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Associate Professor Jane Hanrahan

BSc (Hons) PhD (Warwick) MRACI Grad Dip EdStudies (Higher Ed)
Associate Professor, Pharmaceutical Sciences

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 2078
Fax +61 2 9351 4391

Biographical details

Associate Jane Professor Hanrahan has a BSc (Hons) from the University of Sydney. Jane undertook her PhD from The University of Warwick (UK) as a Teaching Fellow from 1991-95. From 1996-97 she undertook postdoctoral research at the University of Cardiff (UK), returning to the University of Sydney in 1997 as a Postdoctoral Research Associate in the department of Pharmacology.

In 2002 Jane was appointed to a lectureship in the Faculty of Pharmacy at the University of Sydney, and promoted to Senior Lecturer in 2007 and Associate Professor in 2010. She is currently a member of the University of Sydney Academic Board, chair of the Academic Board Undergraduate Studies Committee and deputy Chair of the Student Appeals Body. In 2013 Jane was appointed to the Therapeutic Goods Administration Advisory Committee on Prescription Medicines.

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Research interests

Associate Professor Hanrahan's research interests focuses on the understanding the role of GABA receptors in anxiety, sleep disorders, schizophrenia, epilepsy and learning and memory, including:

  • Design and synthesis of conformationally restrained GABA analogues
  • Developing molecules that allosterically modulate GABA receptor function
  • Identifying and characterising natural products from traditional herbal medicines

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Selected grants

2013

  • Allosteric Targets on GABA-A Receptors; Hanrahan J, Johnston G, Collins (Chebib) M; National Health and Medical Research Council/Project Grants.

2011

  • Factors influencing pharmacy services in opiod substitution programs; Day C, Chaar B, Fois R, Hanrahan J; Health Administration Corporation/Research Support.

2009

  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins (Chebib) M, Johnston G, Young P, Traini D; National Health and Medical Research Council/Equipment Grants.
  • The GABAergic system in eye growth control and myopia; Schmid K, Collins (Chebib) M, Hanrahan J; National Health and Medical Research Council/Project Grants.

2006

  • GABA c receptor antagonists as agents tor the treatment of memory disorders and myopia.; Hanrahan J, Kaufman G, Serry L; Neuro Therapeutics Ltd/BLO Project.
  • Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser; Lay P, Kable S, Downard K, Johnston G, Hanrahan J, Fisher K, Maschmeyer T, Karuso P, Gore D, McLeod M, Jolliffe K; Australian Research Council (ARC)/LIEF.
  • GABA modulators for the treatment of anxiety, epilepsy and insomnia; Johnston G, Hanrahan J, Collins (Chebib) M, Mewett K; NHMRC/Project.

2004

  • Molecular and Materials Structure Network; Turner P, Kepert C, Collins (Chebib) M, Hambley T, Hanrahan J, Kennedy B, Lay P; Australian Research Council (ARC)/Research Networks (ARCRN).

2003

  • GABAC receptors and GABA release in the thalmus; Hanrahan J; University of Sydney (Sesqui)/New Staff Support Scheme.
  • Constrained analogs of Gabapentin and Pregabalin; Collins (Chebib) M, O'Connor S, Hanrahan J, Johnston G; Pfizer Pty Ltd/BLO Project.

2002

  • Synthesis, testing and development of GABA-C antagonists, including cyclopentene phosphinates; Johnston G, Kaufman G, Serry L, Sharp S, Hanrahan J, Collins (Chebib) M; Polychip Pharmaceuticals Pty.Ltd./BLO Project.
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Selected publications

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Book Chapters

  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, Andrew B~ (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Johnston, G., Hanrahan, J., Collins (Chebib), M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier.

Journals

  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins (Chebib), M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896.
  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581.
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673.
  • Nguyen, T., Howard, S., Hanrahan, J., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and Theoretical Charge Density Distribution in a Host-Guest System: Synthetic Terephthaloyl Receptor Complexed to Adipic Acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116, 5618-5628.
  • Mohammad, A., Hanrahan, J., Sainsbury, E., Chaar, B. (2012). Fitness to practise in pharmacy: a study of impairment in professional practice. International Journal of Clinical Pharmacy, 34(2), 330-341.
  • Fernandez, S., Karim, N., Mewett, K., Collins (Chebib), M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977.
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557.
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins (Chebib), M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301.
  • Hanrahan, J. (2012). Sunscreens. Australian Prescriber, 35(5), 148-151.
  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983.
  • Chaar, B., Brien, J., Hanrahan, J., McLachlan, A., Penm, J., Pont, L. (2011). Experimental Education in Australian Pharmacy: Preceptors' Perspectives. Pharmacy Education, 11(1), 166-171.
  • Hanrahan, J., Collins (Chebib), M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245.
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346.
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209.
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033.
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2, 11-16.
  • Chaar, B., Hanrahan, J., Day, C. (2011). Provision of Opioid Substitution Therapy Services in Australian Pharmacies. The Australasian Medical Journal, 4(4), 210-216.
  • Nasrallah, F., Maher, A., Hanrahan, J., Balcar, V., Rae, C. (2010). Gamma-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. Journal of Neurochemistry, 115(1), 58-67.
  • Gavande, N., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136.
  • Johnston, G., Collins (Chebib), M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977.
  • Matin, A., Gavande, N., Kim, M., Yang, N., Salam, N., Hanrahan, J., Roubin, R., Hibbs, D. (2009). 7-Hydroxy-benzopyran-4-one Derivatives: A Novel Pharmacophore of Peroxisome Proliferator-Activated Receptor and - (PPAR and ) Dual Agonists. Journal of Medicinal Chemistry, 52(21), 6835-6850.
  • Ryan, G., Hanrahan, J., Krass, I., Sainsbury, E., Smith, L. (2009). Best Practices Assessment to Guide Curricular Change in a Bachelor of Pharmacy Program. American Journal of Pharmaceutical Education, 73(1), 1-8.
  • Meng, Q., Niu, Y., Niu, X., Roubin, R., Hanrahan, J. (2009). Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine. Journal of Ethnopharmacology, 124(3), 350-368.
  • Collins (Chebib), M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711.
  • Collins (Chebib), M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457.
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins (Chebib), M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology, 17(20), 7156-7173.
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875.
  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins (Chebib), M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327.
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins (Chebib), M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907.
  • Kumar, R., Collins (Chebib), M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840.
  • Collins (Chebib), M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787.
  • Hanrahan, J., Mewett, K., Collins (Chebib), M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649.
  • Johnston, G., Hanrahan, J., Collins (Chebib), M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.
  • Hall, B., Collins (Chebib), M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104.
  • Crittenden, D., Kumar, R., Hanrahan, J., Collins (Chebib), M., Jordan, M. (2005). Stabilization of zwitterions in solution: Phosphinic and phosphonic acid GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(37), 8398-8409.
  • Hall, B., Collins (Chebib), M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8.
  • Collins (Chebib), M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins (Chebib), M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Allan, R., Greenwood, J., Hambley, T., Hanrahan, J., Hibbs, D., Itani, S., Tran, H., Turner, P. (2004). Studies On Pyridazine Azide Cyclisation Reactions. Organic and Biomolecular Chemistry, 2(12), 1782-8-1788.
  • Hibbs, D., Hanrahan, J., Hursthouse, M., Knight, D., Overgaard, J., Turner, P., Piltz, R., Waller, M. (2003). Experimental and theoretical charge distribution in (Z)-N-methyl-C-phenylnitrone. Organic and Biomolecular Chemistry, 11(6), 1034-1040.
  • Waller, M., Hibbs, D., Overgaard, J., Hanrahan, J., Hambley, T. (2003). Flavone. Acta Crystallographica. Section E: Structure Reports Online, 59(6), o767-o768.
  • Johnston, G., Collins (Chebib), M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Hanrahan, J., Collins (Chebib), M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.
  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Collins (Chebib), M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.

Conferences

  • Campbell, E., Collins (Chebib), M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.

Patents

  • Collins (Chebib), M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins (Chebib), M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins (Chebib), M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.

2012

  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins (Chebib), M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896.
  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581.
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673.
  • Nguyen, T., Howard, S., Hanrahan, J., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and Theoretical Charge Density Distribution in a Host-Guest System: Synthetic Terephthaloyl Receptor Complexed to Adipic Acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116, 5618-5628.
  • Mohammad, A., Hanrahan, J., Sainsbury, E., Chaar, B. (2012). Fitness to practise in pharmacy: a study of impairment in professional practice. International Journal of Clinical Pharmacy, 34(2), 330-341.
  • Fernandez, S., Karim, N., Mewett, K., Collins (Chebib), M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977.
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557.
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins (Chebib), M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301.
  • Hanrahan, J. (2012). Sunscreens. Australian Prescriber, 35(5), 148-151.

2011

  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983.
  • Chaar, B., Brien, J., Hanrahan, J., McLachlan, A., Penm, J., Pont, L. (2011). Experimental Education in Australian Pharmacy: Preceptors' Perspectives. Pharmacy Education, 11(1), 166-171.
  • Hanrahan, J., Collins (Chebib), M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245.
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346.
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209.
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033.
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2, 11-16.
  • Chaar, B., Hanrahan, J., Day, C. (2011). Provision of Opioid Substitution Therapy Services in Australian Pharmacies. The Australasian Medical Journal, 4(4), 210-216.

2010

  • Nasrallah, F., Maher, A., Hanrahan, J., Balcar, V., Rae, C. (2010). Gamma-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. Journal of Neurochemistry, 115(1), 58-67.
  • Gavande, N., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136.
  • Johnston, G., Collins (Chebib), M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977.

2009

  • Matin, A., Gavande, N., Kim, M., Yang, N., Salam, N., Hanrahan, J., Roubin, R., Hibbs, D. (2009). 7-Hydroxy-benzopyran-4-one Derivatives: A Novel Pharmacophore of Peroxisome Proliferator-Activated Receptor and - (PPAR and ) Dual Agonists. Journal of Medicinal Chemistry, 52(21), 6835-6850.
  • Ryan, G., Hanrahan, J., Krass, I., Sainsbury, E., Smith, L. (2009). Best Practices Assessment to Guide Curricular Change in a Bachelor of Pharmacy Program. American Journal of Pharmaceutical Education, 73(1), 1-8.
  • Meng, Q., Niu, Y., Niu, X., Roubin, R., Hanrahan, J. (2009). Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine. Journal of Ethnopharmacology, 124(3), 350-368.
  • Collins (Chebib), M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711.
  • Collins (Chebib), M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins (Chebib), M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins (Chebib), M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457.
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins (Chebib), M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology, 17(20), 7156-7173.
  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, Andrew B~ (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins (Chebib), M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875.

2008

  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins (Chebib), M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327.
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins (Chebib), M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907.
  • Kumar, R., Collins (Chebib), M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840.

2007

  • Collins (Chebib), M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787.

2006

  • Hanrahan, J., Mewett, K., Collins (Chebib), M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649.
  • Johnston, G., Hanrahan, J., Collins (Chebib), M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier.
  • Johnston, G., Hanrahan, J., Collins (Chebib), M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.

2005

  • Hall, B., Collins (Chebib), M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104.
  • Collins (Chebib), M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.
  • Crittenden, D., Kumar, R., Hanrahan, J., Collins (Chebib), M., Jordan, M. (2005). Stabilization of zwitterions in solution: Phosphinic and phosphonic acid GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(37), 8398-8409.

2004

  • Hall, B., Collins (Chebib), M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8.
  • Collins (Chebib), M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins (Chebib), M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Allan, R., Greenwood, J., Hambley, T., Hanrahan, J., Hibbs, D., Itani, S., Tran, H., Turner, P. (2004). Studies On Pyridazine Azide Cyclisation Reactions. Organic and Biomolecular Chemistry, 2(12), 1782-8-1788.

2003

  • Hibbs, D., Hanrahan, J., Hursthouse, M., Knight, D., Overgaard, J., Turner, P., Piltz, R., Waller, M. (2003). Experimental and theoretical charge distribution in (Z)-N-methyl-C-phenylnitrone. Organic and Biomolecular Chemistry, 11(6), 1034-1040.
  • Waller, M., Hibbs, D., Overgaard, J., Hanrahan, J., Hambley, T. (2003). Flavone. Acta Crystallographica. Section E: Structure Reports Online, 59(6), o767-o768.
  • Johnston, G., Collins (Chebib), M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Hanrahan, J., Collins (Chebib), M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.

2002

  • Campbell, E., Collins (Chebib), M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.

2001

  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Collins (Chebib), M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.
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Keywords

Neurosciences; Neuropharmacology; Mental health

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