than $3 million from NH&MRC), and published a career total of 73 articles in high-impact journals, including 14 invited reviews and a further six book chapters. To date, her publications have been cited over 2,200 times and her H-index is 28.

Research interests

  • Asthma
  • COPD
  • Airway inflammation
  • Airway remodelling
  • Post-transcriptional regulation of gene expression
  • Endogenous phosphatases
  • Cellular signalling

Associations

Member, ARC College of Experts (2014-present)

Professor (2014-present)

Respiratory Theme Leader (2013-present)

Chair, Animal Ethics Committee (2009-2012)

Postgraduate Co-ordinator (2008-2010)

Associate Dean (Research & Innovation) (2006-2010)

Associate Professor (2009)

Senior Lecturer (2006)

Lecturer (2002)

NH&MRC CJ Martin Fellow, University of Pennsylvania, USA (1997-2000), then University of Sydney (2001-2002)

Asthma Foundation (NSW) Martin Hardie Research Fellow (1996-1997)

PhD University of Sydney (APA)(1996)

Awards and honours

  • Senior Medical Scientist Award, LIWA (2013)
  • University of Sydney Thompson Fellowship (2011)
  • NSW/ACT Young Tall Poppy Science Award (2006)
  • Senior Medical Scientist Award, AARI (2005)
  • Australian Academy of Science Travel Award (2004)
  • Johnson & Johnson Research Award (2001)

Keywords

Respiratory tract diseases; Asthma

Selected grants

2014

  • Towards Better Therapeutics to Treat Infectious Exacerbations in Asthma and COPD $5,000; Ammit A; DVC Research/HMR+ Implementation Fund – University.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • nanoIR - nanoscale bioimaging with continuous mapping of chemical and physical properties; Gomes V, Dehghani F, Gan Y, Chang L, Jabbarzadeh-Khoei A, McKenzie D, Hanaor D, Zhou F, Chrzanowski W, Braet F, Bilek M, Chan H, Perrier S, O'Neill G, Ammit A, Brand-Miller J, McEwan A, Hawkett B, Kondyurin A, Li Q, Burgess J, Li Z; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • Novel strategies to boost tristetraprolin function: a critical anti-inflammatory protein in asthma; Ammit A, Clark A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Fac of Pharmacy Research Fund; Ammit A; Research Donations/Research Donations.

2011

  • Proteasome inhibition as an anti-inflammatory strategy in asthma and airway remodeling; Ammit A; DVC Research/Thompson Fellowships.

2010

  • MKP-1 as a novel anti-inflammatory strategy in asthma and airway remodelling.; Hibbs D, Ammit A; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Super-resolution fluorescence microscopy; Gaus K, Gandevia S, King N, Allen D, Vadas M, Ammit A, Grewal T, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • Integrating Chemistry and Biology in the Search for New Therapeutics for Alzheimer's disease; Munoz L, Ammit A, Guillemin G, Guillemin G; Alzheimers Australia/Dementia Grants Program.
  • MKP-1 as a novel anti-inflammatory strategy in asthma and airway remodelling; Ammit A, Hibbs D; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Airway smooth muscle control of mast cells in asthma; Brightling C, Hughes M, Brightling C, Ammit A, Burgess J, Armour C; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Understanding corticosteroid-sensitive and -insensitive pathways in airway remodelling; Ammit A, Brewer M, Roth M, Brewer G, Hughes M, Armour C; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • 7500 Real-time PCR instrument plus software; Roufogalis B, Armour C, Collins M, Ammit A, Murray M, Hughes M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • 7500 Real-time PCR instrument; Hughes M, Ammit A, Wicks K, Armour C; Clive & Vera Ramaciotti Foundation/Research Grant.
  • Does deregulated mRNA stability underlie airway inflammation in asthma?; Hughes M, Ammit A, Armour C; Asthma Foundation of NSW/Research Grants.
  • Adhesion regulation of pro-migratory factors in breast cancer.; Ammit A, O'Neill G; University of Sydney/Cancer Research Fund.
  • How do corticosteroids suppress inflammation in airway smooth muscle (ASM) a pivotal immunomodulatory cell in asthma and COPD; Ammit A; Rebecca L Cooper Medical Research Foundation/Rebecca Cooper Medical Research Foundation.

2004

  • Airway smooth muscle - mast cell cross talk in asthma; Hughes M, Ammit A, Armour C, Johnson P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Does deregulated mRNA stability underlie airway inflammation in asthma?; Borger P, Hughes M, Armour C, Ammit A; Asthma Foundation of NSW/Research Grants.

2003

  • Interactions between herbal medicines and the anticoagulant warfarin; Ammit A, Duke C, McLachlan A, Roufogalis B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of sphingosine 1-phosphate in asthma and airway remodelling.; Ammit A; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).
  • The role of interleukin -17 in modulating airway smooth muscle functions in asthma; Ammit A, Armour C; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • Konica Medical Film Processor SRX-101A; Armour C, Collins M, Hughes M, Ammit A, Roufogalis B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Transcriptional regulation of cytokine gene expression in airway smooth muscle by sphigosine 1-phosphate, a novel inflammatory mediator in asthma; Armour C, Ammit A; DVC Research/Research and Development Scheme: Research and Development (R&D).

2001

  • The role of Ras in the proliferation of human airway smooth muscle in asthma; Ammit A; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).
  • SP assay for (1) screening of Novogen compounds for inhibitory activity, and (2) for assay of SPP activity in cells obtained from human subjects to monitor cancer progression, especially in the case of leukaemia.; Ammit A, Husband A; Novogen Limited/Research Grants.

Selected publications

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Book Chapters

  • Manetsch, M., Ramsay, E., Ammit, A. (2009). Asthma and Airway Remodelling: Targeting Mitogen-activated Protein Kinases as Future Therapeutics. In Anne Green and Adam Selinger (Eds.), ISS2009: Genes to Galaxies, (pp. 170-181). Sydney, Australia: The Science Foundation of Physics, University of Sydney.
  • Ammit, A., Panettieri, R. (2003). Airway smooth muscle cell hyperplasia: a therapeutic target in airway remodeling in asthma? In Laurent Meijer, Armelle Jezequel, Michel Roberge (Eds.), Progress in Cell Cycle Research Volume 5: Cell cycle regulators as therapeutic targets, (pp. 49-57). France: Life in Progress Editions.

Journals

  • Che, A., Parmentier, J., Seidel, P., Manetsch, M., Ramsay, E., Alkhouri, H., Ge, Q., Armour, C., Ammit, A. (2014). Corticosteroids Inhibit Sphingosine 1-Phosphate–Induced Interleukin-6 Secretion from Human Airway Smooth Muscle via Mitogen-Activated Protein Kinase Phosphatase 1–Mediated Repression of Mitogen and Stress-Activated Protein Kinase 1. American Journal of Respiratory Cell and Molecular Biology, 50(2), 358-368. [More Information]
  • Alkhouri, H., Poppinga, W., Tania, N., Ammit, A., Schuliga, M. (2014). Regulation of pulmonary inflammation by mesenchymal cells. Pulmonary Pharmacology & Therapeutics, 29(2), 156-165. [More Information]
  • Rahman, M., Alkhouri, H., Tang, F., Che, W., Ge, Q., Ammit, A. (2014). Sphingosine 1-Phosphate Induces Neutrophil Chemoattractant IL-8: Repression by Steroids. PloS One, 9(3), 1-8. [More Information]
  • Im, H., Ammit, A. (2014). The NLRP3 inflammasome: role in airway inflammation. Clinical and Experimental Allergy, 44(2), 160-172. [More Information]
  • Alkhouri, H., Rumzhum, N., Rahman, M., Fitzpatrick, M., De Pedro, M., Oliver, B., Bourke, J., Ammit, A. (2014). TLR2 activation causes tachyphylaxis to b2 -agonists in vitro and ex vivo: modeling bacterial exacerbation. Allergy, 69(9), 1215-1222.
  • Ammit, A. (2013). Glucocorticoid insensitivity as a source of drug targets for respiratory disease. Current opinion in pharmacology, 13(3), 370-376. [More Information]
  • Manetsch, M., Rahman, M., Patel, B., Ramsay, E., Rumzhum, N., Alkhouri, H., Ge, Q., Ammit, A. (2013). Long-acting β2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (mkp-1) in airway smooth muscle cells. PloS One, 8(3), 1-9. [More Information]
  • Xia, Y., Redhu, N., Moir, L., Koziol-White, C., Ammit, A., Al-Alwan, L., Camoretti-Mercado, B., Clifford, R. (2013). Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts. Pulmonary Pharmacology & Therapeutics, 26(1), 64-74. [More Information]
  • Hirota, J., Im, H., Rahman, M., Rumzhum, N., Manetsch, M., Pascoe, C., Bunge, K., Alkhouri, H., Oliver, B., Ammit, A. (2013). The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation. American Journal of Respiratory Cell and Molecular Biology, 49(4), 517-524. [More Information]
  • Alrashdan, Y., Alkhouri, H., Chen, E., Lalor, D., Poniris, M., Henness, S., Brightling, C., Burgess, J., Armour, C., Ammit, A., Hughes, M. (2012). Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement. American Journal of Physiology: Lung Cellular and Molecular Physiology, 302(10), L118-L1127. [More Information]
  • Niimi, K., Ge, Q., Moir, L., Ammit, A., Trian, T., Burgess, J., Black, J., Oliver, B. (2012). B2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers. American Journal of Physiology: Lung Cellular and Molecular Physiology, 302(3), L334-L342. [More Information]
  • Manetsch, M., Ramsay, E., King, E., Seidel, P., Che, A., Ge, Q., Hibbs, D., Newton, R., Ammit, A. (2012). Corticosteroids and B2-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms. British Journal of Pharmacology, 166(7), 2049-2059. [More Information]
  • Allen, J., Seidel, P., Schlosser, T., Ramsay, E., Ge, Q., Ammit, A. (2012). Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition. Journal of Allergy, 2012, 1-6. [More Information]
  • Manetsch, M., Che, A., Seidel, P., Chen, Y., Ammit, A. (2012). MKP-1: A negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells. Cellular Signalling, 24(4), 907-913. [More Information]
  • Che, A., Manetsch, M., Quante, T., Rahman, M., Patel, B., Ge, Q., Ammit, A. (2012). Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1823, 1658-1665. [More Information]
  • Doddareddy, M., Rawling, T., Ammit, A. (2012). Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators. Current Medicinal Chemistry, 19(2), 163-173. [More Information]
  • Manetsch, M., Seidel, P., Heintz, U., Che, A., Hughes, M., Ge, Q., Sukkar, M., Ammit, A. (2012). TLR2 ligand engagement upregulates airway smooth muscle TNF (A) induced cytokine production. AJP: Lung Cellular and Molecular Physiology, 302(9), L838-L845. [More Information]
  • Cowell, L., Zhong, Z., Bradbury, P., Mahmassani, M., Smith, J., Ammit, A., O'Neill, G. (2011). Estradiol stabilizes the 105kD phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1813 (2), 340-345. [More Information]
  • Seidel, P., Roth, M., Ge, Q., Merfort, I., S'ng, C., Ammit, A. (2011). IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES. European Respiratory Journal, 38(6), 1444-1452. [More Information]
  • Thai, A., Xiao, J., Ammit, A., Rohanizadeh, R. (2010). Development of inhalable formulations of anti-inflammatory drugs to potentially treat smoke inhalation injury in burn victims. International Journal of Pharmaceutics, 389, 41-52. [More Information]
  • Munoz, L., Ramsay, E., Manetsch, M., Ge, Q., Peifer, C., Laufer, S., Ammit, A. (2010). Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle. European Journal of Pharmacology, 635, 212-218. [More Information]
  • Moutzouris, J., Che, A., Ramsay, E., Manetsch, M., Alkhouri, H., Bjorkman, A., Schuster, F., Ge, Q., Ammit, A. (2010). Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: Mechanism of action and effect on cytokine secretion. BBA - Bioenergetics, 1803 (3), 416-423. [More Information]
  • Munoz, L., Ammit, A. (2010). Targeting p38 MAPK pathway for the treatment of Alzheimer's disease. Neuropharmacology, 58(3), 561-568. [More Information]
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Parlati, C., Colombo, P., Buttini, F., Young, P., Adi, H., Ammit, A., Traini, D. (2009). Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency. Pharmaceutical Research, 26(5), 1084-1092. [More Information]
  • Ammit, A., Burgess, J., Zuyderduyn, S., Hughes, M., Kaur, M., Lau, J., Hirst, S. (2009). The effect of asthma therapeutics on signalling and transcriptional regulation of airway smooth muscle function. Pulmonary Pharmacology and Therapeutics, 22(5), 446-454. [More Information]
  • Quante, T., Ng, Y., Ramsay, E., Henness, S., Allen, J., Parmentier, J., Ge, Q., Ammit, A. (2008). Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1. American Journal of Respiratory Cell and Molecular Biology, 39(2), 208-217. [More Information]
  • Burgess, J., Lee, J., Ge, Q., Ramsay, E., Poniris, M., Parmentier, J., Roth, M., Johnson, P., Hunt, N., Black, J., Ammit, A. (2008). Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma. Journal of Cellular Physiology, 216(3), 673-679. [More Information]
  • Aktan, F., Henness, S., Tran, V., Duke, C., Roufogalis, B., Ammit, A. (2006). Gingerol Metabolite and a Synthetic Analogue Capsarol (TM) Inhibit Macrophage NF-kappaB Mediated iNOS Gene Expression and Enzyme Activity. Planta Medica: natural products and medicinal plant research, 72(8), 727-734. [More Information]
  • Henness, S., van Thoor, E., Ge, Q., Armour, C., Hughes, M., Ammit, A. (2006). IL-17A acts via p38 MAPK to increase stability of TNF-alpha-induced IL-8 mRNA in human ASM. American Journal of Physiology: Lung Cellular and Molecular Physiology, 290(6), L1283-L1290. [More Information]
  • Osei-Kumah, A., Ammit, A., Smith, R., Ge, Q., Clifton, V. (2006). Inflammatory Mediator Release in Normal Bronchial Smooth Muscle Cells is Altered by Pregnant Maternal and Fetal Plasma Independent of Asthma. Placenta, 27(8), 847-852. [More Information]
  • Ammit, A., Moir, L., Oliver, B., Hughes, M., Alkhouri, H., Ge, Q., Burgess, J., Black, J., Roth, M. (2006). The effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. American Journal of Physiology: Lung Cellular and Molecular Physiology, 292(1), L199-L206. [More Information]
  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2005). Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British Journal of Clinical Pharmacology, 59(4), 425-432. [More Information]
  • Huang, C., Ammit, A., Tliba, O., Kuo, H., Penn, R., Panettieri, R., Amrani, Y. (2005). G-Protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. Journal of Biomedical Science, 12(5), 763-776. [More Information]
  • Krymskaya, V., Goncharova, E., Ammit, A., Lim, P., Goncharov, D., Eszterhas, A., Panettieri, R. (2005). Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration. The F A S E B Journal, 19(3), 428-430.
  • Brightling, C., Ammit, A., Kaur, D., Black, J., Wardlaw, A., Hughes, M., Bradding, P. (2005). The CXCL10/CXCR3 Axis Mediates Human Lung Mast Cell Migration to Asthmatic Airway Smooth Muscle. American Journal of Respiratory and Critical Care Medicine, 171(10), 1103-1108. [More Information]
  • Ammit, A. (2005). The role of mRNA stability in airway remodelling. Pulmonary Pharmacology and Therapeutics, 18(6), 405-415. [More Information]
  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2004). Effect Of St John's Wort And Ginseng On The Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects. British Journal of Clinical Pharmacology, 57(5), 592-599.
  • Henness, S., Johnson, C., Ge, Q., Armour, C., Hughes, M., Ammit, A. (2004). IL-17A augments TNF-α-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability. Journal of Allergy and Clinical Immunology, 114(4), 958-965. [More Information]
  • Lalor, D., Truong, B., Henness, S., Blake, A., Ge, Q., Ammit, A., Armour, C., Hughes, M. (2004). Mechanisms Of Serum Potentiation Of GM-CSF Production By Human Airway Smooth Muscle Cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 287(5, Pt.1), L1007-L1016.
  • Nurtjahja-Tjendraputra, E., Ammit, A., Roufogalis, B., Tran, V., Duke, C. (2003). Effective anti-platelet and cox-1 enzyme inhibitors from pungent constituents of ginger. Thrombosis Research, 111, 259-265.
  • Aktan, F., Henness, S., Roufogalis, B., Ammit, A. (2003). Gypenosides derived from gynostemma pentaphyllum suppress no synthesis in murine macrophages by inhibiting inos enzymatic activity and attenuating nf-kb-mediated inos protein expression. Nitric Oxide: Biology And Chemistry, 8(4), 235-242.
  • McClean, M., Matheson, M., McKay, K., Johnson, P., Rynell, A., Ammit, A., Black, J., Berend, N. (2003). Low lung volume alters contractile properties of airway smooth muscle in sheep. European Respiratory Journal, 22(1), 50-56.
  • Goncharova, E., Ammit, A., Irani, C., Carroll, R., Eszterhas, A., Panettieri, R., Krymskaya, V. (2002). P13K is required for proliferation and migration of human pulmonary vascular smooth muscle cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 283(2, Pt.1), L354-L363.
  • Ammit, A., Lazaar, A., Irani, C., O'Neill, G., Gordon, N., Amrani, Y., Penn, R., Panettieri, R. (2002). Tumor necrosis factor-alpha-induced secretions of RANTES and interleukin-6 from human airway smooth muscle cells: Modulation by glucocorticoids and beta-agonists. American Journal of Respiratory Cell and Molecular Biology, 26(4), 465-474.
  • Krymskaya, V., Ammit, A., Hoffman, R., Eszterhas, A., Panettieri, R. (2001). Activation of class IA P13K stimulates DNA synthesis in human airway smooth muscle cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 280(5, Pt1), L1009-L1018.
  • Koo, K., Ammit, A., Tran, V., Duke, C., Roufogalis, B. (2001). Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thrombosis Research, 103, 387-397.
  • Page, S., Ammit, A., Black, J., Armour, C. (2001). Human mast cell and airway smooth muscle cell interactions: implications for asthma. American Journal of Physiology: Lung Cellular and Molecular Physiology, 281(6, Pt1), L1313-L1323.
  • Ammit, A., Hastie,, A., Edsall,, L., Hoffman, R., Amrani, Y., Krymskaya, V., Kane, S., Peters, S., Penn, R., Spiegel, S., et al (2001). Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. The F A S E B Journal, 15(7), 1212-1214.
  • Ammit, A., Panettieri, R. (2001). The circle of life: cell cycle regulation in airway smooth muscle. Journal of Applied Physiology, 91, 1431-1437.
  • Amrani, Y., Ammit, A., Panettieri, R. (2001). Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: Role of p38 and p42/44 mitogen-activated protein kinases. Molecular Pharmacology, 60(4), 646-655.

2014

  • Che, A., Parmentier, J., Seidel, P., Manetsch, M., Ramsay, E., Alkhouri, H., Ge, Q., Armour, C., Ammit, A. (2014). Corticosteroids Inhibit Sphingosine 1-Phosphate–Induced Interleukin-6 Secretion from Human Airway Smooth Muscle via Mitogen-Activated Protein Kinase Phosphatase 1–Mediated Repression of Mitogen and Stress-Activated Protein Kinase 1. American Journal of Respiratory Cell and Molecular Biology, 50(2), 358-368. [More Information]
  • Alkhouri, H., Poppinga, W., Tania, N., Ammit, A., Schuliga, M. (2014). Regulation of pulmonary inflammation by mesenchymal cells. Pulmonary Pharmacology & Therapeutics, 29(2), 156-165. [More Information]
  • Rahman, M., Alkhouri, H., Tang, F., Che, W., Ge, Q., Ammit, A. (2014). Sphingosine 1-Phosphate Induces Neutrophil Chemoattractant IL-8: Repression by Steroids. PloS One, 9(3), 1-8. [More Information]
  • Im, H., Ammit, A. (2014). The NLRP3 inflammasome: role in airway inflammation. Clinical and Experimental Allergy, 44(2), 160-172. [More Information]
  • Alkhouri, H., Rumzhum, N., Rahman, M., Fitzpatrick, M., De Pedro, M., Oliver, B., Bourke, J., Ammit, A. (2014). TLR2 activation causes tachyphylaxis to b2 -agonists in vitro and ex vivo: modeling bacterial exacerbation. Allergy, 69(9), 1215-1222.

2013

  • Ammit, A. (2013). Glucocorticoid insensitivity as a source of drug targets for respiratory disease. Current opinion in pharmacology, 13(3), 370-376. [More Information]
  • Manetsch, M., Rahman, M., Patel, B., Ramsay, E., Rumzhum, N., Alkhouri, H., Ge, Q., Ammit, A. (2013). Long-acting β2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (mkp-1) in airway smooth muscle cells. PloS One, 8(3), 1-9. [More Information]
  • Xia, Y., Redhu, N., Moir, L., Koziol-White, C., Ammit, A., Al-Alwan, L., Camoretti-Mercado, B., Clifford, R. (2013). Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts. Pulmonary Pharmacology & Therapeutics, 26(1), 64-74. [More Information]
  • Hirota, J., Im, H., Rahman, M., Rumzhum, N., Manetsch, M., Pascoe, C., Bunge, K., Alkhouri, H., Oliver, B., Ammit, A. (2013). The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation. American Journal of Respiratory Cell and Molecular Biology, 49(4), 517-524. [More Information]

2012

  • Alrashdan, Y., Alkhouri, H., Chen, E., Lalor, D., Poniris, M., Henness, S., Brightling, C., Burgess, J., Armour, C., Ammit, A., Hughes, M. (2012). Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement. American Journal of Physiology: Lung Cellular and Molecular Physiology, 302(10), L118-L1127. [More Information]
  • Niimi, K., Ge, Q., Moir, L., Ammit, A., Trian, T., Burgess, J., Black, J., Oliver, B. (2012). B2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers. American Journal of Physiology: Lung Cellular and Molecular Physiology, 302(3), L334-L342. [More Information]
  • Manetsch, M., Ramsay, E., King, E., Seidel, P., Che, A., Ge, Q., Hibbs, D., Newton, R., Ammit, A. (2012). Corticosteroids and B2-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms. British Journal of Pharmacology, 166(7), 2049-2059. [More Information]
  • Allen, J., Seidel, P., Schlosser, T., Ramsay, E., Ge, Q., Ammit, A. (2012). Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition. Journal of Allergy, 2012, 1-6. [More Information]
  • Manetsch, M., Che, A., Seidel, P., Chen, Y., Ammit, A. (2012). MKP-1: A negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells. Cellular Signalling, 24(4), 907-913. [More Information]
  • Che, A., Manetsch, M., Quante, T., Rahman, M., Patel, B., Ge, Q., Ammit, A. (2012). Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1823, 1658-1665. [More Information]
  • Doddareddy, M., Rawling, T., Ammit, A. (2012). Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators. Current Medicinal Chemistry, 19(2), 163-173. [More Information]
  • Manetsch, M., Seidel, P., Heintz, U., Che, A., Hughes, M., Ge, Q., Sukkar, M., Ammit, A. (2012). TLR2 ligand engagement upregulates airway smooth muscle TNF (A) induced cytokine production. AJP: Lung Cellular and Molecular Physiology, 302(9), L838-L845. [More Information]

2011

  • Cowell, L., Zhong, Z., Bradbury, P., Mahmassani, M., Smith, J., Ammit, A., O'Neill, G. (2011). Estradiol stabilizes the 105kD phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1813 (2), 340-345. [More Information]
  • Seidel, P., Roth, M., Ge, Q., Merfort, I., S'ng, C., Ammit, A. (2011). IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES. European Respiratory Journal, 38(6), 1444-1452. [More Information]

2010

  • Thai, A., Xiao, J., Ammit, A., Rohanizadeh, R. (2010). Development of inhalable formulations of anti-inflammatory drugs to potentially treat smoke inhalation injury in burn victims. International Journal of Pharmaceutics, 389, 41-52. [More Information]
  • Munoz, L., Ramsay, E., Manetsch, M., Ge, Q., Peifer, C., Laufer, S., Ammit, A. (2010). Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle. European Journal of Pharmacology, 635, 212-218. [More Information]
  • Moutzouris, J., Che, A., Ramsay, E., Manetsch, M., Alkhouri, H., Bjorkman, A., Schuster, F., Ge, Q., Ammit, A. (2010). Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: Mechanism of action and effect on cytokine secretion. BBA - Bioenergetics, 1803 (3), 416-423. [More Information]
  • Munoz, L., Ammit, A. (2010). Targeting p38 MAPK pathway for the treatment of Alzheimer's disease. Neuropharmacology, 58(3), 561-568. [More Information]

2009

  • Manetsch, M., Ramsay, E., Ammit, A. (2009). Asthma and Airway Remodelling: Targeting Mitogen-activated Protein Kinases as Future Therapeutics. In Anne Green and Adam Selinger (Eds.), ISS2009: Genes to Galaxies, (pp. 170-181). Sydney, Australia: The Science Foundation of Physics, University of Sydney.
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Parlati, C., Colombo, P., Buttini, F., Young, P., Adi, H., Ammit, A., Traini, D. (2009). Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency. Pharmaceutical Research, 26(5), 1084-1092. [More Information]
  • Ammit, A., Burgess, J., Zuyderduyn, S., Hughes, M., Kaur, M., Lau, J., Hirst, S. (2009). The effect of asthma therapeutics on signalling and transcriptional regulation of airway smooth muscle function. Pulmonary Pharmacology and Therapeutics, 22(5), 446-454. [More Information]

2008

  • Quante, T., Ng, Y., Ramsay, E., Henness, S., Allen, J., Parmentier, J., Ge, Q., Ammit, A. (2008). Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1. American Journal of Respiratory Cell and Molecular Biology, 39(2), 208-217. [More Information]
  • Burgess, J., Lee, J., Ge, Q., Ramsay, E., Poniris, M., Parmentier, J., Roth, M., Johnson, P., Hunt, N., Black, J., Ammit, A. (2008). Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma. Journal of Cellular Physiology, 216(3), 673-679. [More Information]

2006

  • Aktan, F., Henness, S., Tran, V., Duke, C., Roufogalis, B., Ammit, A. (2006). Gingerol Metabolite and a Synthetic Analogue Capsarol (TM) Inhibit Macrophage NF-kappaB Mediated iNOS Gene Expression and Enzyme Activity. Planta Medica: natural products and medicinal plant research, 72(8), 727-734. [More Information]
  • Henness, S., van Thoor, E., Ge, Q., Armour, C., Hughes, M., Ammit, A. (2006). IL-17A acts via p38 MAPK to increase stability of TNF-alpha-induced IL-8 mRNA in human ASM. American Journal of Physiology: Lung Cellular and Molecular Physiology, 290(6), L1283-L1290. [More Information]
  • Osei-Kumah, A., Ammit, A., Smith, R., Ge, Q., Clifton, V. (2006). Inflammatory Mediator Release in Normal Bronchial Smooth Muscle Cells is Altered by Pregnant Maternal and Fetal Plasma Independent of Asthma. Placenta, 27(8), 847-852. [More Information]
  • Ammit, A., Moir, L., Oliver, B., Hughes, M., Alkhouri, H., Ge, Q., Burgess, J., Black, J., Roth, M. (2006). The effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. American Journal of Physiology: Lung Cellular and Molecular Physiology, 292(1), L199-L206. [More Information]

2005

  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2005). Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British Journal of Clinical Pharmacology, 59(4), 425-432. [More Information]
  • Huang, C., Ammit, A., Tliba, O., Kuo, H., Penn, R., Panettieri, R., Amrani, Y. (2005). G-Protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. Journal of Biomedical Science, 12(5), 763-776. [More Information]
  • Krymskaya, V., Goncharova, E., Ammit, A., Lim, P., Goncharov, D., Eszterhas, A., Panettieri, R. (2005). Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration. The F A S E B Journal, 19(3), 428-430.
  • Brightling, C., Ammit, A., Kaur, D., Black, J., Wardlaw, A., Hughes, M., Bradding, P. (2005). The CXCL10/CXCR3 Axis Mediates Human Lung Mast Cell Migration to Asthmatic Airway Smooth Muscle. American Journal of Respiratory and Critical Care Medicine, 171(10), 1103-1108. [More Information]
  • Ammit, A. (2005). The role of mRNA stability in airway remodelling. Pulmonary Pharmacology and Therapeutics, 18(6), 405-415. [More Information]

2004

  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2004). Effect Of St John's Wort And Ginseng On The Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects. British Journal of Clinical Pharmacology, 57(5), 592-599.
  • Henness, S., Johnson, C., Ge, Q., Armour, C., Hughes, M., Ammit, A. (2004). IL-17A augments TNF-α-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability. Journal of Allergy and Clinical Immunology, 114(4), 958-965. [More Information]
  • Lalor, D., Truong, B., Henness, S., Blake, A., Ge, Q., Ammit, A., Armour, C., Hughes, M. (2004). Mechanisms Of Serum Potentiation Of GM-CSF Production By Human Airway Smooth Muscle Cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 287(5, Pt.1), L1007-L1016.

2003

  • Ammit, A., Panettieri, R. (2003). Airway smooth muscle cell hyperplasia: a therapeutic target in airway remodeling in asthma? In Laurent Meijer, Armelle Jezequel, Michel Roberge (Eds.), Progress in Cell Cycle Research Volume 5: Cell cycle regulators as therapeutic targets, (pp. 49-57). France: Life in Progress Editions.
  • Nurtjahja-Tjendraputra, E., Ammit, A., Roufogalis, B., Tran, V., Duke, C. (2003). Effective anti-platelet and cox-1 enzyme inhibitors from pungent constituents of ginger. Thrombosis Research, 111, 259-265.
  • Aktan, F., Henness, S., Roufogalis, B., Ammit, A. (2003). Gypenosides derived from gynostemma pentaphyllum suppress no synthesis in murine macrophages by inhibiting inos enzymatic activity and attenuating nf-kb-mediated inos protein expression. Nitric Oxide: Biology And Chemistry, 8(4), 235-242.
  • McClean, M., Matheson, M., McKay, K., Johnson, P., Rynell, A., Ammit, A., Black, J., Berend, N. (2003). Low lung volume alters contractile properties of airway smooth muscle in sheep. European Respiratory Journal, 22(1), 50-56.

2002

  • Goncharova, E., Ammit, A., Irani, C., Carroll, R., Eszterhas, A., Panettieri, R., Krymskaya, V. (2002). P13K is required for proliferation and migration of human pulmonary vascular smooth muscle cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 283(2, Pt.1), L354-L363.
  • Ammit, A., Lazaar, A., Irani, C., O'Neill, G., Gordon, N., Amrani, Y., Penn, R., Panettieri, R. (2002). Tumor necrosis factor-alpha-induced secretions of RANTES and interleukin-6 from human airway smooth muscle cells: Modulation by glucocorticoids and beta-agonists. American Journal of Respiratory Cell and Molecular Biology, 26(4), 465-474.

2001

  • Krymskaya, V., Ammit, A., Hoffman, R., Eszterhas, A., Panettieri, R. (2001). Activation of class IA P13K stimulates DNA synthesis in human airway smooth muscle cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 280(5, Pt1), L1009-L1018.
  • Koo, K., Ammit, A., Tran, V., Duke, C., Roufogalis, B. (2001). Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thrombosis Research, 103, 387-397.
  • Page, S., Ammit, A., Black, J., Armour, C. (2001). Human mast cell and airway smooth muscle cell interactions: implications for asthma. American Journal of Physiology: Lung Cellular and Molecular Physiology, 281(6, Pt1), L1313-L1323.
  • Ammit, A., Hastie,, A., Edsall,, L., Hoffman, R., Amrani, Y., Krymskaya, V., Kane, S., Peters, S., Penn, R., Spiegel, S., et al (2001). Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. The F A S E B Journal, 15(7), 1212-1214.
  • Ammit, A., Panettieri, R. (2001). The circle of life: cell cycle regulation in airway smooth muscle. Journal of Applied Physiology, 91, 1431-1437.
  • Amrani, Y., Ammit, A., Panettieri, R. (2001). Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: Role of p38 and p42/44 mitogen-activated protein kinases. Molecular Pharmacology, 60(4), 646-655.

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