Dr W. Bret Church

BSc (Hons) DipEd PhD
Senior Lecturer

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9036 6569
Fax +61 2 9351 4391

Biographical details

Dr Bret Church joined the Faculty of Pharmacy at the University in 2005, and has a research group with interest in protein-drug interactions, specifically with interest in targets in cancer, diabetes and schizophrenia. He is part of a Group in Biomolecular Structure and Informatics.He has over 25 years experience in research in the fields of crystallography, computational drug design and bioinformatics.

Dr Church completed a PhD at the University of Sydney working on a blue copper protein, with time spent at Brookhaven National Laboratory, New York. He was then appointed a Alberta Heritage Fund for Medical Research post-doctoral fellow in the Department of Biochemistry at the University of Alberta, Edmonton, Canada, working on target proteins, including lysosomal storage disease. He spent three years in the biotechnology industry in California, before returning to Australia.

Dr Church established a molecular modelling laboratory at the Garvan Institute for Medical Research where he continued studies of computational drug design in the neurosciences and in inflammation. In 2001 he began his academic career and was part of a team to establish Molecular Biotechnology at the University of Sydney.

His research work has been supported by the Australian Research Council, National Health and Medical Research Council of Australia, Australian Synchrotron, Australian Institute of Nuclear Science and Engineering, Rebecca Cooper Foundation for Medical Research, and others.

Research interests

My interests are in structure-based drug design and particularly the use of biophysical techniques, structural biology and structural bioinformatics to help understand the relationships between drug targets and drugs to be applied to drug discovery.

Abnormal levels of kynurenic acid (KA) have been thought to accompany several neuropsychiatric diseases, especially schizophrenia. This is consistent with the role of KA as an antagonist acting at the glutamate-binding site of the N-methyl D-aspartic acid receptor. Production of this metabolite by kynurenine aminotransferases could contribute to pathophysiology of psychoses, making the kynurenine pathway a valuable target for the treatment of such diseases. On this basis, novel inhibitors of the human kynurenine aminotransferases will be valuable, and we have been pursuing their design.

Over 700 depositions to the data bank holding protein structures are made every month. Each entry may be a new structure, a structure with a new inhibitor or a mutant. These structures are providing more data in the quest for realistic assessments of molecular recognition and interaction, which are the basis for all cellular processes, and therefore of great interest for studies in therapeutic intervention. We are interested in the analysis of available protein structures to further prediction methods. Of great importance have been recent protein structures such as the adrenergic, dopamine and histamine receptors, representing the first of the highly resolved G-protein coupled receptor structures. Areas of specific interest are the G-protein coupled receptors, but also other membrane-bound targets. With an understanding of genomic sequencing, automated tools may be a way to expedite the pipeline directly from the potential drug targets to the discovery of drug candidates.

Keywords

Atherosclerosis; Schizophrenia; Bioinformatics; Inflammation; Drug design

Honours project opportunities

  • Herd Immune Antibody Profiling for Conserved Epitopes of Neisseria Meningococcus
  • Broad Acting Antibodies to Highly Conserved Influenza Protein Epitopes for Universal Vaccines
  • Herd Immune Antibody Profiling for Conserved Epitopes of Ebola.

Selected grants

2013

  • A Research Platform for exploring the Genotype - Phenotype Nexus; Harry E, Paulsen I, Wilkins M, Waterhouse P, Scott R, Djordjevic S, Neilan B, Cavicchioli R, Charles I, Packer N, Rose R, Firth N, Hutvagner G, Whitchurch C, Willows R, Church W; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Investigation of a novel contrast reagent for small angle x-ray contrast variation scattering; Church W; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
  • Determination by small angle x-ray scattering of the structure of the HAMLET-like anti-cancer complexes during their creation; Church W; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
  • Determination by small angle x-ray scattering of the phase of dilute oleic acid at high pH; Church W; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
  • Perpetual Synchrotron Travel Grants Account for Dr W.Bret Church; Church W; Australian Synchrotron Company Limited/Funding Application for Interstate User Groups.

2012

  • The solution structure of HAMLET: deterated alpha-lactalbumin in complex with hydrogenated oleic acid; Church W; Australian Institute of Nuclear Science and Engineering (AINSE)/Access to Facilities and/or Services.

2011

  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins M, Johnston G, Young P, Traini D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Automated analysis of the 2D and 3D structural properties of membrane spanning proteins using a novel sequence-independent method; Church W; DVC Research/Bridging Support Grant.
  • Detection of proetrin functional structural motifs for genomics; Church W; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).

Selected publications

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Book Chapters

  • Keane, F., Chowdhury, S., Yao, T., Nadvi, N., Gall, M., Chen, Y., Osborne, B., Ribeiro, A., Church, W., McCaughan, G., Gorrell, M., Yu, M. (2012). Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy. In Ben Dunn (Eds.), Proteinases as Drug Targets, (pp. 118-144). Cambridge, UK: RSC Publishing.

Journals

  • Nematollahi, A., Aminimoghadamfarouj, N., Church, W. (2014). Essential structural features of novel antischizophrenic drugs: a review. Medicinal Chemistry, 10(6), 541-549. [More Information]
  • Tessier, D., Laroum, S., Duval, B., Rath, E., Church, W., Hao, J. (2014). In silico evaluation of the influence of the translocon on partitioning of membrane segments. BMC Bioinformatics, 15, 156. [More Information]
  • Rath, E., Duff, A., Håkansson, A., Knott, R., Church, W. (2014). Small-angle X-ray scattering of BAMLET at pH 12: A complex of α-lactalbumin and oleic acid. Proteins: Structure, Function, and Bioinformatics, 82(7), 1400-1408. [More Information]
  • Lee, H., Lee, H., Lee, L., Teber, E., Church, W. (2014). The use of soluble protein structures in modeling helical proteins in a layered membrane. Journal of Biomolecular Structure & Dynamics, 32(2), 308-318. [More Information]
  • Rath, E., Tessier, D., Campbell, A., Lee, H., Werner, T., Salam, N., Lee, L., Church, W. (2013). A benchmark server using high resolution protein structure data, and benchmark results for membrane helix predictions. BMC Bioinformatics, 14(1), 1-11. [More Information]
  • Zhou, F., Zheng, J., Zhu, L., Jodal, A., Cui, P., Wong, K., Gurney, H., Church, W., Murray, M. (2013). Functional Analysis of Novel Polymorphisms in the Human SLCO1A2 Gene that Encodes the Transporter OATP1A2. The AAPS Journal, 15(4), 1099-1108. [More Information]
  • Werner, T., Church, W. (2013). Kink characterization and modeling in transmembrane protein structures. Journal of Chemical Information and Modeling, 53(11), 2926-2936. [More Information]
  • Hamzeh-Mivehroud, M., Alizadeh, A., Morris, M., Church, W., Dastmalchi, S. (2013). Phage display as a technology delivering on the promise of peptide drug discovery. Drug Discovery Today, 18(23-24), 1144-1157. [More Information]
  • Lee, L., Bryant, K., Bouveret, R., Lei, P., Duff, A., Harrop, S., Huang, E., Harvey, R., Gelb, M., Gray, P., Church, W., et al (2013). Selective Inhibition of Human Group IIA-secreted Phospholipase a 2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes. Journal of Biological Chemistry, 288(21), 15269-15279. [More Information]
  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
  • Lynch, G., Selleck, P., Church, W., Sullivan, J. (2012). Seasoned adaptive antibody immunity for highly pathogenic pandemic influenza in humans. Immunology and Cell Biology, 90(2), 149-158. [More Information]
  • Werner, T., Morris, M., Dastmalchi, S., Church, W. (2012). Structural modelling and dynamics of proteins for insights into drug interactions. Advanced Drug Delivery Reviews, 64(4), 323-343. [More Information]
  • Bryant, K., Bidgood, M., Lei, P., Taberner, M., Salom, C., Kumar, V., Lee, L., Church, W., Courtenay, B., Smart, B., et al (2011). A Bifunctional Role for Group IIA Secreted Phospholipase A2 in Human Rheumatoid Fibroblast-like Synoviocyte Arachidonic Acid Metabolism. Journal of Biological Chemistry, 286(4), 2492-2503. [More Information]
  • Broadhead, G., Mun, H., Avlani, V., Jourdon, O., Church, W., Christopoulos, A., Delbridge, L., Conigrave, A. (2011). Allosteric Modulation of the Calcium-sensing Receptor by y-Glutamyl Peptides Inhibition of PTH Secretion, Suppression of Intracellular cAMP Levels and A Common Mechanism of Action with L-Amino Acids. Journal of Biological Chemistry, 286(11), 8786-8797. [More Information]
  • Li, N., Yun, P., Jeffries, C., Langley, D., Gamsjaeger, R., Church, W., Hunter, N., Collyer, C. (2011). The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis. Molecular Microbiology, 81(5), 1358-1373. [More Information]
  • Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427. [More Information]
  • Yu, M., Yao, T., Chowdhury, S., Nadvi, N., Osborne, B., Church, W., McCaughan, G., Gorrell, M. (2010). The dipeptidyl peptidase IV family in cancer and cell biology. The FEBS Journal, 277(5), 1126-1144. [More Information]
  • Zhang, Y., Chen, M., Church, W., Lau, K., Larkum, A., Jermiin, L. (2010). The molecular structure of the IsiA-Photosystem I supercomplex, modelled from high-resolution, crystal structures of Photosystem I and the CP43 protein. BBA - Bioenergetics, 1797 (4), 457-465. [More Information]
  • Morris, M., Dastmalchi, S., Church, W. (2009). Rhodopsin: Structure, signal transduction and oligomerisation. The International Journal of Biochemistry and Cell Biology, 41(4), 721-724. [More Information]
  • Dastmalchi, S., Church, W., Morris, M. (2008). Modelling the structures of G protein-coupled receptors aided by three-dimensional validation. BMC Bioinformatics, 9(S1), S14-1-S14-13. [More Information]
  • Park, J., Knott, H., Nadvi, N., Collyer, C., Wang, X., Church, W., Gorrell, M. (2008). Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation. The Open Enzyme Inhibition Journal, 1, 52-60.
  • Daly, K., Church, W., Nicholas, K., Williamson, P. (2007). Comparative Modeling of Marsupial MHC Class I Molecules Identifies Structural Polymorphisms Affecting Functional Motifs. Journal of Experimental Zoology. Part A: Ecological Genetics and Physiology, 307A (11), 611-624. [More Information]
  • Dastmalchi, S., Beheshti, S., Morris, M., Church, W. (2007). Prediction of rotational orientation of transmembrane helical segments of integral membrane proteins using new environment-based propensities for amino acids derived from structural analyses. The FEBS Journal, 274(10), 2653-2660. [More Information]
  • Teber, E., Crawford, E., Bolton, K., Van Dyk, D., Schofield, P., Kapoor, V., Church, W. (2006). Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and exploration. BMC Bioinformatics, 7(33), Article 33-1-33-9. [More Information]
  • Lynch, G., Turville, S., Carter, B., Sloane, A., Chan, A., Muljadi, N., Li, S., Low, L., Armati, P., Raison, R., Zoellner, H., Williamson, P., Cunningham, A., Church, W. (2006). Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: Resolution of a novel CD4 isoform. Immunology and Cell Biology, 84(2), 154-165. [More Information]
  • Dastmalchi, S., Church, W., Morris, M., Iismaa, T., Mackay, J. (2004). Presence of transient helical segments in the galanin-like peptide evident from 1H NMR, circular dichroism, and prediction studies. Journal of Structural Biology, 146(3), 261-271.
  • Shui, W., Wong, R., Graham, S., Lee, L., Church, W. (2003). A new approach to protein structure and function analysis using semi-structured databases. Journal of Research and Practice in Information Technology, 19(-), 61-69.
  • Barry, J., Leong, G., Church, W., Issa, L., Eisman, J., Gardiner, E. (2003). Interactions of SKIP/NCoA-62, TFIIB, and Retinoid X Receptor with Vitamin D Receptor Helix H10 Residues. Journal of Biological Chemistry, 278(10), 8224-8228.
  • Kwok, J., Kapoor, R., Gotoda, T., Iwamoto, Y., Iizuka, Y., Yamada, N., Isaacs, K., Kushwaha, V., Church, W., Schofield, P., et al (2002). A Missense Mutation in Kynurenine Aminotransferase-1 in Spontaneously Hypertensive Rats. Journal of Biological Chemistry, 277(39), 35779-35782.
  • Dastmalchi, S., Kobus, F., Iismaa, T., Morris, M., Church, W. (2002). Comparison of the transmembrane helices of bovine rhodopsin in the crystal structure and the C α template based on cryo-electron microscopy maps and sequence analysis of the G protein-coupled receptors. Molecular Simulation, 28(8), 845-851.
  • Church, W., Jones, K., Kuiper, D., Shine, J., Iismaa, T. (2002). Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity. Protein Engineering, 15(4), 313-323.
  • Church, W., Inglis, A., Tseng, A., Duell, R., Lei, P., Bryant, K., Scott, K. (2001). A novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibition. Journal of Biological Chemistry, 276(35), 33156-33164.
  • Dastmalchi, S., Morris, M., Church, W. (2001). Modeling of the structural features of integral-membrane proteins using reverse-environment prediction of integral membrane protein structure (REPIMPS). Protein Science, 10(8), 1529-1538.

Conferences

  • Lukov, L., Chawla, S., Church, W. (2005). Conditional Random Fields for Transmembrane Helix Prediction. The Ninth Pacific-Asia Conference on Knowledge Discovery and Data Mining, Berlin: Springer.
  • Lai, P., Kaplan, W., Church, W., Wong, R. (2004). Informative 3D Visualization Of Multiple Protein Structures. Second Conference on Asia-Pacific Bioinformatics (APBC 2004), Australia: Australian Computer Society.

2014

  • Nematollahi, A., Aminimoghadamfarouj, N., Church, W. (2014). Essential structural features of novel antischizophrenic drugs: a review. Medicinal Chemistry, 10(6), 541-549. [More Information]
  • Tessier, D., Laroum, S., Duval, B., Rath, E., Church, W., Hao, J. (2014). In silico evaluation of the influence of the translocon on partitioning of membrane segments. BMC Bioinformatics, 15, 156. [More Information]
  • Rath, E., Duff, A., Håkansson, A., Knott, R., Church, W. (2014). Small-angle X-ray scattering of BAMLET at pH 12: A complex of α-lactalbumin and oleic acid. Proteins: Structure, Function, and Bioinformatics, 82(7), 1400-1408. [More Information]
  • Lee, H., Lee, H., Lee, L., Teber, E., Church, W. (2014). The use of soluble protein structures in modeling helical proteins in a layered membrane. Journal of Biomolecular Structure & Dynamics, 32(2), 308-318. [More Information]

2013

  • Rath, E., Tessier, D., Campbell, A., Lee, H., Werner, T., Salam, N., Lee, L., Church, W. (2013). A benchmark server using high resolution protein structure data, and benchmark results for membrane helix predictions. BMC Bioinformatics, 14(1), 1-11. [More Information]
  • Zhou, F., Zheng, J., Zhu, L., Jodal, A., Cui, P., Wong, K., Gurney, H., Church, W., Murray, M. (2013). Functional Analysis of Novel Polymorphisms in the Human SLCO1A2 Gene that Encodes the Transporter OATP1A2. The AAPS Journal, 15(4), 1099-1108. [More Information]
  • Werner, T., Church, W. (2013). Kink characterization and modeling in transmembrane protein structures. Journal of Chemical Information and Modeling, 53(11), 2926-2936. [More Information]
  • Hamzeh-Mivehroud, M., Alizadeh, A., Morris, M., Church, W., Dastmalchi, S. (2013). Phage display as a technology delivering on the promise of peptide drug discovery. Drug Discovery Today, 18(23-24), 1144-1157. [More Information]
  • Lee, L., Bryant, K., Bouveret, R., Lei, P., Duff, A., Harrop, S., Huang, E., Harvey, R., Gelb, M., Gray, P., Church, W., et al (2013). Selective Inhibition of Human Group IIA-secreted Phospholipase a 2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes. Journal of Biological Chemistry, 288(21), 15269-15279. [More Information]

2012

  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
  • Lynch, G., Selleck, P., Church, W., Sullivan, J. (2012). Seasoned adaptive antibody immunity for highly pathogenic pandemic influenza in humans. Immunology and Cell Biology, 90(2), 149-158. [More Information]
  • Werner, T., Morris, M., Dastmalchi, S., Church, W. (2012). Structural modelling and dynamics of proteins for insights into drug interactions. Advanced Drug Delivery Reviews, 64(4), 323-343. [More Information]
  • Keane, F., Chowdhury, S., Yao, T., Nadvi, N., Gall, M., Chen, Y., Osborne, B., Ribeiro, A., Church, W., McCaughan, G., Gorrell, M., Yu, M. (2012). Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy. In Ben Dunn (Eds.), Proteinases as Drug Targets, (pp. 118-144). Cambridge, UK: RSC Publishing.

2011

  • Bryant, K., Bidgood, M., Lei, P., Taberner, M., Salom, C., Kumar, V., Lee, L., Church, W., Courtenay, B., Smart, B., et al (2011). A Bifunctional Role for Group IIA Secreted Phospholipase A2 in Human Rheumatoid Fibroblast-like Synoviocyte Arachidonic Acid Metabolism. Journal of Biological Chemistry, 286(4), 2492-2503. [More Information]
  • Broadhead, G., Mun, H., Avlani, V., Jourdon, O., Church, W., Christopoulos, A., Delbridge, L., Conigrave, A. (2011). Allosteric Modulation of the Calcium-sensing Receptor by y-Glutamyl Peptides Inhibition of PTH Secretion, Suppression of Intracellular cAMP Levels and A Common Mechanism of Action with L-Amino Acids. Journal of Biological Chemistry, 286(11), 8786-8797. [More Information]
  • Li, N., Yun, P., Jeffries, C., Langley, D., Gamsjaeger, R., Church, W., Hunter, N., Collyer, C. (2011). The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis. Molecular Microbiology, 81(5), 1358-1373. [More Information]

2010

  • Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427. [More Information]
  • Yu, M., Yao, T., Chowdhury, S., Nadvi, N., Osborne, B., Church, W., McCaughan, G., Gorrell, M. (2010). The dipeptidyl peptidase IV family in cancer and cell biology. The FEBS Journal, 277(5), 1126-1144. [More Information]
  • Zhang, Y., Chen, M., Church, W., Lau, K., Larkum, A., Jermiin, L. (2010). The molecular structure of the IsiA-Photosystem I supercomplex, modelled from high-resolution, crystal structures of Photosystem I and the CP43 protein. BBA - Bioenergetics, 1797 (4), 457-465. [More Information]

2009

  • Morris, M., Dastmalchi, S., Church, W. (2009). Rhodopsin: Structure, signal transduction and oligomerisation. The International Journal of Biochemistry and Cell Biology, 41(4), 721-724. [More Information]

2008

  • Dastmalchi, S., Church, W., Morris, M. (2008). Modelling the structures of G protein-coupled receptors aided by three-dimensional validation. BMC Bioinformatics, 9(S1), S14-1-S14-13. [More Information]
  • Park, J., Knott, H., Nadvi, N., Collyer, C., Wang, X., Church, W., Gorrell, M. (2008). Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation. The Open Enzyme Inhibition Journal, 1, 52-60.

2007

  • Daly, K., Church, W., Nicholas, K., Williamson, P. (2007). Comparative Modeling of Marsupial MHC Class I Molecules Identifies Structural Polymorphisms Affecting Functional Motifs. Journal of Experimental Zoology. Part A: Ecological Genetics and Physiology, 307A (11), 611-624. [More Information]
  • Dastmalchi, S., Beheshti, S., Morris, M., Church, W. (2007). Prediction of rotational orientation of transmembrane helical segments of integral membrane proteins using new environment-based propensities for amino acids derived from structural analyses. The FEBS Journal, 274(10), 2653-2660. [More Information]

2006

  • Teber, E., Crawford, E., Bolton, K., Van Dyk, D., Schofield, P., Kapoor, V., Church, W. (2006). Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and exploration. BMC Bioinformatics, 7(33), Article 33-1-33-9. [More Information]
  • Lynch, G., Turville, S., Carter, B., Sloane, A., Chan, A., Muljadi, N., Li, S., Low, L., Armati, P., Raison, R., Zoellner, H., Williamson, P., Cunningham, A., Church, W. (2006). Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: Resolution of a novel CD4 isoform. Immunology and Cell Biology, 84(2), 154-165. [More Information]

2005

  • Lukov, L., Chawla, S., Church, W. (2005). Conditional Random Fields for Transmembrane Helix Prediction. The Ninth Pacific-Asia Conference on Knowledge Discovery and Data Mining, Berlin: Springer.

2004

  • Lai, P., Kaplan, W., Church, W., Wong, R. (2004). Informative 3D Visualization Of Multiple Protein Structures. Second Conference on Asia-Pacific Bioinformatics (APBC 2004), Australia: Australian Computer Society.
  • Dastmalchi, S., Church, W., Morris, M., Iismaa, T., Mackay, J. (2004). Presence of transient helical segments in the galanin-like peptide evident from 1H NMR, circular dichroism, and prediction studies. Journal of Structural Biology, 146(3), 261-271.

2003

  • Shui, W., Wong, R., Graham, S., Lee, L., Church, W. (2003). A new approach to protein structure and function analysis using semi-structured databases. Journal of Research and Practice in Information Technology, 19(-), 61-69.
  • Barry, J., Leong, G., Church, W., Issa, L., Eisman, J., Gardiner, E. (2003). Interactions of SKIP/NCoA-62, TFIIB, and Retinoid X Receptor with Vitamin D Receptor Helix H10 Residues. Journal of Biological Chemistry, 278(10), 8224-8228.

2002

  • Kwok, J., Kapoor, R., Gotoda, T., Iwamoto, Y., Iizuka, Y., Yamada, N., Isaacs, K., Kushwaha, V., Church, W., Schofield, P., et al (2002). A Missense Mutation in Kynurenine Aminotransferase-1 in Spontaneously Hypertensive Rats. Journal of Biological Chemistry, 277(39), 35779-35782.
  • Dastmalchi, S., Kobus, F., Iismaa, T., Morris, M., Church, W. (2002). Comparison of the transmembrane helices of bovine rhodopsin in the crystal structure and the C α template based on cryo-electron microscopy maps and sequence analysis of the G protein-coupled receptors. Molecular Simulation, 28(8), 845-851.
  • Church, W., Jones, K., Kuiper, D., Shine, J., Iismaa, T. (2002). Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity. Protein Engineering, 15(4), 313-323.

2001

  • Church, W., Inglis, A., Tseng, A., Duell, R., Lei, P., Bryant, K., Scott, K. (2001). A novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibition. Journal of Biological Chemistry, 276(35), 33156-33164.
  • Dastmalchi, S., Morris, M., Church, W. (2001). Modeling of the structural features of integral-membrane proteins using reverse-environment prediction of integral membrane protein structure (REPIMPS). Protein Science, 10(8), 1529-1538.

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