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Dr Fanfan Zhou

BSc Biopharmaceutics, PhD
Lecturer, Pharmaceutics

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9036 3015
Fax +61 2 9036 3244

Biographical details

Dr Fanfan Zhou is a lecturer in pharmaceutics at the Faculty of Pharmacy at the University of Sydney. She graduated witha BSc, China Pharmaceutical University & Nanjing University, China in 2002 and PhD, Rutgers, the State University of New Jersey, USA in 2008.

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Research interests

Drug transporters are the functional cell surface membrane proteins, which are playing critical roles in drug absorption, distribution and elimination. Because of their unique characters to transport structural specific drugs, they have been widely studied as the targets of drug development.
My research interests are to explore the molecular regulation of critical solute carrier drug transporter families (SLCs) as well as the influenc of the SLCpharmacogenetic variations on pharmacokinetic performance of various drugs, such as anti-HIV drugs, antibiotics and anti-cancer drugs.
My research work will contribute to:

  • Investigate the regulatory mechanisms of SLCtransporters.
  • Elucidate the roles ofSLC transporters played in drug absorption and disposition.
  • Explore the interactions of a wide range of clinical relevant compounds with SLC transporters.
  • Demonstrate therelationship betweenSLC pharmacogenetic variations and drug pharmacokinetic performance.

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Selected grants

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons J, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson J, dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao S, Byrne S, Zhou F, Buckland M, Grewal (, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho P, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • Novel cellular trafficking mechanisms for the drug influx transporter, human Organic Anion Transporting Polypeptide 1a2 (Oatp1a2); Zhou F, Murray M; National Health and Medical Research Council/Project Grants.

2009

  • Organic anion transporting polypeptide 1A2 pharmocogenetcs in the determination of personalized treatment protocols with imatinib; Zhou F, Murray M, McLachlan A; Pharmacy Research Trust of NSW/Research Support.
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Selected publications

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Journals

  • Cui, P., Rawling, T., Bourget, K., Kim, T., Duke, C., Doddareddy, M., Hibbs, D., Zhou, F., Tattam, B., Petrovic, N., Murray, M. (2012). Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. Journal of Medicinal Chemistry, 55(16), 7163-7172.
  • Zhou, F., Li, Z., Lam, P., Zhu, L., Wang, K. (2012). Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs). Journal of Pharmacogenomics & Pharmacoproteomics, 3(6), 1-8.
  • Ghassabian, S., Rawling, T., Zhou, F., Doddareddy, M., Tattam, B., Hibbs, D., Edwards, R., Cui, P., Murray, M. (2012). Role of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolites. Biochemical Pharmacology, 84(2), 215-223.
  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, (., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699.
  • Zhou, F., Lee, A., Krafczyk, K., Zhu, L., Murray, M. (2011). Protein Kinase C Regulates the Internalization and Function of the Human Organic Anion Transporting Polypeptide 1A2. British Journal of Pharmacology, 162(6), 1380-1388.
  • Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427.
  • Cui, P., Lee, A., Zhou, F., Murray, M. (2010). Impaired transactivation of the human CYP2J2 arachidonic acid epoxygenase gene in HepG2 cells subjected to nitrative stress. British Journal of Pharmacology, 159(7), 1440-1449.
  • Murray, M., Cui, P., Zhou, F. (2010). Roles of Mitogen-Activated Protein Kinases in the Regulation of CYP Genes. Current Drug Metabolism, 11(10), 850-858.
  • Zhou, F., Xu, W., Tanaka, K., You, G. (2008). Comparison of the Interaction of Human Organic Anion Transporter hOAT4 with PDZ Proteins between Kidney Cells and Placental Cells. Pharmaceutical Research, 25(2), 475-480.
  • Zhou, F., You, G. (2007). Molecular Insights into the Structure-Function Relationship of Organic Anion Transporters OATs. Pharmaceutical Research, 24(1), 28-36.
  • Zhou, F., Hong, M., You, G. (2007). Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. American Journal of Physiology: Endocrinology and Metabolism (Print), 293, E57-E61.
  • Hong, M., Zhou, F., Lee, K., You, G. (2007). The putative transmembrane segment 7 of human organic anion transporter hOAT1 dictates transporter substrate binding and stability. Journal of Pharmacology and Experimental Therapeutics, 320(3), 1209-1215.
  • Zhou, F., Illsley, N., You, G. (2006). Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. European Journal of Pharmaceutical Sciences, 27(5), 518-523.
  • Hong, M., Xu, W., Yoshida, T., Tanaka, K., Wolf, D., Zhou, F., Inouye, M., You, G. (2005). Human organic anion transporter hOAT1 forms homooligomers. Journal of Biological Chemistry, 280(37), 32285-32290.
  • Zhou, F., Xu, W., Hong, M., Pan, Z., Sinko, P., Ma, J., You, G. (2005). The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Molecular Pharmacology, 67(3), 868-876.
  • Hong, M., Zhou, F., You, G. (2004). Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. Journal of Biological Chemistry, 279(30), 31478-31482.
  • Tanaka, K., Zhou, F., Kuze, K., You, G. (2004). Cysteine residues in the organic anion transporter mOAT1. Biochemical Journal, 380(1), 283-287.
  • Zhou, F., Pan, Z., Ma, J., You, G. (2004). Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). Biochemical Journal, 384(1), 87-92.
  • Tanaka, K., Xu, W., Zhou, F., You, G. (2004). Role of glycosylation in the organic anion transporter OAT1. Journal of Biological Chemistry, 279(15), 14961-14966.
  • Zhou, F., Tanaka, K., Pan, Z., Ma, J., You, G. (2004). The role of glycine residues in the function of human organic anion transporter 4. Molecular Pharmacology, 65(5), 1141-1147.
  • Zhou, F., Tanaka, K., Soares, M., You, G. (2003). Characterization of an organic anion transport system in a placental cell line. American Journal of Physiology: Endocrinology and Metabolism (Print), 285(5), E1103-E1109.

2012

  • Cui, P., Rawling, T., Bourget, K., Kim, T., Duke, C., Doddareddy, M., Hibbs, D., Zhou, F., Tattam, B., Petrovic, N., Murray, M. (2012). Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. Journal of Medicinal Chemistry, 55(16), 7163-7172.
  • Zhou, F., Li, Z., Lam, P., Zhu, L., Wang, K. (2012). Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs). Journal of Pharmacogenomics & Pharmacoproteomics, 3(6), 1-8.
  • Ghassabian, S., Rawling, T., Zhou, F., Doddareddy, M., Tattam, B., Hibbs, D., Edwards, R., Cui, P., Murray, M. (2012). Role of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolites. Biochemical Pharmacology, 84(2), 215-223.

2011

  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, (., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699.
  • Zhou, F., Lee, A., Krafczyk, K., Zhu, L., Murray, M. (2011). Protein Kinase C Regulates the Internalization and Function of the Human Organic Anion Transporting Polypeptide 1A2. British Journal of Pharmacology, 162(6), 1380-1388.

2010

  • Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427.
  • Cui, P., Lee, A., Zhou, F., Murray, M. (2010). Impaired transactivation of the human CYP2J2 arachidonic acid epoxygenase gene in HepG2 cells subjected to nitrative stress. British Journal of Pharmacology, 159(7), 1440-1449.
  • Murray, M., Cui, P., Zhou, F. (2010). Roles of Mitogen-Activated Protein Kinases in the Regulation of CYP Genes. Current Drug Metabolism, 11(10), 850-858.

2008

  • Zhou, F., Xu, W., Tanaka, K., You, G. (2008). Comparison of the Interaction of Human Organic Anion Transporter hOAT4 with PDZ Proteins between Kidney Cells and Placental Cells. Pharmaceutical Research, 25(2), 475-480.

2007

  • Zhou, F., You, G. (2007). Molecular Insights into the Structure-Function Relationship of Organic Anion Transporters OATs. Pharmaceutical Research, 24(1), 28-36.
  • Zhou, F., Hong, M., You, G. (2007). Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. American Journal of Physiology: Endocrinology and Metabolism (Print), 293, E57-E61.
  • Hong, M., Zhou, F., Lee, K., You, G. (2007). The putative transmembrane segment 7 of human organic anion transporter hOAT1 dictates transporter substrate binding and stability. Journal of Pharmacology and Experimental Therapeutics, 320(3), 1209-1215.

2006

  • Zhou, F., Illsley, N., You, G. (2006). Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. European Journal of Pharmaceutical Sciences, 27(5), 518-523.

2005

  • Hong, M., Xu, W., Yoshida, T., Tanaka, K., Wolf, D., Zhou, F., Inouye, M., You, G. (2005). Human organic anion transporter hOAT1 forms homooligomers. Journal of Biological Chemistry, 280(37), 32285-32290.
  • Zhou, F., Xu, W., Hong, M., Pan, Z., Sinko, P., Ma, J., You, G. (2005). The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Molecular Pharmacology, 67(3), 868-876.

2004

  • Hong, M., Zhou, F., You, G. (2004). Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. Journal of Biological Chemistry, 279(30), 31478-31482.
  • Tanaka, K., Zhou, F., Kuze, K., You, G. (2004). Cysteine residues in the organic anion transporter mOAT1. Biochemical Journal, 380(1), 283-287.
  • Zhou, F., Pan, Z., Ma, J., You, G. (2004). Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). Biochemical Journal, 384(1), 87-92.
  • Tanaka, K., Xu, W., Zhou, F., You, G. (2004). Role of glycosylation in the organic anion transporter OAT1. Journal of Biological Chemistry, 279(15), 14961-14966.
  • Zhou, F., Tanaka, K., Pan, Z., Ma, J., You, G. (2004). The role of glycine residues in the function of human organic anion transporter 4. Molecular Pharmacology, 65(5), 1141-1147.

2003

  • Zhou, F., Tanaka, K., Soares, M., You, G. (2003). Characterization of an organic anion transport system in a placental cell line. American Journal of Physiology: Endocrinology and Metabolism (Print), 285(5), E1103-E1109.
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Keywords

Pharmaceutical Sciences; Cancer; Pharmacogenomics; Molecular biology; Pharmacology

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