Associate Professor Jane Hanrahan

BSc (Hons) PhD (Warwick) MRACI Grad Dip EdStudies (Higher Ed)
Associate Professor, Pharmaceutical Sciences

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 2078
Fax +61 2 9351 4391

Biographical details

Associate Jane Professor Hanrahan has a BSc (Hons) from the University of Sydney. Jane undertook her PhD from The University of Warwick (UK) as a Teaching Fellow from 1991-95. From 1996-97 she undertook postdoctoral research at the University of Cardiff (UK), returning to the University of Sydney in 1997 as a Postdoctoral Research Associate in the department of Pharmacology.

In 2002 Jane was appointed to a lectureship in the Faculty of Pharmacy at the University of Sydney, and promoted to Senior Lecturer in 2007 and Associate Professor in 2010. She is currently a member of the University of Sydney Academic Board, chair of the Academic Board Undergraduate Studies Committee and deputy Chair of the Student Appeals Body. In 2013 Jane was appointed to the Therapeutic Goods Administration Advisory Committee on Prescription Medicines.

Research interests

Associate Professor Hanrahan's research interests focuses on the understanding the role of GABA receptors in anxiety, sleep disorders, schizophrenia, epilepsy and learning and memory, including:

  • Design and synthesis of conformationally restrained GABA analogues
  • Developing molecules that allosterically modulate GABA receptor function
  • Identifying and characterising natural products from traditional herbal medicines

Keywords

Neurosciences; Neuropharmacology; Mental health

Selected grants

2013

  • Sydney Neuroscience Network; Balleine B, Absalom N, Braddon-Mitchell D, Callaghan S, Chawla S, Christie M, Collins M, Einfeld S, Grieve S, Haber P, Hanrahan J, Harris A, Hickie I, Kassiou M, Kril J, Meikle S, Morris R, Ramos F, Rong Y, Sue C; DVC Research/Research Network Scheme (SyReNS).
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Allosteric Targets on GABA-A Receptors; Hanrahan J, Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Factors influencing pharmacy services in opiod substitution programs; Day C, Chaar B, Fois R, Hanrahan J; Health Administration Corporation/Research Support.

2009

  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins M, Johnston G, Young P, Traini D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The GABAergic system in eye growth control and myopia; Schmid K, Collins M, Hanrahan J; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • GABA c receptor antagonists as agents tor the treatment of memory disorders and myopia.; Hanrahan J, Kaufman G, Serry L; Neuro Therapeutics Ltd/BLO Project.
  • Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser; Lay P, Kable S, Downard K, Johnston G, Hanrahan J, Fisher K, Maschmeyer T, Karuso P, Gore D, McLeod M, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • GABA modulators for the treatment of anxiety, epilepsy and insomnia; Johnston G, Hanrahan J, Collins M, Mewett K; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Molecular and Materials Structure Network; Turner P, Kepert C, Collins M, Hambley T, Hanrahan J, Kennedy B, Lay P; Australian Research Council (ARC)/Research Networks (ARCRN).

2003

  • Constrained analogs of Gabapentin and Pregabalin; Collins M, O'Connor S, Hanrahan J, Johnston G; Pfizer Pty Ltd/Research Grants.
  • GABAC receptors and GABA release in the thalmus; Hanrahan J; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).

2002

  • Synthesis, testing and development of GABA-C antagonists, including cyclopentene phosphinates; Johnston G, Kaufman G, Serry L, Sharp S, Hanrahan J, Collins M; Polychip Pharmaceuticals Pty.Ltd./BLO Project.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, A.B. (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]

Journals

  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Collins, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PLoS One, 9(1), 1-16. [More Information]
  • Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. (2014). Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone. Neurochemical Research, 39, 1068-1078. [More Information]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Collins, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. A C S Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Meng, Q., Roubin, R., Hanrahan, J. (2013). Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. Journal of Ethnopharmacology, 148(1), 229-238. [More Information]
  • Chaar, B., Wang, H., Day, C., Hanrahan, J., Winstock, A., Fois, R. (2013). Factors influencing pharmacy services in opioid substitution treatment. Drug and Alcohol Review, 32(4), 426-434. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Collins, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]
  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Nguyen, T., Howard, S., Hanrahan, J., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and Theoretical Charge Density Distribution in a Host-Guest System: Synthetic Terephthaloyl Receptor Complexed to Adipic Acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116, 5618-5628. [More Information]
  • Mohammad, A., Hanrahan, J., Sainsbury, E., Chaar, B. (2012). Fitness to practise in pharmacy: a study of impairment in professional practice. International Journal of Clinical Pharmacy, 34(2), 330-341. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]
  • Hanrahan, J. (2012). Sunscreens. Australian Prescriber, 35(5), 148-151.
  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Chaar, B., Brien, J., Hanrahan, J., McLachlan, A., Penm, J., Pont, L. (2011). Experimental Education in Australian Pharmacy: Preceptors' Perspectives. Pharmacy Education, 11(1), 166-171.
  • Hanrahan, J., Collins, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2(1), 11-16. [More Information]
  • Chaar, B., Hanrahan, J., Day, C. (2011). Provision of Opioid Substitution Therapy Services in Australian Pharmacies. The Australasian Medical Journal, 4(4), 210-216. [More Information]
  • Nasrallah, F., Maher, A., Hanrahan, J., Balcar, V., Rae, C. (2010). Gamma-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. Journal of Neurochemistry, 115(1), 58-67. [More Information]
  • Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Matin, A., Gavande, N., Kim, M., Yang, N., Salam, N., Hanrahan, J., Roubin, R., Hibbs, D. (2009). 7-Hydroxy-benzopyran-4-one Derivatives: A Novel Pharmacophore of Peroxisome Proliferator-Activated Receptor and - (PPAR and ) Dual Agonists. Journal of Medicinal Chemistry, 52(21), 6835-6850. [More Information]
  • Ryan, G., Hanrahan, J., Krass, I., Sainsbury, E., Smith, L. (2009). Best Practices Assessment to Guide Curricular Change in a Bachelor of Pharmacy Program. American Journal of Pharmaceutical Education, 73(1), 1-8.
  • Meng, Q., Niu, Y., Niu, X., Roubin, R., Hanrahan, J. (2009). Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine. Journal of Ethnopharmacology, 124(3), 350-368. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Collins, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]
  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Collins, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]
  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Crittenden, D., Kumar, R., Hanrahan, J., Collins, M., Jordan, M. (2005). Stabilization of zwitterions in solution: Phosphinic and phosphonic acid GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(37), 8398-8409. [More Information]
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Allan, R., Greenwood, J., Hambley, T., Hanrahan, J., Hibbs, D., Itani, S., Tran, H., Turner, P. (2004). Studies On Pyridazine Azide Cyclisation Reactions. Organic and Biomolecular Chemistry, 2(12), 1782-8-1788.
  • Hibbs, D., Hanrahan, J., Hursthouse, M., Knight, D., Overgaard, J., Turner, P., Piltz, R., Waller, M. (2003). Experimental and theoretical charge distribution in (Z)-N-methyl-C-phenylnitrone. Organic and Biomolecular Chemistry, 11(6), 1034-1040.
  • Waller, M., Hibbs, D., Overgaard, J., Hanrahan, J., Hambley, T. (2003). Flavone. Acta Crystallographica. Section E: Structure Reports Online, 59(6), o767-o768.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Hanrahan, J., Collins, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.
  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.

Conferences

  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.

Patents

  • Collins, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.

2014

  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Collins, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PLoS One, 9(1), 1-16. [More Information]
  • Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. (2014). Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone. Neurochemical Research, 39, 1068-1078. [More Information]

2013

  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Collins, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. A C S Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Meng, Q., Roubin, R., Hanrahan, J. (2013). Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. Journal of Ethnopharmacology, 148(1), 229-238. [More Information]
  • Chaar, B., Wang, H., Day, C., Hanrahan, J., Winstock, A., Fois, R. (2013). Factors influencing pharmacy services in opioid substitution treatment. Drug and Alcohol Review, 32(4), 426-434. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Collins, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]

2012

  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Nguyen, T., Howard, S., Hanrahan, J., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and Theoretical Charge Density Distribution in a Host-Guest System: Synthetic Terephthaloyl Receptor Complexed to Adipic Acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116, 5618-5628. [More Information]
  • Mohammad, A., Hanrahan, J., Sainsbury, E., Chaar, B. (2012). Fitness to practise in pharmacy: a study of impairment in professional practice. International Journal of Clinical Pharmacy, 34(2), 330-341. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]
  • Hanrahan, J. (2012). Sunscreens. Australian Prescriber, 35(5), 148-151.

2011

  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Chaar, B., Brien, J., Hanrahan, J., McLachlan, A., Penm, J., Pont, L. (2011). Experimental Education in Australian Pharmacy: Preceptors' Perspectives. Pharmacy Education, 11(1), 166-171.
  • Hanrahan, J., Collins, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2(1), 11-16. [More Information]
  • Chaar, B., Hanrahan, J., Day, C. (2011). Provision of Opioid Substitution Therapy Services in Australian Pharmacies. The Australasian Medical Journal, 4(4), 210-216. [More Information]

2010

  • Nasrallah, F., Maher, A., Hanrahan, J., Balcar, V., Rae, C. (2010). Gamma-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. Journal of Neurochemistry, 115(1), 58-67. [More Information]
  • Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]

2009

  • Matin, A., Gavande, N., Kim, M., Yang, N., Salam, N., Hanrahan, J., Roubin, R., Hibbs, D. (2009). 7-Hydroxy-benzopyran-4-one Derivatives: A Novel Pharmacophore of Peroxisome Proliferator-Activated Receptor and - (PPAR and ) Dual Agonists. Journal of Medicinal Chemistry, 52(21), 6835-6850. [More Information]
  • Ryan, G., Hanrahan, J., Krass, I., Sainsbury, E., Smith, L. (2009). Best Practices Assessment to Guide Curricular Change in a Bachelor of Pharmacy Program. American Journal of Pharmaceutical Education, 73(1), 1-8.
  • Meng, Q., Niu, Y., Niu, X., Roubin, R., Hanrahan, J. (2009). Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine. Journal of Ethnopharmacology, 124(3), 350-368. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Collins, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, A.B. (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]

2008

  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Collins, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]

2007

  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]

2006

  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.

2005

  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Collins, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.
  • Crittenden, D., Kumar, R., Hanrahan, J., Collins, M., Jordan, M. (2005). Stabilization of zwitterions in solution: Phosphinic and phosphonic acid GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(37), 8398-8409. [More Information]

2004

  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Allan, R., Greenwood, J., Hambley, T., Hanrahan, J., Hibbs, D., Itani, S., Tran, H., Turner, P. (2004). Studies On Pyridazine Azide Cyclisation Reactions. Organic and Biomolecular Chemistry, 2(12), 1782-8-1788.

2003

  • Hibbs, D., Hanrahan, J., Hursthouse, M., Knight, D., Overgaard, J., Turner, P., Piltz, R., Waller, M. (2003). Experimental and theoretical charge distribution in (Z)-N-methyl-C-phenylnitrone. Organic and Biomolecular Chemistry, 11(6), 1034-1040.
  • Waller, M., Hibbs, D., Overgaard, J., Hanrahan, J., Hambley, T. (2003). Flavone. Acta Crystallographica. Section E: Structure Reports Online, 59(6), o767-o768.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Hanrahan, J., Collins, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.

2002

  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.

2001

  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.

For support on your academic profile contact .