Dr Hien Duong


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Biographical details

Dr Hien Duong was awarded a highly competitive Endeavour Postgraduate Scholarship and joined Centre of Advanced Macromolecular Design (CAMD) in 2007 for her PhD. She then commenced her postdoctoral academic career in Australian Centre for NanoMedicine (established by UNSW in 2011). In 2014, she joined the Key Centre for Polymers and Colloids, School of Chemistry, the University of Sydney, working on an ARC linkage grant with Dulux Australia. In 2016, she joined the Institute for Biomedical Materials & Devices (IBMD), School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney as a Senior Research Fellow. Recently, Dr Duong took up the position of lecturer in Pharmaceutical Sciences at the University of Sydney. Dr Duong has published more than 40 peer-reviewed journal articles relating to using smart nanomaterials for drug delivery in high-impact journals including Nature Nanotechnology, ACS Nano, Chemical Sciencce, Chemical Communication and Angewandte Chemie International Edition. During her postdoctoral appointments, she mentored over 20 students in the area of using different platforms prepared by Reversible Addition Fragmentation Chain Transfer (RAFT) techniques for drug delivery.

Research interests

Her research is multidisciplinary which focuses on the new concepts and ideas to engineer novel materials and devices at nanoscale. The ultimate goal is to utilize the nanotechnology in the form of nanoparticles to extend our life in two ways: i) early detection of life-threatening diseases and ii) improvement of their current therapy. Her research area includes polymer synthesis, fabrication and characterization of organic, inorganic and biocompatible nanomaterials for biomedical applications. She has extensive experience in understanding the interface between polymer synthesis and biomedical science. She is also interested in the development of powerful fluorescence microscopic techniques to study the fate of nanoparticles in the live cells.

Teaching and supervision

PHAR1822 - Physical Pharmaceutics and Formulation A

PHAR2823 - Physical Pharmaceutics and Formulation B

Current research students

Project title Research student
Multimodal nanoparticles to overcome antibiotic resistance Ophelia HUANG
Acetalated dextran formulations for cancer and infection treatment Deeksha LAHORI

Associations

Australian Institute for Nanoscale Science and Technology (AINST)

Australian Research Council Nanotechnology Network (ARCNN).

Polymer Division of the Royal Australian Chemical Institute (RACI)

Awards and honours

10/2015 Monash Engineering Women's Leadership Award

07/2011 Runner-up prize in International Nanomedicine conference in 2011

09/2009 Postgraduate Research Student Scholarship, the University of New South Wales

03/2007 Endeavour Postgraduate Award for PhD degree at UNSW

03/2003 Australian Development Scholarships (ADS) for Masters degree at UNSW

Selected grants

2018

  • Inhaled therapy for chronic lung infections using a "triple-hit" nano-in-microparticle formulation; Leung S, Duong H, Kwok P, Zhang L; Office of Global Engagement/Partnership Collaboration Awards.

2017

  • Novel 3-in-1 formulation for prostate cancer treatment; Duong H, Nebhani L; Office of Global Engagement/India Development Fund.
  • Ultra-high-performance microbalance, XPR2; Varamini P, Duong H, Grewal T, Kayser V, Gelissen I, Chrzanowski W, Boddy A; University of Sydney, Faculty of Pharmacy/Equipment Grant.

Selected publications

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Book Chapters

  • Duong, H., Nguyen, D., Neto, C., Hawkett, B. (2018). Synthesis and applications of polymeric Janus nanoparticles. In Zhiqun Lin and Bo Li (Eds.), Soft, hard, and hybrid Janus Structures: Synthesis, Self-Assembly, and Applications, (pp. 31-68). London: World Scientific Publishing. [More Information]

Journals

  • Das, T., Choong, H., Kwang, Y., Chan, H., Manos, J., Kwok, P., Duong, H. (2019). Spray-Dried Particles of Nitric Oxide-Modified Glutathione for the Treatment of Chronic Lung Infection. Molecular Pharmaceutics, 16(4), 1723-1731. [More Information]
  • Chen, Y., Duong, H., Wen, S., Mi, C., Zhou, Y., Shimoni, O., Valenzuela, S., Jin, D. (2018). Exonuclease III-Assisted Upconversion Resonance Energy Transfer in a Wash-Free Suspension DNA Assay. Analytical Chemistry, 90(1), 663-668. [More Information]
  • Pelras, T., Duong, H., Kim, B., Hawkett, B., Muellner, M. (2017). A 'grafting from' approach to polymer nanorods for pH-triggered intracellular drug delivery. Polymer, 112, 244-251. [More Information]
  • Hinde, E., Thammasiraphop, K., Duong, H., Yeow, J., Karagoz, B., Boyer, C., Gooding, J., Gaus, K. (2017). Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release. Nature Nanotechnology, 12(81), 89. [More Information]
  • Nguyen, T., Selvanayagam, R., Ho, K., Chen, R., Kutty, S., Rice, S., Kumar, N., Barraud, N., Duong, H., Boyer, C. (2016). Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles. Chemical Science, 7(2), 1016-1027. [More Information]
  • Adnan, N., Cheng, Y., Ong, N., Kamaruddin, T., Rozlan, E., Schmidt, T., Duong, H., Boyer, C. (2016). Effect of gold nanoparticle shapes for phototherapy and drug delivery. Polymer Chemistry, 7(16), 2888-2903. [More Information]
  • Fu, C., Bongers, A., Wang, K., Yang, B., Zhao, Y., Wu, H., Wei, Y., Duong, H., Wang, Z., Tao, L. (2016). Facile synthesis of a multifunctional copolymer via a concurrent RAFT-enzymatic system for theranostic applications. Polymer Chemistry, 7(3), 546-552. [More Information]
  • Duong, H. (2015). Biomimetic polymers responsive to a biological signaling molecule: Nitric oxide (NO) triggered reversible self-assembly of single macromolecular chains into nanoparticles. Journal of Controlled Release, 213, e55-e56. [More Information]
  • Kurniawansyah, F., Duong, H., Danh, L., Mammucari, R., Vittorio, O., Boyer, C., Foster, N. (2015). Inhalable curcumin formulations: Micronization and bioassay. Chemical Engineering Journal, 279, 799-808. [More Information]
  • Nguyen, T., Duong, H., Selvanayagam, R., Boyer, C., Barraud, N. (2015). Iron oxide nanoparticle-mediated hyperthermia stimulates dispersal in bacterial biofilms and enhances antibiotic efficcya. Scientific Reports, 5, 1-15. [More Information]
  • Li, Y., Duong, H., Laurent, S., Macmillan, A., Whan, R., Elst, L., Muller, R., Hu, J., Lowe, A., Boyer, C., et al (2015). Nanoparticles based on star polymers as theranostic vectors: endosomal-triggered drug release combined with mri sensitivity. Advanced Healthcare Materials, 4(1), 148-156. [More Information]
  • Xu, J., Shanmugam, S., Duong, H., Boyer, C. (2015). Organo-photocatalysts for photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization. Polymer Chemistry, 6(31), 5615-5624. [More Information]
  • Le-Masurier, S., Duong, H., Boyer, C., Granville, A. (2015). Surface modification of polydopamine coated particles via glycopolymer brush synthesis for protein binding and FLIM testing. Polymer Chemistry, 6(13), 2504-2511. [More Information]
  • Duong, H., Dong, Z., Su, L., Boyer, C., George, J., Davis, T., Wang, J. (2015). The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension. Small, 11(19), 2291-2304. [More Information]
  • Hu, J., Whittaker, M., Duong, H., Li, Y., Boyer, C., Davis, T. (2014). Biomimetic polymers responsive to a biological signaling molecule: nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles. Angewandte Chemie - International Edition, 53(30), 7779-7784. [More Information]
  • Sagnella, S., Duong, H., Macmillan, A., Boyer, C., Whan, R., McCarroll, J., Davis, T., Kavallaris, M. (2014). Dextran-based doxorubicin nanocarriers with improved tumor penetration. Biomacromolecules, 15(1), 262-275. [More Information]
  • Duong, H., Adnan, N., Barraud, N., Basuki, J., Kutty, S., Jung, K., Kumar, N., Davis, T., Boyer, C. (2014). Functional gold nanoparticles for the storage and controlled release of nitric oxide: applications in biofilm dispersal and intracellular delivery. Journal of Materials Chemistry B, 2(31), 5003-5011. [More Information]
  • Basuki, J., Esser, L., Duong, H., Zhang, Q., Wilson, P., Whittaker, M., Haddleton, D., Boyer, C., Davis, T. (2014). Magnetic nanoparticles with diblock glycopolymer shells give lectin concentration-dependent MRI signals and selective cell uptake. Chemical Science, 5(2), 715-726. [More Information]
  • Duong, H., Jung, K., Kutty, S., Augustina, S., Adnan, N., Basuki, J., Kumar, N., Davis, T., Barraud, N., Boyer, C. (2014). Nanoparticle (star polymer) delivery of nitric oxide effectively negates pseudomonas aeruginosa biofilm formation. Biomacromolecules, 15(7), 2583-2589. [More Information]
  • Duong, H., Ho, A., Davis, T., Boyer, C. (2014). Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide. Journal of Polymer Science, Part A: Polymer Chemistry, 52(15), 2099-2103. [More Information]
  • Karagoz, B., Esser, L., Duong, H., Basuki, J., Boyer, C., Davis, T. (2014). Polymerization-Induced Self-Assembly (PISA) - control over the morphology of nanoparticles for drug delivery applications. Polymer Chemistry, 5(2), 350-355. [More Information]
  • Boyer, C., Teo, J., Phillips, P., Erlich, R., Sagnella, S., Sharbeen, G., Dwarte, T., Duong, H., Goldstein, D., Davis, T., et al (2013). Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers. Molecular Pharmaceutics, 10(6), 2435-2444. [More Information]
  • Scarano, W., Duong, H., Lu, H., de Souza, P., Stenzel, M. (2013). Folate conjugation to polymeric micelles via boronic acid ester to deliver platinum drugs to ovarian cancer cell lines. Biomacromolecules, 14(4), 962-975. [More Information]
  • N'Guyen, T., Duong, H., Basuki, J., Montembault, V., Pascual, S., Guibert, C., Fresnais, J., Boyer, C., Davis, T., Fontaine, L. (2013). Functional iron oxide magnetic nanoparticles with hyperthermia-induced drug release ability by using a combination of orthogonal click reactions. Angewandte Chemie - International Edition, 52(52), 14152-14156. [More Information]
  • Duong, H., Kamarudin, Z., Erlich, R., Li, Y., Jones, M., Kavallaris, M., Boyer, C., Davis, T. (2013). Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers. Chemical Communications, 49(39), 4190-4192. [More Information]
  • Basuki, J., Duong, H., Macmillan, A., Whan, R., Boyer, C., Davis, T. (2013). Polymer-grafted, nonfouling, magnetic nanoparticles designed to selectively store and release molecules via ionic interactions. Macromolecules, 46(17), 7043-7054. [More Information]
  • Li, Y., Duong, H., Jones, M., Basuki, J., Hu, J., Boyer, C., Davis, T. (2013). Selective postmodification of copolymer backbones bearing different activated esters with disparate reactivities. ACS Macro Letters, 2(10), 912-917. [More Information]
  • Basuki, J., Duong, H., Macmillan, A., Erlich, R., Esser, L., Akerfeldt, M., Whan, R., Kavallaris, M., Boyer, C., Davis, T. (2013). Using fluorescence lifetime imaging microscopy to monitor theranostic nanoparticle uptake and intracellular doxorubicin release. ACS Nano, 7(11), 10175-10189. [More Information]
  • Duong, H., Hughes, F., Sagnella, S., Kavallaris, M., Macmillan, A., Whan, R., Hook, J., Davis, T., Boyer, C. (2012). Functionalizing biodegradable dextran scaffolds using living radical polymerization: new versatile nanoparticles for the delivery of therapeutic molecules. Molecular Pharmaceutics, 9(11), 3046-3061. [More Information]
  • Li, Y., Beija, M., laurent, S., Elst, L., Duong, H., Lowe, A., Davis, T., Boyer, C., Muller, R. (2012). Macromolecular ligands for gadolinium mri contrast agents. Macromolecules, 45(10), 4196-4204. [More Information]
  • Beija, M., Li, Y., Duong, H., laurent, S., Elst, L., Muller, R., Davis, T., Boyer, C., Lowe, A. (2012). Polymer-gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes. Journal of Materials Chemistry, 22(40), 21382-21386. [More Information]
  • Lui, J., Duong, H., Whittaker, M., Davis, T., Boyer, C. (2012). Synthesis of functional core, star polymers via RAFT polymerization for drug delivery applications. Macromolecular Rapid Communications, 33(9), 760-766. [More Information]
  • Duong, H., Huynh, V., de Souza, P., Stenzel, M. (2010). Core-cross-linked micelles synthesized by clicking bifunctional Pt(IV) anticancer drugs to isocyanates. Biomacromolecules, 11(9), 2290-2299. [More Information]

2019

  • Das, T., Choong, H., Kwang, Y., Chan, H., Manos, J., Kwok, P., Duong, H. (2019). Spray-Dried Particles of Nitric Oxide-Modified Glutathione for the Treatment of Chronic Lung Infection. Molecular Pharmaceutics, 16(4), 1723-1731. [More Information]

2018

  • Chen, Y., Duong, H., Wen, S., Mi, C., Zhou, Y., Shimoni, O., Valenzuela, S., Jin, D. (2018). Exonuclease III-Assisted Upconversion Resonance Energy Transfer in a Wash-Free Suspension DNA Assay. Analytical Chemistry, 90(1), 663-668. [More Information]
  • Duong, H., Nguyen, D., Neto, C., Hawkett, B. (2018). Synthesis and applications of polymeric Janus nanoparticles. In Zhiqun Lin and Bo Li (Eds.), Soft, hard, and hybrid Janus Structures: Synthesis, Self-Assembly, and Applications, (pp. 31-68). London: World Scientific Publishing. [More Information]

2017

  • Pelras, T., Duong, H., Kim, B., Hawkett, B., Muellner, M. (2017). A 'grafting from' approach to polymer nanorods for pH-triggered intracellular drug delivery. Polymer, 112, 244-251. [More Information]
  • Hinde, E., Thammasiraphop, K., Duong, H., Yeow, J., Karagoz, B., Boyer, C., Gooding, J., Gaus, K. (2017). Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release. Nature Nanotechnology, 12(81), 89. [More Information]

2016

  • Nguyen, T., Selvanayagam, R., Ho, K., Chen, R., Kutty, S., Rice, S., Kumar, N., Barraud, N., Duong, H., Boyer, C. (2016). Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles. Chemical Science, 7(2), 1016-1027. [More Information]
  • Adnan, N., Cheng, Y., Ong, N., Kamaruddin, T., Rozlan, E., Schmidt, T., Duong, H., Boyer, C. (2016). Effect of gold nanoparticle shapes for phototherapy and drug delivery. Polymer Chemistry, 7(16), 2888-2903. [More Information]
  • Fu, C., Bongers, A., Wang, K., Yang, B., Zhao, Y., Wu, H., Wei, Y., Duong, H., Wang, Z., Tao, L. (2016). Facile synthesis of a multifunctional copolymer via a concurrent RAFT-enzymatic system for theranostic applications. Polymer Chemistry, 7(3), 546-552. [More Information]

2015

  • Duong, H. (2015). Biomimetic polymers responsive to a biological signaling molecule: Nitric oxide (NO) triggered reversible self-assembly of single macromolecular chains into nanoparticles. Journal of Controlled Release, 213, e55-e56. [More Information]
  • Kurniawansyah, F., Duong, H., Danh, L., Mammucari, R., Vittorio, O., Boyer, C., Foster, N. (2015). Inhalable curcumin formulations: Micronization and bioassay. Chemical Engineering Journal, 279, 799-808. [More Information]
  • Nguyen, T., Duong, H., Selvanayagam, R., Boyer, C., Barraud, N. (2015). Iron oxide nanoparticle-mediated hyperthermia stimulates dispersal in bacterial biofilms and enhances antibiotic efficcya. Scientific Reports, 5, 1-15. [More Information]
  • Li, Y., Duong, H., Laurent, S., Macmillan, A., Whan, R., Elst, L., Muller, R., Hu, J., Lowe, A., Boyer, C., et al (2015). Nanoparticles based on star polymers as theranostic vectors: endosomal-triggered drug release combined with mri sensitivity. Advanced Healthcare Materials, 4(1), 148-156. [More Information]
  • Xu, J., Shanmugam, S., Duong, H., Boyer, C. (2015). Organo-photocatalysts for photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization. Polymer Chemistry, 6(31), 5615-5624. [More Information]
  • Le-Masurier, S., Duong, H., Boyer, C., Granville, A. (2015). Surface modification of polydopamine coated particles via glycopolymer brush synthesis for protein binding and FLIM testing. Polymer Chemistry, 6(13), 2504-2511. [More Information]
  • Duong, H., Dong, Z., Su, L., Boyer, C., George, J., Davis, T., Wang, J. (2015). The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension. Small, 11(19), 2291-2304. [More Information]

2014

  • Hu, J., Whittaker, M., Duong, H., Li, Y., Boyer, C., Davis, T. (2014). Biomimetic polymers responsive to a biological signaling molecule: nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles. Angewandte Chemie - International Edition, 53(30), 7779-7784. [More Information]
  • Sagnella, S., Duong, H., Macmillan, A., Boyer, C., Whan, R., McCarroll, J., Davis, T., Kavallaris, M. (2014). Dextran-based doxorubicin nanocarriers with improved tumor penetration. Biomacromolecules, 15(1), 262-275. [More Information]
  • Duong, H., Adnan, N., Barraud, N., Basuki, J., Kutty, S., Jung, K., Kumar, N., Davis, T., Boyer, C. (2014). Functional gold nanoparticles for the storage and controlled release of nitric oxide: applications in biofilm dispersal and intracellular delivery. Journal of Materials Chemistry B, 2(31), 5003-5011. [More Information]
  • Basuki, J., Esser, L., Duong, H., Zhang, Q., Wilson, P., Whittaker, M., Haddleton, D., Boyer, C., Davis, T. (2014). Magnetic nanoparticles with diblock glycopolymer shells give lectin concentration-dependent MRI signals and selective cell uptake. Chemical Science, 5(2), 715-726. [More Information]
  • Duong, H., Jung, K., Kutty, S., Augustina, S., Adnan, N., Basuki, J., Kumar, N., Davis, T., Barraud, N., Boyer, C. (2014). Nanoparticle (star polymer) delivery of nitric oxide effectively negates pseudomonas aeruginosa biofilm formation. Biomacromolecules, 15(7), 2583-2589. [More Information]
  • Duong, H., Ho, A., Davis, T., Boyer, C. (2014). Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide. Journal of Polymer Science, Part A: Polymer Chemistry, 52(15), 2099-2103. [More Information]
  • Karagoz, B., Esser, L., Duong, H., Basuki, J., Boyer, C., Davis, T. (2014). Polymerization-Induced Self-Assembly (PISA) - control over the morphology of nanoparticles for drug delivery applications. Polymer Chemistry, 5(2), 350-355. [More Information]

2013

  • Boyer, C., Teo, J., Phillips, P., Erlich, R., Sagnella, S., Sharbeen, G., Dwarte, T., Duong, H., Goldstein, D., Davis, T., et al (2013). Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers. Molecular Pharmaceutics, 10(6), 2435-2444. [More Information]
  • Scarano, W., Duong, H., Lu, H., de Souza, P., Stenzel, M. (2013). Folate conjugation to polymeric micelles via boronic acid ester to deliver platinum drugs to ovarian cancer cell lines. Biomacromolecules, 14(4), 962-975. [More Information]
  • N'Guyen, T., Duong, H., Basuki, J., Montembault, V., Pascual, S., Guibert, C., Fresnais, J., Boyer, C., Davis, T., Fontaine, L. (2013). Functional iron oxide magnetic nanoparticles with hyperthermia-induced drug release ability by using a combination of orthogonal click reactions. Angewandte Chemie - International Edition, 52(52), 14152-14156. [More Information]
  • Duong, H., Kamarudin, Z., Erlich, R., Li, Y., Jones, M., Kavallaris, M., Boyer, C., Davis, T. (2013). Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers. Chemical Communications, 49(39), 4190-4192. [More Information]
  • Basuki, J., Duong, H., Macmillan, A., Whan, R., Boyer, C., Davis, T. (2013). Polymer-grafted, nonfouling, magnetic nanoparticles designed to selectively store and release molecules via ionic interactions. Macromolecules, 46(17), 7043-7054. [More Information]
  • Li, Y., Duong, H., Jones, M., Basuki, J., Hu, J., Boyer, C., Davis, T. (2013). Selective postmodification of copolymer backbones bearing different activated esters with disparate reactivities. ACS Macro Letters, 2(10), 912-917. [More Information]
  • Basuki, J., Duong, H., Macmillan, A., Erlich, R., Esser, L., Akerfeldt, M., Whan, R., Kavallaris, M., Boyer, C., Davis, T. (2013). Using fluorescence lifetime imaging microscopy to monitor theranostic nanoparticle uptake and intracellular doxorubicin release. ACS Nano, 7(11), 10175-10189. [More Information]

2012

  • Duong, H., Hughes, F., Sagnella, S., Kavallaris, M., Macmillan, A., Whan, R., Hook, J., Davis, T., Boyer, C. (2012). Functionalizing biodegradable dextran scaffolds using living radical polymerization: new versatile nanoparticles for the delivery of therapeutic molecules. Molecular Pharmaceutics, 9(11), 3046-3061. [More Information]
  • Li, Y., Beija, M., laurent, S., Elst, L., Duong, H., Lowe, A., Davis, T., Boyer, C., Muller, R. (2012). Macromolecular ligands for gadolinium mri contrast agents. Macromolecules, 45(10), 4196-4204. [More Information]
  • Beija, M., Li, Y., Duong, H., laurent, S., Elst, L., Muller, R., Davis, T., Boyer, C., Lowe, A. (2012). Polymer-gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes. Journal of Materials Chemistry, 22(40), 21382-21386. [More Information]
  • Lui, J., Duong, H., Whittaker, M., Davis, T., Boyer, C. (2012). Synthesis of functional core, star polymers via RAFT polymerization for drug delivery applications. Macromolecular Rapid Communications, 33(9), 760-766. [More Information]

2010

  • Duong, H., Huynh, V., de Souza, P., Stenzel, M. (2010). Core-cross-linked micelles synthesized by clicking bifunctional Pt(IV) anticancer drugs to isocyanates. Biomacromolecules, 11(9), 2290-2299. [More Information]

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