Dr Fanfan Zhou

BSc Biopharmaceutics, PhD
Lecturer, Pharmaceutics

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9036 3015
Fax +61 2 9036 3244

Biographical details

Dr Fanfan Zhou is a lecturer in pharmaceutics at the Faculty of Pharmacy at the University of Sydney. She graduated witha BSc, China Pharmaceutical University & Nanjing University, China in 2002 and PhD, Rutgers, the State University of New Jersey, USA in 2008.

Research interests

Drug transporters are the functional cell surface membrane proteins, which are playing critical roles in drug absorption, distribution and elimination. Because of their unique characters to transport structural specific drugs, they have been widely studied as the targets of drug development.

My research interests are to explore the molecular regulation of critical solute carrier drug transporter families (SLCs) as well as the influenc of the SLCpharmacogenetic variations on pharmacokinetic performance of various drugs, such as anti-HIV drugs, antibiotics and anti-cancer drugs.

My research work will contribute to:

  • Investigate the regulatory mechanisms of SLCtransporters.
  • Elucidate the roles ofSLC transporters played in drug absorption and disposition.
  • Explore the interactions of a wide range of clinical relevant compounds with SLC transporters.
  • Demonstrate therelationship betweenSLC pharmacogenetic variations and drug pharmacokinetic performance.

Keywords

Pharmaceutical Sciences; Cancer; Pharmacogenomics; Molecular biology; Pharmacology

PhD and master's project opportunities

Selected grants

2013

  • nanoIR - nanoscale bioimaging with continuous mapping of chemical and physical properties; Gomes V, Dehghani F, Gan Y, Chang L, Jabbarzadeh-Khoei A, McKenzie D, Hanaor D, Zhou F, Chrzanowski W, Braet F, Bilek M, Chan H, Perrier S, O'Neill G, Ammit A, Brand-Miller J, McEwan A, Hawkett B, Kondyurin A, Li Q, Burgess J, Li Z; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel cellular trafficking mechanisms for the drug influx transporter, human Organic Anion Transporting Polypeptide 1a2 (Oatp1a2); Zhou F, Murray M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Organic anion transporting polypeptide 1A2 pharmocogenetcs in the determination of personalized treatment protocols with imatinib; Zhou F, Murray M, McLachlan A; Pharmacy Research Trust of NSW/Research Support.

Selected publications

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Journals

  • Ren, T., Han, Z., Yang, C., Hang, Y., Fang, D., Wang, K., Zhu, X., Ji, X., Zhou, F. (2014). Association of SLC22A4 gene polymorphism with Rheumatoid arthritis in the Chinese population. Journal of Biochemical and Molecular Toxicology (Online), 28(5), 206-210. [More Information]
  • Wang, K., Zhou, F., Zhu, L., Zhu, X., Zhang, K., Zhu, L. (2014). High level soluble expression, purification, and characterization of human ciliary neruonotrophic factor in Escherichia coli by single protein production system. Protein Expression and Purification, 96, 8-13. [More Information]
  • Li, Z., Cheung, F., Zheng, J., Chan, T., Zhu, L., Zhou, F. (2014). Interaction of the Bioactive Flavonol, Icariin, with the Essential Human Solute Carrier Transporters. Journal of Biochemical and Molecular Toxicology (Online), 28(2), 91-97. [More Information]
  • Wang, K., Zhou, F., Zhu, X., Zhang, K., Huang, B., Zhu, L., Zhu, L. (2014). Neuroprotective properties of ciliary neurotrophic factor on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells. Folia Neuropathologica, 52(2), 121-127. [More Information]
  • Zheng, J., Chan, T., Cheung, F., Zhu, L., Murray, M., Zhou, F. (2014). PDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability. PLoS One, 9(4), 1-11. [More Information]
  • Wang, K., Zhu, L., Zhu, X., Zhang, K., Huang, B., Zhang, J., Zhang, Y., Zhu, L., Zhou, B., Zhou, F. (2014). Protective Effect of Paeoniflorin on AB 25-35- Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction. Cellular and Molecular Neurobiology, 34(2), 227-234. [More Information]
  • Johnston, R., Rawling, T., Chan, T., Zhou, F., Murray, M. (2014). Selective Inhibition of Human Solute Carrier Transporters by Multikinase Inhibitors. Drug Metabolism and Disposition, 42(11), 1851-1857. [More Information]
  • Wang, K., Zhang, K., Lv, Z., Zhu, X., Zhu, L., Zhou, F. (2014). Ultrasensitive detection of microRNA with isothermal amplification and a time-resolved fluorescence sensor. Biosensors and Bioelectronics, 57, 91-95. [More Information]
  • Zhu, X., Wang, K., Zhang, K., Zhu, L., Zhou, F. (2014). Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicology Letters, 227(1), 65-73. [More Information]
  • Cui, P., Rawling, T., Gillani, T., Bourget, K., Wang, X., Zhou, F., Murray, M. (2013). Anti-proliferative actions of N'-desmethylsorafenib in human breast cancer cells. Biochemical Pharmacology, 86(3), 419-427. [More Information]
  • Zhou, F., Zheng, J., Zhu, L., Jodal, A., Cui, P., Wong, K., Gurney, H., Church, W., Murray, M. (2013). Functional Analysis of Novel Polymorphisms in the Human SLCO1A2 Gene that Encodes the Transporter OATP1A2. The AAPS Journal, 15(4), 1099-1108. [More Information]
  • Toh, D., Cheung, F., Murray, M., Pern, T., Lee, E., Zhou, F. (2013). Functional Analysis of Novel Variants in the Organic Cation/Ergothioneine Transporter 1 Identified in Singapore Populations. Molecular Pharmaceutics, 10(7), 2509-2516. [More Information]
  • Chan, T., Li, Z., Zheng, J., Cheung, F., Zhu, L., Zhou, F. (2013). Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters. World Journal of Pharmacology, 2(4), 115-121. [More Information]
  • Wang, K., Pei, H., Huang, B., Zhu, X., Zhang, J., Zhou, B., Zhu, L., Zhang, Y., Zhou, F. (2013). The Expression of ABC Efflux Pump, Rv1217c-Rv1218c, and Its Association with Multidrug Resistance of Mycobacterium tuberculosis in China. Current Microbiology, 66(3), 222-226. [More Information]
  • Xu, F., Li, Z., Zheng, J., Cheung, F., Chan, T., Zhu, L., Zhuge, H., Zhou, F. (2013). The Inhibitory Effects of the Bioactive Components Isolated from Scutellaria Baicalensis on the Cellular Uptake Mediated by the Essential Solute Carrier Transporters. Journal of Pharmaceutical Sciences, 102(11), 4205-4211. [More Information]
  • Zhu, X., Wang, K., Zhang, K., Huang, B., Zhang, J., Zhang, Y., Zhu, L., Zhou, B., Zhou, F. (2013). Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway. International Journal of Molecular Sciences, 14(9), 18041-18055. [More Information]
  • Cui, P., Rawling, T., Bourget, K., Kim, T., Duke, C., Doddareddy, M., Hibbs, D., Zhou, F., Tattam, B., Petrovic, N., Murray, M. (2012). Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. Journal of Medicinal Chemistry, 55(16), 7163-7172. [More Information]
  • Zhou, F., Li, Z., Lam, P., Zhu, L., Wang, K. (2012). Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs). Journal of Pharmacogenomics & Pharmacoproteomics, 3(6), 1-8. [More Information]
  • Ghassabian, S., Rawling, T., Zhou, F., Doddareddy, M., Tattam, B., Hibbs, D., Edwards, R., Cui, P., Murray, M. (2012). Role of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolites. Biochemical Pharmacology, 84(2), 215-223. [More Information]
  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, T., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699. [More Information]
  • Zhou, F., Lee, A., Krafczyk, K., Zhu, L., Murray, M. (2011). Protein Kinase C Regulates the Internalization and Function of the Human Organic Anion Transporting Polypeptide 1A2. British Journal of Pharmacology, 162(6), 1380-1388. [More Information]
  • Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427. [More Information]
  • Cui, P., Lee, A., Zhou, F., Murray, M. (2010). Impaired transactivation of the human CYP2J2 arachidonic acid epoxygenase gene in HepG2 cells subjected to nitrative stress. British Journal of Pharmacology, 159(7), 1440-1449. [More Information]
  • Murray, M., Cui, P., Zhou, F. (2010). Roles of Mitogen-Activated Protein Kinases in the Regulation of CYP Genes. Current Drug Metabolism, 11(10), 850-858. [More Information]
  • Zhou, F., Xu, W., Tanaka, K., You, G. (2008). Comparison of the Interaction of Human Organic Anion Transporter hOAT4 with PDZ Proteins between Kidney Cells and Placental Cells. Pharmaceutical Research, 25(2), 475-480. [More Information]
  • Zhou, F., You, G. (2007). Molecular Insights into the Structure-Function Relationship of Organic Anion Transporters OATs. Pharmaceutical Research, 24(1), 28-36. [More Information]
  • Zhou, F., Hong, M., You, G. (2007). Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. American Journal of Physiology: Endocrinology and Metabolism, 293, E57-E61.
  • Hong, M., Zhou, F., Lee, K., You, G. (2007). The putative transmembrane segment 7 of human organic anion transporter hOAT1 dictates transporter substrate binding and stability. Journal of Pharmacology and Experimental Therapeutics, 320(3), 1209-1215.
  • Zhou, F., Illsley, N., You, G. (2006). Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. European Journal of Pharmaceutical Sciences, 27(5), 518-523. [More Information]
  • Hong, M., Xu, W., Yoshida, T., Tanaka, K., Wolf, D., Zhou, F., Inouye, M., You, G. (2005). Human organic anion transporter hOAT1 forms homooligomers. Journal of Biological Chemistry, 280(37), 32285-32290.
  • Zhou, F., Xu, W., Hong, M., Pan, Z., Sinko, P., Ma, J., You, G. (2005). The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Molecular Pharmacology, 67(3), 868-876.
  • Hong, M., Zhou, F., You, G. (2004). Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. Journal of Biological Chemistry, 279(30), 31478-31482.
  • Tanaka, K., Zhou, F., Kuze, K., You, G. (2004). Cysteine residues in the organic anion transporter mOAT1. Biochemical Journal, 380(1), 283-287.
  • Zhou, F., Pan, Z., Ma, J., You, G. (2004). Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). Biochemical Journal, 384(1), 87-92.
  • Tanaka, K., Xu, W., Zhou, F., You, G. (2004). Role of glycosylation in the organic anion transporter OAT1. Journal of Biological Chemistry, 279(15), 14961-14966.
  • Zhou, F., Tanaka, K., Pan, Z., Ma, J., You, G. (2004). The role of glycine residues in the function of human organic anion transporter 4. Molecular Pharmacology, 65(5), 1141-1147.
  • Zhou, F., Tanaka, K., Soares, M., You, G. (2003). Characterization of an organic anion transport system in a placental cell line. American Journal of Physiology: Endocrinology and Metabolism, 285(5), E1103-E1109.

2014

  • Ren, T., Han, Z., Yang, C., Hang, Y., Fang, D., Wang, K., Zhu, X., Ji, X., Zhou, F. (2014). Association of SLC22A4 gene polymorphism with Rheumatoid arthritis in the Chinese population. Journal of Biochemical and Molecular Toxicology (Online), 28(5), 206-210. [More Information]
  • Wang, K., Zhou, F., Zhu, L., Zhu, X., Zhang, K., Zhu, L. (2014). High level soluble expression, purification, and characterization of human ciliary neruonotrophic factor in Escherichia coli by single protein production system. Protein Expression and Purification, 96, 8-13. [More Information]
  • Li, Z., Cheung, F., Zheng, J., Chan, T., Zhu, L., Zhou, F. (2014). Interaction of the Bioactive Flavonol, Icariin, with the Essential Human Solute Carrier Transporters. Journal of Biochemical and Molecular Toxicology (Online), 28(2), 91-97. [More Information]
  • Wang, K., Zhou, F., Zhu, X., Zhang, K., Huang, B., Zhu, L., Zhu, L. (2014). Neuroprotective properties of ciliary neurotrophic factor on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells. Folia Neuropathologica, 52(2), 121-127. [More Information]
  • Zheng, J., Chan, T., Cheung, F., Zhu, L., Murray, M., Zhou, F. (2014). PDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability. PLoS One, 9(4), 1-11. [More Information]
  • Wang, K., Zhu, L., Zhu, X., Zhang, K., Huang, B., Zhang, J., Zhang, Y., Zhu, L., Zhou, B., Zhou, F. (2014). Protective Effect of Paeoniflorin on AB 25-35- Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction. Cellular and Molecular Neurobiology, 34(2), 227-234. [More Information]
  • Johnston, R., Rawling, T., Chan, T., Zhou, F., Murray, M. (2014). Selective Inhibition of Human Solute Carrier Transporters by Multikinase Inhibitors. Drug Metabolism and Disposition, 42(11), 1851-1857. [More Information]
  • Wang, K., Zhang, K., Lv, Z., Zhu, X., Zhu, L., Zhou, F. (2014). Ultrasensitive detection of microRNA with isothermal amplification and a time-resolved fluorescence sensor. Biosensors and Bioelectronics, 57, 91-95. [More Information]
  • Zhu, X., Wang, K., Zhang, K., Zhu, L., Zhou, F. (2014). Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicology Letters, 227(1), 65-73. [More Information]

2013

  • Cui, P., Rawling, T., Gillani, T., Bourget, K., Wang, X., Zhou, F., Murray, M. (2013). Anti-proliferative actions of N'-desmethylsorafenib in human breast cancer cells. Biochemical Pharmacology, 86(3), 419-427. [More Information]
  • Zhou, F., Zheng, J., Zhu, L., Jodal, A., Cui, P., Wong, K., Gurney, H., Church, W., Murray, M. (2013). Functional Analysis of Novel Polymorphisms in the Human SLCO1A2 Gene that Encodes the Transporter OATP1A2. The AAPS Journal, 15(4), 1099-1108. [More Information]
  • Toh, D., Cheung, F., Murray, M., Pern, T., Lee, E., Zhou, F. (2013). Functional Analysis of Novel Variants in the Organic Cation/Ergothioneine Transporter 1 Identified in Singapore Populations. Molecular Pharmaceutics, 10(7), 2509-2516. [More Information]
  • Chan, T., Li, Z., Zheng, J., Cheung, F., Zhu, L., Zhou, F. (2013). Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters. World Journal of Pharmacology, 2(4), 115-121. [More Information]
  • Wang, K., Pei, H., Huang, B., Zhu, X., Zhang, J., Zhou, B., Zhu, L., Zhang, Y., Zhou, F. (2013). The Expression of ABC Efflux Pump, Rv1217c-Rv1218c, and Its Association with Multidrug Resistance of Mycobacterium tuberculosis in China. Current Microbiology, 66(3), 222-226. [More Information]
  • Xu, F., Li, Z., Zheng, J., Cheung, F., Chan, T., Zhu, L., Zhuge, H., Zhou, F. (2013). The Inhibitory Effects of the Bioactive Components Isolated from Scutellaria Baicalensis on the Cellular Uptake Mediated by the Essential Solute Carrier Transporters. Journal of Pharmaceutical Sciences, 102(11), 4205-4211. [More Information]
  • Zhu, X., Wang, K., Zhang, K., Huang, B., Zhang, J., Zhang, Y., Zhu, L., Zhou, B., Zhou, F. (2013). Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway. International Journal of Molecular Sciences, 14(9), 18041-18055. [More Information]

2012

  • Cui, P., Rawling, T., Bourget, K., Kim, T., Duke, C., Doddareddy, M., Hibbs, D., Zhou, F., Tattam, B., Petrovic, N., Murray, M. (2012). Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. Journal of Medicinal Chemistry, 55(16), 7163-7172. [More Information]
  • Zhou, F., Li, Z., Lam, P., Zhu, L., Wang, K. (2012). Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs). Journal of Pharmacogenomics & Pharmacoproteomics, 3(6), 1-8. [More Information]
  • Ghassabian, S., Rawling, T., Zhou, F., Doddareddy, M., Tattam, B., Hibbs, D., Edwards, R., Cui, P., Murray, M. (2012). Role of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolites. Biochemical Pharmacology, 84(2), 215-223. [More Information]

2011

  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, T., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699. [More Information]
  • Zhou, F., Lee, A., Krafczyk, K., Zhu, L., Murray, M. (2011). Protein Kinase C Regulates the Internalization and Function of the Human Organic Anion Transporting Polypeptide 1A2. British Journal of Pharmacology, 162(6), 1380-1388. [More Information]

2010

  • Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427. [More Information]
  • Cui, P., Lee, A., Zhou, F., Murray, M. (2010). Impaired transactivation of the human CYP2J2 arachidonic acid epoxygenase gene in HepG2 cells subjected to nitrative stress. British Journal of Pharmacology, 159(7), 1440-1449. [More Information]
  • Murray, M., Cui, P., Zhou, F. (2010). Roles of Mitogen-Activated Protein Kinases in the Regulation of CYP Genes. Current Drug Metabolism, 11(10), 850-858. [More Information]

2008

  • Zhou, F., Xu, W., Tanaka, K., You, G. (2008). Comparison of the Interaction of Human Organic Anion Transporter hOAT4 with PDZ Proteins between Kidney Cells and Placental Cells. Pharmaceutical Research, 25(2), 475-480. [More Information]

2007

  • Zhou, F., You, G. (2007). Molecular Insights into the Structure-Function Relationship of Organic Anion Transporters OATs. Pharmaceutical Research, 24(1), 28-36. [More Information]
  • Zhou, F., Hong, M., You, G. (2007). Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. American Journal of Physiology: Endocrinology and Metabolism, 293, E57-E61.
  • Hong, M., Zhou, F., Lee, K., You, G. (2007). The putative transmembrane segment 7 of human organic anion transporter hOAT1 dictates transporter substrate binding and stability. Journal of Pharmacology and Experimental Therapeutics, 320(3), 1209-1215.

2006

  • Zhou, F., Illsley, N., You, G. (2006). Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. European Journal of Pharmaceutical Sciences, 27(5), 518-523. [More Information]

2005

  • Hong, M., Xu, W., Yoshida, T., Tanaka, K., Wolf, D., Zhou, F., Inouye, M., You, G. (2005). Human organic anion transporter hOAT1 forms homooligomers. Journal of Biological Chemistry, 280(37), 32285-32290.
  • Zhou, F., Xu, W., Hong, M., Pan, Z., Sinko, P., Ma, J., You, G. (2005). The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Molecular Pharmacology, 67(3), 868-876.

2004

  • Hong, M., Zhou, F., You, G. (2004). Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. Journal of Biological Chemistry, 279(30), 31478-31482.
  • Tanaka, K., Zhou, F., Kuze, K., You, G. (2004). Cysteine residues in the organic anion transporter mOAT1. Biochemical Journal, 380(1), 283-287.
  • Zhou, F., Pan, Z., Ma, J., You, G. (2004). Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). Biochemical Journal, 384(1), 87-92.
  • Tanaka, K., Xu, W., Zhou, F., You, G. (2004). Role of glycosylation in the organic anion transporter OAT1. Journal of Biological Chemistry, 279(15), 14961-14966.
  • Zhou, F., Tanaka, K., Pan, Z., Ma, J., You, G. (2004). The role of glycine residues in the function of human organic anion transporter 4. Molecular Pharmacology, 65(5), 1141-1147.

2003

  • Zhou, F., Tanaka, K., Soares, M., You, G. (2003). Characterization of an organic anion transport system in a placental cell line. American Journal of Physiology: Endocrinology and Metabolism, 285(5), E1103-E1109.

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