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Associate Professor Colin Duke

BSc Qld, PhD James Cook MRACI
Associate Professor, Pharmaceutical Chemistry

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 2321
Fax +61 2 9351 4391

Biographical details

Associate Professor Colin Duke has completed BSc studies in Botany and Chemistry majoring in Chemistry; BSc (Hons) and PhD studies on natural products isolation, identification and syntheses. Associate Professor Duke has extensive experience in the isolation, characterisation and activity evaluation of biologically-active substances from natural and synthetic sources for medicinal/nutritional uses and/or research tools. He has more than 100 publications in scientific literature to his name, spanning areas of synthetic chemistry, natural product chemistry, phytochemistry and mechanistic toxicology.

His studies carried out in the last 15 years at the Faculty of Pharmacy, University of Sydney include specific biological tests and screens used to detect biologically-active substances that are potentially useful for the treatment of viral, neurological, cardiovascular, cancer and other diseases.
Associate Professor Duke’s recent research is focused on new methods to efficiently identify potentially useful bioactive compounds from complex natural materials. Studies on propolis (a resinous material collected by honeybees from plants), has resulted in the identification of novel bioactive phenolic substances from Australian endemic plants. Structure-activity studies carried out with these and other substances have led to major industry-funded projects.

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Research interests

  • Investigation of biologically-active substances from natural and synthetic sources for therapeutic purposes and/or research tools.
  • Use of specific biological tests and screens are used to detect biologically active substances potentially useful for the treatment of viral, neurological, cardiovascular, cancer and other diseases. Isolation of bioactive substances detected in extracts of selected plants, their identification and evaluation as potential drugs, lead substances for drug development and/or research tools.
  • Syntheses of biologically-active natural products and analogues, structure-activity relationships and drug design.
  • Investigation of the chemical profiles of selected medicinal herbs by extraction, analysis, identification and quantification of chemical constituents. Evaluation of medicinal effects attributed to herbs by examining published information about the pharmacological activity of the constituents, or by subjecting extracts or isolated constituents to relevant analytical, chemical and/or biological assays.
  • Discovery of Australian plants with medicinal potential.

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Selected grants

2012

  • Pharmacological development of synthetic analogues of cytochrome P450-mediated omega-3 fatty acid epoxides as novel anti-metastatic agents; Murray M, Duke C, Cui P, Ching L, Dunstan C; National Health and Medical Research Council/Project Grants.

2009

  • Updating information contained in The University of Sydney, Herb-Drug Interaction Database; McLachlan A, Duke C, Roufogalis B; UnityHealth Pty Ltd/Research Support.
  • Ginger-based agents for delaying the onset of metabolic syndrome: type-2 diabetes and dyslipidemia; Roufogalis B, Tran V, Duke C; Australian Research Council/Linkage Projects (LP).

2008

  • Australian propolis as a source of complementary medicines; Duke C, Duke R, Tran V; National Health and Medical Research Council/Project Grants.

2007

  • Gypenosides as novel anti-atherosclerotic agents through modulation of the LXR signal transduction pathway.; Duke C; University of Sydney/Bridging Support.

2003

  • Interactions between herbal medicines and the anticoagulant warfarin; Ammit A, Duke C, McLachlan A, Roufogalis B; NHMRC/Project.

2002

  • Role of flavonoids from phytomedicines in herb-drug interactions mediated by p-glycoprotein; Roufogalis B, Duke C; NHMRC/Project.
  • Synthetic derivatives of capsaicin and gingerols as analgesics acting at the vanilloid receptor; Roufogalis B, Duke C; Australian Research Council (ARC)/Discovery Projects (DP).
  • Epoxy essential fatty acids and their triglycerides: health implications; Duke C; University of Sydney (Sesqui)/Research & Development.

2001

  • Safety Valuation of processed oil with respect to Alkaloid and Epoxy-Lipid content; Bennett M, Duke C; Ucom Two Pty Ltd/BLO Project.

2000

  • Anti-Inflammatory studies of ginger extracts, gingerols and derivatives; Duke C; BLO Research Partners/Thursday Plantation Laboratories Ltd.
  • Ginger as a source of herbal medicines and new chemcial entities for the treatment of pain and inflammation; Roufogalis B, Duke C; Australian Research Council (ARC)/Spirt Grants.
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Selected publications

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Books

  • Duke, C., Goh, P., McLachlan, A., Roufogalis, B. (2001). Complementary Medicines. Australia: Pharmaceutical Society of Australia.

Book Chapters

  • Vlachojannis, J., Duke, R., Tran, V., Duke, C., Chrubasik, S. (2009). Anti-inflammatory herbal medicines for the control of pain. In Carpinella, Maria Cecilia~Rai, Mahendra~ (Eds.), Novel Therapeutic Agents from Plants, (pp. 339-367). New Hampshire, USA: Science Publishers Inc.
  • Naumovski, V., Duke, R., Tran, V., Li, Q., Tattam, B., Roufogalis, B., Duke, C. (2008). Current methods in the isolation and characterisation of saponins from Gynostemma pentaphyllum. In Francesco Epifano (Eds.), Current Trends in Phytochemistry, (pp. 283-309). Kerala, India: Research Signpost.
  • Li, Q., Duke, C., Roufogalis, B. (2002). The progress of Chinese medicine in Australia. In Kelvin Chan, Henry Lee (Eds.), the Way Forward for Chinese Medicine, (pp. 173-190). London & New York: BMJ Publishing Group.

Journals

  • Cui, P., Rawling, T., Bourget, K., Kim, T., Duke, C., Doddareddy, M., Hibbs, D., Zhou, F., Tattam, B., Petrovic, N., Murray, M. (2012). Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. Journal of Medicinal Chemistry, 55(16), 7163-7172.
  • Li, Y., Tran, V., Duke, C., Roufogalis, B. (2012). Gingerols of Zingiber officinale Enhance Glucose Uptake by Increasing Cell Surface GLUT4 in Cultured L6 Myotubes. Planta Medica: natural products and medicinal plant research, 78(14), 1549-1555.
  • Abu-Mellal, A., Koolaji, N., Duke, R., Tran, V., Duke, C. (2012). Prenylated cinnamate and stilbenes from Kangaroo Island propolis and their antioxidant activity. Phytochemistry, 77, 251-259.
  • Li, Y., Tran, V., Duke, C., Roufogalis, B. (2012). Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. Evidence-Based Complementary and Alternative Medicine, 2012, 1-10.
  • Tran, V., Duke, R., Abu-Mellal, A., Duke, C. (2012). Propolis with high flavonoid content collected by honey bees from Acacia paradoxa. Phytochemistry, 81, 126-132.
  • Duke, C., van Haaften, C., Tran, V. (2011). Efficient Isolation of an Anti-Cancer Sesquiterpene Lactone from Calomeria amaranthoides by Steam Distillation. Green and Sustainable Chemistry, 1, 123-127.
  • Tran, V., Marks, D., Duke, R., Bebawy, M., Duke, C., Roufogalis, B. (2011). Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions. Nutrition and Cancer: an international journal, 63(3), 435-443.
  • van Haaften, C., Duke, C., Weerheim, A., Smit, N., van Haard, P., Darroudi, F., Trimbos, B. (2011). Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers. Journal of Experimental and Clinical Cancer Research, 30(1), 29-1-29-6.
  • Li, Z., Yang, D., Duke, C., Dong, W. (2011). Synthesis and MS/NMR characterization of the isomers of di-hydroxylated fatty acid. Zhongshan Daxue Xuebao (Acta Scientiarum Naturalium Universitatis Sunyatseni), 50(5), 75-78.
  • Rawling, T., Duke, C., Cui, P., Murray, M. (2010). Facile and Stereoselective Synthesis of (Z)-15-Octadecenoic Acid and (Z)-16-Nonadecenoic Acid: Monounsaturated Omega-3 Fatty Acids. Lipids, 45(2), 159-165.
  • Cole, N., Sou, P., Ngo, A., Tsang, K., Severino, J., Arun, S., Duke, C., Reeve, V. (2010). Topical 'Sydney' Propolis Protects against UV-Radiation-Induced Inflammation, Lipid Peroxidation and Immune Suppression in Mouse Skin. International Archives Of Allergy And Immunology, 152(2), 87-97.
  • Fu, S., Tattam, B., Duke, C., Ramzan, I. (2009). High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites. Biomedical Chromatography, 23(1), 81-91.
  • Li, Z., Tran, V., Duke, R., Ng, C., Yang, D., Duke, C. (2009). Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. Chemistry and Physics of Lipids, 158, 39-45.
  • Cui, P., Zhang, W., Hook, J., Tattam, B., Duke, C., Murray, M. (2009). Synthesis and NMR characterization of the methyl esters of eicosapentaenoic acid monoepoxides. Chemistry and Physics of Lipids, 159(1), 30-37.
  • Cui, P., Duke, R., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. Chemistry and Physics of Lipids, 152(2), 122-130.
  • Cui, P., Duke, R., Tattam, B., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 2: mass spectral characterization. Chemistry and Physics of Lipids, 152(2), 65-70.
  • Hesse, C., Naumovski, V., Duke, C., Davies, N., Roufogalis, B. (2007). Phytopreventative effects of Gynostemma pentaphyllum against acute indomethacin-induced gastrointestinal and renal toxicity in rats. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 21(6), 523-530.
  • Bhattarai, S., Tran, V., Duke, C. (2007). Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. Journal of Pharmaceutical and Biomedical Analysis, 45(4), 648-653.
  • Tran, V., Kantharaj, R., Roufogalis, B., Duke, C. (2006). An Efficient and Facile Synthesis of Capsaicin-Like Compounds as Agonists of the TRPV1 Receptor. European Journal of Organic Chemistry, 2006 (13), 2970-2976.
  • Aktan, F., Henness, S., Tran, V., Duke, C., Roufogalis, B., Ammit, A. (2006). Gingerol Metabolite and a Synthetic Analogue Capsarol (TM) Inhibit Macrophage NF-kappaB Mediated iNOS Gene Expression and Enzyme Activity. Planta Medica: natural products and medicinal plant research, 72(8), 727-734.
  • Huang, H., Li, Y., Naumovski, V., Tran, V., Li, Q., Duke, C., Roufogalis, B. (2006). Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. Journal of Biomedical Science, 13(4), 535-548.
  • Huang, H., Tran, V., Duke, R., Tan, S., Chrubasik, S., Roufogalis, B., Duke, C. (2006). Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kB activation. Journal of Ethnopharmacology, 104(1-2), 149-155.
  • Lee, J., Duke, R., Tran, V., Hook, J., Duke, C. (2006). Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry, 67(23), 2550-2560.
  • Naumovski, V., Duke, R., Turner, P., Duke, C. (2005). (20S)-2 alpha,3 beta,12 beta-trihydroxydammar-24-ene 20-O-beta-D-glucopyranoside (Gynosaponin TN1) as the 2.5-methanol solvate. Acta Crystallographica. Section E: Structure Reports Online, E61, o1239-o1241.
  • Huang, H., Naumovski, V., Salam, N., Duke, R., Tran, V., Duke, C., Roufogalis, B. (2005). A novel LXR-a activator identified from the natural product Gynostemma pentaphyllum. Biochemical Pharmacology, 70(9), 1298-1308.
  • Naumovski, V., Huang, H., Tran, V., Li, Q., Duke, C., Roufogalis, B. (2005). Chemistry and pharmacology of Gynostemma pentaphyllum. Phytochemistry Reviews, 4(3-Feb), 197-219.
  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2005). Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British Journal of Clinical Pharmacology, 59(4), 425-432.
  • Naumovski, V., Li, Q., Duke, C. (2005). Gynostemma pentaphyllum cultivation in Sydney, Australia and its comparison with products from China. Journal of Applied Horticulture, 7(2), 99-104.
  • Mather, L., Duke, C., Ladd, L., Copeland, S., Gallagher, G., Chang, D. (2004). Direct Cardiac Effects Of Coronary Site-Directed Thiopental And Its Enantiomers - A Comparison To Propofol In Conscious Sheep. Anesthesiology, 101(2), 354-364.
  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2004). Effect Of St John's Wort And Ginseng On The Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects. British Journal of Clinical Pharmacology, 57(5), 592-599.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2004). Herb-Drug Interactions: An Evidence Based Approach. Current Medicinal Chemistry, 11(11), 1513-1525.
  • Collins (Chebib), M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Nurtjahja-Tjendraputra, E., Ammit, A., Roufogalis, B., Tran, V., Duke, C. (2003). Effective anti-platelet and cox-1 enzyme inhibitors from pungent constituents of ginger. Thrombosis Research, 111, 259-265.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Garlic-drug interactions. The Journal of Complementary Medicine, 11, 57-59.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Ginkgo biloba interactions. The Journal of Complementary Medicine, 11, 70-72.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Interaction or over-reaction? Journal of Alternative and Complementary Medicine: research on paradigm, practice, and policy, 11, 60-61.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Liquorice-drug interactions. The Journal of Complementary Medicine, 11, 40-43.
  • Duke, C. (2003). Omega-3 fatty acids and hypertension. Pharmacy News, 11, 12c-16c.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). St John's wort interactions. Journal of Alternative and Complementary Medicine: research on paradigm, practice, and policy, 11, 66-68.
  • Li, Q., Duke, C., Roufogalis, B. (2003). The quality and safety of traditional Chinese medicines. Australian Prescriber, 26(6), 128-130.
  • Dedov, V., Tran, V., Duke, C., Connor, M., Christie, M., Mandadi, S., Roufogalis, B. (2002). Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology, 137(6), 793-798.
  • Duke, R., Collins (Chebib), M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Li, Q., Duke, C., Roufogalis, B. (2001). A new approach to advanced educaiton in herbal medicines established at the University of Sydney. Australian Journal of Chinese Medicine, , 82-84.
  • Tjendraputra, E., Tran, V., Liu-Brennan, D., Roufogalis, B., Duke, C. (2001). Effect of Ginger Constituents and Synthetic Analogues on Cyclooxygenase-2 Enzyme in Intact Cells. Bioorganic Chemistry, 29(3), 156-163.
  • Tjendraputra, E., Tran, V., Liu-Brennan, D., Roufogalis, B., Duke, C. (2001). Effects of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorganic Chemistry, 29(3), 156-163.
  • Koo, K., Ammit, A., Tran, V., Duke, C., Roufogalis, B. (2001). Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thrombosis Research, 103, 387-397.
  • Bhattarai, S., Tran, V., Duke, C. (2001). The stability of gingerol and shogaol in aqueous solutions. Journal of Pharmaceutical Sciences, 90, 1658-1664.

Conferences

  • Murray, M., Zhang, W., Duke, C., Ramzan, I. (2006). Accumulation of esterified polyunsaturated fatty acids in hepatic steatosis impairs microsomal clozapine oxidation. Australian Health and Medical Research Congress, Melbourne: Australian Health and Medical Research Congress.
  • Li, Q., Duke, C., Roufogalis, B. (2002). An integrative east-west herbal medicine education model in Sydney. First International Symposium on TCM Education.
  • Roufogalis, B., Dedov, V., Tran, V., Duke, C. (2002). Development of gingerols and synthetic derivatives for pain and inflammation. 5th Australia/Japan Symposium on Drug Design and Development.
  • Li, Q., Duke, C., Roufogalis, B. (2001). Innovative approach to education of hebal medicine. Ed-Health, : World Scientific Publishing.

Patents

  • Roufogalis, B., Duke, C., Tran, V. (2010). Medicinal Uses Of Phenylalkanols And Derivatives (Gingerol Analogues). Patent No. 2307028. Canada.
  • Roufogalis, B., Duke, C., Tran, V. (2006). Medicinal Uses Of Phenylalkanols And Derivatives. Patent No. 1056700.

2012

  • Cui, P., Rawling, T., Bourget, K., Kim, T., Duke, C., Doddareddy, M., Hibbs, D., Zhou, F., Tattam, B., Petrovic, N., Murray, M. (2012). Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. Journal of Medicinal Chemistry, 55(16), 7163-7172.
  • Li, Y., Tran, V., Duke, C., Roufogalis, B. (2012). Gingerols of Zingiber officinale Enhance Glucose Uptake by Increasing Cell Surface GLUT4 in Cultured L6 Myotubes. Planta Medica: natural products and medicinal plant research, 78(14), 1549-1555.
  • Abu-Mellal, A., Koolaji, N., Duke, R., Tran, V., Duke, C. (2012). Prenylated cinnamate and stilbenes from Kangaroo Island propolis and their antioxidant activity. Phytochemistry, 77, 251-259.
  • Li, Y., Tran, V., Duke, C., Roufogalis, B. (2012). Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. Evidence-Based Complementary and Alternative Medicine, 2012, 1-10.
  • Tran, V., Duke, R., Abu-Mellal, A., Duke, C. (2012). Propolis with high flavonoid content collected by honey bees from Acacia paradoxa. Phytochemistry, 81, 126-132.

2011

  • Duke, C., van Haaften, C., Tran, V. (2011). Efficient Isolation of an Anti-Cancer Sesquiterpene Lactone from Calomeria amaranthoides by Steam Distillation. Green and Sustainable Chemistry, 1, 123-127.
  • Tran, V., Marks, D., Duke, R., Bebawy, M., Duke, C., Roufogalis, B. (2011). Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions. Nutrition and Cancer: an international journal, 63(3), 435-443.
  • van Haaften, C., Duke, C., Weerheim, A., Smit, N., van Haard, P., Darroudi, F., Trimbos, B. (2011). Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers. Journal of Experimental and Clinical Cancer Research, 30(1), 29-1-29-6.
  • Li, Z., Yang, D., Duke, C., Dong, W. (2011). Synthesis and MS/NMR characterization of the isomers of di-hydroxylated fatty acid. Zhongshan Daxue Xuebao (Acta Scientiarum Naturalium Universitatis Sunyatseni), 50(5), 75-78.

2010

  • Rawling, T., Duke, C., Cui, P., Murray, M. (2010). Facile and Stereoselective Synthesis of (Z)-15-Octadecenoic Acid and (Z)-16-Nonadecenoic Acid: Monounsaturated Omega-3 Fatty Acids. Lipids, 45(2), 159-165.
  • Roufogalis, B., Duke, C., Tran, V. (2010). Medicinal Uses Of Phenylalkanols And Derivatives (Gingerol Analogues). Patent No. 2307028. Canada.
  • Cole, N., Sou, P., Ngo, A., Tsang, K., Severino, J., Arun, S., Duke, C., Reeve, V. (2010). Topical 'Sydney' Propolis Protects against UV-Radiation-Induced Inflammation, Lipid Peroxidation and Immune Suppression in Mouse Skin. International Archives Of Allergy And Immunology, 152(2), 87-97.

2009

  • Vlachojannis, J., Duke, R., Tran, V., Duke, C., Chrubasik, S. (2009). Anti-inflammatory herbal medicines for the control of pain. In Carpinella, Maria Cecilia~Rai, Mahendra~ (Eds.), Novel Therapeutic Agents from Plants, (pp. 339-367). New Hampshire, USA: Science Publishers Inc.
  • Fu, S., Tattam, B., Duke, C., Ramzan, I. (2009). High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites. Biomedical Chromatography, 23(1), 81-91.
  • Li, Z., Tran, V., Duke, R., Ng, C., Yang, D., Duke, C. (2009). Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. Chemistry and Physics of Lipids, 158, 39-45.
  • Cui, P., Zhang, W., Hook, J., Tattam, B., Duke, C., Murray, M. (2009). Synthesis and NMR characterization of the methyl esters of eicosapentaenoic acid monoepoxides. Chemistry and Physics of Lipids, 159(1), 30-37.

2008

  • Naumovski, V., Duke, R., Tran, V., Li, Q., Tattam, B., Roufogalis, B., Duke, C. (2008). Current methods in the isolation and characterisation of saponins from Gynostemma pentaphyllum. In Francesco Epifano (Eds.), Current Trends in Phytochemistry, (pp. 283-309). Kerala, India: Research Signpost.
  • Cui, P., Duke, R., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. Chemistry and Physics of Lipids, 152(2), 122-130.
  • Cui, P., Duke, R., Tattam, B., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 2: mass spectral characterization. Chemistry and Physics of Lipids, 152(2), 65-70.

2007

  • Hesse, C., Naumovski, V., Duke, C., Davies, N., Roufogalis, B. (2007). Phytopreventative effects of Gynostemma pentaphyllum against acute indomethacin-induced gastrointestinal and renal toxicity in rats. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 21(6), 523-530.
  • Bhattarai, S., Tran, V., Duke, C. (2007). Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. Journal of Pharmaceutical and Biomedical Analysis, 45(4), 648-653.

2006

  • Murray, M., Zhang, W., Duke, C., Ramzan, I. (2006). Accumulation of esterified polyunsaturated fatty acids in hepatic steatosis impairs microsomal clozapine oxidation. Australian Health and Medical Research Congress, Melbourne: Australian Health and Medical Research Congress.
  • Tran, V., Kantharaj, R., Roufogalis, B., Duke, C. (2006). An Efficient and Facile Synthesis of Capsaicin-Like Compounds as Agonists of the TRPV1 Receptor. European Journal of Organic Chemistry, 2006 (13), 2970-2976.
  • Aktan, F., Henness, S., Tran, V., Duke, C., Roufogalis, B., Ammit, A. (2006). Gingerol Metabolite and a Synthetic Analogue Capsarol (TM) Inhibit Macrophage NF-kappaB Mediated iNOS Gene Expression and Enzyme Activity. Planta Medica: natural products and medicinal plant research, 72(8), 727-734.
  • Huang, H., Li, Y., Naumovski, V., Tran, V., Li, Q., Duke, C., Roufogalis, B. (2006). Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. Journal of Biomedical Science, 13(4), 535-548.
  • Huang, H., Tran, V., Duke, R., Tan, S., Chrubasik, S., Roufogalis, B., Duke, C. (2006). Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kB activation. Journal of Ethnopharmacology, 104(1-2), 149-155.
  • Lee, J., Duke, R., Tran, V., Hook, J., Duke, C. (2006). Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry, 67(23), 2550-2560.
  • Roufogalis, B., Duke, C., Tran, V. (2006). Medicinal Uses Of Phenylalkanols And Derivatives. Patent No. 1056700.

2005

  • Naumovski, V., Duke, R., Turner, P., Duke, C. (2005). (20S)-2 alpha,3 beta,12 beta-trihydroxydammar-24-ene 20-O-beta-D-glucopyranoside (Gynosaponin TN1) as the 2.5-methanol solvate. Acta Crystallographica. Section E: Structure Reports Online, E61, o1239-o1241.
  • Huang, H., Naumovski, V., Salam, N., Duke, R., Tran, V., Duke, C., Roufogalis, B. (2005). A novel LXR-a activator identified from the natural product Gynostemma pentaphyllum. Biochemical Pharmacology, 70(9), 1298-1308.
  • Naumovski, V., Huang, H., Tran, V., Li, Q., Duke, C., Roufogalis, B. (2005). Chemistry and pharmacology of Gynostemma pentaphyllum. Phytochemistry Reviews, 4(3-Feb), 197-219.
  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2005). Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British Journal of Clinical Pharmacology, 59(4), 425-432.
  • Naumovski, V., Li, Q., Duke, C. (2005). Gynostemma pentaphyllum cultivation in Sydney, Australia and its comparison with products from China. Journal of Applied Horticulture, 7(2), 99-104.

2004

  • Mather, L., Duke, C., Ladd, L., Copeland, S., Gallagher, G., Chang, D. (2004). Direct Cardiac Effects Of Coronary Site-Directed Thiopental And Its Enantiomers - A Comparison To Propofol In Conscious Sheep. Anesthesiology, 101(2), 354-364.
  • Jiang, X., Williams, K., Liauw, W., Ammit, A., Roufogalis, B., Duke, C., Day, R., McLachlan, A. (2004). Effect Of St John's Wort And Ginseng On The Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects. British Journal of Clinical Pharmacology, 57(5), 592-599.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2004). Herb-Drug Interactions: An Evidence Based Approach. Current Medicinal Chemistry, 11(11), 1513-1525.

2003

  • Collins (Chebib), M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Nurtjahja-Tjendraputra, E., Ammit, A., Roufogalis, B., Tran, V., Duke, C. (2003). Effective anti-platelet and cox-1 enzyme inhibitors from pungent constituents of ginger. Thrombosis Research, 111, 259-265.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Garlic-drug interactions. The Journal of Complementary Medicine, 11, 57-59.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Ginkgo biloba interactions. The Journal of Complementary Medicine, 11, 70-72.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Interaction or over-reaction? Journal of Alternative and Complementary Medicine: research on paradigm, practice, and policy, 11, 60-61.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). Liquorice-drug interactions. The Journal of Complementary Medicine, 11, 40-43.
  • Duke, C. (2003). Omega-3 fatty acids and hypertension. Pharmacy News, 11, 12c-16c.
  • Coxeter, P., McLachlan, A., Duke, C., Roufogalis, B. (2003). St John's wort interactions. Journal of Alternative and Complementary Medicine: research on paradigm, practice, and policy, 11, 66-68.
  • Li, Q., Duke, C., Roufogalis, B. (2003). The quality and safety of traditional Chinese medicines. Australian Prescriber, 26(6), 128-130.

2002

  • Li, Q., Duke, C., Roufogalis, B. (2002). An integrative east-west herbal medicine education model in Sydney. First International Symposium on TCM Education.
  • Roufogalis, B., Dedov, V., Tran, V., Duke, C. (2002). Development of gingerols and synthetic derivatives for pain and inflammation. 5th Australia/Japan Symposium on Drug Design and Development.
  • Dedov, V., Tran, V., Duke, C., Connor, M., Christie, M., Mandadi, S., Roufogalis, B. (2002). Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology, 137(6), 793-798.
  • Duke, R., Collins (Chebib), M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Li, Q., Duke, C., Roufogalis, B. (2002). The progress of Chinese medicine in Australia. In Kelvin Chan, Henry Lee (Eds.), the Way Forward for Chinese Medicine, (pp. 173-190). London & New York: BMJ Publishing Group.

2001

  • Li, Q., Duke, C., Roufogalis, B. (2001). A new approach to advanced educaiton in herbal medicines established at the University of Sydney. Australian Journal of Chinese Medicine, , 82-84.
  • Duke, C., Goh, P., McLachlan, A., Roufogalis, B. (2001). Complementary Medicines. Australia: Pharmaceutical Society of Australia.
  • Tjendraputra, E., Tran, V., Liu-Brennan, D., Roufogalis, B., Duke, C. (2001). Effect of Ginger Constituents and Synthetic Analogues on Cyclooxygenase-2 Enzyme in Intact Cells. Bioorganic Chemistry, 29(3), 156-163.
  • Tjendraputra, E., Tran, V., Liu-Brennan, D., Roufogalis, B., Duke, C. (2001). Effects of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorganic Chemistry, 29(3), 156-163.
  • Koo, K., Ammit, A., Tran, V., Duke, C., Roufogalis, B. (2001). Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thrombosis Research, 103, 387-397.
  • Li, Q., Duke, C., Roufogalis, B. (2001). Innovative approach to education of hebal medicine. Ed-Health, : World Scientific Publishing.
  • Bhattarai, S., Tran, V., Duke, C. (2001). The stability of gingerol and shogaol in aqueous solutions. Journal of Pharmaceutical Sciences, 90, 1658-1664.
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