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Professor Iqbal Ramzan

Dean

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone EA to the Dean: + 61 2 9351 2831
Fax + 61 2 9351 6950

Biographical details

Professor Ramzan completed his Pharmacy training in New Zealand and his research degrees at The University of Sydney obtaining his MSc and PhD specialising in Drug Pharmacokinetics and Pharmacodynamics.

Professor Ramzan spent five years at the State University of New York, Buffalo where he carried out postdoctoral training with Distinguished Professor Gerhard Levy. He also held Faculty appointment at the same institution and was Assistant Professor of Pharmaceutical Sciences at the University of Pittsburgh. Professor Ramzan returned to Australia in 1988 where he has held academic positions as Lecturer, Senior Lecturer, Associate Professor and Professor before being formally appointed Dean of the Faculty of Pharmacy in 2008.
Professor Ramzan is an author/co-author of 100 scientific publications in the areas of pharmacokinetics, pharmacodynamics, drug metabolism and drug toxicity. In addition to his role as Dean of Pharmacy, he is a PhD examiner, reviewer for peer reviewed journals and continues to supervise graduate students. Professor Ramzan is a registered pharmacist and holds a Diploma of the Australian Institute of Company Directors.
Professor Ramzan also served two terms as a Fellow of The University of Sydney Senate.

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Research interests

  • Pharmacokinetics and pharmacodynamics of drugs with particular interest in drug pharmacogenetics.
  • Pharmacological and adverse effects of herbal medicines.

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Associations

  • Member of the Executive Committee of the Council of Pharmacy Schools (Aus & NZ)
  • Member of the Advisory Committee on Prescription Medicines (ACPM) Pharmaceutical Subcommittee
  • Board Member of the Asian Association of Schools of Pharmacy

Previous roles include:

  • President of the Asian Association of Schools of Pharmacy
  • Chair of the University of Sydney's Animal Ethics Committee
  • Member of the NSW Animal Research Review Panel
  • Member of the NSW Poisons Advisory Committee

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Selected grants

2011

  • Scanning Ion Conductance Microscope (SICM); Ramzan I; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2010

  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal (, Fleming S, Murphy C, Grau G, Weninger W, dos Remedios C, Wimmer-Kleikamp S, Stevens-Kalceff M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation; Jones A, Zhou H, Cairney J, Einav I, Swain M, Murphy C, Seibel M, Ringer S, Li Q, Darendeliler M, Wang X, Zhang Y, Hand S, Archer M, Ramzan I, Young P, Traini D, Richardson D, Masters A; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2008

  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials and Medical Research; Lay P, McNaughton D, Maschmeyer T, Potts D, Swain M, Grau G, Sorrell T, Ramzan I, Beardall J, Bernard C, Marshall C, Dutkiewicz A, Penny D, Wood B, Yang W, Soon L, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • High Resolution Field Emission Scanning Electron Microscopy (FESEM) Platform for Characterisation at; Ringer S, Barton G, Ramzan I, Copeland L, Potts D, Braet F, Grillet C, Lay P, Murphy C, Cairney J, Ferry M, Eggleton B, McKenzie D, Masters A, Parker A, Overall R, Weiss A, Ruys A, Sorrell C, Ye L, Harris A, Ranzi G; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • High-Resolution Field Emission Scanning Electron Microscopy (FESEM) Platform for Characterisation at the Nanometre-Level; Cairney J, Ringer S, Braet F, Ferry M, Sorrell C, Ye L, Ruys A, Barton G, Harris A, Ranzi G, Eggleton B, Grillet C, Mckenzie D, Lay P, Masters A, Parker A, Overall R, Weiss A, Murphy C, Ramzan I, Copeland L, Potts D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological Materials, and Medical Research; Bernard C, Marshall C, Wood B, Potts D, Penny D, Dutkiewicz A, Grau G, Sorrell T, Swain M, Yang W, Soon L, Lay P, McNaughton D, Maschmeyer T, Ramzan I, Beardall J, Traini D, Carter E; Australian Research Council (ARC)/LIEF.

2007

  • High-resolution electron tomographic facility for nanoanlytical characterization in the material an; Braet F, Ramzan I, Ringer S, Soon L, Liu Z, Hambley T, Lay P, Warr G, Thordarson P, Murphy C, dos Remedios C, Weiss A, Parker A; Australian Research Council (ARC)/LIEF.

2006

  • Phenotyping of CYP enzymes - Development of the "Sydney Cocktail"; Chetty M, Ramzan I; Rebecca Cooper Medical Research Foundation/Rebecca Cooper Medical Research Foundation.

2004

  • Impact of human cytochrome P450 3A allelic variants on the toxicity of docetaxel and irinotecan; Clarke S, Ramzan I, Murray M; University of Sydney/Cancer Research Fund.
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Selected publications

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Book Chapters

  • McLachlan, A., Ramzan, I. (2010). Misuse of Formulations in the Aged Care Setting. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 95-104). New York: Springer Science + Business Media.
  • Witkam, L., Maat, B., Ramzan, I. (2008). Ginkgo biloba in Alzheimer's Disease: Bilobalide as an Acetylcholinesterase Inhibitor? In V. K. Singh & J. N. Govil (Eds.), Recent Progress in Medicinal Plants, Phytopharmacology and Therapeutic Values III, (pp. 411-413). United States: Studium Press, LLC.
  • Ramzan, I., Fu, S., Cohn, G. (2008). Kava in the treatment of alcoholism and other diseases. In R. Watson and V. Preedy (Eds.), Botanical Medicine in Clinical Practice, (pp. 709-715). United Kingdom: CAB international.
  • Ramzan, I., Tran, V. (2004). Chemistry Of Kava And Kavalactones. In Y. N. Singh (Eds.), Kava from Ethnology to Pharmacology, (pp. 76-103). Boca Raton, Fla. ; London: CRC Press.

Journals

  • Fu, S., Rowe, A., Ramzan, I. (2012). Kavalactone metabolism in rat liver microsomes. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 26(7), 1057-1061.
  • Fu, S., Rowe, A., Ramzan, I. (2012). Kavalactone Metabolism in the Isolated Perfused Rat Liver. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 26(12), 1813-1816.
  • Zhang, L., Rowe, A., Braet, F., Ramzan, I. (2012). Macrophage depletion ameliorates kavalactone damage in the isolated perfused rat liver. The Journal of Toxicological Sciences, 37(2), 447-453.
  • Tan, A., Konczak, I., Ramzan, I., Sze, D. (2011). Antioxidant and cytoprotective activities of native Australian fruit polyphenols. Food Research International, 44(7), 2034-2040.
  • Rowe, A., Zhang, L., Hussain, A., Braet, F., Ramzan, I. (2011). Assessment and histological analysis of the IPRL technique for sequential in situ liver biopsy. Comparative Hepatology, 10, 7-1-7-7.
  • Rowe, A., Narlawar, R., Groundwater, P., Ramzan, I. (2011). Kavalactone Pharmacophores for Major Cellular Drug Targets. Mini - Reviews in Medicinal Chemistry, 11(1), 79-83.
  • Tang, J., Dunlop, R., Rowe, A., Rodgers, K., Ramzan, I. (2011). Kavalactones Yangonin and Methysticin Induce Apoptosis in Human Hepatocytes (HepG2) In Vitro. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 25, 417-423.
  • Tan, A., Konczak, I., Sze, D., Ramzan, I. (2011). Molecular pathways for cancer chemoprevention by dietary phytochemicals. Nutrition and Cancer: an international journal, 63(4), 495-505.
  • Tan, A., Konczak, I., Ramzan, I., Sze, D. (2011). Native Australian Fruit Polyphenols Inhibit Cell Viability and Induce Apoptosis in Human Cancer Cell Lines. Nutrition and Cancer: an international journal, 63(3), 444-455.
  • Tan, A., Hou, D., Konczak, I., Tanigawa, S., Ramzan, I., Sze, D. (2011). Native Australian fruit polyphenols inhibit COX-2 and iNOS expression in LPS-activated murine macrophages. Food Research International, 44(7), 2362-2367.
  • Tan, A., Konczak, I., Ramzan, I., Zabaras, D., Sze, D. (2011). Potential Antioxidant, Antiinflammatory, and Proapoptotic Anticancer Activities of Kakadu Plum and Illawarra Plum Polyphenolic Fractions. Nutrition and Cancer: an international journal, 63(7), 1074-1084.
  • Rowe, A., Zhang, L., Ramzan, I. (2011). Toxicokinetics of Kava. Advances in Pharmacological Sciences, 2011 (Article ID 326724), 326724-1-326724-6.
  • Zhang, L., Rowe, A., Ramzan, I. (2010). Does inflammation play a role in kava hepatotoxicity? Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 25, 629-30.
  • Weekes, L., Ramzan, I. (2010). Generic medicines--how confident should we be? Pacific Health Dialog: a publication of the Pacific Basin Officers Training Program and the Fiji School of Medicine, 16(2), 109-111.
  • Ghassabian, S., Chetty, M., Tattam, B., Glen, J., Rahme, J., Stankovic, Z., Ramzan, I., Murray, M., McLachlan, A. (2010). The participation of cytochrome P450 3A4 in clozapine biotransformation is detected in people with schizophrenia by high-throughput in vivo phenotyping. Journal of Clinical Psychopharmacology, 30(5), 629-631.
  • Tan, A., Konczak, I., Sze, D., Ramzan, I. (2010). Towards the discovery of novel phytochemicals for disease prevention from native Australian plants: an ethnobotanical approach. Asia Pacific Journal of Clinical Nutrition, 19(3), 330-334.
  • Ghassabian, S., Chetty, M., Tattam, B., Glen, J., Rahme, J., Stankovic, Z., Ramzan, I., Murray, M., McLachlan, A. (2009). A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients. Therapeutic Drug Monitoring, 31(2), 239-246.
  • Fois, R., Mewes, B., McLachlan, A., Ramzan, I. (2009). Compounded medicines and 'off label' prescribing - A case for more guidance. Australian Family Physician, 38(1/2), 16-20.
  • Fu, S., Tattam, B., Duke, C., Ramzan, I. (2009). High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites. Biomedical Chromatography, 23(1), 81-91.
  • Chetty, M., D'Esposito, F., Zhang, W., Glen, J., Dore, G., Stankovic, Z., Edwards, R., Ramzan, I., Murray, M. (2009). In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. British Journal of Clinical Pharmacology, 68(4), 574-579.
  • Li, X., Ramzan, I. (2009). Role of Ethanol in Kava Hepatotoxicity. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 24(4), 475-480.
  • D'Esposito, F., Tattam, B., Ramzan, I., Murray, M. (2008). A liquid chromatography/electrospray ionization mass spectrometry (LC-MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 875(2), 522-530.
  • Fu, S., Korkmaz, E., Braet, F., Ngo, Q., Ramzan, I. (2008). Influence of kavain on hepatic ultrastructure. World Journal of Gastroenterology, 14(4), 541-546.
  • Zhang, W., D'Esposito, F., Edwards, R., Ramzan, I., Murray, M. (2008). Interindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic Microsomes. Drug Metabolism and Disposition, 36(12), 2547-2555.
  • McLachlan, A., Ramzan, I., Milne, R. (2007). Frequently asked questions about generic medicines. Australian Prescriber, 30(2), 41-43.
  • Zhang, W., Ramzan, I., Murray, M. (2007). Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis. Journal of Pharmacology and Experimental Therapeutics, 322(2), 770-777.
  • Obligacion, R., Murray, M., Ramzan, I. (2006). Drug-Metabolizing Enzymes and Review Transporters: Expression in the Human Prostate and Roles in Prostate Drug Disposition. Journal Of Andrology, 27(2), 138-150.
  • Anke, J., Fu, S., Ramzan, I. (2006). Kavalactones fail to inhibit alcohol dehydrogenase in vitro. Phytomedicine, 13(3), 192-195.
  • McLachlan, A., Ramzan, I. (2006). Meals and Medicines. Australian Prescriber, 29(2), 40-42.
  • Ramzan, I., McLachlan, A. (2005). Anti-epileptics switching problem?. But where is the evidence? Australian Journal of Pharmacy, 86, 772-820.
  • Ramzan, I., McLachlan, A. (2005). Generic arguments. Australian Pharmacist, 24, 501-502.
  • Hong, Y., Ramzan, I., McLachlan, A. (2005). Hepatobiliary disposition of liposomal amphotericin B in the isolated perfused rat liver. Journal of Pharmaceutical Sciences, 94(1), 169-176.
  • Pearce, G., McLachlan, A., Ramzan, I. (2004). Bioequivalence: How, Why and What Does it Really Mean? Journal of Pharmacy Practice and Research, 34(3), 195-200.
  • Hong, Y., Ramzan, I., McLachlan, A. (2004). Disposition Of Amphotericin B In The Isolated Perfused Rat Liver. Journal of Pharmacy and Pharmacology, 56(1), 35-41.
  • Rana, J., Ramzan, I., Baker, A. (2004). Droperidol Concentrations At Onset Of Catalepsy In Rats. Die Pharmazie: an international journal of pharmaceutical sciences, 59(3), 235-236.
  • Anke, J., Ramzan, I. (2004). Kava Hepatotoxicity: Are We Any Closer To The Truth? Planta Medica: natural products and medicinal plant research, 70(3), 193-196.
  • O'Halloran, P., Hosseini Yeganeh, M., McBride, L., Ramzan, I. (2004). Onset And Offset Pharmacodynamics Of Propofol. Die Pharmazie: an international journal of pharmaceutical sciences, 59(1), 76-77.
  • Anke, J., Ramzan, I. (2004). Pharmacokinetic And Pharmacodynamic Drug Interactions With Kava (Piper Methysticum Forst. F.). Journal of Ethnopharmacology, 93(2-3), 153-160.
  • Mequid, S., Ramzan, I. (2004). Serum Cholinesterase Inhibition By Omeprazole And Lansoprazole. Die Pharmazie: an international journal of pharmaceutical sciences, 59(9), 733-733.
  • Krabesri, S., Ramzan, I., Brandom, B. (2003). Interaction of Mivacurium with Vecuronium or Succinylcholine: Isobolographic Analysis. Thai Journal of Pharmacology, 11, 191-192.
  • Gao, L., Ramzan, I., Baker, A. (2003). Recuronium infusion requirements and plasma concentrations at constant levels of neuromuscular paralysis during three phases of liver transplantation. Journal Of Clinical Anesthesia, 15(4), 257-266.
  • Law, J., Ramzan, I. (2003). Serum cholinesterase activity in spontaneously hypertensive rats. Thai Journal of Pharmacology, 11, 189-190.
  • Sasongko, L., Ramzan, I., Williams, K., McLachlan, A. (2002). Muscle distribution of the neuromuscular blocker gallami using microdialysis. Journal of Pharmaceutical Sciences, 91(3), 769-775.
  • Hosseini Yeganeh, M., Ramzan, I. (2002). Pharmacokinetics of H2-Antagonists during propofol or thiopentone anaesthesia in rats. Indian Journal of Pharmacology, 34(1), 56-58.
  • Gao, L., Ramzan, I., Baker, B. (2002). Rocuronium plasma concentrations during three phases of liver transplantation: relationship with early postoperative graft liver function. British Journal of Anaesthesia, 88(6), 764-770.
  • Sasongko, L., Ramzan, I., McLachlan, A., Williams, K. (2001). Application of a high-performance liquid chromatographic assay for the neuromuscular blocker gallamine to analysis of rat plasma, muscle and microdialysate samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 754, 467-475.
  • Gao, L., Ramzan, I., Baker, A. (2001). Gas chromatographic-mass spectrometric assay for rocuronium with potential for quantifying its metabolite, 17-desacetylrocuronium, in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 757, 207-214.
  • Ramzan, I., Baker, A., Rana, J. (2001). In vitro neuromuscular effects of droperidol in rats. Die Pharmazie: an international journal of pharmaceutical sciences, 56, 4-4.
  • Gao, L., Ramzan, I., Baker, A. (2001). Neuromuscular paralysis as a pharmacodynamic probe to assess organ function during liver transplantation. Journal Of Clinical Anesthesia, 12, 615-620.

Conferences

  • Murray, M., Zhang, W., Duke, C., Ramzan, I. (2006). Accumulation of esterified polyunsaturated fatty acids in hepatic steatosis impairs microsomal clozapine oxidation. Australian Health and Medical Research Congress, Melbourne: Australian Health and Medical Research Congress.
  • D'Esposito, F., Tattam, B., Ramzan, I., Murray, M. (2006). Development of a high throughput LC/MS/MS method for the determination of the anticancer agent irinotecan and its two major metabolites. Australian Health and Medical Research Congress, Melbourne: Australian Health and Medical Research Congress.
  • Murray, M., Zhang, W., Ramzan, I. (2006). HEPATIC LIPID ACCUMULATION IN EXPERIMENTAL STEATOSIS INFLUENCES MICROSOMAL CLOZAPINE OXIDATION CAPACITY.
  • Murray, M., Zhang, W., Ramzan, I. (2006). Hepatic lipid accumulation in experimental steatosis influences microsomal clozapine oxidation capacity. 14th North American ISSX (International Society for the Study of Xenobiotics) Meeting, United States: Informa Healthcare.
  • Garlapati, R., Ramzan, I. (2001). Degradation of succinylcholine (SCh, suxamethonium) in human plasma. Australasian Society of Clinical nd Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, : World Scientific Publishing.
  • Basha, Z., Ramzan, I. (2001). Efficiency of plasma pseudo-cholinesterase inhibition by anti-cholinesterase agents. Australasian Society of Clinical nd Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, : World Scientific Publishing.
  • Digges, P., Ramzan, I. (2001). Metabolism of fluticasone propionate (FP) in subcellular (S-I) fraction of rat lung tissue. APSA, : World Scientific Publishing.

2012

  • Fu, S., Rowe, A., Ramzan, I. (2012). Kavalactone metabolism in rat liver microsomes. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 26(7), 1057-1061.
  • Fu, S., Rowe, A., Ramzan, I. (2012). Kavalactone Metabolism in the Isolated Perfused Rat Liver. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 26(12), 1813-1816.
  • Zhang, L., Rowe, A., Braet, F., Ramzan, I. (2012). Macrophage depletion ameliorates kavalactone damage in the isolated perfused rat liver. The Journal of Toxicological Sciences, 37(2), 447-453.

2011

  • Tan, A., Konczak, I., Ramzan, I., Sze, D. (2011). Antioxidant and cytoprotective activities of native Australian fruit polyphenols. Food Research International, 44(7), 2034-2040.
  • Rowe, A., Zhang, L., Hussain, A., Braet, F., Ramzan, I. (2011). Assessment and histological analysis of the IPRL technique for sequential in situ liver biopsy. Comparative Hepatology, 10, 7-1-7-7.
  • Rowe, A., Narlawar, R., Groundwater, P., Ramzan, I. (2011). Kavalactone Pharmacophores for Major Cellular Drug Targets. Mini - Reviews in Medicinal Chemistry, 11(1), 79-83.
  • Tang, J., Dunlop, R., Rowe, A., Rodgers, K., Ramzan, I. (2011). Kavalactones Yangonin and Methysticin Induce Apoptosis in Human Hepatocytes (HepG2) In Vitro. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 25, 417-423.
  • Tan, A., Konczak, I., Sze, D., Ramzan, I. (2011). Molecular pathways for cancer chemoprevention by dietary phytochemicals. Nutrition and Cancer: an international journal, 63(4), 495-505.
  • Tan, A., Konczak, I., Ramzan, I., Sze, D. (2011). Native Australian Fruit Polyphenols Inhibit Cell Viability and Induce Apoptosis in Human Cancer Cell Lines. Nutrition and Cancer: an international journal, 63(3), 444-455.
  • Tan, A., Hou, D., Konczak, I., Tanigawa, S., Ramzan, I., Sze, D. (2011). Native Australian fruit polyphenols inhibit COX-2 and iNOS expression in LPS-activated murine macrophages. Food Research International, 44(7), 2362-2367.
  • Tan, A., Konczak, I., Ramzan, I., Zabaras, D., Sze, D. (2011). Potential Antioxidant, Antiinflammatory, and Proapoptotic Anticancer Activities of Kakadu Plum and Illawarra Plum Polyphenolic Fractions. Nutrition and Cancer: an international journal, 63(7), 1074-1084.
  • Rowe, A., Zhang, L., Ramzan, I. (2011). Toxicokinetics of Kava. Advances in Pharmacological Sciences, 2011 (Article ID 326724), 326724-1-326724-6.

2010

  • Zhang, L., Rowe, A., Ramzan, I. (2010). Does inflammation play a role in kava hepatotoxicity? Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 25, 629-30.
  • Weekes, L., Ramzan, I. (2010). Generic medicines--how confident should we be? Pacific Health Dialog: a publication of the Pacific Basin Officers Training Program and the Fiji School of Medicine, 16(2), 109-111.
  • McLachlan, A., Ramzan, I. (2010). Misuse of Formulations in the Aged Care Setting. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 95-104). New York: Springer Science + Business Media.
  • Ghassabian, S., Chetty, M., Tattam, B., Glen, J., Rahme, J., Stankovic, Z., Ramzan, I., Murray, M., McLachlan, A. (2010). The participation of cytochrome P450 3A4 in clozapine biotransformation is detected in people with schizophrenia by high-throughput in vivo phenotyping. Journal of Clinical Psychopharmacology, 30(5), 629-631.
  • Tan, A., Konczak, I., Sze, D., Ramzan, I. (2010). Towards the discovery of novel phytochemicals for disease prevention from native Australian plants: an ethnobotanical approach. Asia Pacific Journal of Clinical Nutrition, 19(3), 330-334.

2009

  • Ghassabian, S., Chetty, M., Tattam, B., Glen, J., Rahme, J., Stankovic, Z., Ramzan, I., Murray, M., McLachlan, A. (2009). A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients. Therapeutic Drug Monitoring, 31(2), 239-246.
  • Fois, R., Mewes, B., McLachlan, A., Ramzan, I. (2009). Compounded medicines and 'off label' prescribing - A case for more guidance. Australian Family Physician, 38(1/2), 16-20.
  • Fu, S., Tattam, B., Duke, C., Ramzan, I. (2009). High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites. Biomedical Chromatography, 23(1), 81-91.
  • Chetty, M., D'Esposito, F., Zhang, W., Glen, J., Dore, G., Stankovic, Z., Edwards, R., Ramzan, I., Murray, M. (2009). In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. British Journal of Clinical Pharmacology, 68(4), 574-579.
  • Li, X., Ramzan, I. (2009). Role of Ethanol in Kava Hepatotoxicity. Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, 24(4), 475-480.

2008

  • D'Esposito, F., Tattam, B., Ramzan, I., Murray, M. (2008). A liquid chromatography/electrospray ionization mass spectrometry (LC-MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 875(2), 522-530.
  • Witkam, L., Maat, B., Ramzan, I. (2008). Ginkgo biloba in Alzheimer's Disease: Bilobalide as an Acetylcholinesterase Inhibitor? In V. K. Singh & J. N. Govil (Eds.), Recent Progress in Medicinal Plants, Phytopharmacology and Therapeutic Values III, (pp. 411-413). United States: Studium Press, LLC.
  • Fu, S., Korkmaz, E., Braet, F., Ngo, Q., Ramzan, I. (2008). Influence of kavain on hepatic ultrastructure. World Journal of Gastroenterology, 14(4), 541-546.
  • Zhang, W., D'Esposito, F., Edwards, R., Ramzan, I., Murray, M. (2008). Interindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic Microsomes. Drug Metabolism and Disposition, 36(12), 2547-2555.
  • Ramzan, I., Fu, S., Cohn, G. (2008). Kava in the treatment of alcoholism and other diseases. In R. Watson and V. Preedy (Eds.), Botanical Medicine in Clinical Practice, (pp. 709-715). United Kingdom: CAB international.

2007

  • McLachlan, A., Ramzan, I., Milne, R. (2007). Frequently asked questions about generic medicines. Australian Prescriber, 30(2), 41-43.
  • Zhang, W., Ramzan, I., Murray, M. (2007). Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis. Journal of Pharmacology and Experimental Therapeutics, 322(2), 770-777.

2006

  • Murray, M., Zhang, W., Duke, C., Ramzan, I. (2006). Accumulation of esterified polyunsaturated fatty acids in hepatic steatosis impairs microsomal clozapine oxidation. Australian Health and Medical Research Congress, Melbourne: Australian Health and Medical Research Congress.
  • D'Esposito, F., Tattam, B., Ramzan, I., Murray, M. (2006). Development of a high throughput LC/MS/MS method for the determination of the anticancer agent irinotecan and its two major metabolites. Australian Health and Medical Research Congress, Melbourne: Australian Health and Medical Research Congress.
  • Obligacion, R., Murray, M., Ramzan, I. (2006). Drug-Metabolizing Enzymes and Review Transporters: Expression in the Human Prostate and Roles in Prostate Drug Disposition. Journal Of Andrology, 27(2), 138-150.
  • Murray, M., Zhang, W., Ramzan, I. (2006). HEPATIC LIPID ACCUMULATION IN EXPERIMENTAL STEATOSIS INFLUENCES MICROSOMAL CLOZAPINE OXIDATION CAPACITY.
  • Murray, M., Zhang, W., Ramzan, I. (2006). Hepatic lipid accumulation in experimental steatosis influences microsomal clozapine oxidation capacity. 14th North American ISSX (International Society for the Study of Xenobiotics) Meeting, United States: Informa Healthcare.
  • Anke, J., Fu, S., Ramzan, I. (2006). Kavalactones fail to inhibit alcohol dehydrogenase in vitro. Phytomedicine, 13(3), 192-195.
  • McLachlan, A., Ramzan, I. (2006). Meals and Medicines. Australian Prescriber, 29(2), 40-42.

2005

  • Ramzan, I., McLachlan, A. (2005). Anti-epileptics switching problem?. But where is the evidence? Australian Journal of Pharmacy, 86, 772-820.
  • Ramzan, I., McLachlan, A. (2005). Generic arguments. Australian Pharmacist, 24, 501-502.
  • Hong, Y., Ramzan, I., McLachlan, A. (2005). Hepatobiliary disposition of liposomal amphotericin B in the isolated perfused rat liver. Journal of Pharmaceutical Sciences, 94(1), 169-176.

2004

  • Pearce, G., McLachlan, A., Ramzan, I. (2004). Bioequivalence: How, Why and What Does it Really Mean? Journal of Pharmacy Practice and Research, 34(3), 195-200.
  • Ramzan, I., Tran, V. (2004). Chemistry Of Kava And Kavalactones. In Y. N. Singh (Eds.), Kava from Ethnology to Pharmacology, (pp. 76-103). Boca Raton, Fla. ; London: CRC Press.
  • Hong, Y., Ramzan, I., McLachlan, A. (2004). Disposition Of Amphotericin B In The Isolated Perfused Rat Liver. Journal of Pharmacy and Pharmacology, 56(1), 35-41.
  • Rana, J., Ramzan, I., Baker, A. (2004). Droperidol Concentrations At Onset Of Catalepsy In Rats. Die Pharmazie: an international journal of pharmaceutical sciences, 59(3), 235-236.
  • Anke, J., Ramzan, I. (2004). Kava Hepatotoxicity: Are We Any Closer To The Truth? Planta Medica: natural products and medicinal plant research, 70(3), 193-196.
  • O'Halloran, P., Hosseini Yeganeh, M., McBride, L., Ramzan, I. (2004). Onset And Offset Pharmacodynamics Of Propofol. Die Pharmazie: an international journal of pharmaceutical sciences, 59(1), 76-77.
  • Anke, J., Ramzan, I. (2004). Pharmacokinetic And Pharmacodynamic Drug Interactions With Kava (Piper Methysticum Forst. F.). Journal of Ethnopharmacology, 93(2-3), 153-160.
  • Mequid, S., Ramzan, I. (2004). Serum Cholinesterase Inhibition By Omeprazole And Lansoprazole. Die Pharmazie: an international journal of pharmaceutical sciences, 59(9), 733-733.

2003

  • Krabesri, S., Ramzan, I., Brandom, B. (2003). Interaction of Mivacurium with Vecuronium or Succinylcholine: Isobolographic Analysis. Thai Journal of Pharmacology, 11, 191-192.
  • Gao, L., Ramzan, I., Baker, A. (2003). Recuronium infusion requirements and plasma concentrations at constant levels of neuromuscular paralysis during three phases of liver transplantation. Journal Of Clinical Anesthesia, 15(4), 257-266.
  • Law, J., Ramzan, I. (2003). Serum cholinesterase activity in spontaneously hypertensive rats. Thai Journal of Pharmacology, 11, 189-190.

2002

  • Sasongko, L., Ramzan, I., Williams, K., McLachlan, A. (2002). Muscle distribution of the neuromuscular blocker gallami using microdialysis. Journal of Pharmaceutical Sciences, 91(3), 769-775.
  • Hosseini Yeganeh, M., Ramzan, I. (2002). Pharmacokinetics of H2-Antagonists during propofol or thiopentone anaesthesia in rats. Indian Journal of Pharmacology, 34(1), 56-58.
  • Gao, L., Ramzan, I., Baker, B. (2002). Rocuronium plasma concentrations during three phases of liver transplantation: relationship with early postoperative graft liver function. British Journal of Anaesthesia, 88(6), 764-770.

2001

  • Sasongko, L., Ramzan, I., McLachlan, A., Williams, K. (2001). Application of a high-performance liquid chromatographic assay for the neuromuscular blocker gallamine to analysis of rat plasma, muscle and microdialysate samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 754, 467-475.
  • Garlapati, R., Ramzan, I. (2001). Degradation of succinylcholine (SCh, suxamethonium) in human plasma. Australasian Society of Clinical nd Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, : World Scientific Publishing.
  • Basha, Z., Ramzan, I. (2001). Efficiency of plasma pseudo-cholinesterase inhibition by anti-cholinesterase agents. Australasian Society of Clinical nd Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, : World Scientific Publishing.
  • Gao, L., Ramzan, I., Baker, A. (2001). Gas chromatographic-mass spectrometric assay for rocuronium with potential for quantifying its metabolite, 17-desacetylrocuronium, in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 757, 207-214.
  • Ramzan, I., Baker, A., Rana, J. (2001). In vitro neuromuscular effects of droperidol in rats. Die Pharmazie: an international journal of pharmaceutical sciences, 56, 4-4.
  • Digges, P., Ramzan, I. (2001). Metabolism of fluticasone propionate (FP) in subcellular (S-I) fraction of rat lung tissue. APSA, : World Scientific Publishing.
  • Gao, L., Ramzan, I., Baker, A. (2001). Neuromuscular paralysis as a pharmacodynamic probe to assess organ function during liver transplantation. Journal Of Clinical Anesthesia, 12, 615-620.
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Keywords

Mental health

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